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Skin care by washing with water is not inferior to washing with a cleanser in children with atopic dermatitis in remission in summer: WASH study 对于夏季特应性皮炎缓解期的儿童来说,用清水洗脸的护肤效果并不比用清洁剂洗脸差:讲卫生运动研究
IF 6.8 2区 医学 Q1 ALLERGY Pub Date : 2024-02-02 DOI: 10.1016/j.alit.2024.01.007
Yukiko Katoh , Osamu Natsume , Ryuhei Yasuoka , Satoshi Hayano , Eisaku Okada , Yutaka Ito , Akira Sakai , Yoko Monna , Fumitaka Takayanagi , Yusuke Inuzuka , Yuji Sakakura

Background

Washing with water is not inferior to washing with soaps and detergents in children with atopic dermatitis (AD) in remission during the fall-winter seasons. We investigated whether this finding varies during summer based on the type of cleanser (soaps and detergents).

Methods

This evaluator-blinded, pragmatic, randomized, and non-inferiority study enrolled patients with AD whose eczema was controlled following regular steroid ointment application 2 days/week. For 8 ± 4 weeks, participants washed their upper and lower limbs with a cleanser on one side and with water alone on the other. Each participant chose either a weakly alkaline soap or an acidic detergent. The primary outcome was the Eczema Area and Severity Index (EASI) score at week 8 ± 4.

Results

The data of 43 of the 47 registered participants were analyzed. The median patient age was 44 (23–99) months; 28 and 15 participants chose weakly alkaline and acidic cleansers, respectively. At week 8 ± 4, EASI scores of the water and cleanser sides were 0.00 (0.00–0.40) and 0.15 (0.00–0.40), respectively (p = 0.74). The difference between both sides was 0.00 (−0.07 to 0.14); the limits of the 95 % confidence interval did not reach the pre-specified non-inferiority margin. No difference was observed in the median Patient-Oriented Eczema Measure score, number of additional steroid ointment applications, and occurrences of skin infections. There were no differences between the cleanser types in any of the results.

Conclusions

We demonstrated that washing with water was not inferior to that with a cleanser in patients with AD in the maintenance phase during summer, regardless of the type of cleanser.

背景对于秋冬季节病情缓解的特应性皮炎(AD)患儿,用清水清洗并不比用肥皂和清洁剂清洗效果差。我们研究了这一结论在夏季是否会因清洁剂(肥皂和清洁剂)的类型而有所不同。方法这项由评估者盲法、实用性、随机和非劣效的研究招募了在每周 2 天定期涂抹类固醇软膏后湿疹得到控制的特应性皮炎患者。在 8 ± 4 周的时间里,参与者一侧用清洁剂清洗上肢和下肢,另一侧只用清水清洗。每位参与者可选择弱碱性肥皂或酸性清洁剂。主要结果是第 8 周 ± 4 时的湿疹面积和严重程度指数 (EASI) 评分。结果分析了 47 名注册参与者中 43 人的数据。患者年龄中位数为 44(23-99)个月;分别有 28 和 15 名参与者选择了弱碱性和酸性清洁剂。第 8 ± 4 周时,水和洁面产品双方的 EASI 分数分别为 0.00(0.00-0.40)和 0.15(0.00-0.40)(p = 0.74)。双方的差异为 0.00(-0.07 至 0.14);95% 置信区间的界限未达到预先指定的非劣效性界限。在 "以患者为导向的湿疹测量"(Patient-Oriented Eczema Measure)的中位数评分、额外使用类固醇药膏的次数以及皮肤感染发生率方面均未观察到差异。结论我们的研究表明,对于处于夏季维持阶段的AD患者来说,无论使用哪种清洁剂,用清水洗脸的效果都不比用清洁剂差。
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引用次数: 0
Effect of atopic conditions on development and recurrences of infectious keratitis 特应性疾病对传染性角膜炎发病和复发的影响
IF 6.8 2区 医学 Q1 ALLERGY Pub Date : 2024-02-02 DOI: 10.1016/j.alit.2024.01.008
Yutaka Omatsu, Yumiko Shimizu, Tomoko Haruki, Yoshitsugu Inoue, Dai Miyazaki

Background

Atopic conditions are known to be associated with viral and bacterial infections. The purpose of this study was to determine the relationship between the effects of atopic conditions on the severity and recurrence of ocular infections including herpes simplex virus (HSV).

Methods

This study was performed on 474 consecutive patients with infectious keratitis caused by bacteria, fungus, acanthamoeba, HSV, or varicella-zoster virus. The relationships between the atopic condition and specific infectious pathogens and HSV were determined using real-time PCR.

Results

Our findings showed that atopic dermatitis (AD) was significantly associated with the incidence of HSV keratitis (odds ratio (OR), 10.2; P = 0.000). Other associations with AD were observed only with bacteria in an adverse manner. HSV proliferation in the lesions of patients with HSV keratitis whose AD was associated with non-infectious atopic blepharitis were significantly greater by 145-folds (P = 0.000). The presence of asthma or allergic rhinitis also increased the HSV DNA copy numbers.

A recurrence of HSV keratitis was observed in 70 patients (43.2 %), and mean time to recurrence was 1647 days. Cox proportional hazard model indicated that the epithelial type of HSV recurrence but not the stromal type was associated with atopic conditions especially with AD. The factors significantly associated with a recurrence was AD associated with non-infectious atopic blepharitis (HR: 6.11, P = 0.000) and asthma (HR: 3.03, P = 0.025).

