The identification of chronic medical conditions and its associated mortality has led to the emergence of less invasive methods for medical diagnostic imaging. This work proposes a Computer Aided Diagnostic tool useful in automatic classification of kidney images as normal, simple cysts, kidney stones and the less investigated complex cystic renal cell carcinoma. The first part of the work investigates an effective despeckling algorithm with a proposed adaptive wavelet based denoising technique. Encouraging increased PSNR values ranging from 15 dB to 24 dB were obtained. Second part of work suggests a set of wavelet coefficient based feature set which showed a classification accuracy of 92.2%, better by 20.3% to 0.8% against existing methods. The final part of the work to develop a complete tool for kidney image classification combines the proposed wavelet based features with three existing statistical based feature sets yielded a classification accuracy of 96.9%. The suggested features were extracted from the region of interest from an image set. A reduced feature set of 18 from the original size of 163 was obtained using principal component analysis and applied for training a support vector machine classifier.
{"title":"Image Texture Based Hybrid Diagnostic Tool for Kidney Disease Classification","authors":"P. Sreelatha, M. Ezhilarasi","doi":"10.1166/jmihi.2018.2527","DOIUrl":"https://doi.org/10.1166/jmihi.2018.2527","url":null,"abstract":"The identification of chronic medical conditions and its associated mortality has led to the emergence of less invasive methods for medical diagnostic imaging. This work proposes a Computer Aided Diagnostic tool useful in automatic classification of kidney images as normal, simple cysts,\u0000 kidney stones and the less investigated complex cystic renal cell carcinoma. The first part of the work investigates an effective despeckling algorithm with a proposed adaptive wavelet based denoising technique. Encouraging increased PSNR values ranging from 15 dB to 24 dB were obtained. Second\u0000 part of work suggests a set of wavelet coefficient based feature set which showed a classification accuracy of 92.2%, better by 20.3% to 0.8% against existing methods. The final part of the work to develop a complete tool for kidney image classification combines the proposed wavelet based\u0000 features with three existing statistical based feature sets yielded a classification accuracy of 96.9%. The suggested features were extracted from the region of interest from an image set. A reduced feature set of 18 from the original size of 163 was obtained using principal component analysis\u0000 and applied for training a support vector machine classifier.","PeriodicalId":49032,"journal":{"name":"Journal of Medical Imaging and Health Informatics","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72597131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-01DOI: 10.1166/JMIHI.2018.25311769
K. Alfarhan, M. Y. Mashor, A. Zakaria, M. Omar
Sudden cardiac death (SCD) is one of the cardiovascular diseases that lead to millions of deaths worldwide every year. The aim of the present work is to propose a method for reducing the mortality rate of the SCD patients by an early prediction for SCD from the ECG signal. Normal and SCD MIT databases were used in this research work. One minute segments of ECG signals were segmented from MIT databases where these segments are ten minutes before sudden cardiac arrest (SCA) onset. The collected raw ECG signals were subjected to filter to remove the noise and then normalized. A frequency-domain feature and time-domain features were extracted from the Q-T segment, Q-T interval, R-R interval and QRS interval. The features were normalized to improve the performance of the classifier. Artificial intelligence classifiers; namely, K-nearest neighbor (KNN) and linear discriminant analysis (LDA) were used separately on SCD and normal ECG signals. The highest classification accuracy obtained for KNN and LDA are 97% and 95.5% respectively.
