Pub Date : 2024-11-01DOI: 10.1016/j.jcct.2024.06.007
Thomas Sartoretti, Lukas J. Moser, Stéphane Rusek, Filippo Civaia, Philippe Rossi, Alessandro Candreva, Robert Manka, Matthias Eberhard, Hatem Alkadhi, Victor Mergen
{"title":"Photon-counting detector coronary CT angiography: Defining the optimal monoenergetic level for grading of calcified coronary stenosis","authors":"Thomas Sartoretti, Lukas J. Moser, Stéphane Rusek, Filippo Civaia, Philippe Rossi, Alessandro Candreva, Robert Manka, Matthias Eberhard, Hatem Alkadhi, Victor Mergen","doi":"10.1016/j.jcct.2024.06.007","DOIUrl":"10.1016/j.jcct.2024.06.007","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 6","pages":"Pages 616-617"},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141322200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jcct.2024.08.007
Amelie Paquin, Thais Coutinho
{"title":"Getting older by a decade after preeclampsia","authors":"Amelie Paquin, Thais Coutinho","doi":"10.1016/j.jcct.2024.08.007","DOIUrl":"10.1016/j.jcct.2024.08.007","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 6","pages":"Pages 541-542"},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jcct.2024.08.009
Sarah Verhemel , Rutger-Jan Nuis , Mark van den Dorpel , Rik Adrichem , Mauricio Felippi de Sá Marchi , Alexander Hirsch , Joost Daemen , Ricardo P.J. Budde , Nicolas M. Van Mieghem
Transcatheter aortic valve replacement (TAVR) is preferred therapy for elderly patients with severe aortic stenosis (AS) and increasingly used in younger patient populations with good safety and efficacy outcomes. However, cardiac conduction abnormalities remain a frequent complication after TAVR ranging from relative benign interventriculair conduction delays to prognostically relevant left bundle branch block and complete atrio-ventricular (AV) block requiring permanent pacemaker implantation (PPI). Although clinical, procedural and electrocardiographic factors have been identified as predictors of this complication, there is a need for advanced strategies to control the burden of conduction defects particularly as TAVR shifts towards younger populations. This state of the art review highlights the value of ECG-synchronized computed tomographic angiography (CTA) evaluation of the aortic root to better understand and manage conduction problems post-TAVR. An update on CTA derived anatomic features related to conduction issues is provided and complemented with computational framework modelling. This CTA-derived 3-dimensional anatomical reconstruction tool generates patient-specific TAVR simulations enabling operators to adapt procedural strategy and implantation technique to mitigate conduction abnormality risks.
{"title":"Computed tomography to predict pacemaker need after transcatheter aortic valve replacement","authors":"Sarah Verhemel , Rutger-Jan Nuis , Mark van den Dorpel , Rik Adrichem , Mauricio Felippi de Sá Marchi , Alexander Hirsch , Joost Daemen , Ricardo P.J. Budde , Nicolas M. Van Mieghem","doi":"10.1016/j.jcct.2024.08.009","DOIUrl":"10.1016/j.jcct.2024.08.009","url":null,"abstract":"<div><div>Transcatheter aortic valve replacement (TAVR) is preferred therapy for elderly patients with severe aortic stenosis (AS) and increasingly used in younger patient populations with good safety and efficacy outcomes. However, cardiac conduction abnormalities remain a frequent complication after TAVR ranging from relative benign interventriculair conduction delays to prognostically relevant left bundle branch block and complete atrio-ventricular (AV) block requiring permanent pacemaker implantation (PPI). Although clinical, procedural and electrocardiographic factors have been identified as predictors of this complication, there is a need for advanced strategies to control the burden of conduction defects particularly as TAVR shifts towards younger populations. This state of the art review highlights the value of ECG-synchronized computed tomographic angiography (CTA) evaluation of the aortic root to better understand and manage conduction problems post-TAVR. An update on CTA derived anatomic features related to conduction issues is provided and complemented with computational framework modelling. This CTA-derived 3-dimensional anatomical reconstruction tool generates patient-specific TAVR simulations enabling operators to adapt procedural strategy and implantation technique to mitigate conduction abnormality risks.