Conclusions

Atopic conditions, especially AD with atopic blepharitis, are significantly associated with the development, increased proliferation, and shorter time to a recurrence on HSV keratitis.

背景众所周知,特应性疾病与病毒和细菌感染有关。本研究的目的是确定特应性条件对包括单纯疱疹病毒(HSV)在内的眼部感染的严重程度和复发率的影响之间的关系。方法本研究对连续 474 例由细菌、真菌、棘阿米巴、HSV 或水痘-带状疱疹病毒引起的感染性角膜炎患者进行了研究。结果我们的研究结果表明,特应性皮炎(AD)与 HSV 角膜炎的发病率显著相关(比值比 (OR),10.2;P = 0.000)。其他与特应性皮炎的关联仅与细菌的不良反应有关。AD与非感染性特应性眼睑炎相关的HSV角膜炎患者病变部位的HSV增殖明显增加了145倍(P = 0.000)。70名患者(43.2%)观察到HSV角膜炎复发,平均复发时间为1647天。Cox比例危险模型显示,HSV复发的上皮型与特应性条件有关,尤其是与AD有关,而基质型与特应性条件无关。与复发明显相关的因素是与非感染性特应性眼睑炎相关的 AD(HR:6.11,P = 0.000)和哮喘(HR:3.03,P = 0.025)。
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引用次数: 0
Influence of household pet ownership and filaggrin loss-of-function mutations on eczema prevalence in children: A birth cohort study 家庭饲养宠物和 filaggrin 功能缺失突变对儿童湿疹发病率的影响:出生队列研究
IF 6.8 2区 医学 Q1 ALLERGY Pub Date : 2024-02-01 DOI: 10.1016/j.alit.2024.01.003
Kenji Toyokuni , Kiwako Yamamoto-Hanada , Limin Yang , Kouhei Hagino , Daisuke Harama , Marei Omori , Yasuaki Matsumoto , Daichi Suzuki , Kotaro Umezawa , Kazuma Takada , Mami Shimada , Seiko Hirai , Fumi Ishikawa , Sayaka Hamaguchi , Mayako Saito-Abe , Miori Sato , Yumiko Miyaji , Shigenori Kabashima , Tatsuki Fukuie , Emiko Noguchi , Yukihiro Ohya

Background

The association between pet exposure in infancy, early childhood eczema, and FLG mutations remains unclear.

Methods

This was a birth cohort study performed in Tokyo, Japan. The primary outcome was current eczema based on questionnaire responses collected repeatedly from birth to 5 years of age. Generalized estimating equations and generalized linear modeling were used to evaluate the association.

Results

Data from 1448 participants were used for analyses. Household dog ownership during gestation, early infancy, and 18 months of age significantly reduced the risk of current eczema. Household cat ownership also reduced the risk of current eczema, albeit without statistical significance. The combined evaluation of children from households with pets, be it cats, dogs or both, the risk of current eczema at 1–5 years of age was lower in those with household pet exposure ownership during gestation (RR = 0.59, 95 % CI 0.45–0.77) and at 6 months (RR = 0.49, 95 % CI 0.36–0.68). , Reduced risks of eczema were also observed at 2–5 (RR = 0.52, 95 % CI 0.37–0.73) and 3–5 years of age (RR = 0.50 95 % CI 0.35–0.74) when the respective household pet ownership were evaluated at 18 months and 3 years of age. These protective associations of reduced risk of eczema were only observed in children without FLG mutations.

Conclusions

Household dog and pet (dog, cat, or both) ownership was protective against early childhood eczema in a birth cohort dataset. This protective association was observed only in children without FLG mutations, which should be confirmed in studies with larger cohorts.

背景婴儿期接触宠物、儿童早期湿疹和FLG突变之间的关系仍不清楚。方法这是在日本东京进行的一项出生队列研究。主要结果是根据从出生到5岁期间反复收集的问卷调查结果得出的当前湿疹情况。结果对 1448 名参与者的数据进行了分析。在妊娠期、婴儿早期和 18 个月大时家中养狗可显著降低目前患湿疹的风险。养猫的家庭也能降低目前患湿疹的风险,尽管没有统计学意义。对有宠物(猫、狗或两者)家庭的儿童进行综合评估后发现,在妊娠期(RR = 0.59,95 % CI 0.45-0.77)和 6 个月大时(RR = 0.49,95 % CI 0.36-0.68)拥有家庭宠物的儿童在 1-5 岁时患湿疹的风险较低。在 2-5 岁(RR = 0.52,95 % CI 0.37-0.73)和 3-5 岁(RR = 0.50,95 % CI 0.35-0.74)时,如果分别在 18 个月和 3 岁时对家庭宠物拥有情况进行评估,也会发现湿疹风险降低。结论在一个出生队列数据集中,家庭养狗和宠物(狗、猫或两者)对儿童早期湿疹具有保护作用。只有在没有FLG基因突变的儿童中才能观察到这种保护作用,这一点应在更大规模的队列研究中得到证实。
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引用次数: 0
Three-year prognosis after low-dose oral food challenge for children with wheat allergy 对小麦过敏儿童进行低剂量口服食物挑战后的三年预后。
IF 6.8 2区 医学 Q1 ALLERGY Pub Date : 2024-02-01 DOI: 10.1016/j.alit.2024.01.004
Takaaki Itonaga , Noriyuki Yanagida , Ken-ichi Nagakura , Tomoyuki Asaumi , Mai Tokunaga , Makoto Nishino , Kyohei Takahashi , Kiyotake Ogura , Sakura Sato , Motohiro Ebisawa

Background

Low-dose oral food challenge (LD-OFC) is an approach to avoid complete elimination in high-risk patients with wheat allergy (WA). We examined the 3-year prognosis after LD-OFC among patients who passed and failed LD-OFC.