{"title":"Automated Electrocardiogram Signals Based Risk Marker for Early Sudden Cardiac Death Prediction","authors":"K. Alfarhan, M. Y. Mashor, A. Zakaria, M. Omar","doi":"10.1166/JMIHI.2018.25311769","DOIUrl":"https://doi.org/10.1166/JMIHI.2018.25311769","url":null,"abstract":"Sudden cardiac death (SCD) is one of the cardiovascular diseases that lead to millions of deaths worldwide every year. The aim of the present work is to propose a method for reducing the mortality rate of the SCD patients by an early prediction for SCD from the ECG signal. Normal and\u0000 SCD MIT databases were used in this research work. One minute segments of ECG signals were segmented from MIT databases where these segments are ten minutes before sudden cardiac arrest (SCA) onset. The collected raw ECG signals were subjected to filter to remove the noise and then normalized.\u0000 A frequency-domain feature and time-domain features were extracted from the Q-T segment, Q-T interval, R-R interval and QRS interval. The features were normalized to improve the performance of the classifier. Artificial intelligence classifiers; namely, K-nearest neighbor (KNN) and\u0000 linear discriminant analysis (LDA) were used separately on SCD and normal ECG signals. The highest classification accuracy obtained for KNN and LDA are 97% and 95.5% respectively.","PeriodicalId":49032,"journal":{"name":"Journal of Medical Imaging and Health Informatics","volume":"94 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88473734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jia-Jun Qiu, Yue Wu, Bei Hui, Jia Chen, Lin Ji, Min Wang
Purpose: To explore the feasibility of classifying hepatocellular carcinoma (HCC) and hepatic hemangioma (HEM) using texture features of non-enhanced computed tomography (CT) images, especially to investigate the effectiveness of a novel texture analysis method based on the combination of wavelet and co-occurrence matrix. Methods: 269 patients were retrospectively analyzed, including 129 HCCs and 140 HEMs. We cropped tumor regions of interest (ROIs) on non-enhanced CT images, and then used four texture analysis methods to extract quantitative data of the ROIs: gray-level histogram (GLH), gray-level co-occurrence matrix (GLCM), reverse biorthogonal wavelet transform (RBWT), and reverse biorthogonal wavelet co-occurrence matrix (RBCM). The RBCM was a novel method proposed in this study that combined wavelet transform and co-occurrence matrix. It discretized wavelet coefficient matrices based on the statistical characteristics of the training set. Thus, four sets of texture features were obtained. We then conducted classification studies using support vector machine on each set of texture features. 10-fold cross training and testing were used in the classifications, and their results were evaluated and compared. In addition, we tested the significant differences in the texture features of the RBCM method and explored the possible relationships between textures and lesion types. Results: The RBCM method achieved the best classification performance: its average accuracy was 82.14%; its average AUC (area under the receiver operating characteristic curve) was 0.8423. In addition, using the methods of GLH, GLCM, and RBWT, their average accuracies were 75.81%, 78.79%, and 78.8%, respectively. Conclusions: It indicates that the developed texture analysis methods are rewarding for computer-aided diagnosis of HCC and HEM based on non-enhanced CT images. Furthermore, the distinguishing ability of the proposed RBCM method is more pronounced.
