Pub Date : 2023-11-05DOI: 10.36329/jkcm/2023/v2.i10.13365
None Derin A. salih1, None Kamaran Abdoulrahman2
This study's objective is to assess the Advanced glycation end products (AGEs), oxidative stress and antioxidant parameters in sera of leukemia patients and control group. In the present study we measured the concentration of serum levels of carboxymethyl-lysine (CML), pyrraline, Nitric Oxide (NO), Malondialdehyde (MDA), superoxide dismutase (SOD), catalase and glutathione (GSH) in leukemia patients and control group. This study was performed on 80 individuals, 50 children, men and women with leukemia patients (20 females and 30 males) and 30 healthy individuals (children, women and men, 12 females and 18 males) as control group who had no leukemia. The results show that the median and mean serum level of each CML, MDA and GSH are significantly, but CAT and SOD are insignificantly higher in leukemia patients than in control group (CML= 479.3 (411.1, 545.4) ng/ml (p value <0.0001), (MDA= 175.7 (160.8, 191.8) ng/ml (p value= 0.0357), (GSH= 5.772 ± 0.3615) μg/ ml (p value= 0.0194), (CAT= 6.857 (6.281, 7.425) ng/ml (p value= 0.8193) and (SOD= 1.111 (0.8918, 1.478) ng/ml (p value= 0.0891). The median serum level of Pyrraline and NO are insignificantly lower in leukemia patients compared to control group (Pyrraline= 156.9 (137.3, 179.0) pg/ml (p value = 0.8995) and (NO= 119.3 (96.66,192.6) μmol/L (p value= 0.2289). The correlation analysis demonstrates that there are significantly positive correlations between serum CML and MDA (r= 0.3487) (p value= 0.0152) and between serum pyrraline with MDA (r= 0.3838) (p value = 0.0093) and GSH (r= 0.3371) (p value= 0.0236).
{"title":"Evaluation of Advanced Glycation End Products and other Biochemical Parameters in Patients with Leukemia","authors":"None Derin A. salih1, None Kamaran Abdoulrahman2","doi":"10.36329/jkcm/2023/v2.i10.13365","DOIUrl":"https://doi.org/10.36329/jkcm/2023/v2.i10.13365","url":null,"abstract":"This study's objective is to assess the Advanced glycation end products (AGEs), oxidative stress and antioxidant parameters in sera of leukemia patients and control group. In the present study we measured the concentration of serum levels of carboxymethyl-lysine (CML), pyrraline, Nitric Oxide (NO), Malondialdehyde (MDA), superoxide dismutase (SOD), catalase and glutathione (GSH) in leukemia patients and control group. This study was performed on 80 individuals, 50 children, men and women with leukemia patients (20 females and 30 males) and 30 healthy individuals (children, women and men, 12 females and 18 males) as control group who had no leukemia. The results show that the median and mean serum level of each CML, MDA and GSH are significantly, but CAT and SOD are insignificantly higher in leukemia patients than in control group (CML= 479.3 (411.1, 545.4) ng/ml (p value <0.0001), (MDA= 175.7 (160.8, 191.8) ng/ml (p value= 0.0357), (GSH= 5.772 ± 0.3615) μg/ ml (p value= 0.0194), (CAT= 6.857 (6.281, 7.425) ng/ml (p value= 0.8193) and (SOD= 1.111 (0.8918, 1.478) ng/ml (p value= 0.0891). The median serum level of Pyrraline and NO are insignificantly lower in leukemia patients compared to control group (Pyrraline= 156.9 (137.3, 179.0) pg/ml (p value = 0.8995) and (NO= 119.3 (96.66,192.6) μmol/L (p value= 0.2289). The correlation analysis demonstrates that there are significantly positive correlations between serum CML and MDA (r= 0.3487) (p value= 0.0152) and between serum pyrraline with MDA (r= 0.3838) (p value = 0.0093) and GSH (r= 0.3371) (p value= 0.0236).","PeriodicalId":489104,"journal":{"name":"Journal of Kufa for Chemical Sciences","volume":"119 23","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-05DOI: 10.36329/jkcm/2023/v2.i10.11021
Alaa E. Sultan, None Hussein I.Abdullah, None Abdul qadier H. Niama
In the present work, silver oxide nanoparticles (Ag2O-NPs) were used as an adsorption surface for removing nickel and lead ions from aqueous solutions, the surface properties were studied using various techniques like Fourier-transform infrared spectroscopy (FTIR) spectra shown the functional groups present in the synthesis silver oxides nanoparticles, X-ray diffraction (XRD) confirmed the crystalline nature of Ag2O-NPs with a crystallite size 38.69 nm, field emission scanning-electron-microscopy(FE-SEM) images showed that the Ag2O-NPs has spherical shape, and the presence of elemental silver signals of the silver oxide nanoparticles was confirmed by energy dispersive x-ray (EDX) analysis spectrum.Adsorption experiments were carried out in order to determine the effect of contact time, adsorbent dose, and temperature on adsorption capacity, as well as to track the removal of Ni (II) and Pb(II) by Ag2O nanoparticles. Experiments showed that 50 min was a good choice as the ideal contact time to remove Ni (II) and Pb(II) ions, the optimal quantity of adsorption is approximately 200 (mg/l), and the optimal temperature that can be used to remove Ni(II) and Pb(II) ions is 298K. The results showed that both Ag(I) and Ni(II) could be effectively removed from aqueous solutions.
