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Photon-counting detector coronary CT angiography: Defining the optimal monoenergetic level for grading of calcified coronary stenosis 光子计数探测器冠状动脉 CT 血管造影:确定钙化冠状动脉狭窄分级的最佳单能级。
IF 5.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-01 DOI: 10.1016/j.jcct.2024.06.007
Thomas Sartoretti, Lukas J. Moser, Stéphane Rusek, Filippo Civaia, Philippe Rossi, Alessandro Candreva, Robert Manka, Matthias Eberhard, Hatem Alkadhi, Victor Mergen
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引用次数: 0
Getting older by a decade after preeclampsia 先兆子痫后十年变老。
IF 5.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-01 DOI: 10.1016/j.jcct.2024.08.007
Amelie Paquin, Thais Coutinho
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引用次数: 0
Computed tomography to predict pacemaker need after transcatheter aortic valve replacement 通过计算机断层扫描预测经导管主动脉瓣置换术后起搏器的需求。
IF 5.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-01 DOI: 10.1016/j.jcct.2024.08.009
Sarah Verhemel , Rutger-Jan Nuis , Mark van den Dorpel , Rik Adrichem , Mauricio Felippi de Sá Marchi , Alexander Hirsch , Joost Daemen , Ricardo P.J. Budde , Nicolas M. Van Mieghem
Transcatheter aortic valve replacement (TAVR) is preferred therapy for elderly patients with severe aortic stenosis (AS) and increasingly used in younger patient populations with good safety and efficacy outcomes. However, cardiac conduction abnormalities remain a frequent complication after TAVR ranging from relative benign interventriculair conduction delays to prognostically relevant left bundle branch block and complete atrio-ventricular (AV) block requiring permanent pacemaker implantation (PPI). Although clinical, procedural and electrocardiographic factors have been identified as predictors of this complication, there is a need for advanced strategies to control the burden of conduction defects particularly as TAVR shifts towards younger populations. This state of the art review highlights the value of ECG-synchronized computed tomographic angiography (CTA) evaluation of the aortic root to better understand and manage conduction problems post-TAVR. An update on CTA derived anatomic features related to conduction issues is provided and complemented with computational framework modelling. This CTA-derived 3-dimensional anatomical reconstruction tool generates patient-specific TAVR simulations enabling operators to adapt procedural strategy and implantation technique to mitigate conduction abnormality risks.
经导管主动脉瓣置换术(TAVR)是重度主动脉瓣狭窄(AS)老年患者的首选治疗方法,并越来越多地用于年轻患者,具有良好的安全性和有效性。然而,心脏传导异常仍是 TAVR 术后的常见并发症,从相对良性的室间传导延迟到预后相关的左束支传导阻滞和需要植入永久起搏器(PPI)的完全性房室传导阻滞。虽然临床、手术和心电图因素已被确定为这一并发症的预测因素,但仍需要先进的策略来控制传导缺陷的负担,尤其是在 TAVR 向年轻人群转移的过程中。这篇最新技术综述强调了对主动脉根部进行心电图同步计算机断层扫描(CTA)评估的价值,以更好地了解和处理 TAVR 术后的传导问题。本文提供了与传导问题相关的 CTA 衍生解剖特征的最新信息,并辅以计算框架建模。这种由 CTA 导出的三维解剖重建工具可生成针对特定患者的 TAVR 模拟,使操作人员能够调整手术策略和植入技术,以降低传导异常风险。
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引用次数: 0
Coronary computed tomography angiography for the diagnosis of significant left main coronary artery disease 冠状动脉计算机断层扫描血管造影用于诊断重要的左冠状动脉主干疾病。
IF 5.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-01 DOI: 10.1016/j.jcct.2024.10.012
Carlos M. Campos, Hector M. Garcia-Garcia
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引用次数: 0
Biventricular reverse-remodeling after transcatheter mitral valve replacement with the Tendyne™ system 使用 Tendyne™ 系统进行经导管二尖瓣置换术后的双心室反向重塑。
IF 5.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-01 DOI: 10.1016/j.jcct.2024.06.003
Miho Fukui, Paul Sorajja, David WM. Muller, Evan Walser-Kuntz, Larissa I. Stanberry, Vasilis C. Babaliaros, Vinod H. Thourani, Nicolas Dumonteil, Darren Walters, Gry Dahle, Paul A. Grayburn, Marvin H. Eng, Michael L. Chuang, Benjamin Sun, Philipp Blanke, Alison Duncan, João L. Cavalcante
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引用次数: 0
3D Landmark scout imaging accurately assesses presence and extent of coronary calcification with lower radiation exposure 三维地标扫描成像可准确评估冠状动脉钙化的存在和程度,且辐射量较低。
IF 5.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-01 DOI: 10.1016/j.jcct.2024.07.012
Alexa E. Golbus , John L. Schuzer , Shirley F. Rollison , Kathie C. Bronson , Scott P. Baute , Marcus Y. Chen

