Pub Date : 2009-05-01DOI: 10.1016/J.NURPRA.2009.02.009
Kathleen R. Tusaie, Sheri Acierto, A. Murray, K. Fitzgerald, S. Chiu
{"title":"Screening for Adolescent Self-Injury: A Survey of Ohio Advanced Practice Nurses","authors":"Kathleen R. Tusaie, Sheri Acierto, A. Murray, K. Fitzgerald, S. Chiu","doi":"10.1016/J.NURPRA.2009.02.009","DOIUrl":"https://doi.org/10.1016/J.NURPRA.2009.02.009","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"41 1","pages":"359-364"},"PeriodicalIF":1.0,"publicationDate":"2009-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.NURPRA.2009.02.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54868585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-01DOI: 10.1016/j.nurpra.2009.01.011
S. Wilbanks, S. Wilbanks
{"title":"Test Your KnowledgePediatric Obesity","authors":"S. Wilbanks, S. Wilbanks","doi":"10.1016/j.nurpra.2009.01.011","DOIUrl":"https://doi.org/10.1016/j.nurpra.2009.01.011","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"5 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2009-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nurpra.2009.01.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54868376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-01DOI: 10.1016/j.nurpra.2009.01.010
S. Wilbanks, S. Wilbanks
{"title":"Test Your KnowledgeTeen Substance Abuse","authors":"S. Wilbanks, S. Wilbanks","doi":"10.1016/j.nurpra.2009.01.010","DOIUrl":"https://doi.org/10.1016/j.nurpra.2009.01.010","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"5 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2009-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nurpra.2009.01.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54868319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-10-01DOI: 10.1016/J.NURPRA.2008.08.005
Laura A. Ruby
{"title":"Polycystic Ovarian Syndrome: An Evidence-Based Approach to Reducing Metabolic Consequences","authors":"Laura A. Ruby","doi":"10.1016/J.NURPRA.2008.08.005","DOIUrl":"https://doi.org/10.1016/J.NURPRA.2008.08.005","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"4 1","pages":"697-704"},"PeriodicalIF":1.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.NURPRA.2008.08.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54864495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-05-01DOI: 10.1016/J.NURPRA.2008.03.008
S. Wilbanks, S. Wilbanks
{"title":"Test Your KnowledgeMenopause","authors":"S. Wilbanks, S. Wilbanks","doi":"10.1016/J.NURPRA.2008.03.008","DOIUrl":"https://doi.org/10.1016/J.NURPRA.2008.03.008","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"4 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2008-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.NURPRA.2008.03.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54861970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-07-01DOI: 10.1016/J.NURPRA.2007.05.002
Pamela Wadsworth
{"title":"Plan B: Dual Label: The Nurse Practitioner's Role in Education and Provision","authors":"Pamela Wadsworth","doi":"10.1016/J.NURPRA.2007.05.002","DOIUrl":"https://doi.org/10.1016/J.NURPRA.2007.05.002","url":null,"abstract":"","PeriodicalId":48727,"journal":{"name":"Jnp-Journal for Nurse Practitioners","volume":"73 1","pages":"470-474"},"PeriodicalIF":1.0,"publicationDate":"2007-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.NURPRA.2007.05.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54855405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The potent antioxidant properties of rosemary (Rosmarinus officinalis) extracts have been attributed to its major diterpene, carnosic acid. Carnosic acid has received considerable attention in food science and biomedicine, but little is known about its function in the plant in vivo. We recently found that highly oxidized diterpenes increase in rosemary plants exposed to drought and high light stress as a result of the antioxidant activity of carnosic acid (S. Munné-Bosch, K. Schwarz, L. Alegre [1999] Plant Physiol 121: 1047-1052). To elucidate the significance of the antioxidant function of carnosic acid in vivo we measured the relative amounts of carnosic acid and its metabolites in different compartments of rosemary leaves. Subcellular localization studies show that carnosic acid protects chloroplasts from oxidative stress in vivo by following a highly regulated compartmentation of oxidation products. Carnosic acid scavenges free radicals within the chloroplasts, giving rise to diterpene alcohols, mainly isorosmanol. This oxidation product is O-methylated within the chloroplasts, and the resulting form, 11,12-di-O-methylisorosmanol, is transferred to the plasma membrane. This appears to represent a mechanism of a way out for free radicals from chloroplasts. Carnosic acid also undergoes direct O-methylation within the chloroplasts, and its derived product, 12-O-methylcarnosic acid, accumulates in the plasma membrane. O-methylated diterpenes do not display antioxidant activity, but they may influence the stability of the plasma membrane. This study shows the relevance of the compartmentation of carnosic acid metabolism to the protection of rosemary plants from oxidative stress in vivo.
迷迭香（Rosmarinus officinalis）提取物的强效抗氧化特性归功于其主要的二萜--肉豆蔻酸。肉苁蓉酸在食品科学和生物医学领域受到了广泛关注，但人们对其在植物体内的功能却知之甚少。我们最近发现，在受到干旱和强光胁迫的迷迭香植物中，高度氧化的二萜会增加，这是肉豆蔻酸抗氧化活性的结果（S. Munné-Bosch, K. Schwarz, L. Alegre [1999] Plant Physiol 121: 1047-1052）。为了阐明左旋肉碱在体内抗氧化功能的重要性，我们测量了迷迭香叶片不同区块中左旋肉碱及其代谢物的相对含量。亚细胞定位研究表明，肌肽酸通过高度调节氧化产物的分区，保护叶绿体免受体内氧化应激。肉豆蔻酸清除叶绿体内的自由基，生成二萜醇，主要是异马那酚。这种氧化产物在叶绿体内被 O-甲基化，生成的 11,12-二-O-甲基异山梨醇被转移到质膜上。这似乎是叶绿体中自由基的一种出路机制。肉豆蔻酸也会在叶绿体内直接进行 O-甲基化，其衍生产物 12-O-甲基肉豆蔻酸会在质膜上积聚。O-甲基化的二萜不具有抗氧化活性，但可能会影响质膜的稳定性。这项研究表明，肉豆蔻酸代谢的分区与保护迷迭香植物免受体内氧化应激有关。
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