{"title":"Adsorption Study of Ni (II) and Pb (II) by Silver oxide Nanoparticles","authors":"Alaa E. Sultan, None Hussein I.Abdullah, None Abdul qadier H. Niama","doi":"10.36329/jkcm/2023/v2.i10.11021","DOIUrl":"https://doi.org/10.36329/jkcm/2023/v2.i10.11021","url":null,"abstract":"In the present work, silver oxide nanoparticles (Ag2O-NPs) were used as an adsorption surface for removing nickel and lead ions from aqueous solutions, the surface properties were studied using various techniques like Fourier-transform infrared spectroscopy (FTIR) spectra shown the functional groups present in the synthesis silver oxides nanoparticles, X-ray diffraction (XRD) confirmed the crystalline nature of Ag2O-NPs with a crystallite size 38.69 nm, field emission scanning-electron-microscopy(FE-SEM) images showed that the Ag2O-NPs has spherical shape, and the presence of elemental silver signals of the silver oxide nanoparticles was confirmed by energy dispersive x-ray (EDX) analysis spectrum.Adsorption experiments were carried out in order to determine the effect of contact time, adsorbent dose, and temperature on adsorption capacity, as well as to track the removal of Ni (II) and Pb(II) by Ag2O nanoparticles. Experiments showed that 50 min was a good choice as the ideal contact time to remove Ni (II) and Pb(II) ions, the optimal quantity of adsorption is approximately 200 (mg/l), and the optimal temperature that can be used to remove Ni(II) and Pb(II) ions is 298K. The results showed that both Ag(I) and Ni(II) could be effectively removed from aqueous solutions.","PeriodicalId":489104,"journal":{"name":"Journal of Kufa for Chemical Sciences","volume":"120 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-05DOI: 10.36329/jkcm/2023/v2.i10.13886
None Rasha Hasan Jasim, None Sara Sattar Jabbar
When blood flow to the heart muscle is impeded, fat and cholesterol build up on the inner wall of the heart, causing coronary heart disease (CHD), myocardial infarction (MI), and sudden cardiac death are just a few of the diseases that can occur in CAD as a result of atherosclerosis. A catheter is used during Percutaneous Coronary Intervention (PCI), also known as angioplasty, a non-surgical procedure to squeeze a balloon or stent into a narrowing area to restore blood flow to the myocardium. Therefore, it is treated with medication to widen or open up the veins in the heart muscle that contain plaque accumulation that results in stenosis in order to avoid the coronary artery blockage from occurring again. The key CVD risk factor is lipid profile and some biochemicals parameters, and each kind these parameters are associated with an increase in the incidence of MI. Anabolic processes, energy metabolism, and blood sugar levels are all controlled by the hormone insulin. Glycosylated hemoglobin (HbA1c) is frequently used to measure the average blood glucose levels of a person based on the age. The resulting values also help to diagnose diabetes mellitus by determining the blood sugar level. Elevated aminotransferase levels indicating liver function, have attracted great concern as potential novel markers of cardiovascular risk assessment. Although blood urea nitrogen (BUN), creatinine (Cr), and electrolytes is not the mainstay of diagnosis in MI patients, they may have a role in providing a more detailed view of the complications and mortality rates.