</div></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 6","pages":"Pages 597-608"},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jcct.2024.10.012
Carlos M. Campos, Hector M. Garcia-Garcia
{"title":"Coronary computed tomography angiography for the diagnosis of significant left main coronary artery disease","authors":"Carlos M. Campos, Hector M. Garcia-Garcia","doi":"10.1016/j.jcct.2024.10.012","DOIUrl":"10.1016/j.jcct.2024.10.012","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 6","pages":"Pages 551-552"},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jcct.2024.06.003
Miho Fukui, Paul Sorajja, David WM. Muller, Evan Walser-Kuntz, Larissa I. Stanberry, Vasilis C. Babaliaros, Vinod H. Thourani, Nicolas Dumonteil, Darren Walters, Gry Dahle, Paul A. Grayburn, Marvin H. Eng, Michael L. Chuang, Benjamin Sun, Philipp Blanke, Alison Duncan, João L. Cavalcante
{"title":"Biventricular reverse-remodeling after transcatheter mitral valve replacement with the Tendyne™ system","authors":"Miho Fukui, Paul Sorajja, David WM. Muller, Evan Walser-Kuntz, Larissa I. Stanberry, Vasilis C. Babaliaros, Vinod H. Thourani, Nicolas Dumonteil, Darren Walters, Gry Dahle, Paul A. Grayburn, Marvin H. Eng, Michael L. Chuang, Benjamin Sun, Philipp Blanke, Alison Duncan, João L. Cavalcante","doi":"10.1016/j.jcct.2024.06.003","DOIUrl":"10.1016/j.jcct.2024.06.003","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 6","pages":"Pages 613-615"},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jcct.2024.07.012
Alexa E. Golbus , John L. Schuzer , Shirley F. Rollison , Kathie C. Bronson , Scott P. Baute , Marcus Y. Chen
Background
Cardiac CT for coronary artery calcium (CAC) scoring exposes patients to 1 mSv of radiation. A new CT scout method utilizing ultra-low dose CT (3D Landmark) offers tomographic cross-sectional imaging, which provides axial images from which CAC can be estimated. The purpose of our study is to analyze the association between estimated CAC burden on 3D Landmark scout imaging vs dedicated ECG-gated CACS.
Methods
Consecutive patients over a 9-month period undergoing non-contrast ECG-gated CACS planned with 3D Landmark scout imaging were included. Extent of CAC on 3D Landmark scout imaging was scored from 0 to 3 (none, mild, moderate, severe). Agatston CACS was converted to an ordinal score from 0 to 3, corresponding to absent (0), mild (1–99), moderate (100–400), or severe (>400). Fischer's exact test, weighted kappa coefficient, and paired t-tests were used for analysis.
Results
Of 150 patients, 51.3% were female with mean age 49.0 ± 16.8 and BMI 28.6 ± 12.3. Sensitivity of 3D Landmark in identifying calcium was 96.2%, with specificity of 100%. There was strong interrater agreement between 3D Landmark calcium scoring and CACS, with weighted kappa coefficient 0.97 ± 0.01(CI 0.95–0.99).
Radiation dose-length-product was significantly lower for 3D Landmark imaging vs. dedicated ECG-gated CACS (9.7 ± 3.6 vs 43.8 ± 26.4 mGy cm, p < 0.001) despite longer scan length (465.0 ± 160.8 vs 123.0 ± 12.7 mm, respectively).
Conclusion
Estimated coronary artery calcium on 3D Landmark scout images correlates strongly with Agatston CACS, demonstrating utility in assessing cardiovascular risk without introducing additional radiation or costs.