Background

Cardiac CT for coronary artery calcium (CAC) scoring exposes patients to 1 ​mSv of radiation. A new CT scout method utilizing ultra-low dose CT (3D Landmark) offers tomographic cross-sectional imaging, which provides axial images from which CAC can be estimated. The purpose of our study is to analyze the association between estimated CAC burden on 3D Landmark scout imaging vs dedicated ECG-gated CACS.

Methods

Consecutive patients over a 9-month period undergoing non-contrast ECG-gated CACS planned with 3D Landmark scout imaging were included. Extent of CAC on 3D Landmark scout imaging was scored from 0 to 3 (none, mild, moderate, severe). Agatston CACS was converted to an ordinal score from 0 to 3, corresponding to absent (0), mild (1–99), moderate (100–400), or severe (>400). Fischer's exact test, weighted kappa coefficient, and paired t-tests were used for analysis.

Results

Of 150 patients, 51.3% were female with mean age 49.0 ​± ​16.8 and BMI 28.6 ​± ​12.3. Sensitivity of 3D Landmark in identifying calcium was 96.2%, with specificity of 100%. There was strong interrater agreement between 3D Landmark calcium scoring and CACS, with weighted kappa coefficient 0.97 ​± ​0.01(CI 0.95–0.99).
Radiation dose-length-product was significantly lower for 3D Landmark imaging vs. dedicated ECG-gated CACS (9.7 ​± ​3.6 vs 43.8 ​± ​26.4 ​mGy ​cm, p ​< ​0.001) despite longer scan length (465.0 ​± ​160.8 vs 123.0 ​± ​12.7 ​mm, respectively).

Conclusion

Estimated coronary artery calcium on 3D Landmark scout images correlates strongly with Agatston CACS, demonstrating utility in assessing cardiovascular risk without introducing additional radiation or costs.
背景:用于冠状动脉钙化(CAC)评分的心脏 CT 会对患者造成 1 mSv 的辐射。一种利用超低剂量 CT(3D Landmark)的新型 CT 扫描方法可提供断层横断面成像,从而提供可估算 CAC 的轴向图像。我们的研究旨在分析 3D Landmark 扫描成像与专用心电图门控 CACS 估算的 CAC 负荷之间的关联:方法:纳入在 9 个月内接受非对比心电图导向 CACS 的连续患者,计划使用 3D Landmark 扫描成像。三维地标扫描成像显示的 CAC 范围从 0 到 3(无、轻度、中度、重度)。Agatston CACS 被转换为 0 至 3 的序数得分,分别对应无(0)、轻度(1-99)、中度(100-400)或重度(>400)。分析采用费舍尔精确检验、加权卡帕系数和配对 t 检验:150名患者中,51.3%为女性,平均年龄(49.0±16.8)岁,体重指数(28.6±12.3)。3D Landmark 鉴定钙的灵敏度为 96.2%,特异性为 100%。3D Landmark钙质评分与CACS之间的评分者间一致性很高,加权卡帕系数为0.97 ± 0.01(CI 0.95-0.99)。三维地标成像与专用心电图门控 CACS 相比,辐射剂量-长度-乘积明显更低(9.7 ± 3.6 vs 43.8 ± 26.4 mGy cm, p 结论:三维地标成像与专用心电图门控 CACS 相比,辐射剂量-长度-乘积明显更低:三维地标扫描图像上估计的冠状动脉钙化与阿加特斯通 CACS 密切相关,显示了在评估心血管风险方面的实用性,而无需引入额外的辐射或成本。
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引用次数: 0
STress computed tomogRaphy perfusion and stress cArdiac magnetic resonance for ThE manaGement of suspected or known coronarY artery disease: resources and outcomes impact 用于疑似或已知冠状动脉疾病治疗的应力计算机断层扫描灌注和应力心脏磁共振:资源和结果影响。
IF 5.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-01 DOI: 10.1016/j.jcct.2024.08.001
Andrea Baggiano , Francesca Baessato , Saima Mushtaq , Andrea Daniele Annoni , Francesco Cannata , Maria Ludovica Carerj , Alberico Del Torto , Fabio Fazzari , Alberto Formenti , Antonio Frappampina , Laura Fusini , Daniele Junod , Maria Elisabetta Mancini , Valentina Mantegazza , Riccardo Maragna , Francesca Marchetti , Francesco Paolo Sbordone , Luigi Tassetti , Alessandra Volpe , Marco Guglielmo , Gianluca Pontone