Methods

Children with immediate-type WA aged ≤6 years with a history of reaction to ≤390 mg of wheat protein underwent their first LD-OFC with 52 mg (baseline LD-OFC). After passing the LD-OFC, children stepped up to 390, 1300, and 5200 mg step-by-step every 3–6 months. After failing LD-OFC, children repeated LD-OFC every 6–12 months. We assessed wheat tolerance defined as consuming 5200 mg without symptoms for 3 years after baseline LD-OFC.

Results

The median age of 124 children was 2.4 years, and the wheat- and ω-5-gliadin-specific immunoglobulin E (IgE) levels (kUA/L) were 23.6 and 2.1, respectively. Upon baseline LD-OFC, 57% passed (LD-tolerant), whereas 43% failed (LD-reactive). Within 3 years, 38% of the LD-reactive group passed re-administered LD-OFC, and 70% of all participants avoided complete elimination. The percentage of the participants who became capable of consuming 390 mg (87% vs. 18%), 1300 mg (78% vs. 13%), and acquired tolerance (70% vs. 13%) was significantly higher in the LD-tolerant group than in the LD-reactive group (p < 0.001). Predictors of persistent WA in the LD-tolerant group were older age (adjusted odds ratio, 1.63), ω-5-gliadin-specific IgE level (1.62 per 10-fold increase), and other food allergies (1.94).

Conclusions

LD-tolerant patients frequently acquired wheat tolerance within 3 years. Even if once positive, one-third could pass the re-administered LD-OFC within 3 years.

背景:低剂量口服食物挑战(LD-OFC)是避免小麦过敏(WA)高危患者完全排除食物过敏的一种方法。我们研究了通过和未通过 LD-OFC 的患者接受 LD-OFC 后的 3 年预后情况:方法:年龄≤6 岁、对≤390 毫克小麦蛋白有反应史的即刻型 WA 儿童接受了首次 LD-OFC,剂量为 52 毫克(基线 LD-OFC)。通过 LD-OFC 后,儿童每 3-6 个月逐步增加至 390、1300 和 5200 毫克。LD-OFC失败后,儿童每6-12个月重复一次LD-OFC。我们对小麦耐受性进行了评估,小麦耐受性的定义是:在基线 LD-OFC 后的 3 年中,食用 5200 毫克小麦而无症状:124名儿童的中位年龄为2.4岁,小麦和ω-5-gliadin特异性免疫球蛋白E(IgE)水平(kUA/L)分别为23.6和2.1。在基线 LD-OFC 测试中,57% 的人通过了测试(耐受 LD),43% 的人未通过测试(LD 反应)。3 年内,38% 的低密度脂蛋白胆固醇反应组通过了重新进行的低密度脂蛋白胆固醇测试,70% 的参与者避免了完全消除低密度脂蛋白胆固醇。能够摄入 390 毫克(87% 对 18%)、1300 毫克(78% 对 13%)和获得耐受性(70% 对 13%)的参与者比例,LD 耐受组明显高于 LD 反应组(P 结论:LD 耐受组与 LD 反应组之间存在差异:LD耐受患者经常在 3 年内获得小麦耐受性。即使曾经呈阳性反应,三分之一的患者也能在 3 年内通过再次施用的 LD-OFC 测试。
{"title":"Three-year prognosis after low-dose oral food challenge for children with wheat allergy","authors":"Takaaki Itonaga ,&nbsp;Noriyuki Yanagida ,&nbsp;Ken-ichi Nagakura ,&nbsp;Tomoyuki Asaumi ,&nbsp;Mai Tokunaga ,&nbsp;Makoto Nishino ,&nbsp;Kyohei Takahashi ,&nbsp;Kiyotake Ogura ,&nbsp;Sakura Sato ,&nbsp;Motohiro Ebisawa","doi":"10.1016/j.alit.2024.01.004","DOIUrl":"10.1016/j.alit.2024.01.004","url":null,"abstract":"<div><h3>Background</h3><p>Low-dose oral food challenge (LD-OFC) is an approach to avoid complete elimination in high-risk patients with wheat allergy (WA). We examined the 3-year prognosis after LD-OFC among patients who passed and failed LD-OFC.</p></div><div><h3>Methods</h3><p>Children with immediate-type WA aged ≤6 years with a history of reaction to ≤390 mg of wheat protein underwent their first LD-OFC with 52 mg (baseline LD-OFC). After passing the LD-OFC, children stepped up to 390, 1300, and 5200 mg step-by-step every 3–6 months. After failing LD-OFC, children repeated LD-OFC every 6–12 months. We assessed wheat tolerance defined as consuming 5200 mg without symptoms for 3 years after baseline LD-OFC.</p></div><div><h3>Results</h3><p>The median age of 124 children was 2.4 years, and the wheat- and ω-5-gliadin-specific immunoglobulin E (IgE) levels (kU<sub>A</sub>/L) were 23.6 and 2.1, respectively. Upon baseline LD-OFC, 57% passed (LD-tolerant), whereas 43% failed (LD-reactive). Within 3 years, 38% of the LD-reactive group passed re-administered LD-OFC, and 70% of all participants avoided complete elimination. The percentage of the participants who became capable of consuming 390 mg (87% vs. 18%), 1300 mg (78% vs. 13%), and acquired tolerance (70% vs. 13%) was significantly higher in the LD-tolerant group than in the LD-reactive group (<em>p</em> &lt; 0.001). Predictors of persistent WA in the LD-tolerant group were older age (adjusted odds ratio, 1.63), ω-5-gliadin-specific IgE level (1.62 per 10-fold increase), and other food allergies (1.94).</p></div><div><h3>Conclusions</h3><p>LD-tolerant patients frequently acquired wheat tolerance within 3 years. Even if once positive, one-third could pass the re-administered LD-OFC within 3 years.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 3","pages":"Pages 416-421"},"PeriodicalIF":6.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893024000054/pdfft?md5=0621f6990616f6bcdc79301e95b7e6a5&pid=1-s2.0-S1323893024000054-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139651976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of nasal polyp-derived innate lymphoid cells in staphylococcal enterotoxin-induced cellular responses 鼻息肉衍生的先天性淋巴细胞在葡萄球菌肠毒素诱导的细胞反应中的作用
IF 6.8 2区 医学 Q1 ALLERGY Pub Date : 2024-02-01 DOI: 10.1016/j.alit.2024.01.005
Kengo Kanai , Aiko Oka , Shin Kariya , Tazuko Fujiwara , Takaya Higaki , Seiichiro Makihara , Takenori Haruna , Maki Akamatsu , Kazunori Nishizaki , Mizuo Ando , Mitsuhiro Okano
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引用次数: 0
A systematic review and meta-analysis of macrolides in the management of adult patients with asthma 大环内酯类药物治疗成年哮喘患者的系统回顾和荟萃分析
IF 6.8 2区 医学 Q1 ALLERGY Pub Date : 2024-01-30 DOI: 10.1016/j.alit.2024.01.002
Hiroshi Ohnishi , Toshihito Otani , Yoshihiro Kanemitsu , Tatsuya Nagano , Johsuke Hara , Masamitsu Eitoku