{"title":"3D Landmark scout imaging accurately assesses presence and extent of coronary calcification with lower radiation exposure","authors":"Alexa E. Golbus , John L. Schuzer , Shirley F. Rollison , Kathie C. Bronson , Scott P. Baute , Marcus Y. Chen","doi":"10.1016/j.jcct.2024.07.012","DOIUrl":"10.1016/j.jcct.2024.07.012","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac CT for coronary artery calcium (CAC) scoring exposes patients to 1 mSv of radiation. A new CT scout method utilizing ultra-low dose CT (3D Landmark) offers tomographic cross-sectional imaging, which provides axial images from which CAC can be estimated. The purpose of our study is to analyze the association between estimated CAC burden on 3D Landmark scout imaging vs dedicated ECG-gated CACS.</div></div><div><h3>Methods</h3><div>Consecutive patients over a 9-month period undergoing non-contrast ECG-gated CACS planned with 3D Landmark scout imaging were included. Extent of CAC on 3D Landmark scout imaging was scored from 0 to 3 (none, mild, moderate, severe). Agatston CACS was converted to an ordinal score from 0 to 3, corresponding to absent (0), mild (1–99), moderate (100–400), or severe (>400). Fischer's exact test, weighted kappa coefficient, and paired t-tests were used for analysis.</div></div><div><h3>Results</h3><div>Of 150 patients, 51.3% were female with mean age 49.0 ± 16.8 and BMI 28.6 ± 12.3. Sensitivity of 3D Landmark in identifying calcium was 96.2%, with specificity of 100%. There was strong interrater agreement between 3D Landmark calcium scoring and CACS, with weighted kappa coefficient 0.97 ± 0.01(CI 0.95–0.99).</div><div>Radiation dose-length-product was significantly lower for 3D Landmark imaging vs. dedicated ECG-gated CACS (9.7 ± 3.6 vs 43.8 ± 26.4 mGy cm, p < 0.001) despite longer scan length (465.0 ± 160.8 vs 123.0 ± 12.7 mm, respectively).</div></div><div><h3>Conclusion</h3><div>Estimated coronary artery calcium on 3D Landmark scout images correlates strongly with Agatston CACS, demonstrating utility in assessing cardiovascular risk without introducing additional radiation or costs.</div></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 6","pages":"Pages 593-596"},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jcct.2024.08.001
Andrea Baggiano , Francesca Baessato , Saima Mushtaq , Andrea Daniele Annoni , Francesco Cannata , Maria Ludovica Carerj , Alberico Del Torto , Fabio Fazzari , Alberto Formenti , Antonio Frappampina , Laura Fusini , Daniele Junod , Maria Elisabetta Mancini , Valentina Mantegazza , Riccardo Maragna , Francesca Marchetti , Francesco Paolo Sbordone , Luigi Tassetti , Alessandra Volpe , Marco Guglielmo , Gianluca Pontone
Background
The aim of this study is to describe resources and outcomes of coronary computed tomography angiography plus Stress CT perfusion (CCTA + Stress-CTP) and stress cardiovascular magnetic resonance (Stress-CMR) in symptomatic patients with suspected or known CAD.
Methods
Six hundred and twenty-four consecutive symptomatic patients with intermediate to high-risk pretest likelihood for CAD or previous history of revascularization referred to our hospital for clinically indicated CCTA + Stress-CTP or Stress-CMR were enrolled. Stress-CTP scans were performed in 223 patients while 401 patients performed Stress-CMR. Patient follow-up was performed at 1 year after index test performance. Endpoints were all cardiac events, as a combined endpoint of revascularization, non-fatal MI and death, and hard cardiac events, as combined endpoint of non-fatal MI and death.
Results
Twenty-nine percent of patients who underwent CCTA + Stress-CTP received revascularization, 7% of subjects assessed with Stress-CMR were treated invasively, and a low number of non-fatal MI and death was observed with both strategies (hard events in 0.4% of patients that had CCTA + Stress-CTP as index test, and in 3% of patients evaluated with Stress-CMR). According to the predefined endpoints, CCTA + Stress-CTP group showed high rate of all cardiac events and low rate of hard cardiac events, respectively. The cumulative costs were 1970 ± 2506 Euro and 733 ± 1418 Euro for the CCTA + Stress-CTP group and Stress-CMR group, respectively.