Background

The aim of this study is to describe resources and outcomes of coronary computed tomography angiography plus Stress CT perfusion (CCTA ​+ ​Stress-CTP) and stress cardiovascular magnetic resonance (Stress-CMR) in symptomatic patients with suspected or known CAD.

Methods

Six hundred and twenty-four consecutive symptomatic patients with intermediate to high-risk pretest likelihood for CAD or previous history of revascularization referred to our hospital for clinically indicated CCTA ​+ ​Stress-CTP or Stress-CMR were enrolled. Stress-CTP scans were performed in 223 patients while 401 patients performed Stress-CMR. Patient follow-up was performed at 1 year after index test performance. Endpoints were all cardiac events, as a combined endpoint of revascularization, non-fatal MI and death, and hard cardiac events, as combined endpoint of non-fatal MI and death.

Results

Twenty-nine percent of patients who underwent CCTA ​+ ​Stress-CTP received revascularization, 7% of subjects assessed with Stress-CMR were treated invasively, and a low number of non-fatal MI and death was observed with both strategies (hard events in 0.4% of patients that had CCTA ​+ ​Stress-CTP as index test, and in 3% of patients evaluated with Stress-CMR). According to the predefined endpoints, CCTA ​+ ​Stress-CTP group showed high rate of all cardiac events and low rate of hard cardiac events, respectively. The cumulative costs were 1970 ​± ​2506 Euro and 733 ​± ​1418 Euro for the CCTA ​+ ​Stress-CTP group and Stress-CMR group, respectively.

