Journal of Cardiovascular Computed Tomography最新文献

{"title":"Completeness of revascularization by FFRCT in stable angina: Association to adverse cardiovascular outcomes","authors":"Kristian Tækker Madsen ,&nbsp;Bjarne Linde Nørgaard ,&nbsp;Kristian Altern Øvrehus ,&nbsp;Jesper Møller Jensen ,&nbsp;Erik Parner ,&nbsp;Erik Lerkevang Grove ,&nbsp;Martin B. Mortensen ,&nbsp;Nadia Iraqi ,&nbsp;Timothy A. Fairbairn ,&nbsp;Koen Nieman ,&nbsp;Manesh R. Patel ,&nbsp;Campbell Rogers ,&nbsp;Sarah Mullen ,&nbsp;Hans Mickley ,&nbsp;Kristian Korsgaard Thomsen ,&nbsp;Hans Erik Bøtker ,&nbsp;Jonathon Leipsic ,&nbsp;Niels Peter Rønnow Sand","doi":"10.1016/j.jcct.2024.07.007","DOIUrl":"10.1016/j.jcct.2024.07.007","url":null,"abstract":"<div><h3>Background</h3><p>The prognostic impact of complete coronary revascularization relative to non-invasive testing methods is unknown.</p></div><div><h3>Objectives</h3><p>To assess the association between completeness of revascularization defined by CTA-derived fractional flow reserve (FFR_CT) and cardiovascular outcomes in patients with stable angina.</p></div><div><h3>Methods</h3><p>Multicenter 3-year follow-up study of patients with new onset stable angina and ≥ 30% stenosis by CTA. The lesion-specific FFR_CT value (two cm-distal-to-stenosis) was registered in all vessels with stenosis and considered abnormal when ≤ 0.80. Patients with FFR_CT ≤ 0.80 were categorized as: Completely revascularized (CR-FFR_CT), all vessels with FFR_CT ≤ 0.80 revascularized; incompletely revascularized (IR-FFR_CT), ≥ 1 vessels with FFR_CT ≤ 0.80 non-revascularized. Early revascularization (&lt; 90 days from index CTA) categorized vessels as revascularized. The primary endpoint comprised cardiovascular death and non-fatal myocardial infarction; the secondary endpoint vessel-specific late revascularization and non-fatal myocardial infarction.</p></div><div><h3>Results</h3><p>Amongst 900 patients and 1759 vessels, FFR_CT was ≤ 0.80 in 377 (42%) patients, 536 (30%) vessels; revascularization was performed in 244 (27%) patients, 340 (19%) vessels. Risk of the primary endpoint was higher for IR-FFR_CT (15/210 [7.1%]) compared to CR-FFR_CT (4/167 [2.4%]), RR: 2.98; 95% CI: 1.01–8.8, p ​= ​0.036, and to normal FFR_CT (3/523 [0.6%]), RR: 12.45; 95% CI: 3.6–42.6, p ​&lt; ​0.001. Incidence of the secondary endpoint was higher in non-revascularized vessels with FFR_CT ≤ 0.80 (29/250 [12%]) compared to revascularized vessels with FFR_CT ≤ 0.80 (5/286 [1.7%]), p ​= ​0.001, and to vessels with FFR_CT &gt; 0.80 (10/1223 [0.8%]), p ​&lt; ​0.001.</p></div><div><h3>Conclusion</h3><p>Incomplete revascularization of patients with lesion-specific FFR_CT ≤ 0.80 is associated to unfavorable cardiovascular outcomes compared to those with complete revascularization or FFR_CT &gt; 0.80.</p></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 5","pages":"Pages 494-502"},"PeriodicalIF":5.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1934592524003952/pdfft?md5=c2cbb17e53d2423dfd396564a4f7159a&pid=1-s2.0-S1934592524003952-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141725413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter Regarding Article “The effect of CTCA guided selective invasive graft assessment on coronary angiographic parameters and outcomes: Insights from the BYPASS-CTCA trial”","authors":"Matthew Kelham,&nbsp;Anthony Mathur,&nbsp;Daniel A. Jones","doi":"10.1016/j.jcct.2024.06.005","DOIUrl":"10.1016/j.jcct.2024.06.005","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 5","pages":"Page 516"},"PeriodicalIF":5.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on CTCA-guided selective invasive graft assessment in BYPASS-CTCA trial","authors":"","doi":"10.1016/j.jcct.2024.06.006","DOIUrl":"10.1016/j.jcct.2024.06.006","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 5","pages":"Pages 514-515"},"PeriodicalIF":5.