Background

The efficacy of macrolides in the management of asthma has been studied but remains controversial. We conducted a systematic review and meta-analysis of macrolides in the management of adult patients with asthma.

Methods

Randomized controlled trials of macrolides used in adult patients with asthma were searched for in MEDLINE, EMBASE, PsycINFO, Cochrane Library, CINAHL, and Igaku Chuo Zasshi databases to evaluate the efficacy and safety of macrolides.

Results

Seventeen reports with macrolide treatment durations ranging from 6 to 48 weeks were included. Macrolides did not reduce exacerbations requiring hospitalization, severe exacerbations, or rescue use of short-acting beta-2 agonist inhalers; improve lung function; decrease peripheral blood or sputum neutrophil counts; or decrease fractional exhaled nitric oxide compared to placebo. Macrolides statistically improved asthma control and quality of life but by less than the minimal clinically important difference. Peripheral blood eosinophil counts as well as serum and sputum eosinophilic cationic protein concentrations were significantly decreased with macrolides compared to placebo. The improvement of asthma symptoms and airway hyperresponsiveness varied by study. The safety profile of macrolides was comparable to that of placebo.

Conclusions

Although macrolides have some useful clinical aspects, there is not sufficient evidence to recommend their use in the management of adult patients with asthma.

背景对大环内酯类药物治疗哮喘的疗效进行了研究,但仍存在争议。方法在 MEDLINE、EMBASE、PsycINFO、Cochrane Library、CINAHL 和 Igaku Chuo Zasshi 等数据库中检索大环内酯类药物用于成人哮喘患者的随机对照试验,以评估大环内酯类药物的疗效和安全性。与安慰剂相比,大环内酯类药物不能减少需要住院治疗的病情加重、严重病情加重或短效β2受体激动剂吸入剂的抢救使用;不能改善肺功能;不能降低外周血或痰中中性粒细胞计数;也不能降低呼出一氧化氮的分数。据统计,大环内酯类药物可改善哮喘控制和生活质量,但改善幅度小于最小临床重要性差异。与安慰剂相比,大环内酯类药物能显著降低外周血嗜酸性粒细胞计数以及血清和痰中嗜酸性粒细胞阳离子蛋白浓度。不同研究对哮喘症状和气道高反应性的改善程度各不相同。大环内酯类药物的安全性与安慰剂相当。结论虽然大环内酯类药物在临床方面有一些作用,但没有足够的证据建议将其用于成年哮喘患者的治疗。
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引用次数: 0
Cluster analysis of phenotypes, job exposure, and inflammatory patterns in elderly and nonelderly asthma patients 对老年和非老年哮喘患者的表型、工作接触和炎症模式进行聚类分析
IF 6.8 2区 医学 Q1 ALLERGY Pub Date : 2024-01-29 DOI: 10.1016/j.alit.2024.01.001
Yung-Chi Chuang , Hsin-Hua Tsai , Meng-Chih Lin , Chao-Chien Wu , Yuan-Chung Lin , Tsu-Nai Wang

Background

Asthma has been identified as different phenotypes due to various risk factors. Age differences may have potential effects on asthma phenotypes. Our study aimed to identify potential asthma phenotypes among adults divided by age as either younger or older than 65 years. We also compared differences in blood granulocyte patterns, occupational asthmagens, and asthma control-related outcomes among patient phenotype clusters.

