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Application of three-dimensional visualization technology in early surgical repair of bile duct injury during laparoscopic cholecystectomy. 三维可视化技术在腹腔镜胆囊切除术胆管损伤早期手术修复中的应用。
IF 1.6 3区 医学 Q2 SURGERY Pub Date : 2024-09-27 DOI: 10.1186/s12893-024-02571-4
Zhiqi Yang, Jing Liu, Lang Wu, Yang Ding, Songbo Ma, Wentao Yan, Yong Lan, Xiaochun Sha, Jianbin Cheng, Zhiming Ma, Minghao Li

Objective: This study aimed to explore the application value of three-dimensional (3D) visualization technology in the early surgical repair of bile duct injury during laparoscopic cholecystectomy (LC).

Methods: A retrospective analysis was conducted on the clinical data of 15 patients who underwent early surgical repair of bile duct injury during LC with the assistance of 3D visualization technology at the Hepatobiliary Surgery Department of Ningxia Hui Autonomous Region People's Hospital from January 2019 to December 2022. Postoperative efficacy and long-term follow-up outcomes were summarized.

Results: Before the repair surgery, 15 cases of bile duct injury during LC were evaluated using 3D visualization technology according to the Strasberg-Bismuth classification: 2 cases of type C, 4 of type E1, 3 of type E2, 3 of type E3, and 3 of type E4. Intraoperative findings were consistent with the 3D visualization reconstruction results, and all patients successfully underwent hepaticojejunostomy using Roux-en-Y anastomosis guided by the 3D visualization navigation. The time interval between LC and bile duct repair surgery ranged from 5 to 28 (14.2 ± 9.7) days. The surgical time was between 120 and 190 (156.40 ± 23.92) min, and estimated blood loss ranged from 80 to 250 (119.66 ± 47.60) mL. The length of hospital stay ranged from 12 to 25 days (median: 16 days). One patient experienced mild bile leakage after the operation, which healed with conservative treatment. All patients were followed up for 12-56 months (median: 34 months) without any loss to follow-up. During the follow-up period, no complications, such as anastomotic stricture or stone formation, were observed.

Conclusion: The application of 3D visualization technology for preoperative evaluation and intraoperative navigation can accurately and effectively facilitate early surgical repair of bile duct injury during LC and has clinical value for promotion and application.

目的本研究旨在探讨三维可视化技术在腹腔镜胆囊切除术(LC)中胆管损伤早期手术修复中的应用价值:方法:对2019年1月至2022年12月在宁夏回族自治区人民医院肝胆外科接受三维可视化技术辅助下LC术中胆管损伤早期手术修复的15例患者的临床资料进行回顾性分析。对术后疗效及长期随访结果进行总结:修复手术前,利用三维可视化技术对15例LC术中胆管损伤病例按照Strasberg-Bismuth分型进行评估:C型2例,E1型4例,E2型3例,E3型3例,E4型3例。术中发现与三维可视化重建结果一致,所有患者都在三维可视化导航的引导下成功地进行了肝空肠吻合术和 Roux-en-Y 吻合术。肝空肠吻合术与胆管修复手术之间的时间间隔为5至28天(14.2±9.7)天。手术时间为120至190(156.40±23.92)分钟,估计失血量为80至250(119.66±47.60)毫升。住院时间从 12 天到 25 天不等(中位数:16 天)。一名患者术后出现轻度胆汁渗漏,经保守治疗后痊愈。所有患者均接受了 12-56 个月(中位数:34 个月)的随访,无任何失访。随访期间,未发现吻合口狭窄或结石形成等并发症:结论:应用三维可视化技术进行术前评估和术中导航,可准确有效地促进 LC 期胆管损伤的早期手术修复,具有临床推广应用价值。
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引用次数: 0
Risk factors and distribution pattern of lateral lymph node recurrence after central neck dissection for cN1a papillary thyroid carcinoma. cN1a 甲状腺乳头状癌颈部中央切除术后侧淋巴结复发的风险因素和分布模式
IF 1.6 3区 医学 Q2 SURGERY Pub Date : 2024-09-27 DOI: 10.1186/s12893-024-02564-3
Binbin Long, Mingxu Luo, Ke Zhou, Tao Zheng, Wenfang Li

Background: The indication and extent of selective lateral neck dissection (LND) for cN1a papillary thyroid carcinoma (PTC) remain uncertain. The present study aimed to identify potential predictors and distribution pattern of lateral lymph node recurrence (LLNR) after central neck dissection in cN1a PTC patients.

Methods: The cN1a PTC patients who underwent initial central neck dissection at our centre were retrospectively reviewed, and the median follow-up period was 6.8 years. Reoperation with LND was performed when LLNR was confirmed. Risk factors for LLNR were identified, and the metastatic status of each lateral level was recorded.