Conclusions

The use of CCTA ​+ ​Stress-CTP strategy was associated with high referral to revascularization but with a favourable trend in terms of hard cardiac events and diagnostic yield in identifying individuals at lower risk of adverse events despite the presence of CAD.
背景:本研究旨在描述冠状动脉计算机断层扫描血管造影加应激CT灌注(CCTA + Stress-CTP)和应激心血管磁共振(Stress-CMR)在疑似或已知CAD的无症状患者中的资源和结果:本院连续收治了624名有症状的患者,这些患者的CAD预试验可能性为中到高风险,或既往有血管再通史,转诊至本院接受临床指征的CCTA + Stress-CTP或Stress-CMR检查。223名患者进行了应激CTP扫描,401名患者进行了应激CMR扫描。患者随访时间为指数检查后 1 年。终点为所有心脏事件(血管重建、非致命心肌梗死和死亡的综合终点)和硬性心脏事件(非致命心肌梗死和死亡的综合终点):接受 CCTA + Stress-CTP 检查的患者中有 29% 接受了血管再通治疗,接受 Stress-CMR 评估的受试者中有 7% 接受了有创治疗,两种方法都能观察到较少的非致命性心肌梗死和死亡病例(以 CCTA + Stress-CTP 作为指标检查的患者中有 0.4% 发生了硬性心肌梗死,接受 Stress-CMR 评估的患者中有 3% 发生了硬性心肌梗死)。根据预设终点,CCTA + Stress-CTP 组的所有心脏事件发生率高,而硬性心脏事件发生率低。CCTA + Stress-CTP 组和 Stress-CMR 组的累计费用分别为 1970 ± 2506 欧元和 733 ± 1418 欧元:结论:使用 CCTA + Stress-CTP 策略与较高的血管再通转诊率有关,但在硬性心脏事件和诊断结果方面,尽管存在 CAD,但在识别不良事件风险较低的个体方面,趋势良好。
{"title":"STress computed tomogRaphy perfusion and stress cArdiac magnetic resonance for ThE manaGement of suspected or known coronarY artery disease: resources and outcomes impact","authors":"Andrea Baggiano ,&nbsp;Francesca Baessato ,&nbsp;Saima Mushtaq ,&nbsp;Andrea Daniele Annoni ,&nbsp;Francesco Cannata ,&nbsp;Maria Ludovica Carerj ,&nbsp;Alberico Del Torto ,&nbsp;Fabio Fazzari ,&nbsp;Alberto Formenti ,&nbsp;Antonio Frappampina ,&nbsp;Laura Fusini ,&nbsp;Daniele Junod ,&nbsp;Maria Elisabetta Mancini ,&nbsp;Valentina Mantegazza ,&nbsp;Riccardo Maragna ,&nbsp;Francesca Marchetti ,&nbsp;Francesco Paolo Sbordone ,&nbsp;Luigi Tassetti ,&nbsp;Alessandra Volpe ,&nbsp;Marco Guglielmo ,&nbsp;Gianluca Pontone","doi":"10.1016/j.jcct.2024.08.001","DOIUrl":"10.1016/j.jcct.2024.08.001","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study is to describe resources and outcomes of coronary computed tomography angiography plus Stress CT perfusion (CCTA ​+ ​Stress-CTP) and stress cardiovascular magnetic resonance (Stress-CMR) in symptomatic patients with suspected or known CAD.</div></div><div><h3>Methods</h3><div>Six hundred and twenty-four consecutive symptomatic patients with intermediate to high-risk pretest likelihood for CAD or previous history of revascularization referred to our hospital for clinically indicated CCTA ​+ ​Stress-CTP or Stress-CMR were enrolled. Stress-CTP scans were performed in 223 patients while 401 patients performed Stress-CMR. Patient follow-up was performed at 1 year after index test performance. Endpoints were all cardiac events, as a combined endpoint of revascularization, non-fatal MI and death, and hard cardiac events, as combined endpoint of non-fatal MI and death.</div></div><div><h3>Results</h3><div>Twenty-nine percent of patients who underwent CCTA ​+ ​Stress-CTP received revascularization, 7% of subjects assessed with Stress-CMR were treated invasively, and a low number of non-fatal MI and death was observed with both strategies (hard events in 0.4% of patients that had CCTA ​+ ​Stress-CTP as index test, and in 3% of patients evaluated with Stress-CMR). According to the predefined endpoints, CCTA ​+ ​Stress-CTP group showed high rate of all cardiac events and low rate of hard cardiac events, respectively. The cumulative costs were 1970 ​± ​2506 Euro and 733 ​± ​1418 Euro for the CCTA ​+ ​Stress-CTP group and Stress-CMR group, respectively.</div></div><div><h3>Conclusions</h3><div>The use of CCTA ​+ ​Stress-CTP strategy was associated with high referral to revascularization but with a favourable trend in terms of hard cardiac events and diagnostic yield in identifying individuals at lower risk of adverse events despite the presence of CAD.</div></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 6","pages":"Pages 553-558"},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aortic dimensions in women with previous pre-eclampsia 曾患先兆子痫的妇女的主动脉尺寸。
IF 5.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-01 DOI: 10.1016/j.jcct.2024.06.001
Emma L.R. Møller , Maria G. Hauge , Michael H.C. Pham , Peter Damm , Klaus F. Kofoed , Andreas Fuchs , Jørgen T. Kühl , Per E. Sigvardsen , Anne S. Ersbøll , Marianne Johansen , Børge G. Nordestgaard , Lars V. Køber , Finn Gustafsson , Jesper J. Linde

Background

Pre-eclampsia is a pregnancy related disorder associated with hypertension and vascular inflammation, factors that are also involved in the pathological pathway of aortic dilatation and aneurysm development. It is, however, unknown if younger women with previous pre-eclampsia have increased aortic dimensions. We tested the hypothesis that previous pre-eclampsia is associated with increased aortic dimensions in younger women.