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of aortic valve calcification volume score for identification of significant aortic stenosis on non-electrocardiographic-gated computed tomography compared to the Agatston scoring system","authors":"Kotaro Ouchi ,&nbsp;Toru Sakuma ,&nbsp;Ayumi Nojiri ,&nbsp;Rui Kano ,&nbsp;Takahiro Higuchi ,&nbsp;Jun Hasumi ,&nbsp;Takayuki Suzuki ,&nbsp;Akira Ogihara ,&nbsp;Hiroya Ojiri ,&nbsp;Makoto Kawai","doi":"10.1016/j.jcct.2024.03.014","DOIUrl":"10.1016/j.jcct.2024.03.014","url":null,"abstract":"<div><h3>Background</h3><p>Considering the absence of reports validating the precision of the volume score and the relationship between the volume and Agatston scores, this study evaluated the accuracy of the volume score compared to the Agatston score for the quantitative measurement of aortic valve calcification (AVC) on non-electrocardiographic-gated computed tomography (CT).</p></div><div><h3>Methods</h3><p>We retrospectively analysed the AVC scores of 5385 patients who underwent transthoracic echocardiography between March 1, 2013 and December 26, 2019 ​at our institution, using non-contrast non-electrocardiographic-gated CT. The thresholds for significant aortic stenosis (AS) were computed using receiver operating characteristic curves based on the AVC scores. The area under the curve (AUC) of the Agatston and volume scores for significant AS were compared to evaluate the accuracy of the scoring method.</p></div><div><h3>Results</h3><p>All sex-specific AVC thresholds of the volume score for significant AS (moderate and high AS severity, moderate and high AS severity without discordance, discordant severe AS, and concordant severe AS) showed high sensitivity and specificity (AUC, 0.978–0.996; sensitivity, 94.2–98.4%; specificity, 90.1–100%). No significant differences in the AUC were observed between the Agatston and volume scores for significant AS in male and female patients.</p></div><div><h3>Conclusion</h3><p>All volume score threshold values showed high sensitivity and specificity for identifying significant AS. The accuracy of the test for AVC thresholds of the volume score for significant AS was comparable to that of the Agatston score. Our findings raise questions about the significance of weighting calcium density in the Agatston score for assessing AS severity.</p></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 4","pages":"Pages 352-362"},"PeriodicalIF":5.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-enabled cardiac chambers volumetry in coronary artery calcium scans (AI-CACTM) predicts heart failure and outperforms NT-proBNP: The multi-ethnic study of Atherosclerosis","authors":"Morteza Naghavi ,&nbsp;Anthony Reeves ,&nbsp;Matthew Budoff ,&nbsp;Dong Li ,&nbsp;Kyle Atlas ,&nbsp;Chenyu Zhang ,&nbsp;Thomas Atlas ,&nbsp;Sion K. Roy ,&nbsp;Claudia I. Henschke ,&nbsp;Nathan D. Wong ,&nbsp;Christopher Defilippi ,&nbsp;Daniel Levy ,&nbsp;David F. Yankelevitz","doi":"10.1016/j.jcct.2024.04.006","DOIUrl":"10.1016/j.jcct.2024.04.006","url":null,"abstract":"<div><h3>Introduction</h3><p>Coronary artery calcium (CAC) scans contain useful information beyond the Agatston CAC score that is not currently reported. We recently reported that artificial intelligence (AI)-enabled cardiac chambers volumetry in CAC scans (AI-CAC™) predicted incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis (MESA). In this study, we investigated the performance of AI-CAC cardiac chambers for prediction of incident heart failure (HF).</p></div><div><h3>Methods</h3><p>We applied AI-CAC to 5750 CAC scans of asymptomatic individuals (52% female, White 40%, Black 26%, Hispanic 22% Chinese 12%) free of known cardiovascular disease at the MESA baseline examination (2000–2002). We used the 15-year outcomes data and compared the time-dependent area under the curve (AUC) of AI-CAC volumetry versus NT-proBNP, Agatston score, and 9 known clinical risk factors (age, gender, diabetes, current smoking, hypertension medication, systolic and diastolic blood pressure, LDL, HDL for predicting incident HF over 15 years.