{"title":"A Novel Texture Analysis Method Based on Reverse Biorthogonal Wavelet and Co-Occurrence Matrix Applied for Classification of Hepatocellular Carcinoma and Hepatic Hemangioma","authors":"Jia-Jun Qiu, Yue Wu, Bei Hui, Jia Chen, Lin Ji, Min Wang","doi":"10.1166/JMIHI.2018.2516","DOIUrl":"https://doi.org/10.1166/JMIHI.2018.2516","url":null,"abstract":"Purpose: To explore the feasibility of classifying hepatocellular carcinoma (HCC) and hepatic hemangioma (HEM) using texture features of non-enhanced computed tomography (CT) images, especially to investigate the effectiveness of a novel texture analysis method based on the combination\u0000 of wavelet and co-occurrence matrix. Methods: 269 patients were retrospectively analyzed, including 129 HCCs and 140 HEMs. We cropped tumor regions of interest (ROIs) on non-enhanced CT images, and then used four texture analysis methods to extract quantitative data of the ROIs: gray-level\u0000 histogram (GLH), gray-level co-occurrence matrix (GLCM), reverse biorthogonal wavelet transform (RBWT), and reverse biorthogonal wavelet co-occurrence matrix (RBCM). The RBCM was a novel method proposed in this study that combined wavelet transform and co-occurrence matrix. It discretized\u0000 wavelet coefficient matrices based on the statistical characteristics of the training set. Thus, four sets of texture features were obtained. We then conducted classification studies using support vector machine on each set of texture features. 10-fold cross training and testing were used\u0000 in the classifications, and their results were evaluated and compared. In addition, we tested the significant differences in the texture features of the RBCM method and explored the possible relationships between textures and lesion types. Results: The RBCM method achieved the best\u0000 classification performance: its average accuracy was 82.14%; its average AUC (area under the receiver operating characteristic curve) was 0.8423. In addition, using the methods of GLH, GLCM, and RBWT, their average accuracies were 75.81%, 78.79%, and 78.8%, respectively. Conclusions:\u0000 It indicates that the developed texture analysis methods are rewarding for computer-aided diagnosis of HCC and HEM based on non-enhanced CT images. Furthermore, the distinguishing ability of the proposed RBCM method is more pronounced.","PeriodicalId":49032,"journal":{"name":"Journal of Medical Imaging and Health Informatics","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82473319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Special Section on Emerging Trends in Health Informatics","authors":"E. Abdulhay","doi":"10.1166/jmihi.2018.2520","DOIUrl":"https://doi.org/10.1166/jmihi.2018.2520","url":null,"abstract":"","PeriodicalId":49032,"journal":{"name":"Journal of Medical Imaging and Health Informatics","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85333632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To investigate the clinical effect of laparoscopic surgery combined with drug therapy in the treatment of ovarian endometriosis. Methods: 10 cases of patient who underwent laparoscopic surgery due to ovarian cyst, infertility and Dysmenorrhea at the department where the author worked from January 2011 to January 2012 were reviewed, the patients were treated with triptorelin acetate for 3–6 months. Results: The pathological report of all the surgical specimens was definitely diagnosed as ovarian endometriosis, a postoperative follow-up was conducted on a regular basis, there were 3 cases of recurrence, 21 cases of remitted dysmenorrhea, and 8 cases of pregnancy. Conclusion: The postoperative application of Triptorelin acetate combined with laparoscopic surgery is a better method to treat ovarian endometriosis, and it can improve the pregnancy rate of infertile patients.
{"title":"Analysis on Clinical Effect of Laparoscopic Surgery in the Treatment of Ovarian Endometriosis Cyst and Prevention of Its Recurrence","authors":"Xin Jin, Nannan Wang, Guilin Li","doi":"10.1166/jmihi.2018.2535","DOIUrl":"https://doi.org/10.1166/jmihi.2018.2535","url":null,"abstract":"To investigate the clinical effect of laparoscopic surgery combined with drug therapy in the treatment of ovarian endometriosis. Methods: 10 cases of patient who underwent laparoscopic surgery due to ovarian cyst, infertility and Dysmenorrhea at the department where the author\u0000 worked from January 2011 to January 2012 were reviewed, the patients were treated with triptorelin acetate for 3–6 months. Results: The pathological report of all the surgical specimens was definitely diagnosed as ovarian endometriosis, a postoperative