Results: Of the 310 patients enrolled in the present study, fifty-eight patients (18.7%) presented with LLNR. Six independent factors, including tumour diameter, pathological T4 stage, number of involved central lymph nodes, pTNM stage, extrathyroidal extension, and I131 treatment (P values < 0.05) were identified via multivariate analysis. LLNR was found at level II in 26 patients (44.8%), level III in 38 patients (65.5%), level IV in 30 patients (51.7%), and level V in 8 patients (13.8%). The number of positive lateral lymph nodes at levels II, III, IV and V was 44 (22.9%), 76 (39.6%), 63 (32.8%), and 9 (4.9%), respectively.

Conclusions: For cN1a PTC patients who underwent central neck dissection, tumour diameter ≥ 2 cm, pathological T4 stage, number of involved central lymph nodes ≥ 3, pTNM stage III-IV, extrathyroidal extension, and failure to receive I131 treatment were independent predictors of LLNR, which was more likely to occur at levels III and IV.

背景:cN1a甲状腺乳头状癌(PTC)选择性颈侧淋巴结清扫术(LND)的适应症和范围仍不确定。本研究旨在确定 cN1a PTC 患者颈部中央切除术后侧淋巴结复发(LLNR)的潜在预测因素和分布模式:回顾性研究了在本中心接受初次颈部中央切除术的cN1a PTC患者,中位随访时间为6.8年。当确认LLNR时,再进行LND手术。确定了LLNR的风险因素,并记录了每个侧位的转移状态:在本研究登记的 310 名患者中,有 58 名患者(18.7%)出现 LLNR。肿瘤直径、病理T4分期、受累中央淋巴结数量、pTNM分期、甲状腺外扩展和I131治疗等六个独立因素(P值 结论:对于cN1a PTC患者,LLNR的发生率较高:对于接受颈部中央切除术的 cN1a PTC 患者,肿瘤直径≥ 2 厘米、病理 T4 分期、受累中央淋巴结数量≥ 3 个、pTNM 分期 III-IV、甲状腺外扩展和未接受 I131 治疗是 LLNR 的独立预测因素,而 LLNR 更有可能发生在 III 和 IV 期。
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引用次数: 0
Whether T-tube biliary drainage is necessary after pancreaticoduodenectomy: a single-center retrospective study. 胰十二指肠切除术后是否需要 T 管胆道引流:一项单中心回顾性研究。
IF 1.6 3区 医学 Q2 SURGERY Pub Date : 2024-09-20 DOI: 10.1186/s12893-024-02570-5
Xin Luo, Xinbin Zhuo, Xianchao Lin, Ronggui Lin, Yuanyuan Yang, Congfei Wang, Haizong Fang, Heguang Huang, Fengchun Lu

Background: Postoperative complications of pancreaticoduodenectomy (PD) are still a thorny problem. This study aims to verify the preventative impact of T-tube on them.

Methods: The electronic medical records and follow-up data of patients who received pancreaticoduodenectomy in our center from July 2016 to June 2020 were reviewed. According to whether T tube was placed during the operation, the patients were divided into T-tube group and not-T-tube group. Propensity score matching analysis was performed to minimize selection bias.

Results: A total of 330 patients underwent PD (Not-T-tube group =226, T-tube group=104). Propensity score matching resulted in 222 patients for further analysis (Not-T-tube group =134, T-tube group=88). Patients' demographics were comparable in the matched cohorts. Significantly higher incidences of clinically relevant postoperative pancreatic fistula (CR-POPF) ((14 (10.45%) VS 20 (22.73%)), P=0.013) were observed in the T-tube group. The total incidence of biliary anastomotic stricture (BAS) was 3.15%. The incidence was slightly lower in the T-tube group, but there was no statistically significant differentiation (6 (4.48%) VS 1 (1.14%), P=0.317).

Conclusions: It is not feasible to prevent postoperative complications with the application of a T-tube in PD.