{"title":"Biochemical Study For Evaluation of some Clinical Parameters as Predictors of Myocardial Infarction in Patients With Type 2 Diabetes Mellitus Undergoing Elective Percutaneous Coronary Intervention","authors":"None Rasha Hasan Jasim, None Sara Sattar Jabbar","doi":"10.36329/jkcm/2023/v2.i10.13886","DOIUrl":"https://doi.org/10.36329/jkcm/2023/v2.i10.13886","url":null,"abstract":"When blood flow to the heart muscle is impeded, fat and cholesterol build up on the inner wall of the heart, causing coronary heart disease (CHD), myocardial infarction (MI), and sudden cardiac death are just a few of the diseases that can occur in CAD as a result of atherosclerosis. A catheter is used during Percutaneous Coronary Intervention (PCI), also known as angioplasty, a non-surgical procedure to squeeze a balloon or stent into a narrowing area to restore blood flow to the myocardium. Therefore, it is treated with medication to widen or open up the veins in the heart muscle that contain plaque accumulation that results in stenosis in order to avoid the coronary artery blockage from occurring again. The key CVD risk factor is lipid profile and some biochemicals parameters, and each kind these parameters are associated with an increase in the incidence of MI. Anabolic processes, energy metabolism, and blood sugar levels are all controlled by the hormone insulin. Glycosylated hemoglobin (HbA1c) is frequently used to measure the average blood glucose levels of a person based on the age. The resulting values also help to diagnose diabetes mellitus by determining the blood sugar level. Elevated aminotransferase levels indicating liver function, have attracted great concern as potential novel markers of cardiovascular risk assessment. Although blood urea nitrogen (BUN), creatinine (Cr), and electrolytes is not the mainstay of diagnosis in MI patients, they may have a role in providing a more detailed view of the complications and mortality rates.","PeriodicalId":489104,"journal":{"name":"Journal of Kufa for Chemical Sciences","volume":"120 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The present study was disigned to invistigate the effect of plasmin-plasminogen system variable which is plasminogen activator inhibitor-1 (PAI-1) on the occurrence of the development of malignant and benign tumors. In addition to illustrate the oxidative stress effect on the malignant and benign tumors occuring and complication progress. Which involving Glutathione Peroxidase (GPx) and Hydrogen Peroxide H2O2. On the other hand, current study amied to nominate the most suitable variant as an effective tumor marker
{"title":"Variation of PAI-1 and oxidant-antioxidant status in Four Human Cancers","authors":"Zahraa Hayder Razzaq Al_Ali, None Elham Abed Mahdi","doi":"10.36329/jkcm/2023/v2.i10.10983","DOIUrl":"https://doi.org/10.36329/jkcm/2023/v2.i10.10983","url":null,"abstract":"Objective: The present study was disigned to invistigate the effect of plasmin-plasminogen system variable which is plasminogen activator inhibitor-1 (PAI-1) on the occurrence of the development of malignant and benign tumors. In addition to illustrate the oxidative stress effect on the malignant and benign tumors occuring and complication progress. Which involving Glutathione Peroxidase (GPx) and Hydrogen Peroxide H2O2. On the other hand, current study amied to nominate the most suitable variant as an effective tumor marker","PeriodicalId":489104,"journal":{"name":"Journal of Kufa for Chemical Sciences","volume":"119 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-05DOI: 10.36329/jkcm/2023/v2.i10.11877
Prof. Dr. Mohammed Z. Ghdhayeb, None Mohammad Kadhum Talib
Preparation of new complexes of silver(I) and palladium(II)-NHC using imidazolium salts were derived through methylimidazole with 2-chloro-N-(4-chlorophenyl) acetamide under certain conditions of temperature and certain solvents, to be synthesized silver complex from the reaction of substituted imidazolium salts with Ag2O using in situ deprotonation technique giving derived structures in good yield. To synthesis Pd(II)-NHC complexes were used Ag(I)-NHC complexes were used as transfer reagents using the transmetallation technique to prepare their respective. The free ligands and their complexes were characterized based on (FT-IR, Melting point, TLC, 1HNMR, 13C-NMR, high-resolution mass spectra and UV). The biological activity studies show
采用甲基咪唑与2-氯- n -(4-氯苯基)乙酰胺在一定温度和溶剂条件下制备了咪唑盐络合物银(I)和钯(II)- nhc，取代咪唑盐与Ag2O用原位去质子化技术反应合成了银络合物，得到了收率高的衍生结构。合成Pd(II)-NHC配合物采用Ag(I)-NHC配合物作为转移试剂采用金属化技术分别制备。利用FT-IR、熔点、TLC、1HNMR、13C-NMR、高分辨率质谱和UV对游离配体及其配合物进行了表征。生物活性研究表明