follow-up was conducted\u0000 on a regular basis, there were 3 cases of recurrence, 21 cases of remitted dysmenorrhea, and 8 cases of pregnancy. Conclusion: The postoperative application of Triptorelin acetate combined with laparoscopic surgery is a better method to treat ovarian endometriosis, and it can improve\u0000 the pregnancy rate of infertile patients.","PeriodicalId":49032,"journal":{"name":"Journal of Medical Imaging and Health Informatics","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82199602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Alzimami, N. Abuhadi, A. Alanazi, O. Kadri, A. Alfuraih, Z. Podolyák, D. Bradley, M. Mahmoud, S. Sassi
Purpose: The wide availability and reputation for accuracy of the single-photon emission computed tomography (SPECT) of the myocardium has made it a top global choice for nuclear cardiology procedures. The goal of this research is to determine the effectiveness and measurable accuracy of 3D iterative reconstruction algorithms compared to filtered back projection techniques for cardiac SPECT images. Effectiveness is determined by the ability of the various techniques to produce accurate cardiac SPECT images. Materials and Methods: A Siemens Symbia T16 SPECT/CT scanner was used to acquire SPECT/CT images and the Monte Carlo simulations whilst a GATE package was used with the implementation of Infinia™ (GE) dual head SPECT gamma camera–simulated data. The recordings were acquired from point and linear sources and a cardiac insert was created along with a simulation of a computerized phantom XCAT. Result: The results of this study demonstrated an improvement in image quality and the use of a Flash 3D algorithm relative to FBP technique enhances its accuracy. The data presented in this article further show that the image quality of myocardium images and quantification accuracy, particularly for high-resolution studies reconstructed using the Flash 3D algorithm, can be greatly affected by a respiratory-induced motion. Conclusion: Image quality and quantification accuracy can be better improved with respiratory-gating techniques, utilization of ordered-subsets maximization (OSEM) algorithms with attenuation and scatter correction. A simulation of respiratory-induced motion resulted in a reconstructed SPECT recording of 73% reduction in the quantified image resolution for Flash 3D and 43% for FBP. It also caused the underestimation for the left ventricle volume by 18% using FBP and 41% for the Flash 3D. In conclusion, our physical phantom studies and Monte Carlo simulation studies agree with the main hypothesis of our investigation. They showed improvement in image quality with increased accuracy when using the Flash 3D algorithm relative to the FBP technique.
{"title":"Optimization of Accurate Quantification in Single-Photon Emission Computed Tomography Myocardial Imaging","authors":"K. Alzimami, N. Abuhadi, A. Alanazi, O. Kadri, A. Alfuraih, Z. Podolyák, D. Bradley, M. Mahmoud, S. Sassi","doi":"10.1166/jmihi.2018.2517","DOIUrl":"https://doi.org/10.1166/jmihi.2018.2517","url":null,"abstract":"Purpose: The wide availability and reputation for accuracy of the single-photon emission computed tomography (SPECT) of the myocardium has made it a top global choice for nuclear cardiology procedures. The goal of this research is to determine the effectiveness and measurable\u0000 accuracy of 3D iterative reconstruction algorithms compared to filtered back projection techniques for cardiac SPECT images. Effectiveness is determined by the ability of the various techniques to produce accurate cardiac SPECT images. Materials and Methods: A Siemens Symbia T16 SPECT/CT\u0000 scanner was used to acquire SPECT/CT images and the Monte Carlo simulations whilst a GATE package was used with the implementation of Infinia™ (GE) dual head SPECT gamma camera–simulated data. The recordings were acquired from point and linear sources and a cardiac insert\u0000 was created along with a simulation of a computerized phantom XCAT. Result: The results of this study demonstrated an improvement in image quality and the use of a Flash 3D