Physical Review B最新文献

Superficial temporal artery (STA) to middle cerebral artery (MCA) bypass surgery for internal carotid artery (ICA) occlusive disease necessarily requires sufficient external carotid artery (ECA) blood flow. Surgical bypass is therefore precluded if there is common carotid artery (CCA) occlusion. Here we present two such cases: one patient had a CCA occlusion and the other had an ICA occlusion and ECA stenosis. Both had failed medical management, and were therefore treated with angioplasty and stenting of the ECA, followed by STA-MCA bypass. We describe the clinical and radiologic outcomes of these cases, and remark on the potential pitfalls associated with this novel approach.

Objective: Childhood trauma is highly prevalent and can have a negative impact on the development of socioemotional processes resulting in a higher vulnerability for mental disorders in adulthood. Previous studies have associated the severity of childhood trauma with deficits in social functioning, such as a negative attention bias, suggesting altered social information processing as a mechanism underlying the association between childhood trauma and transdiagnostic psychopathologies.

Method: In a cross-sectional setup with a total of 103 participants (26 with major depressive disorder, MDD; 24 with posttraumatic stress disorder, PTSD; 22 with somatic symptom disorder, SDD; and 31 healthy volunteers, HV), this study applied eye tracking in an emotion recognition paradigm. Reaction times, accuracy, and gaze behavior were analyzed for 4 different facial expressions as a function of self-reported childhood trauma and diagnosis. The aim was to investigate to what extent emotion processing is associated with (a) childhood trauma, (b) psychopathology, and (c) respective interacting effects.

Results: Patients showed higher reaction times and error rates overall in classifying emotions than HVs, especially for the recognition of anger and fear. Individuals with a diagnosis of PTSD and MDD were particularly slow in their response to these emotions. Higher scores of reported childhood trauma were associated with faster responses for classifying anger and fear and slower initiation of eye movements for SSD, MDD, and HVs for anger.

Conclusion: These findings indicate that childhood trauma may contribute to attentional and information-processing biases relevant for social interaction. Identifying individual social deficits offers implications for tailored therapeutic interventions. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Research into the disequilibrium of microglial phenotypes has become an area of intense focus in neurodegenerative disease as a potential mechanism that contributes to chronic neuroinflammation and neuronal loss in Parkinson's disease (PD). There is growing evidence that neuroinflammation accompanies and may promote progression of alpha-synuclein (Asyn)-induced nigral dopaminergic (DA) degeneration. From a therapeutic perspective, development of immunomodulatory strategies that dampen overproduction of pro-inflammatory cytokines from chronically activated immune cells and induce a pro-phagocytic phenotype is expected to promote Asyn removal and protect vulnerable neurons. Cannabinoid receptor-2 (CB2) is highly expressed on activated microglia and peripheral immune cells, is upregulated in the substantia nigra of individuals with PD and in mouse models of nigral degeneration. Furthermore, modulation of CB2 protects against rotenone-induced nigral degeneration; however, CB2 has not been pharmacologically and selectively targeted in an Asyn model of PD. Here, we report that 7 weeks of peripheral administration of CB2 inverse agonist SMM-189 reduced phosphorylated (pSer129) alpha-synuclein in the substantia nigra compared to vehicle treatment. Additionally, SMM-189 delayed Asyn-induced immune cell infiltration into the brain as determined by flow cytometry, increased CD68 protein expression, and elevated wound-healing-immune-mediator gene expression. Additionally, peripheral immune cells increased wound-healing non-classical monocytes and decreased pro-inflammatory classical monocytes. In vitro analysis of RAW264.7 macrophages treated with lipopolysaccharide (LPS) and SMM-189 revealed increased phagocytosis as measured by the uptake of fluorescence of pHrodo E. coli bioparticles. Together, results suggest that targeting CB2 with SMM-189 skews immune cell function toward a phagocytic phenotype and reduces toxic aggregated species of Asyn. Our novel findings demonstrate that CB2 may be a target to modulate inflammatory and immune responses in proteinopathies.

The Covid-19 pandemic has highlighted the precarity of urban society, illustrating both opportunities and challenges. Teleworking rates increased dramatically during the pandemic and may be sustained over the long term. For transportation planners, these changes belie the broader questions of how the geography of work and commuting will change based on pandemic-induced shifts in teleworking and what this will mean for society and policymaking. This study focuses on these questions by using survey data (n = 2580) gathered in the autumn of 2021 to explore the geography of current and prospective telework. The study focuses on the Greater Golden Horseshoe, the mega-region in Southern Ontario, representing a fifth of Canadians. Survey data document telework practices before and during the pandemic, including prospective future telework practices. Inferential models are used to develop working-from-home scenarios which are allocated spatially based on respondents' locations of work and residence. Findings indicate that telework appears to be poised to increase most relative to pre-pandemic levels around downtown Toronto based on locations of work, but increases in teleworking are more dispersed based on employees' locations of residence. Contrary to expectations by many, teleworking is not significantly linked to home-work disconnect - suggesting that telework is poised to weaken the commute-housing trade-off embedded in bid rent theory. Together, these results portend a poor outlook for downtown urban agglomeration economies but also more nuanced impacts than simply inducing sprawl.