{"title":"Antibacterial activity, synthesis and characterization of a new Ag(I) and Pd(II) complexes with N-heterocyclic carbene","authors":"Prof. Dr. Mohammed Z. Ghdhayeb, None Mohammad Kadhum Talib","doi":"10.36329/jkcm/2023/v2.i10.11877","DOIUrl":"https://doi.org/10.36329/jkcm/2023/v2.i10.11877","url":null,"abstract":"Preparation of new complexes of silver(I) and palladium(II)-NHC using imidazolium salts were derived through methylimidazole with 2-chloro-N-(4-chlorophenyl) acetamide under certain conditions of temperature and certain solvents, to be synthesized silver complex from the reaction of substituted imidazolium salts with Ag2O using in situ deprotonation technique giving derived structures in good yield. To synthesis Pd(II)-NHC complexes were used Ag(I)-NHC complexes were used as transfer reagents using the transmetallation technique to prepare their respective. The free ligands and their complexes were characterized based on (FT-IR, Melting point, TLC, 1HNMR, 13C-NMR, high-resolution mass spectra and UV). The biological activity studies show","PeriodicalId":489104,"journal":{"name":"Journal of Kufa for Chemical Sciences","volume":"120 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-05DOI: 10.36329/jkcm/2023/v2.i10.10724
Qusay Hays, None Dakhil Zughayir Mutlaq
Prostate cancer is one of the most common malignant diseases in men, and the design of new chemical compounds against prostate cancer is one of the challenges faced by modern medicine. In this study, we prepared and characterized a new series of thiohydantoin derivatives by reacting maleimide derivatives (1C-4) with cyclohexyl isothiocyanate.The prepared compounds were diagnosed using (FT-IR ,1H-NMR ,13C-NMR ).MTT assay was used to determine the activity of the prepared compounds against prostate cancer cell lines, as the data indicated, based on IC50 values, that the prepared compounds do not have anti-prostate cancer activity. The prepared compounds were also studied against selected types of bacteria and fungi, as the data indicated that some of the prepared series compounds had anti-bacterial and anti-fungal activity under study, as the compound 4C showed a high anti-staph activity.
{"title":"Synthesis, characterization of a new series of thiohydantoin derivatives and study their biological activity against prostate cancer and microbes.","authors":"Qusay Hays, None Dakhil Zughayir Mutlaq","doi":"10.36329/jkcm/2023/v2.i10.10724","DOIUrl":"https://doi.org/10.36329/jkcm/2023/v2.i10.10724","url":null,"abstract":"Prostate cancer is one of the most common malignant diseases in men, and the design of new chemical compounds against prostate cancer is one of the challenges faced by modern medicine. In this study, we prepared and characterized a new series of thiohydantoin derivatives by reacting maleimide derivatives (1C-4) with cyclohexyl isothiocyanate.The prepared compounds were diagnosed using (FT-IR ,1H-NMR ,13C-NMR ).MTT assay was used to determine the activity of the prepared compounds against prostate cancer cell lines, as the data indicated, based on IC50 values, that the prepared compounds do not have anti-prostate cancer activity. The prepared compounds were also studied against selected types of bacteria and fungi, as the data indicated that some of the prepared series compounds had anti-bacterial and anti-fungal activity under study, as the compound 4C showed a high anti-staph activity.","PeriodicalId":489104,"journal":{"name":"Journal of Kufa for Chemical Sciences","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-05DOI: 10.36329/jkcm/2023/v2.i10.13885
None Rasha Hasan Jasim, None Sara Sattar Jabbar
Galectin-3(Gal-3) belongs to lectins family binding β-galactoside that have at least one of the carbohydrate recognition domains (CRDs) in their own structure, which located on chromosome 14 (14q22.3).Gal-3Plays an important role in modulating cardiac inflammation and fibrosis. Therefore, LGALS3 gene, encoding galectin-3 protein, which considered promising candidate for the genetic study of cardiovascular diseases (CVDs),and evaluating the association between LGALS3 gene polymorphisms and the susceptibility and prognosis of myocardial infarction(MI) .Gal-is a pleiotropic molecule expressed on the cell membrane, within the cytoplasm or the nucleus. It has been proposed to function as a mediator of inflammation, fibrosis, cell adhesion, apoptosis, and chemotaxis. It is highly expressed in macrophages within and atherosclerotic plaques.galectin-3 can mediate production of profibrotic factors and collagen accumulation in a variety of diseases. The role of galectIn-3 in regulating macrophage invasion and consequent modulation of atherosclerotic plaque phenotype. Finally, the current study concluded that the amount of LGALS-3 gene expression is related to rs4652 SNP variant in patients with MI due toT2D complications.