Conclusions
The use of CCTA + Stress-CTP strategy was associated with high referral to revascularization but with a favourable trend in terms of hard cardiac events and diagnostic yield in identifying individuals at lower risk of adverse events despite the presence of CAD.
{"title":"STress computed tomogRaphy perfusion and stress cArdiac magnetic resonance for ThE manaGement of suspected or known coronarY artery disease: resources and outcomes impact","authors":"Andrea Baggiano , Francesca Baessato , Saima Mushtaq , Andrea Daniele Annoni , Francesco Cannata , Maria Ludovica Carerj , Alberico Del Torto , Fabio Fazzari , Alberto Formenti , Antonio Frappampina , Laura Fusini , Daniele Junod , Maria Elisabetta Mancini , Valentina Mantegazza , Riccardo Maragna , Francesca Marchetti , Francesco Paolo Sbordone , Luigi Tassetti , Alessandra Volpe , Marco Guglielmo , Gianluca Pontone","doi":"10.1016/j.jcct.2024.08.001","DOIUrl":"10.1016/j.jcct.2024.08.001","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study is to describe resources and outcomes of coronary computed tomography angiography plus Stress CT perfusion (CCTA + Stress-CTP) and stress cardiovascular magnetic resonance (Stress-CMR) in symptomatic patients with suspected or known CAD.</div></div><div><h3>Methods</h3><div>Six hundred and twenty-four consecutive symptomatic patients with intermediate to high-risk pretest likelihood for CAD or previous history of revascularization referred to our hospital for clinically indicated CCTA + Stress-CTP or Stress-CMR were enrolled. Stress-CTP scans were performed in 223 patients while 401 patients performed Stress-CMR. Patient follow-up was performed at 1 year after index test performance. Endpoints were all cardiac events, as a combined endpoint of revascularization, non-fatal MI and death, and hard cardiac events, as combined endpoint of non-fatal MI and death.</div></div><div><h3>Results</h3><div>Twenty-nine percent of patients who underwent CCTA + Stress-CTP received revascularization, 7% of subjects assessed with Stress-CMR were treated invasively, and a low number of non-fatal MI and death was observed with both strategies (hard events in 0.4% of patients that had CCTA + Stress-CTP as index test, and in 3% of patients evaluated with Stress-CMR). According to the predefined endpoints, CCTA + Stress-CTP group showed high rate of all cardiac events and low rate of hard cardiac events, respectively. The cumulative costs were 1970 ± 2506 Euro and 733 ± 1418 Euro for the CCTA + Stress-CTP group and Stress-CMR group, respectively.</div></div><div><h3>Conclusions</h3><div>The use of CCTA + Stress-CTP strategy was associated with high referral to revascularization but with a favourable trend in terms of hard cardiac events and diagnostic yield in identifying individuals at lower risk of adverse events despite the presence of CAD.</div></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 6","pages":"Pages 553-558"},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jcct.2024.06.001
Emma L.R. Møller , Maria G. Hauge , Michael H.C. Pham , Peter Damm , Klaus F. Kofoed , Andreas Fuchs , Jørgen T. Kühl , Per E. Sigvardsen , Anne S. Ersbøll , Marianne Johansen , Børge G. Nordestgaard , Lars V. Køber , Finn Gustafsson , Jesper J. Linde
Background
Pre-eclampsia is a pregnancy related disorder associated with hypertension and vascular inflammation, factors that are also involved in the pathological pathway of aortic dilatation and aneurysm development. It is, however, unknown if younger women with previous pre-eclampsia have increased aortic dimensions. We tested the hypothesis that previous pre-eclampsia is associated with increased aortic dimensions in younger women.
Methods
The study was a cross-sectional cohort study of women with previous pre-eclampsia, aged 40–55, from the PRECIOUS population matched by age and parity with women from the general population. Using contrast-enhanced CT, aortic diameters were measured in the aortic root, ascending aorta, descending aorta, at the level of the diaphragm, suprarenal aorta, and infrarenal aorta.