algorithm relative to FBP technique enhances its accuracy. The data presented in this article further show that\u0000 the image quality of myocardium images and quantification accuracy, particularly for high-resolution studies reconstructed using the Flash 3D algorithm, can be greatly affected by a respiratory-induced motion. Conclusion: Image quality and quantification accuracy can be better improved\u0000 with respiratory-gating techniques, utilization of ordered-subsets maximization (OSEM) algorithms with attenuation and scatter correction. A simulation of respiratory-induced motion resulted in a reconstructed SPECT recording of 73% reduction in the quantified image resolution for Flash 3D\u0000 and 43% for FBP. It also caused the underestimation for the left ventricle volume by 18% using FBP and 41% for the Flash 3D. In conclusion, our physical phantom studies and Monte Carlo simulation studies agree with the main hypothesis of our investigation. They showed improvement in image\u0000 quality with increased accuracy when using the Flash 3D algorithm relative to the FBP technique.","PeriodicalId":49032,"journal":{"name":"Journal of Medical Imaging and Health Informatics","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77945610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Prabhu, R. Puviarasi, S. Mole, T. Jarin, E. Gajendran
Wireless medical devices shall considerably improve the proficiency and effectiveness in medical segments. Recent wireless inventions enable reduced design, thus becomes inexpensive for manufacturing. Huge quantity of individual information is measured and communicated in wireless manner, consequently safety precautions are needed to be integrated with these wireless technologies. The evaluation strategies for Wireless Ultra Wideband communication towards orthopedic surgical scheme has been explained in this paper. Every devices considered in this paper are identical with each others towards their elementary objective. However, they vary towards different real-world applications. The devices enumerated in this paper have shared operating frequency bands of 2.4 GHz ISM Band and UWB frequency ranging from 3.1 GHz to 10.6 GHz. Every devices entailed here is positioned to fit within the operating frequencies either at 2.4 GHz or 3.1 GHz to 10.6 GHz. This paper targets on protective patient-privacy which is deemed to be energetic characteristics towards isolated patient monitoring schemes. Considering the rise in quantity of feasible wireless medicinal products, this paper targets in the engagement of different wireless standards and measured data on the basis of dissimilar rates. Thus, the foremost significant in this work is towards supplementing the quantity of integration in wireless medical monitoring schemes. Similarly, as the applications of implantable and ingestible wireless medical approaches are becoming increased, they offer easy accessing towards data collecting and data which are previously dreadful, and this has been considered as a vital parameter in this paper. Hence, there becomes bigger possibility towards improving exactness of wireless positioning arrangements. When complications of the system increase, the prevailing protocols shall not be appropriate for superior and satisfactory bandwidth pertaining real-time application, thereby few protocols have been worked out to encounter this issue. Therefore, the major contributions in this paper include advanced speediness, superior data rate designs and effective protocols. In this paper, all the structures entailed have the potential to assist doctors for improving the dominance in lives of patients, thus application development is properly discussed for progressing with these implements.