{"title":"Influence of LGALS3 Gene Polymorphism as A Potential Predictor for Cardiopathy Complication of Type 2 Diabetes Mellitus","authors":"None Rasha Hasan Jasim, None Sara Sattar Jabbar","doi":"10.36329/jkcm/2023/v2.i10.13885","DOIUrl":"https://doi.org/10.36329/jkcm/2023/v2.i10.13885","url":null,"abstract":"Galectin-3(Gal-3) belongs to lectins family binding β-galactoside that have at least one of the carbohydrate recognition domains (CRDs) in their own structure, which located on chromosome 14 (14q22.3).Gal-3Plays an important role in modulating cardiac inflammation and fibrosis. Therefore, LGALS3 gene, encoding galectin-3 protein, which considered promising candidate for the genetic study of cardiovascular diseases (CVDs),and evaluating the association between LGALS3 gene polymorphisms and the susceptibility and prognosis of myocardial infarction(MI) .Gal-is a pleiotropic molecule expressed on the cell membrane, within the cytoplasm or the nucleus. It has been proposed to function as a mediator of inflammation, fibrosis, cell adhesion, apoptosis, and chemotaxis. It is highly expressed in macrophages within and atherosclerotic plaques.galectin-3 can mediate production of profibrotic factors and collagen accumulation in a variety of diseases. The role of galectIn-3 in regulating macrophage invasion and consequent modulation of atherosclerotic plaque phenotype. Finally, the current study concluded that the amount of LGALS-3 gene expression is related to rs4652 SNP variant in patients with MI due toT2D complications.","PeriodicalId":489104,"journal":{"name":"Journal of Kufa for Chemical Sciences","volume":"119 21","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-05DOI: 10.36329/jkcm/2023/v2.i10.13888
None Muhsn Ali hazam,, None Raheem Jameel Mahesein, None H. N. K. AL-Salman
pyrazoline was synthesized as a derivative, then the polymerization of pyrazoline was carried out with fusidic acid and zinc oxide. All the physical properties affecting the construction process, such as Thin-layer chromatography, solubility, the effect of buffer solutions, and temperatures, were studied. Physical diagnostics such as DSC, TGA, and FT-IR were also investigated. The study of the biological activity of the polymer resulting from the interaction of pyrimidine with fusidic acid and zinc oxide, where the study was conducted against three types of bacteria, and the results of the study were compared with the activity of fusidic acid alone once and with zinc oxide alone again as a control. The results showed that the process of polymerization of pyrazoline with fusidic acid and zinc oxide gives more excellent results against bacteria compared to fusidic acid alone and zinc oxide alone.