Results
1355 women (684 with previous pre-eclampsia and 671 from the general population), with a mean (standard deviation) age of 46.9 (4.4) were included. The pre-eclampsia group had larger mean (standard deviation) aortic diameters (mm) in all measured segments from the ascending to the infrarenal aorta (ascending: 33.4 (4.0) vs. 31.4 (3.7), descending: 23.9 (2.1) vs. 23.3 (2.0), diaphragm: 20.8 (1.8) vs. 20.4 (1.8), suprarenal: 22.9 (1.9) vs. 22.0 (2.0), infrarenal: 19.3 (1.6) vs. 18.6 (1.7), p < 0.001 for all, also after adjustment for age, height, parity, menopause, dyslipidemia, smoking and chronic hypertension. Guideline-defined ascending aortic aneurysms were found in 8 vs 2 women (p = 0.12).
Conclusions
Women with previous pre-eclampsia have larger aortic dimensions compared with women from the general population. Pre-eclampsia was found to be an independent risk factor associated with a larger aortic diameter.
背景:子痫前期是一种与高血压和血管炎症有关的妊娠相关疾病,这些因素也参与了主动脉扩张和动脉瘤形成的病理过程。然而,曾患先兆子痫的年轻女性是否会导致主动脉尺寸增大,目前尚不清楚。我们对曾患先兆子痫的年轻女性主动脉尺寸增大的假设进行了检验:该研究是一项横断面队列研究,研究对象是 PRECIOUS 群体中 40-55 岁曾患先兆子痫的女性,她们的年龄和均龄与普通人群中的女性相匹配。通过对比增强 CT,测量了主动脉根部、升主动脉、降主动脉、膈水平、肾上主动脉和肾下主动脉的直径:共纳入 1355 名妇女(684 名曾患有先兆子痫,671 名来自普通人群),平均(标准差)年龄为 46.9(4.4)岁。先兆子痫组从升主动脉到肾下主动脉的所有测量节段的主动脉直径(毫米)的平均值(标准差)都较大(升主动脉:33.4(4.0)):升主动脉:33.4 (4.0) vs. 31.4 (3.7),降主动脉:23.9 (2.1) vs. 31.4 (3.7):23.9 (2.1) vs. 23.3 (2.0),膈:20.8 (1.8) vs. 20.4 (1.8),肾上:22.9 (1.9) vs. 22.0 (2.0),肾下:19.3 (1.6) vs. 18.6 (1.7),P 结论:与普通人群相比,曾患子痫前期的女性主动脉尺寸更大。研究发现,先兆子痫是导致主动脉直径增大的一个独立风险因素。
{"title":"Aortic dimensions in women with previous pre-eclampsia","authors":"Emma L.R. Møller , Maria G. Hauge , Michael H.C. Pham , Peter Damm , Klaus F. Kofoed , Andreas Fuchs , Jørgen T. Kühl , Per E. Sigvardsen , Anne S. Ersbøll , Marianne Johansen , Børge G. Nordestgaard , Lars V. Køber , Finn Gustafsson , Jesper J. Linde","doi":"10.1016/j.jcct.2024.06.001","DOIUrl":"10.1016/j.jcct.2024.06.001","url":null,"abstract":"<div><h3>Background</h3><div>Pre-eclampsia is a pregnancy related disorder associated with hypertension and vascular inflammation, factors that are also involved in the pathological pathway of aortic dilatation and aneurysm development. It is, however, unknown if younger women with previous pre-eclampsia have increased aortic dimensions. We tested the hypothesis that previous pre-eclampsia is associated with increased aortic dimensions in younger women.</div></div><div><h3>Methods</h3><div>The study was a cross-sectional cohort study of women with previous pre-eclampsia, aged 40–55, from the PRECIOUS population matched by age and parity with women from the general population. Using contrast-enhanced CT, aortic diameters were measured in the aortic root, ascending aorta, descending aorta, at the level of the diaphragm, suprarenal aorta, and infrarenal aorta.</div></div><div><h3>Results</h3><div>1355 women (684 with previous pre-eclampsia and 671 from the general population), with a mean (standard deviation) age of 46.9 (4.4) were included. The pre-eclampsia group had larger mean (standard deviation) aortic diameters (mm) in all measured segments from the ascending to the infrarenal aorta (ascending: 33.4 (4.0) vs. 31.4 (3.7), descending: 23.9 (2.1) vs. 23.3 (2.0), diaphragm: 20.8 (1.8) vs. 20.4 (1.8), suprarenal: 22.9 (1.9) vs. 22.0 (2.0), infrarenal: 19.3 (1.6) vs. 18.6 (1.7), p < 0.001 for all, also after adjustment for age, height, parity, menopause, dyslipidemia, smoking and chronic hypertension. Guideline-defined ascending aortic aneurysms were found in 8 vs 2 women (p = 0.12).