Methods

The study was a cross-sectional cohort study of women with previous pre-eclampsia, aged 40–55, from the PRECIOUS population matched by age and parity with women from the general population. Using contrast-enhanced CT, aortic diameters were measured in the aortic root, ascending aorta, descending aorta, at the level of the diaphragm, suprarenal aorta, and infrarenal aorta.

Results

1355 women (684 with previous pre-eclampsia and 671 from the general population), with a mean (standard deviation) age of 46.9 (4.4) were included. The pre-eclampsia group had larger mean (standard deviation) aortic diameters (mm) in all measured segments from the ascending to the infrarenal aorta (ascending: 33.4 (4.0) vs. 31.4 (3.7), descending: 23.9 (2.1) vs. 23.3 (2.0), diaphragm: 20.8 (1.8) vs. 20.4 (1.8), suprarenal: 22.9 (1.9) vs. 22.0 (2.0), infrarenal: 19.3 (1.6) vs. 18.6 (1.7), p ​< ​0.001 for all, also after adjustment for age, height, parity, menopause, dyslipidemia, smoking and chronic hypertension. Guideline-defined ascending aortic aneurysms were found in 8 vs 2 women (p ​= ​0.12).

Conclusions

Women with previous pre-eclampsia have larger aortic dimensions compared with women from the general population. Pre-eclampsia was found to be an independent risk factor associated with a larger aortic diameter.
背景:子痫前期是一种与高血压和血管炎症有关的妊娠相关疾病,这些因素也参与了主动脉扩张和动脉瘤形成的病理过程。然而,曾患先兆子痫的年轻女性是否会导致主动脉尺寸增大,目前尚不清楚。我们对曾患先兆子痫的年轻女性主动脉尺寸增大的假设进行了检验:该研究是一项横断面队列研究,研究对象是 PRECIOUS 群体中 40-55 岁曾患先兆子痫的女性,她们的年龄和均龄与普通人群中的女性相匹配。通过对比增强 CT,测量了主动脉根部、升主动脉、降主动脉、膈水平、肾上主动脉和肾下主动脉的直径:共纳入 1355 名妇女(684 名曾患有先兆子痫,671 名来自普通人群),平均(标准差)年龄为 46.9(4.4)岁。先兆子痫组从升主动脉到肾下主动脉的所有测量节段的主动脉直径(毫米)的平均值(标准差)都较大(升主动脉:33.4(4.0)):升主动脉:33.4 (4.0) vs. 31.4 (3.7),降主动脉:23.9 (2.1) vs. 31.4 (3.7):23.9 (2.1) vs. 23.3 (2.0),膈:20.8 (1.8) vs. 20.4 (1.8),肾上:22.9 (1.9) vs. 22.0 (2.0),肾下:19.3 (1.6) vs. 18.6 (1.7),P 结论:与普通人群相比,曾患子痫前期的女性主动脉尺寸更大。研究发现,先兆子痫是导致主动脉直径增大的一个独立风险因素。
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引用次数: 0
Artificial Intelligence and Machine Learning for Cardiovascular Computed Tomography (CCT): A White Paper of the Society of Cardiovascular Computed Tomography (SCCT) 用于心血管计算机断层扫描(CCT)的人工智能和机器学习:心血管计算机断层扫描学会(SCCT)白皮书。
IF 5.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-01 DOI: 10.1016/j.jcct.2024.08.003
Michelle C. Williams , Jonathan R. Weir-McCall , Lauren A. Baldassarre , Carlo N. De Cecco , Andrew D. Choi , Damini Dey , Marc R. Dweck , Ivana Isgum , Márton Kolossvary , Jonathon Leipsic , Andrew Lin , Michael T. Lu , Manish Motwani , Koen Nieman , Leslee Shaw , Marly van Assen , Edward Nicol
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引用次数: 0
Relationship between plaque burden and plaque vulnerability: Acute coronary syndromes versus chronic coronary syndrome 斑块负担与斑块易损性之间的关系:急性冠状动脉综合征与慢性冠状动脉综合征。
IF 5.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-01 DOI: 10.1016/j.jcct.2024.09.002
Daisuke Kinoshita , Keishi Suzuki , Daichi Fujimoto , Takayuki Niida , Eisuke Usui , Yoshiyasu Minami , Damini Dey , Hang Lee , Iris McNulty , Junya Ako , Maros Ferencik , Tsunekazu Kakuta , Ik-Kyung Jang