{"title":"Study of the biological activity of pyrazoline derivatives with fusidic acid and ZnO as an antibacterial and antioxidant","authors":"None Muhsn Ali hazam,, None Raheem Jameel Mahesein, None H. N. K. AL-Salman","doi":"10.36329/jkcm/2023/v2.i10.13888","DOIUrl":"https://doi.org/10.36329/jkcm/2023/v2.i10.13888","url":null,"abstract":"pyrazoline was synthesized as a derivative, then the polymerization of pyrazoline was carried out with fusidic acid and zinc oxide. All the physical properties affecting the construction process, such as Thin-layer chromatography, solubility, the effect of buffer solutions, and temperatures, were studied. Physical diagnostics such as DSC, TGA, and FT-IR were also investigated. The study of the biological activity of the polymer resulting from the interaction of pyrimidine with fusidic acid and zinc oxide, where the study was conducted against three types of bacteria, and the results of the study were compared with the activity of fusidic acid alone once and with zinc oxide alone again as a control. The results showed that the process of polymerization of pyrazoline with fusidic acid and zinc oxide gives more excellent results against bacteria compared to fusidic acid alone and zinc oxide alone.","PeriodicalId":489104,"journal":{"name":"Journal of Kufa for Chemical Sciences","volume":"119 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-05DOI: 10.36329/jkcm/2023/v2.i10.12523
None Shatha Raheem Helal Alhimidi, None Manal A. Mohammed Al-Jabery, None Nadia Ezzat Alkurbasy, None Muhsen Abood Muhsen Al-Ibadi
Electron density of the interaction of the compound's chemical bonding has been computed using topological analysis. The findings suggest that Os-Os, Os-N, and Os-H bonds have experienced bond critical points (BCP) with corresponding bonds paths (BP). The presence of N-C bridging atoms is significantly impacted by electron density of Os2-Os3 bond distribution therefore no critical point found and bond path. So, due to their positive electron density (b), negative laplacian 2(b), and positive the total energy density H(b) values, the Os-NC, Os-H, and Os-CO bonds all have transit closed-shell topological properties.
{"title":"QTAIM analysis for Metal - Metal and Metal- Non-metal Bonds in Tri-Osmium cluster","authors":"None Shatha Raheem Helal Alhimidi, None Manal A. Mohammed Al-Jabery, None Nadia Ezzat Alkurbasy, None Muhsen Abood Muhsen Al-Ibadi","doi":"10.36329/jkcm/2023/v2.i10.12523","DOIUrl":"https://doi.org/10.36329/jkcm/2023/v2.i10.12523","url":null,"abstract":"Electron density of the interaction of the compound's chemical bonding has been computed using topological analysis. The findings suggest that Os-Os, Os-N, and Os-H bonds have experienced bond critical points (BCP) with corresponding bonds paths (BP). The presence of N-C bridging atoms is significantly impacted by electron density of Os2-Os3 bond distribution therefore no critical point found and bond path. So, due to their positive electron density (b), negative laplacian 2(b), and positive the total energy density H(b) values, the Os-NC, Os-H, and Os-CO bonds all have transit closed-shell topological properties.","PeriodicalId":489104,"journal":{"name":"Journal of Kufa for Chemical Sciences","volume":"120 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-05DOI: 10.36329/jkcm/2023/v2.i10.13419
None Nihayat O. Ahmad, None Kamaran Abdoulrahman
Objective: Cardiovascular diseases is the main reason of mortality in developed and developing nations. Atherosclerosis is the major source of morbidity and mortality. The main cause of coronary artery disease (CAD) is the atherosclerotic plaques formation. Advanced glycation end products (AGEs), such as Nε-(carboxymethyl)-lysine (CML) and pentosidine (PTD) are implicated in vascular disease. The important risk factor for atherosclerosis is the imbalance between oxidative stress and antioxidants. This study is aimed to evaluate the serum AGE, oxidative stress and antioxidant parameters in atherosclerotic patients to compare with control group.
{"title":"Evaluation of Advanced Glycation End Products, Oxidative stress, and Antioxidant Parameters in Patients with Atherosclerosis","authors":"None Nihayat O. Ahmad, None Kamaran Abdoulrahman","doi":"10.36329/jkcm/2023/v2.i10.13419","DOIUrl":"https://doi.org/10.36329/jkcm/2023/v2.i10.13419","url":null,"abstract":"Objective: Cardiovascular diseases is the main reason of mortality in developed and developing nations. Atherosclerosis is the major source of morbidity and mortality. The main cause of coronary artery disease (CAD) is the atherosclerotic plaques formation. Advanced glycation end products (AGEs), such as Nε-(carboxymethyl)-lysine (CML) and pentosidine (PTD) are implicated in vascular disease. The important risk factor for atherosclerosis is the imbalance between oxidative stress and antioxidants. This study is aimed to evaluate the serum AGE, oxidative stress and antioxidant parameters in atherosclerotic patients to compare with control group.","PeriodicalId":489104,"journal":{"name":"Journal of Kufa for Chemical Sciences","volume":"120 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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