</div></div><div><h3>Conclusions</h3><div>Women with previous pre-eclampsia have larger aortic dimensions compared with women from the general population. Pre-eclampsia was found to be an independent risk factor associated with a larger aortic diameter.</div></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 6","pages":"Pages 533-540"},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jcct.2024.08.003
Michelle C. Williams , Jonathan R. Weir-McCall , Lauren A. Baldassarre , Carlo N. De Cecco , Andrew D. Choi , Damini Dey , Marc R. Dweck , Ivana Isgum , Márton Kolossvary , Jonathon Leipsic , Andrew Lin , Michael T. Lu , Manish Motwani , Koen Nieman , Leslee Shaw , Marly van Assen , Edward Nicol
{"title":"Artificial Intelligence and Machine Learning for Cardiovascular Computed Tomography (CCT): A White Paper of the Society of Cardiovascular Computed Tomography (SCCT)","authors":"Michelle C. Williams , Jonathan R. Weir-McCall , Lauren A. Baldassarre , Carlo N. De Cecco , Andrew D. Choi , Damini Dey , Marc R. Dweck , Ivana Isgum , Márton Kolossvary , Jonathon Leipsic , Andrew Lin , Michael T. Lu , Manish Motwani , Koen Nieman , Leslee Shaw , Marly van Assen , Edward Nicol","doi":"10.1016/j.jcct.2024.08.003","DOIUrl":"10.1016/j.jcct.2024.08.003","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 6","pages":"Pages 519-532"},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jcct.2024.09.002
Daisuke Kinoshita , Keishi Suzuki , Daichi Fujimoto , Takayuki Niida , Eisuke Usui , Yoshiyasu Minami , Damini Dey , Hang Lee , Iris McNulty , Junya Ako , Maros Ferencik , Tsunekazu Kakuta , Ik-Kyung Jang
Background
The relationship between plaque burden and microscopic characterization of plaque features as it pertains to clinical presentation has not been fully investigated. The aim of this study was to compare the relationship between plaque burden and plaque vulnerability in patients with acute coronary syndromes (ACS) versus chronic coronary syndrome (CCS).
Methods
Patients who underwent both coronary computed tomography angiography (CTA) and optical coherence tomography (OCT) before coronary intervention were enrolled. All plaques were detected in culprit vessels using CTA, and total plaque volume (TPV) and OCT features were assessed at the corresponding sites. All plaques were divided into three groups according to the tertile levels of TPV (low TPV: <96.5 mm3, moderate TPV: 96.5–164.7 mm3, high TPV: ≥164.8 mm3).
Results
A total of 990 plaques were imaged by OCT in 419 patients: 445 plaques in 190 (45.3%) patients with ACS and 545 in 229 (54.7%) with CCS. Macrophage was more prevalent in plaques with greater TPV in patients who presented with ACS but not in those who presented with CCS (low vs. moderate vs. high TPV group: macrophage 57.4% vs. 71.8% vs. 82.4% in ACS; 63.4% vs. 67.8% vs. 66.7% in CCS; interaction P = 0.004). Lipid arc increased as TPV increased, especially in patients who presented with ACS. Conversely, the layer index increased as TPV increased in patients with CCS.
Conclusion
Greater plaque burden was closely related to higher levels of plaque vulnerability in ACS and greater volume of layered plaque in CCS.
Trial registration
clinicaltrials.gov Identifier: NCT04523194.