Background

The relationship between plaque burden and microscopic characterization of plaque features as it pertains to clinical presentation has not been fully investigated. The aim of this study was to compare the relationship between plaque burden and plaque vulnerability in patients with acute coronary syndromes (ACS) versus chronic coronary syndrome (CCS).

Methods

Patients who underwent both coronary computed tomography angiography (CTA) and optical coherence tomography (OCT) before coronary intervention were enrolled. All plaques were detected in culprit vessels using CTA, and total plaque volume (TPV) and OCT features were assessed at the corresponding sites. All plaques were divided into three groups according to the tertile levels of TPV (low TPV: <96.5 ​mm3, moderate TPV: 96.5–164.7 ​mm3, high TPV: ≥164.8 ​mm3).

Results

A total of 990 plaques were imaged by OCT in 419 patients: 445 plaques in 190 (45.3%) patients with ACS and 545 in 229 (54.7%) with CCS. Macrophage was more prevalent in plaques with greater TPV in patients who presented with ACS but not in those who presented with CCS (low vs. moderate vs. high TPV group: macrophage 57.4% vs. 71.8% vs. 82.4% in ACS; 63.4% vs. 67.8% vs. 66.7% in CCS; interaction P ​= ​0.004). Lipid arc increased as TPV increased, especially in patients who presented with ACS. Conversely, the layer index increased as TPV increased in patients with CCS.

Conclusion

Greater plaque burden was closely related to higher levels of plaque vulnerability in ACS and greater volume of layered plaque in CCS.

Trial registration

clinicaltrials.gov Identifier: NCT04523194.
背景:斑块负荷与斑块显微特征之间的关系与临床表现的关系尚未得到充分研究。本研究旨在比较急性冠状动脉综合征(ACS)患者与慢性冠状动脉综合征(CCS)患者斑块负荷与斑块易损性之间的关系:方法:研究纳入了在冠状动脉介入治疗前接受冠状动脉计算机断层扫描(CTA)和光学相干断层扫描(OCT)的患者。使用 CTA 检测所有罪魁祸首血管中的斑块,并评估相应部位的斑块总体积(TPV)和 OCT 特征。所有斑块按TPV的三级水平分为三组(低TPV:3;中TPV:96.5-164.7 mm3;高TPV:≥164.8 mm3):共对 419 名患者的 990 个斑块进行了 OCT 扫描:190例(45.3%)ACS患者中有445个斑块,229例(54.7%)CCS患者中有545个斑块。在 TPV 较高的斑块中,ACS 患者的巨噬细胞更多,而 CCS 患者则没有(低 TPV 组 vs. 中等 TPV 组 vs. 高 TPV 组:ACS 中巨噬细胞占 57.4% vs. 71.8% vs. 82.4%;CCS 中巨噬细胞占 63.4% vs. 67.8% vs. 66.7%;交互作用 P = 0.004)。脂质弧线随着 TPV 的增加而增加,尤其是在 ACS 患者中。相反,在CCS患者中,层指数随着TPV的增加而增加:结论:ACS患者斑块负担加重与斑块易损性增加密切相关,而CCS患者分层斑块体积增大与斑块易损性增加密切相关:NCT04523194。
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引用次数: 0
期刊
Journal of Cardiovascular Computed Tomography
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