Objective: Cisplatin-associated acute kidney injury is a common clinical event that causes increased morbidity and mortality in cancer patients even if they are categorized as having normal functioning kidneys. We aimed to determine predictive factors that can predict acute kidney injury associated with cisplatin therapy in patients with normal renal function by comparison of pre-chemotherapy estimated glomerular filtration rates calculated separately by Cockcroft and Gault (CG), the Modification of Diet in Renal Disease (MDRD), and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPİ) equations and accompanying patient-associated factors.

Materials and methods: A total of 200 patients diagnosed with lung cancer and determined to have normal functioning kidneys and considered cisplatin eligible by the attending physician before chemotherapy were included in this retrospective study. Acute kidney injury after cisplatin chemotherapy (c-AKI) was determined according to the National Cancer Institute's Common Terminology Criteria for Adverse Events v4.03. Pre-chemotherapy serum laboratory parameters and clinico-histopathological characteristics of patients were recorded from the hospital electronic system. The optimal cut-off for eGFR methods was determined by the area under the receiver operating characteristic curve (ROC-AUC) analysis. Predictive factor analysis for c-AKI was performed by regression analyses.

Results: C-AKI developed in 39 (19.5%) patients. In the univariate analysis, a significant correlation was observed between c-AKI and high body mass index (BMI) before treatment, older age (>62.5), female gender, eGFR by MDRD (≤94.5 mL/min) and eGFR by CKD-EPI (≤91.5 mL/min). There was no relation between eGFR by CG and c-AKI. Two different multivariate models were established. Model 1 showed that female gender (odds ratio [OR] =4.90, 95% confidence interval [CI]: 1.52-15.79, P = 0.008) and eGFR by MDRD less than or equal to 94.5 mL/min (OR = 3.52, 95% CI: 1.68-7.38, P = 0.001) were predictive markers for c-AKI. In Multivariate Model 2, female gender (OR = 5.51, 95% CI: 1.70-17.83, P = 0.004) and eGFR by CKD-EPI less than or equal to 91.5 mL/min (OR = 3.52, 95% CI: 1.67-7.42, P = 0.001) were found to be predictive markers for c-AKI.

Conclusions: This study revealed that eGFR calculated based on MDRD (≤94.5 mL/min/m2) or CKD-EPI (≤91.5 mL/min/m2) before chemotherapy indicates a strong tendency for c-AKI. In addition, we detected a high risk of c-AKI for females compared to their counterparts. Although eGFR 60 mL/min is considered the threshold level to accept patients as cisplatin-eligible, we recommend close follow-up of high-risk patients for cisplatin nephrotoxicity we detected in our models.

Purpose: The study aims to investigate the prevalence of individuals with disabilities who reported using wearable devices, to examine the association between wearable device usage and disability status, and to determine the characteristic of individuals with disabilities associated with wearable device usage using the 2017 Behavioural Risk Factor Surveillance System (BRFSS) through secondary data analysis.

Materials and methods: Data from the 2017 BRFSS of eight states were used in the analysis. Descriptive analysis, chi-square analysis, and multivariable logistic regressions were performed. Subsample analyses were also conducted for individuals with disabilities and different types of disability, including visual impairments, hearing impairments, cognitive disability, independent living disability, self-care disability, and mobility disability on wearable device usage.

Results: 14.6% (95% CI [11.7, 17.5]) of participants with disabilities were wearable device users. Individuals with disabilities were .63 (95% CI [.48, .83], p < 0.001) and .67 (95% CI [.50, .90], p = 0.007) times the odds of individuals without disabilities in using wearable devices, respectively, according to unadjusted and adjusted logistic regression. Individuals with mobility disability were less likely to utilise wearable devices than their counterparts. Among individuals with disabilities, those who were age 65 years or older had a lower odds of using wearable devices (OR = .55, 95% CI [0.35, 0.85), p = 0.007).

Conclusion: Individuals with disabilities are using wearable devices in collecting various health-related information. Further research is needed to determine reasons why individuals with disabilities are not using wearable devices and how individuals with disabilities are using wearable devices.IMPLICATIONS FOR REHABILITATIONWearable devices can track various health-related information such as physical activity levels, sleep patterns, calories intakes, and chronic health conditions.Using nationally represent data, individuals with disabilities have access and utilise wearable devices in free living setting.Compare to individuals without disabilities, individuals with disabilities are less likely to utilise wearable devices in free living setting.Further research is needed to determine the accessibility of wearable devices for individuals with disabilities and its usage in rehabilitation setting.

Interfollicular Hodgkin's lymphoma (IFHL) is a rare pattern of classical Hodgkin's lymphoma (CHL) showing reactive follicular hyperplasia with involvement of the interfollicular area by HL. Two cases are reported in this study having primary IFHL out of total of 500 cases of CHL reported at our center. Diagnosis of IFHL was made on the basis of morphological and immunohistochemical features. As they represent an early stage of the disease, their identification and awareness s very important to get proper treatment at its earliest. This variant is very unusual and is diagnostically challenging for pathologists.