Methods

We recruited nonelderly (<65 years old) (n = 726) and elderly adults (≥65 years old) (n = 201) with mild-to-severe asthma. We conducted a factor analysis to select 17 variables. A two-step cluster analysis was used to classify subjects with asthma phenotypes, and a discriminant analysis was used to verify the classification of cluster results.

Results

There were three clusters with different characteristics identified in both the nonelderly and elderly asthmatic adults. In the nonelderly patient group, cluster 2 (obese, neutrophilic phenotypes) had a 1.85-fold significantly increased risk of asthma exacerbations. Cluster 3 (early-onset, atopy, and smoker with an eosinophil-predominant pattern) had a 2.37-fold risk of asthma exacerbations and higher oral corticosteroid (OCS) use than cluster 1 (late-onset and LMW exposure with paucigranulocytic blood pattern). Among elderly patients, cluster 2 had poor lung function and more ex-smokers. Cluster 3 (early-onset, long asthma duration) had the lowest paucigranulocytic blood pattern percentages in the elderly group.

Conclusions

The novelty of the clusters was found in age-dependent clusters. We identified three distinct phenotypes with heterogeneous characteristics, asthma exacerbations and medicine use in nonelderly and elderly asthmatic patients, respectively. Classification of age-stratified asthma phenotypes may lead to precise identification of patients, which provides personalized disease management.

背景由于各种风险因素,哮喘已被确定为不同的表型。年龄差异可能会对哮喘表型产生潜在影响。我们的研究旨在确定按年龄划分的65岁以下或65岁以上成年人的潜在哮喘表型。方法我们招募了患有轻度至重度哮喘的非老年人(65 岁)(726 人)和老年人(≥65 岁)(201 人)。我们进行了因子分析,选出了 17 个变量。结果在非老年和老年成人哮喘患者中发现了三个具有不同特征的群组。在非老年患者组中,第 2 组(肥胖、中性粒细胞表型)的哮喘恶化风险显著增加了 1.85 倍。与第 1 组(发病较晚、接触 LMW 且有白细胞血型)相比,第 3 组(发病较早、有过敏症、吸烟且以嗜酸性粒细胞为主)的哮喘恶化风险是第 1 组的 2.37 倍,口服皮质类固醇(OCS)的使用率也更高。在老年患者中,第 2 组的肺功能较差,且有更多的前吸烟者。在老年组中,第 3 组(发病早、哮喘持续时间长)的白细胞血型百分比最低。我们在非老年哮喘患者和老年哮喘患者中分别发现了具有异质性特征、哮喘恶化和药物使用的三种不同表型。对年龄分层的哮喘表型进行分类可准确识别患者,从而提供个性化的疾病管理。
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引用次数: 0
15-Hydroxyeicosatrienoic acid induces nasal congestion by changing vascular functions in mice 15-羟基二十碳三烯酸通过改变小鼠的血管功能诱发鼻塞。
IF 6.8 2区 医学 Q1 ALLERGY Pub Date : 2024-01-28 DOI: 10.1016/j.alit.2023.12.007
Noriko Ozaki , Naoaki Sakamoto , Daiki Horikami , Yuri Tachibana , Nanae Nagata , Koji Kobayashi , Yoshino Taira Arai , Masayoshi Sone , Kazuhiro Hirayama , Takahisa Murata

Background

Nasal congestion in allergic rhinitis (AR) is caused by vascular hyperpermeability and vascular relaxation of the nasal mucosa. We previously detected high levels of a lipoxygenation metabolite of dihomogammalinolenic acid, 15-hydroxy-8Z,11Z,13E-eicosatrienoic acid (15-HETrE) in the nasal lavage fluid of AR model mice. Here, we investigated the effects of 15-HETrE on vascular functions associated with nasal congestion.

Methods

We measured 15-HETrE levels in the nasal lavage fluid of ovalbumin-induced AR model mice and nasal discharge of patients with AR. We also assessed nasal congestion and vascular relaxation in mice. Vascular contractility was investigated using isolated mouse aortas.

Results

Five ovalbumin challenges increased 15-HETrE levels in AR model mice. 15-HETrE was also detected in patients who exhibiting AR-related symptoms. Intranasal administration of 15-HETrE elicited dyspnea-related behavior and decreased the nasal cavity volume in mice. Miles assay and whole-mount immunostaining revealed that 15-HETrE administration caused vascular hyperpermeability and relaxation of the nasal mucosa. Intravital imaging demonstrated that 15-HETrE relaxed the ear vessels that were precontracted via thromboxane receptor stimulation. Moreover, 15-HETrE dilated the isolated mouse aortas, and this effect was attenuated by K+ channel inhibitors and prostaglandin D2 (DP) and prostacyclin (IP) receptor antagonists. Additionally, vasodilatory effects of 15-HETrE were accompanied by an increase in intracellular cAMP levels.

Conclusions

Our results indicate that 15-HETrE, whose levels are elevated in the nasal cavity upon AR, can be a novel lipid mediator that exacerbates nasal congestion. Moreover, it can stimulate DP and IP receptors and downstream K+ channels to dilate the nasal mucosal vasculature.