{"title":"Evaluation Strategies for Wireless Ultra Wideband Communication Towards Orthopedic Surgical Scheme","authors":"S. Prabhu, R. Puviarasi, S. Mole, T. Jarin, E. Gajendran","doi":"10.1166/JMIHI.2018.2536","DOIUrl":"https://doi.org/10.1166/JMIHI.2018.2536","url":null,"abstract":"Wireless medical devices shall considerably improve the proficiency and effectiveness in medical segments. Recent wireless inventions enable reduced design, thus becomes inexpensive for manufacturing. Huge quantity of individual information is measured and communicated in wireless manner,\u0000 consequently safety precautions are needed to be integrated with these wireless technologies. The evaluation strategies for Wireless Ultra Wideband communication towards orthopedic surgical scheme has been explained in this paper. Every devices considered in this paper are identical with each\u0000 others towards their elementary objective. However, they vary towards different real-world applications. The devices enumerated in this paper have shared operating frequency bands of 2.4 GHz ISM Band and UWB frequency ranging from 3.1 GHz to 10.6 GHz. Every devices entailed here is positioned\u0000 to fit within the operating frequencies either at 2.4 GHz or 3.1 GHz to 10.6 GHz. This paper targets on protective patient-privacy which is deemed to be energetic characteristics towards isolated patient monitoring schemes. Considering the rise in quantity of feasible wireless medicinal products,\u0000 this paper targets in the engagement of different wireless standards and measured data on the basis of dissimilar rates. Thus, the foremost significant in this work is towards supplementing the quantity of integration in wireless medical monitoring schemes. Similarly, as the applications of\u0000 implantable and ingestible wireless medical approaches are becoming increased, they offer easy accessing towards data collecting and data which are previously dreadful, and this has been considered as a vital parameter in this paper. Hence, there becomes bigger possibility towards improving\u0000 exactness of wireless positioning arrangements. When complications of the system increase, the prevailing protocols shall not be appropriate for superior and satisfactory bandwidth pertaining real-time application, thereby few protocols have been worked out to encounter this issue. Therefore,\u0000 the major contributions in this paper include advanced speediness, superior data rate designs and effective protocols. In this paper, all the structures entailed have the potential to assist doctors for improving the dominance in lives of patients, thus application development is properly\u0000 discussed for progressing with these implements.","PeriodicalId":49032,"journal":{"name":"Journal of Medical Imaging and Health Informatics","volume":"67 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83436746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Rui, Lin Yingping, Lijun Gu, Zhiyan Wang, Jing Zuo, Lin Zha
Nuclear factor kappa B (NF-κB), a key nuclear transcription factor, is associated with prognosis in a variety of human cancers. However, the clinical value of NF-κB in non-small cell lung cancer (NSCLC) is still controversial. Therefore, the aim of this meta-analysis was to obtain an accurate evaluation of the relationship between NF-κB expression and survival prognosis of NSCLC patients based on published articles. PubMed, EMBASE and Web of Science databases were systematically searched for potential articles. A total of 1159 patients from 7 eligible studies comparing prognostic significance of NF-κB expression levels in NSCLC were included in our meta-analysis. I2 statistic and P value were performed to evaluate heterogeneity using Review Manager version 5.3. The results of analysis were presented as hazard ratio (HR) or odds ratios with 95% confidence interval (95% CI). Subgroup analysis based on ethnicity of NSCLC patients was conducted to illustrate the potential discrepancy. Significant heterogeneity was considered at I2 > 50% and P < 0.05, and random-effects model was used. The combined results indicated that higher NF-κB expression was associated with shorter overall survival of NSCLC patients (HR = 2.78, 95% CI = 1.51–5.12, P = 0.001). Moreover, NF-κB expression was closely associated with tumor stage (HR = 0.32, 95% CI = 0.18–0.57, P < 0.0001) and lymph node metastasis (HR = 0.56, 95% CI = 0.38–0.83, P = 0.004). We conclude that NF-κB expression may be a potential unfavorable prognostic marker for NSCLC patients.