背景:斑块负荷与斑块显微特征之间的关系与临床表现的关系尚未得到充分研究。本研究旨在比较急性冠状动脉综合征(ACS)患者与慢性冠状动脉综合征(CCS)患者斑块负荷与斑块易损性之间的关系:方法:研究纳入了在冠状动脉介入治疗前接受冠状动脉计算机断层扫描(CTA)和光学相干断层扫描(OCT)的患者。使用 CTA 检测所有罪魁祸首血管中的斑块,并评估相应部位的斑块总体积(TPV)和 OCT 特征。所有斑块按TPV的三级水平分为三组(低TPV:3;中TPV:96.5-164.7 mm3;高TPV:≥164.8 mm3):共对 419 名患者的 990 个斑块进行了 OCT 扫描:190例(45.3%)ACS患者中有445个斑块,229例(54.7%)CCS患者中有545个斑块。在 TPV 较高的斑块中,ACS 患者的巨噬细胞更多,而 CCS 患者则没有(低 TPV 组 vs. 中等 TPV 组 vs. 高 TPV 组:ACS 中巨噬细胞占 57.4% vs. 71.8% vs. 82.4%;CCS 中巨噬细胞占 63.4% vs. 67.8% vs. 66.7%;交互作用 P = 0.004)。脂质弧线随着 TPV 的增加而增加,尤其是在 ACS 患者中。相反,在CCS患者中,层指数随着TPV的增加而增加:结论:ACS患者斑块负担加重与斑块易损性增加密切相关,而CCS患者分层斑块体积增大与斑块易损性增加密切相关:NCT04523194。
{"title":"Relationship between plaque burden and plaque vulnerability: Acute coronary syndromes versus chronic coronary syndrome","authors":"Daisuke Kinoshita , Keishi Suzuki , Daichi Fujimoto , Takayuki Niida , Eisuke Usui , Yoshiyasu Minami , Damini Dey , Hang Lee , Iris McNulty , Junya Ako , Maros Ferencik , Tsunekazu Kakuta , Ik-Kyung Jang","doi":"10.1016/j.jcct.2024.09.002","DOIUrl":"10.1016/j.jcct.2024.09.002","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between plaque burden and microscopic characterization of plaque features as it pertains to clinical presentation has not been fully investigated. The aim of this study was to compare the relationship between plaque burden and plaque vulnerability in patients with acute coronary syndromes (ACS) versus chronic coronary syndrome (CCS).</div></div><div><h3>Methods</h3><div>Patients who underwent both coronary computed tomography angiography (CTA) and optical coherence tomography (OCT) before coronary intervention were enrolled. All plaques were detected in culprit vessels using CTA, and total plaque volume (TPV) and OCT features were assessed at the corresponding sites. All plaques were divided into three groups according to the tertile levels of TPV (low TPV: <96.5 mm<sup>3</sup>, moderate TPV: 96.5–164.7 mm<sup>3</sup>, high TPV: ≥164.8 mm<sup>3</sup>).</div></div><div><h3>Results</h3><div>A total of 990 plaques were imaged by OCT in 419 patients: 445 plaques in 190 (45.3%) patients with ACS and 545 in 229 (54.7%) with CCS. Macrophage was more prevalent in plaques with greater TPV in patients who presented with ACS but not in those who presented with CCS (low vs. moderate vs. high TPV group: macrophage 57.4% vs. 71.8% vs. 82.4% in ACS; 63.4% vs. 67.8% vs. 66.7% in CCS; interaction <em>P</em> = 0.004). Lipid arc increased as TPV increased, especially in patients who presented with ACS. Conversely, the layer index increased as TPV increased in patients with CCS.</div></div><div><h3>Conclusion</h3><div>Greater plaque burden was closely related to higher levels of plaque vulnerability in ACS and greater volume of layered plaque in CCS.</div></div><div><h3>Trial registration</h3><div><span><span>clinicaltrials.gov</span><svg><path></path></svg></span> Identifier: NCT04523194.</div></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 6","pages":"Pages 559-566"},"PeriodicalIF":5.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}