背景:过敏性鼻炎(AR)的鼻塞是由鼻粘膜血管高渗透性和血管松弛引起的。我们以前曾在 AR 模型小鼠的鼻腔灌洗液中检测到高浓度的二氢骆驼蓬烯酸脂氧代谢产物--15-羟基-8Z,11Z,13E-二十碳三烯酸(15-HETrE)。在此,我们研究了 15-HETrE 对与鼻塞相关的血管功能的影响:方法:我们测量了卵清蛋白诱导的 AR 模型小鼠鼻腔灌洗液和 AR 患者鼻腔分泌物中的 15-HETrE 水平。我们还评估了小鼠的鼻塞和血管松弛情况。使用离体小鼠主动脉对血管收缩性进行了研究:结果:五次卵清蛋白挑战增加了 AR 模型小鼠的 15-HETrE 水平。在出现 AR 相关症状的患者体内也检测到了 15-HETrE。鼻内注射 15-HETrE 会引起小鼠呼吸困难相关行为,并减少鼻腔容积。迈尔斯测定和全图免疫染色显示,15-HETrE 会导致血管高渗透性和鼻黏膜松弛。肉眼成像显示,15-HETrE 使预先收缩的耳血管在血栓素受体的刺激下松弛。此外,15-HETrE 还能扩张离体小鼠主动脉,K+ 通道抑制剂、前列腺素 D2(DP)和前列环素(IP)受体拮抗剂可减轻这种效应。此外,15-HETrE 的血管扩张作用还伴随着细胞内 cAMP 水平的增加:我们的研究结果表明,15-HETrE 是一种新型脂质介质,可加剧鼻塞。此外,它还能刺激 DP 和 IP 受体及下游 K+ 通道,从而扩张鼻粘膜血管。
{"title":"15-Hydroxyeicosatrienoic acid induces nasal congestion by changing vascular functions in mice","authors":"Noriko Ozaki ,&nbsp;Naoaki Sakamoto ,&nbsp;Daiki Horikami ,&nbsp;Yuri Tachibana ,&nbsp;Nanae Nagata ,&nbsp;Koji Kobayashi ,&nbsp;Yoshino Taira Arai ,&nbsp;Masayoshi Sone ,&nbsp;Kazuhiro Hirayama ,&nbsp;Takahisa Murata","doi":"10.1016/j.alit.2023.12.007","DOIUrl":"10.1016/j.alit.2023.12.007","url":null,"abstract":"<div><h3>Background</h3><p>Nasal congestion in allergic rhinitis (AR) is caused by vascular hyperpermeability and vascular relaxation of the nasal mucosa. We previously detected high levels of a lipoxygenation metabolite of dihomogammalinolenic acid, 15-hydroxy-8Z,11Z,13E-eicosatrienoic acid (15-HETrE) in the nasal lavage fluid of AR model mice. Here, we investigated the effects of 15-HETrE on vascular functions associated with nasal congestion.</p></div><div><h3>Methods</h3><p>We measured 15-HETrE levels in the nasal lavage fluid of ovalbumin-induced AR model mice and nasal discharge of patients with AR. We also assessed nasal congestion and vascular relaxation in mice. Vascular contractility was investigated using isolated mouse aortas.</p></div><div><h3>Results</h3><p>Five ovalbumin challenges increased 15-HETrE levels in AR model mice. 15-HETrE was also detected in patients who exhibiting AR-related symptoms. Intranasal administration of 15-HETrE elicited dyspnea-related behavior and decreased the nasal cavity volume in mice. Miles assay and whole-mount immunostaining revealed that 15-HETrE administration caused vascular hyperpermeability and relaxation of the nasal mucosa. Intravital imaging demonstrated that 15-HETrE relaxed the ear vessels that were precontracted via thromboxane receptor stimulation. Moreover, 15-HETrE dilated the isolated mouse aortas, and this effect was attenuated by K<sup>+</sup> channel inhibitors and prostaglandin D<sub>2</sub> (DP) and prostacyclin (IP) receptor antagonists. Additionally, vasodilatory effects of 15-HETrE were accompanied by an increase in intracellular cAMP levels.</p></div><div><h3>Conclusions</h3><p>Our results indicate that 15-HETrE, whose levels are elevated in the nasal cavity upon AR, can be a novel lipid mediator that exacerbates nasal congestion. Moreover, it can stimulate DP and IP receptors and downstream K<sup>+</sup> channels to dilate the nasal mucosal vasculature.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 3","pages":"Pages 464-472"},"PeriodicalIF":6.8,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893024000029/pdfft?md5=383aded651e40fe9aefb4d9b4ba09302&pid=1-s2.0-S1323893024000029-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139576657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling the link between atopic dermatitis and autoimmune diseases in children: Insights from a large-scale cohort study with 15-year follow-up and shared gene ontology analysis 揭示儿童特应性皮炎与自身免疫性疾病之间的联系:一项为期 15 年的大规模队列研究和共享基因本体分析的启示。
IF 6.8 2区 医学 Q1 ALLERGY Pub Date : 2024-01-17 DOI: 10.1016/j.alit.2023.12.005
Jungho Ahn , Seungyong Shin , Gi Chun Lee , Bo Eun Han , Eun Lee , Eun Kyo Ha , Jeewon Shin , Won Seok Lee , Ju Hee Kim , Man Yong Han

Background

Atopic dermatitis and autoimmune diseases are highly heritable conditions that may co-occur from an early age.

Methods

The primary study is a national administrative cohort study involving 499,428 children born in 2002, tracked until 2017. Atopic dermatitis was defined as five or more principal diagnoses of atopic dermatitis and two or more topical steroid prescriptions. We estimated the risks for the occurrence of 41 autoimmune diseases, controlling for risk factors. In addition, we sourced a gene library from the National Library of Medicine to conduct a comprehensive gene ontology. We used Gene Weaver to identify gene set similarity and clustering, and used GeneMania to generate a network for shared genes.