核因子κB (NF-κB)是一种关键的核转录因子，在多种人类癌症中与预后相关。然而，NF-κB在非小细胞肺癌(NSCLC)中的临床价值仍存在争议。因此，本荟萃分析的目的是基于已发表的文献，准确评估NF-κB表达与NSCLC患者生存预后的关系。系统地检索PubMed、EMBASE和Web of Science数据库寻找潜在的文章。我们的荟萃分析纳入了来自7项符合条件的研究的1159例患者，这些研究比较了NF-κB表达水平在非小细胞肺癌中的预后意义。使用Review Manager 5.3版本进行I2统计量和P值评估异质性。分析结果以风险比(HR)或95%置信区间(95% CI)的优势比表示。基于非小细胞肺癌患者的种族进行亚组分析，以说明潜在的差异。I2 > 50%， P < 0.05认为异质性显著，采用随机效应模型。综合结果显示，NF-κB表达升高与NSCLC患者总生存期缩短相关(HR = 2.78, 95% CI = 1.51 ~ 5.12, P = 0.001)。此外，NF-κB表达与肿瘤分期(HR = 0.32, 95% CI = 0.18-0.57, P < 0.0001)和淋巴结转移(HR = 0.56, 95% CI = 0.38-0.83, P = 0.004)密切相关。我们得出结论，NF-κB表达可能是非小细胞肺癌患者潜在的不利预后指标。
{"title":"A Meta Analysis on Prognostic Value of Patients with Non-Small Cell Lung Cancer","authors":"J. Rui, Lin Yingping, Lijun Gu, Zhiyan Wang, Jing Zuo, Lin Zha","doi":"10.1166/jmihi.2018.2564","DOIUrl":"https://doi.org/10.1166/jmihi.2018.2564","url":null,"abstract":"Nuclear factor kappa B (NF-κB), a key nuclear transcription factor, is associated with prognosis in a variety of human cancers. However, the clinical value of NF-κB in non-small cell lung cancer (NSCLC) is still controversial. Therefore, the aim of this meta-analysis\u0000 was to obtain an accurate evaluation of the relationship between NF-κB expression and survival prognosis of NSCLC patients based on published articles. PubMed, EMBASE and Web of Science databases were systematically searched for potential articles. A total of 1159 patients from\u0000 7 eligible studies comparing prognostic significance of NF-κB expression levels in NSCLC were included in our meta-analysis. I2 statistic and P value were performed to evaluate heterogeneity using Review Manager version 5.3. The results of analysis were\u0000 presented as hazard ratio (HR) or odds ratios with 95% confidence interval (95% CI). Subgroup analysis based on ethnicity of NSCLC patients was conducted to illustrate the potential discrepancy. Significant heterogeneity was considered at I2 > 50% and P < 0.05,\u0000 and random-effects model was used. The combined results indicated that higher NF-κB expression was associated with shorter overall survival of NSCLC patients (HR = 2.78, 95% CI = 1.51–5.12, P = 0.001). Moreover, NF-κB expression was closely associated\u0000 with tumor stage (HR = 0.32, 95% CI = 0.18–0.57, P < 0.0001) and lymph node metastasis (HR = 0.56, 95% CI = 0.38–0.83, P = 0.004). We conclude that NF-κB expression may be a potential unfavorable prognostic marker for NSCLC patients.","PeriodicalId":49032,"journal":{"name":"Journal of Medical Imaging and Health Informatics","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87687893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhao Yuchen, Jiao Xinyi, Lv Hong-bo, Yang Xiaolong
To explore the influence of the parturients' mental factors on the delivery mode and postpartum hemorrhage and the nursing intervention countermeasures, the research randomly divided the expectant primiparae hospitalized in our hospital during February 2012–February 2013 into the intervention group and the control group. Wherein, the control group received routine nursing, while the intervention group received nursing intervention based on the routine nursing, to compare the postpartum hemorrhage and satisfaction of the two groups of parturients. Result: 36 of 112 parturients suffered from dysphoria, accounting for 32.14%; 37 parturSients suffered from depression, accounting for 33.04%. The parturients' hemorrhage incidence, postpartum amount of bleeding within 2 h and postpartum amount of bleeding within 24 h all significantly declined compared with those of the control group (x2/t = 3.98, 4.02, 4.96 p < 0.05). The cesarean rate of the control group (7.14%, 4/56) was significantly higher than that of the control group (16.07%, 9/56) (x2 = 4.02 p < 0.05). The postpartum satisfaction of the patients in the intervention group was apparently higher than that of the control group (x2 = 4.26 p < 0.05). Conclusion: The nursing intervention can obviously reduce the incidence of postpartum hemorrhage and improve postpartum satisfaction, so it is worth popularizing.
