Clinics in Colon and Rectal Surgery最新文献

Although surgical resection could provide better survival for patients with colorectal cancer liver metastases (CRLM), the recurrence rate after resection of CRLM remains high. The progress of genome sequencing technologies has greatly improved the molecular understanding of colorectal cancer. In the era of genomics and targeted therapy, genetic mutation analysis is of great significance to guide systemic treatment and identify patients who can benefit from resection of CRLM. RAS and BRAF mutations and microsatellite instability/deficient deoxyribonucleic acid (DNA) mismatch repair status have been incorporated into current clinical practice. Other promising molecular biomarkers such as coexisting gene mutations and circulating tumor DNA are under active investigation. This study aimed to review the prognostic significance of molecular biomarkers in patients with CRLM undergoing metastasectomy based on the current evidence.

The pathogenesis, clinical phenotype, treatment strategy, and family management of hereditary tumor syndromes are different from those of sporadic tumors. Nearly a quarter of patients with colorectal cancer show significant familial aggregation and genetic predisposition, and 5 to 10% are associated with definite genetic factors. According to the clinical phenotype, it can be divided into nonpolyposis syndrome and polyposis syndrome. Among the polyposis syndrome patients with definite clinical symptoms, there are still some patients with unknown etiology (especially attenuated familial adenomatous polyposis), which is a difficult problem in clinical diagnosis and treatment. Therefore, for this rare disease, it is urgent to carry out multicenter studies, complete the gene variation spectrum, explore new pathogenic factors, and accumulate clinical experience. This article mainly introduces the research progress and related work of colorectal polyposis syndrome in China.

Immunotherapy with PD-1 blockade has achieved a great success in colorectal cancers (CRCs) with high microsatellite instability (MSI-H) and deficient mismatch repair (dMMR), and has become the first-line therapy in metastatic setting. Studies of neoadjuvant immunotherapy also report exciting results, showing high rates of clinical complete response (cCR) and pathological complete response. The high efficacy and long duration of response of immunotherapy has prompt attempts to adopt watch-and-wait strategy for patients achieving cCR following the treatment. Thankfully, the watch-and-wait approach has been proposed for nearly 20 years for patients undergoing chemoradiotherapy and has gained ground among patients as well as clinicians. In this narrative review, we combed through the available information on immunotherapy for CRC and on the watch-and-wait strategy in chemoradiotherapy, and looked forward to a future where neoadjuvant immunotherapy as a curative therapy would play a big part in the treatment of MSI-H/dMMR CRC.

Women started to enter the specialty of colon and rectal surgery in the early 1970s. However, it was rare for a woman to hold a leadership position in the specialty before 2000. Since then, considerable progress has been made, although the percentage of women leaders does not yet approach the percentage of women in the field. This article focuses on the history of women in leadership positions in the American Board of Colon and Rectal Surgery, the American Society of Colon and Rectal Surgeons, the American Society of Colon and Rectal Surgeons Research Foundation, and the Association of Program Directors in Colon and Rectal Surgery as well the Diseases of the Colon and Rectum and academic departments. Early women leaders shared some common attributes that have contributed to their success. This article reviews some barriers to increasing the number of women in leadership positions; most will be reviewed in other sections in this issue.

Patients expect high-quality surgical care and increasingly are looking for ways to assess the quality of the surgeon they are seeing, but quality measurement is often more complicated than one might expect. Measurement of individual surgeon quality in a manner that allows for comparison among surgeons is particularly difficult. While the concept of measuring individual surgeon quality has a long history, technology now allows for new and innovative ways to measure and achieve surgical excellence. However, some recent efforts to make surgeon-level quality data publicly available have highlighted the challenges of this work. Through this chapter, the reader will be introduced to a brief history of surgical quality measurement, learn about the current state of quality measurement, and get a glimpse into what the future holds.

Allyship and mentorship are two critical aspects needed not only to promote the growth of success of people around us, but also to advocate for those that are not as fortunate and are often excluded or marginalized. Understanding the distinctions and commonalities between the two, as well as the required interdependence, will go a long way toward ensuring that an impact toward positive change is made in the future.

The concept of equity ensures that each individual is given the environment, treatment, and resources needed to reach an equal outcome to those around them. Equity is central to initiatives for advancing diversity and inclusion among physicians. This article will identify key barriers to equity that women surgeons face within the professional setting. More specifically, inadequate female representation, discrimination in the form of unconscious gender bias and microaggressions, and sexual harassment will be explored regarding their continued threats to gender equity, as well as constructive ways to mitigate these effects.

Despite increasing female representation in U.S. medical schools, women remain underrepresented in academic surgery departments across the country. Even as the gap narrows in academic surgery, female surgeons' professional advancement does not parallel that of their male counterparts. This article explores how to continue to advance women in academic surgery, first by considering the barriers women surgeons face, then offering actionable steps-on the individual, interpersonal, and systems levels-to overcome these barriers and work toward gender equity.

Career transitions are an essential part of the evolution of one's professional life. Transitions can take place at any time and for a variety of reasons. In this article, I review career transitions in the context of my own experiences and offer some advice and guidelines for making a career transition. The article also reviews what opportunities exist for career development and how that can lead to new and future prospects. Finally, achieving work-life balance can be difficult in today's health care landscape. Setting priorities and revisiting one's life plan on a regular basis establishes a professional "true north" to help navigate the challenges and disruptions of health care.