Results

Exposed and unexposed groups included 39,832 and 159,328 children, respectively. During a mean follow-up of 12 years, the exposed group had an increased risk of autoimmune disease (hazard ratio, 1.27 [95 % confidence interval, 1.23–1.32]) compared to the unexposed group. The hazard ratios of autoimmune illnesses consistently increased with two- and five years lag times and alternative atopic dermatitis definitions. Shared genes between atopic dermatitis and autoimmune diseases were associated with comorbidities such as asthma, bronchiolitis, and specific infections. Genetic interactions of these shared genes revealed clustering in Th1, Th2, Th17, and non-classifiable pathways.

Conclusions

Atopic dermatitis was significantly associated with an increased risk of subsequent autoimmune disease. we identified the genetically associated disease in atopic dermatitis patients comorbid with autoimmune disease and demonstrated a genetic network between atopic dermatitis and autoimmune diseases.

背景:特应性皮炎和自身免疫性疾病是高度遗传性疾病,可能从小就同时发生:主要研究是一项全国行政队列研究,涉及 2002 年出生的 499,428 名儿童,追踪至 2017 年。特应性皮炎的定义是五次或五次以上的特应性皮炎主要诊断和两次或两次以上的局部类固醇处方。在控制风险因素的前提下,我们估算了 41 种自身免疫性疾病的发病风险。此外,我们还从美国国家医学图书馆获取了一个基因库,以进行全面的基因本体研究。我们使用 Gene Weaver 来识别基因组的相似性和聚类,并使用 GeneMania 生成共享基因网络:暴露组和未暴露组分别包括 39 832 名和 159 328 名儿童。在平均 12 年的随访期间,与未暴露组相比,暴露组患自身免疫性疾病的风险增加(危险比为 1.27 [95 % 置信区间为 1.23-1.32])。自身免疫性疾病的危险比随着两年和五年的滞后时间以及特应性皮炎的其他定义而不断增加。特应性皮炎和自身免疫性疾病之间的共享基因与哮喘、支气管炎和特定感染等合并症有关。这些共有基因之间的遗传相互作用显示了Th1、Th2、Th17和不可分类途径的聚集:我们确定了特应性皮炎患者合并自身免疫性疾病的遗传相关疾病,并展示了特应性皮炎与自身免疫性疾病之间的遗传网络。
{"title":"Unraveling the link between atopic dermatitis and autoimmune diseases in children: Insights from a large-scale cohort study with 15-year follow-up and shared gene ontology analysis","authors":"Jungho Ahn ,&nbsp;Seungyong Shin ,&nbsp;Gi Chun Lee ,&nbsp;Bo Eun Han ,&nbsp;Eun Lee ,&nbsp;Eun Kyo Ha ,&nbsp;Jeewon Shin ,&nbsp;Won Seok Lee ,&nbsp;Ju Hee Kim ,&nbsp;Man Yong Han","doi":"10.1016/j.alit.2023.12.005","DOIUrl":"10.1016/j.alit.2023.12.005","url":null,"abstract":"<div><h3>Background</h3><p>Atopic dermatitis and autoimmune diseases are highly heritable conditions that may co-occur from an early age.</p></div><div><h3>Methods</h3><p>The primary study is a national administrative cohort study involving 499,428 children born in 2002, tracked until 2017. Atopic dermatitis was defined as five or more principal diagnoses of atopic dermatitis and two or more topical steroid prescriptions. We estimated the risks for the occurrence of 41 autoimmune diseases, controlling for risk factors. In addition, we sourced a gene library from the National Library of Medicine to conduct a comprehensive gene ontology. We used Gene Weaver to identify gene set similarity and clustering, and used GeneMania to generate a network for shared genes.</p></div><div><h3>Results</h3><p>Exposed and unexposed groups included 39,832 and 159,328 children, respectively. During a mean follow-up of 12 years, the exposed group had an increased risk of autoimmune disease (hazard ratio, 1.27 [95 % confidence interval, 1.23–1.32]) compared to the unexposed group. The hazard ratios of autoimmune illnesses consistently increased with two- and five years lag times and alternative atopic dermatitis definitions. Shared genes between atopic dermatitis and autoimmune diseases were associated with comorbidities such as asthma, bronchiolitis, and specific infections. Genetic interactions of these shared genes revealed clustering in Th1, Th2, Th17, and non-classifiable pathways.</p></div><div><h3>Conclusions</h3><p>Atopic dermatitis was significantly associated with an increased risk of subsequent autoimmune disease. we identified the genetically associated disease in atopic dermatitis patients comorbid with autoimmune disease and demonstrated a genetic network between atopic dermatitis and autoimmune diseases.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 2","pages":"Pages 243-254"},"PeriodicalIF":6.8,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023001405/pdfft?md5=93065ae56f068b77c7bede44f12e2397&pid=1-s2.0-S1323893023001405-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of allergies in children younger than 3 years with levels of maternal intake of n-3 polyunsaturated fatty acids or fish during pregnancy: A nationwide birth cohort study, the Japan Environment and Children's Study 3 岁以下儿童的过敏症与母亲在怀孕期间摄入的 n-3 多不饱和脂肪酸或鱼类的水平有关:一项全国性出生队列研究--日本环境与儿童研究
IF 6.8 2区 医学 Q1 ALLERGY Pub Date : 2024-01-13 DOI: 10.1016/j.alit.2023.12.004
Sayaka Tsuji , Yuichi Adachi , Akiko Tsuchida , Kei Hamazaki , Kenta Matsumura , Hidekuni Inadera

Background

N-3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory properties and are expected to prevent the onset of allergies. However, epidemiological studies investigating the relationship between child allergies and maternal intake of n-3 PUFAs or fish have yielded inconsistent results.