</p></div><div><h3>Results</h3><p>Over 15 years of follow-up, 256 HF events accrued. The time-dependent AUC [95% CI] at 15 years for predicting HF with AI-CAC all chambers volumetry (0.86 [0.82,0.91]) was significantly higher than NT-proBNP (0.74 [0.69, 0.77]) and Agatston score (0.71 [0.68, 0.78]) (p ​&lt; ​0.0001), and comparable to clinical risk factors (0.85, p ​= ​0.4141). Category-free Net Reclassification Index (NRI) [95% CI] adding AI-CAC LV significantly improved on clinical risk factors (0.32 [0.16,0.41]), NT-proBNP (0.46 [0.33,0.58]), and Agatston score (0.71 [0.57,0.81]) for HF prediction at 15 years (p ​&lt; ​0.0001).</p></div><div><h3>Conclusion</h3><p>AI-CAC volumetry significantly outperformed NT-proBNP and the Agatston CAC score, and significantly improved the AUC and category-free NRI of clinical risk factors for incident HF prediction.</p></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 4","pages":"Pages 392-400"},"PeriodicalIF":5.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1934592524000807/pdfft?md5=7784c5c7772ee47eae4f7a7cc94434b0&pid=1-s2.0-S1934592524000807-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140790615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Cardiac Ct Within The ESC Guidelines.","authors":"L. Zakkak,&nbsp;R. Rubinstein,&nbsp;A. Orbach","doi":"10.1016/j.jcct.2024.05.056","DOIUrl":"https://doi.org/10.1016/j.jcct.2024.05.056","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 4","pages":"Pages S24-S25"},"PeriodicalIF":5.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison Of Coronary Cta And Stress Testing In Liver Transplant Candidates","authors":"D. Agakishiev,&nbsp;R. Tandon,&nbsp;R. Freese,&nbsp;J. Thompson,&nbsp;P. Nijjar","doi":"10.1016/j.jcct.2024.05.060","DOIUrl":"https://doi.org/10.1016/j.jcct.2024.05.060","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 4","pages":"Page S26"},"PeriodicalIF":5.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Body Mass Index, Testing Performance And Clinical Outcomes In Patients With Stable Chest Pain: Insights From The PRECISE (Prospective Randomized Trial Of The Optimal Evaluation Of Cardiac Symptoms And Revascularization) Trial","authors":"M. Ferencik ,&nbsp;S. Vemulapalli ,&nbsp;M. Nanna ,&nbsp;M. Kelsey ,&nbsp;D. Mark ,&nbsp;J. Leipsic ,&nbsp;N. Ng ,&nbsp;P. Maurovich-Horvat ,&nbsp;S. Mullen ,&nbsp;C. Rogers ,&nbsp;J. Udelson ,&nbsp;P. Douglas","doi":"10.1016/j.jcct.2024.05.087","DOIUrl":"https://doi.org/10.1016/j.jcct.2024.05.087","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 4","pages":"Page S38"},"PeriodicalIF":5.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Impact Of Assessing Plaque Quantification And Local Hemodynamics Of Intermediate Lesions In The Prediction Of Acute Coronary Syndrome","authors":"S. Park ,&nbsp;S. Yang ,&nbsp;K. Lee ,&nbsp;K. Lee ,&nbsp;D. Hwang ,&nbsp;G. Tzimas ,&nbsp;T. Kawasaki ,&nbsp;B. Ko ,&nbsp;B. Bruyne ,&nbsp;B. Nørgaard ,&nbsp;E. Chun ,&nbsp;C. Nam ,&nbsp;H. Matsuo ,&nbsp;T. Kubo ,&nbsp;J. Leipsic ,&nbsp;L. Shaw ,&nbsp;J. Narula ,&nbsp;B. Koo","doi":"10.1016/j.jcct.2024.05.004","DOIUrl":"https://doi.org/10.1016/j.jcct.2024.05.004","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 4","pages":"Pages S1-S2"},"PeriodicalIF":5.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional And Socioeconomic Disparities In Coronary Calcium Scan Utilization Across The United States","authors":"V. Sachs ,&nbsp;C. Scoma ,&nbsp;V. Gorrela ,&nbsp;S. Almeida","doi":"10.1016/j.jcct.2024.05.057","DOIUrl":"https://doi.org/10.1016/j.jcct.2024.05.057","url":null,"abstract":"","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"18 4","pages":"Page S25"},"PeriodicalIF":5.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}