Pub Date : 2016-06-01DOI: 10.1016/j.nurpra.2016.04.010
S. Wilbanks
{"title":"Test Your KnowledgeEffects of Lead Exposure","authors":"S. Wilbanks","doi":"10.1016/j.nurpra.2016.04.010","DOIUrl":"https://doi.org/10.1016/j.nurpra.2016.04.010","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"12 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nurpra.2016.04.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54944933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-01DOI: 10.1016/j.nurpra.2016.03.020
Cindy Cooke
{"title":"From the AANP PresidentMake a Difference","authors":"Cindy Cooke","doi":"10.1016/j.nurpra.2016.03.020","DOIUrl":"https://doi.org/10.1016/j.nurpra.2016.03.020","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"12 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nurpra.2016.03.020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54944633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peanut, soybean, sesame and lentil are members of legumes worldwide consumed by human that can induce food allergy in genetically predisposed individuals. Several protein allergens, mainly water-soluble, have been described. We studied the non water-soluble fraction from these 4 food sources using immunoproteomics tools and techniques. Flour extracts were solubilized in detergent and chaotropes and analysed in 1 and 2 dimensional gel electrophoresis (2D). Results showed numerous proteins exhibiting wide ranges of isoelectric points and relative molecular masses. When IgE immunoreactivities of 18 food allergy patients were individually tested in 1 and 2D western-blots, a very diversified IgE repertoire was observed, reflecting extensive cross-reactivities but also co-sensitizations. Besides already well known and characterized allergens, mass spectrometry analysis allowed the identification of 22 allergens undescribed until now: 10 in peanut, 2 in soybean, 3 in sesame and 7 in lentil. Three allergens are legume storage proteins and the others belong to transport proteins, nucleotide binding proteins and proteins involved in the regulation of metabolism. Seven proteins are potentially similar to allergens described in plants and fungi and 11 are not related to any known allergen. Our results contribute to increase the repertoire of legume allergens that may improve the diagnosis, categorize patients and thus provide a better treatment of patients.
{"title":"[Immunoproteomics of non water-soluble allergens from 4 legumes flours: peanut, soybean, sesame and lentil].","authors":"Hayette Bouakkadia, Aissa Boutebba, Iman Haddad, Joëlle Vinh, Laurence Guilloux, Jean-Pierre Sutra, Hélène Sénéchal, Pascal Poncet","doi":"10.1684/abc.2015.1089","DOIUrl":"10.1684/abc.2015.1089","url":null,"abstract":"<p><p>Peanut, soybean, sesame and lentil are members of legumes worldwide consumed by human that can induce food allergy in genetically predisposed individuals. Several protein allergens, mainly water-soluble, have been described. We studied the non water-soluble fraction from these 4 food sources using immunoproteomics tools and techniques. Flour extracts were solubilized in detergent and chaotropes and analysed in 1 and 2 dimensional gel electrophoresis (2D). Results showed numerous proteins exhibiting wide ranges of isoelectric points and relative molecular masses. When IgE immunoreactivities of 18 food allergy patients were individually tested in 1 and 2D western-blots, a very diversified IgE repertoire was observed, reflecting extensive cross-reactivities but also co-sensitizations. Besides already well known and characterized allergens, mass spectrometry analysis allowed the identification of 22 allergens undescribed until now: 10 in peanut, 2 in soybean, 3 in sesame and 7 in lentil. Three allergens are legume storage proteins and the others belong to transport proteins, nucleotide binding proteins and proteins involved in the regulation of metabolism. Seven proteins are potentially similar to allergens described in plants and fungi and 11 are not related to any known allergen. Our results contribute to increase the repertoire of legume allergens that may improve the diagnosis, categorize patients and thus provide a better treatment of patients. </p>","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"13 1","pages":"690-704"},"PeriodicalIF":0.5,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/abc.2015.1089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67554756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-03-01DOI: 10.1016/j.nurpra.2015.01.033
P. Young
{"title":"Letter to the EditorLetter to the Editor","authors":"P. Young","doi":"10.1016/j.nurpra.2015.01.033","DOIUrl":"https://doi.org/10.1016/j.nurpra.2015.01.033","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"11 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nurpra.2015.01.033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54927350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-06-01DOI: 10.1016/j.nurpra.2014.04.011
S. Wilbanks
{"title":"Test Your KnowledgePulmonary Hypertension","authors":"S. Wilbanks","doi":"10.1016/j.nurpra.2014.04.011","DOIUrl":"https://doi.org/10.1016/j.nurpra.2014.04.011","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"10 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nurpra.2014.04.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54915598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.1016/j.nurpra.2013.11.002
S. Wilbanks
{"title":"Test Your KnowledgeEndometrial Cancer","authors":"S. Wilbanks","doi":"10.1016/j.nurpra.2013.11.002","DOIUrl":"https://doi.org/10.1016/j.nurpra.2013.11.002","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"10 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nurpra.2013.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54911863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-03-01DOI: 10.1016/J.NURPRA.2013.02.011
T. Shafer
{"title":"Letter to the EditorLetter to the Editor","authors":"T. Shafer","doi":"10.1016/J.NURPRA.2013.02.011","DOIUrl":"https://doi.org/10.1016/J.NURPRA.2013.02.011","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"9 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.NURPRA.2013.02.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54905856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-11-01DOI: 10.1016/j.nurpra.2012.09.014
R. Hess
{"title":"Letter to the EditorLetter to the Editor","authors":"R. Hess","doi":"10.1016/j.nurpra.2012.09.014","DOIUrl":"https://doi.org/10.1016/j.nurpra.2012.09.014","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"8 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nurpra.2012.09.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54902722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-06-01DOI: 10.1016/j.nurpra.2012.04.006
M. Edmunds
{"title":"Women Fit at Fifty: A Guide for Living Long, Mary Kathryn Macklin (Ed.). Authorhouse Publishing, Bloomington (2011)","authors":"M. Edmunds","doi":"10.1016/j.nurpra.2012.04.006","DOIUrl":"https://doi.org/10.1016/j.nurpra.2012.04.006","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"8 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nurpra.2012.04.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54897058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-03-01DOI: 10.1016/J.NURPRA.2011.01.018
C. Snyder, Lynda Facchiano
{"title":"An Evidence-based Critical Appraisal of a Topic:: Effectiveness of High Dose Donepezil for Advanced Alzheimer's Disease","authors":"C. Snyder, Lynda Facchiano","doi":"10.1016/J.NURPRA.2011.01.018","DOIUrl":"https://doi.org/10.1016/J.NURPRA.2011.01.018","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"37 1","pages":"201-206"},"PeriodicalIF":1.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.NURPRA.2011.01.018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54881727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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