Methods

Following exclusions from a dataset comprising 103,057 records from the Japan Environment and Children's Study, 72,105 participants were divided into five groups according to mothers' intake of n-3 PUFAs or fish during pregnancy to assess the risk of their children being diagnosed with allergy by 3 years old. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for child allergies were calculated using multivariable logistic regression analyses with reference to the lowest intake group.

Results

Levels of maternal intake of n-3 PUFAs or fish showed inverted associations (i.e., reduced risk) with the incidence of physician-diagnosed allergic rhinoconjunctivitis or parent-reported symptoms of current rhinitis with eye symptoms at different time points and the cumulative incidence from birth to 3 years of age. Inverted associations were also found for current wheeze at 1-<2 years of age and current eczema at 1-<2 and 0-<3 years of age. However, for food allergies, no significant associations were observed in the incidence in each group compared with the lowest intake group at any age.

Conclusions

The findings suggest that n-3 PUFA intake during pregnancy may reduce the risk of developing allergic diseases and symptoms in children. In addition, consumption of n-3 PUFAs or fish is very unlikely to increase the risk of allergy given that the results are from a country with high fish consumption. Trial registration: UMIN000030786 https://rctportal.niph.go.jp/detail/um?trial_id=UMIN000030786.

背景n-3多不饱和脂肪酸(PUFA)具有抗炎特性,有望预防过敏症的发生。方法从日本环境与儿童研究(Japan Environment and Children's Study)的 103,057 个记录数据集中排除后,根据母亲在怀孕期间摄入 n-3 PUFAs 或鱼类的情况将 72,105 名参与者分为五组,以评估其子女在 3 岁前被诊断出过敏的风险。结果母亲的 n-3 PUFAs 或鱼类摄入量水平与不同时间点医生诊断的过敏性鼻结膜炎发病率或家长报告的当前鼻炎症状和眼部症状以及从出生到 3 岁的累积发病率呈倒置关系(即风险降低)。1-<2 岁时的喘息和 1-<2 岁及 0-<3 岁时的湿疹也存在反向关联。结论 研究结果表明,孕期摄入 n-3 PUFA 可降低儿童患过敏性疾病和过敏症状的风险。此外,鉴于研究结果来自一个鱼类消费量较高的国家,因此食用 n-3 PUFA 或鱼类不太可能增加过敏风险。试验注册:umin000030786 https://rctportal.niph.go.jp/detail/um?trial_id=UMIN000030786。
{"title":"Association of allergies in children younger than 3 years with levels of maternal intake of n-3 polyunsaturated fatty acids or fish during pregnancy: A nationwide birth cohort study, the Japan Environment and Children's Study","authors":"Sayaka Tsuji ,&nbsp;Yuichi Adachi ,&nbsp;Akiko Tsuchida ,&nbsp;Kei Hamazaki ,&nbsp;Kenta Matsumura ,&nbsp;Hidekuni Inadera","doi":"10.1016/j.alit.2023.12.004","DOIUrl":"10.1016/j.alit.2023.12.004","url":null,"abstract":"<div><h3>Background</h3><p>N-3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory properties and are expected to prevent the onset of allergies. However, epidemiological studies investigating the relationship between child allergies and maternal intake of n-3 PUFAs or fish have yielded inconsistent results.</p></div><div><h3>Methods</h3><p>Following exclusions from a dataset comprising 103,057 records from the Japan Environment and Children's Study, 72,105 participants were divided into five groups according to mothers' intake of n-3 PUFAs or fish during pregnancy to assess the risk of their children being diagnosed with allergy by 3 years old. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for child allergies were calculated using multivariable logistic regression analyses with reference to the lowest intake group.</p></div><div><h3>Results</h3><p>Levels of maternal intake of n-3 PUFAs or fish showed inverted associations (i.e., reduced risk) with the incidence of physician-diagnosed allergic rhinoconjunctivitis or parent-reported symptoms of current rhinitis with eye symptoms at different time points and the cumulative incidence from birth to 3 years of age. Inverted associations were also found for current wheeze at 1-&lt;2 years of age and current eczema at 1-&lt;2 and 0-&lt;3 years of age. However, for food allergies, no significant associations were observed in the incidence in each group compared with the lowest intake group at any age.</p></div><div><h3>Conclusions</h3><p>The findings suggest that n-3 PUFA intake during pregnancy may reduce the risk of developing allergic diseases and symptoms in children. In addition, consumption of n-3 PUFAs or fish is very unlikely to increase the risk of allergy given that the results are from a country with high fish consumption. <em>Trial registration</em>: UMIN000030786 <span>https://rctportal.niph.go.jp/detail/um?trial_id=UMIN000030786</span><svg><path></path></svg>.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 2","pages":"Pages 282-289"},"PeriodicalIF":6.8,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023001399/pdfft?md5=a8dfb91dcfe73f986ecbddd82c6cd71d&pid=1-s2.0-S1323893023001399-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139464561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Allergology International
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