为探讨产妇心理因素对分娩方式及产后出血的影响及护理干预对策，本研究将2012年2月至2013年2月在我院住院的准初产妇随机分为干预组和对照组。其中，对照组接受常规护理，干预组在常规护理的基础上进行护理干预，比较两组产妇产后出血情况及满意度。结果:112例产妇中有36例出现烦躁不安，占32.14%;37例产妇患有抑郁症，占33.04%。与对照组相比，产妇出血发生率、产后2 h内出血量、产后24 h内出血量均显著下降(x2/t = 3.98、4.02、4.96 p < 0.05)。对照组剖宫产率(7.14%，4/56)显著高于对照组(16.07%，9/56)(x2 = 4.02 p < 0.05)。干预组患者的产后满意度明显高于对照组(x2 = 4.26 p < 0.05)。结论:护理干预可明显降低产后出血发生率，提高产后满意度，值得推广。
{"title":"ANOVA Based Sleep Quality Index Analysis on Mental State and Sleep Quality Quantification","authors":"Zhao Yuchen, Jiao Xinyi, Lv Hong-bo, Yang Xiaolong","doi":"10.1166/JMIHI.2018.2528","DOIUrl":"https://doi.org/10.1166/JMIHI.2018.2528","url":null,"abstract":"To explore the influence of the parturients' mental factors on the delivery mode and postpartum hemorrhage and the nursing intervention countermeasures, the research randomly divided the expectant primiparae hospitalized in our hospital during February 2012–February 2013 into\u0000 the intervention group and the control group. Wherein, the control group received routine nursing, while the intervention group received nursing intervention based on the routine nursing, to compare the postpartum hemorrhage and satisfaction of the two groups of parturients. Result:\u0000 36 of 112 parturients suffered from dysphoria, accounting for 32.14%; 37 parturSients suffered from depression, accounting for 33.04%. The parturients' hemorrhage incidence, postpartum amount of bleeding within 2 h and postpartum amount of bleeding within 24 h all significantly declined compared\u0000 with those of the control group (x2/t = 3.98, 4.02, 4.96 p < 0.05). The cesarean rate of the control group (7.14%, 4/56) was significantly higher than that of the control group (16.07%, 9/56) (x2 = 4.02 p < 0.05). The postpartum satisfaction of the\u0000 patients in the intervention group was apparently higher than that of the control group (x2 = 4.26 p < 0.05). Conclusion: The nursing intervention can obviously reduce the incidence of postpartum hemorrhage and improve postpartum satisfaction, so it is worth popularizing.","PeriodicalId":49032,"journal":{"name":"Journal of Medical Imaging and Health Informatics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82489943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tianchi Zhang, Jian Zhang, Jing Zhang, Melvyn L. Smith
One of the most established region-based segmentation methods is the region based C-V model. This method formulates the image segmentation problem as a level set or improved level set clustering problem. However, the existing level set C-V model fails to perform well in the presence of noisy and incomplete data or when there is similarity between the objects and background, especially for clustering or segmentation tasks in medical images where objects appear vague and poorly contrasted in greyscale. In this paper, we modify the level set C-V model using a two-step modified Nash equilibrium approach. Firstly, a standard deviation using an entropy payoff approach is employed and secondly a two-step similarity clustering based approach is applied to the modified Nash equilibrium. One represents a maximum similarity within the clustered regions and the other the minimum similarity between the clusters. Finally, an improved C-V model based on a two-step modified Nash equilibrium is proposed to smooth the object contour during the image segmentation. Experiments demonstrate that the proposed method has good performance for segmenting noisy and poorly contrasting regions within medical images.
{"title":"Two-Step Modified Nash Equilibrium Method for Medical Image Segmentation Based on an Improved C-V Model","authors":"Tianchi Zhang, Jian Zhang, Jing Zhang, Melvyn L. Smith","doi":"10.1166/JMIHI.2018.2521","DOIUrl":"https://doi.org/10.1166/JMIHI.2018.2521","url":null,"abstract":"One of the most established region-based segmentation methods is the region based C-V model. This method formulates the image segmentation problem as a level set or improved level set clustering problem. However, the existing level set C-V model fails to perform well in the presence\u0000 of noisy and incomplete data or when there is similarity between the objects and background, especially for clustering or segmentation tasks in medical images where objects appear vague and poorly contrasted in greyscale. In this paper, we modify the level set C-V model using a two-step modified\u0000 Nash equilibrium approach. Firstly, a standard deviation using an entropy payoff approach is employed and secondly a two-step similarity clustering based approach is applied to the modified Nash equilibrium. One represents a maximum similarity within the clustered regions and the other the\u0000 minimum similarity between the clusters. Finally, an improved C-V model based on a two-step modified Nash equilibrium is proposed to smooth the object contour during the image segmentation. Experiments demonstrate that the proposed method has good performance for segmenting noisy and poorly\u0000 contrasting regions within medical images.","PeriodicalId":49032,"journal":{"name":"Journal of Medical Imaging and Health Informatics","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82619727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：