背景:胰十二指肠切除术(PD)术后并发症仍是一个棘手的问题。本研究旨在验证 T 型管对预防并发症的影响:方法:回顾性分析本中心 2016 年 7 月至 2020 年 6 月期间接受胰十二指肠切除术患者的电子病历和随访资料。根据手术中是否放置 T 型管,将患者分为 T 型管组和非 T 型管组。为减少选择偏倚,进行了倾向评分匹配分析:共有330名患者接受了腹腔镜手术(未置管组=226人,置管组=104人)。倾向得分匹配后,有222名患者接受了进一步分析(非试管组=134人,试管组=88人)。配对组患者的人口统计学特征相当。临床相关的术后胰瘘(CR-POPF)发生率(14 (10.45%) VS 20 (22.73%),P=0.013)明显高于T管组。胆道吻合口狭窄(BAS)的总发生率为 3.15%。T型管组的发生率略低,但差异无统计学意义(6 (4.48%) VS 1 (1.14%),P=0.317):结论:在腹腔镜手术中应用 T 型管预防术后并发症是不可行的。
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引用次数: 0
Observations from the first 100 cases of intraoperative MRI – experiences, trends and short-term outcomes 术中磁共振成像的前 100 例观察--经验、趋势和短期结果
IF 1.9 3区 医学 Q2 SURGERY Pub Date : 2024-09-19 DOI: 10.1186/s12893-024-02569-y
Hanna Barchéus, Christoffer Peischl, Isabella M. Björkman-Burtscher, Christina Pettersson, Anja Smits, Daniel Nilsson, Dan Farahmand, Johanna Eriksson, Thomas Skoglund, Alba Corell
We sought to analyze, in well-defined clinical setting, the first 100 patients treated at the intraoperative MRI (iMRI) hybrid surgical theatre at our facility in a population-based setting to evaluate which pathologies are best approached with iMRI assisted surgeries, as this is not yet clearly defined. Patients undergoing surgery in the 3T iMRI hybrid surgical theatre at our neurosurgical department between December 2017 to May 2021 were included after informed consent. Demographic, clinical, surgical, histological, radiological and outcome parameters, as well as variables related to iMRI, were retrospectively collected and analyzed. Patients were subdivided into adult and pediatric cohorts. Various neurosurgical procedures were performed; resection of tumors and epileptic foci, endoscopic skull base procedures including pituitary lesions, deep brain stimulation (DBS) and laser interstitial thermal therapy (LITT). In total, 41 patients were pediatric. An iMRI scan was carried out in 96% of cases and led to continuation of surgery in 50% of cases, mainly due to visualized remaining pathological tissue (95.2%). Median time to iMRI from intubation was 280 min and median total duration of surgery was 445 min. The majority of patients experienced no postoperative complications (70%), 13 patients suffered permanent postoperative deficits, predominantly visual. Herein, we demonstrate the first 100 patients undergoing neurosurgery aided by iMRI at our facility since introduction. Indications for surgery differed between pediatric and adult patients. The iMRI was utilized for tumor surgeries, particularly adult low-grade gliomas and pediatric tumors, as well as for epilepsy surgery and DBS. In this heterogenous population, iMRI led to continuation of surgery in 50%. To establish the benefit in maximizing the extent of resection in these brain pathologies future studies are recommended. Not applicable.
我们试图在明确界定的临床环境中,以人群为基础,分析在我院术中磁共振成像(iMRI)混合手术室接受治疗的首批100名患者,以评估哪些病症最适合在iMRI辅助下进行手术,因为这一点尚未明确界定。经知情同意后,纳入了2017年12月至2021年5月期间在本院神经外科3T iMRI混合手术室接受手术的患者。回顾性收集并分析了人口统计学、临床、手术、组织学、放射学和结果参数,以及与 iMRI 相关的变量。患者被细分为成人组和儿童组。患者接受了各种神经外科手术:肿瘤和癫痫灶切除术、内窥镜颅底手术(包括垂体病变)、脑深部刺激(DBS)和激光间质热疗(LITT)。共有 41 名患者为儿科患者。96%的病例进行了iMRI扫描,50%的病例继续进行了手术,主要原因是看到了残留的病理组织(95.2%)。从插管到进行 iMRI 扫描的中位时间为 280 分钟,手术总时间的中位数为 445 分钟。大多数患者术后无并发症(70%),13 名患者术后出现永久性障碍,主要是视力障碍。在此,我们展示了本机构自引入 iMRI 以来,接受 iMRI 辅助神经外科手术的前 100 名患者的情况。儿童患者和成人患者的手术指征有所不同。iMRI 被用于肿瘤手术,尤其是成人低级别胶质瘤和小儿肿瘤,以及癫痫手术和 DBS。在这一异质性人群中,50% 的 iMRI 使手术得以继续。为了确定在这些脑部病变中最大限度地扩大切除范围的益处,建议今后进行研究。不适用。
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引用次数: 0
Short-term safety and effectiveness of conversion from sleeve gastrectomy to Ring augmented Roux-en-Y gastric bypass 从袖状胃切除术转为环形增强型 Roux-en-Y 胃旁路术的短期安全性和有效性
IF 1.9 3区 医学 Q2 SURGERY Pub Date : 2024-09-19 DOI: 10.1186/s12893-024-02552-7
Kayleigh Ann Martina van Dam, Evelien de Witte, Pieter Petrus Henricus Luciën Broos, Jan Willem M. Greve, Evert-Jan Gijsbert Boerma
Weight recurrence, suboptimal clinical response and functional disorder (such as reflux) after a Sleeve Gastrectomy (SG) are problems that may require conversional surgery. For reflux, conversion to Roux-en-Y Gastric Bypass (RYGB) is considered effective. Regarding treatment for suboptimal clinical response, the technique of choice remains a subject of debate. This study aims to evaluate the safety and effectiveness of conversion from SG to Ring-augmented RYGB ( RaRYGB). All laparoscopic SG to RaRYGB conversions performed between January 2016 and January 2022 were included. Primary outcome was percentage total weight loss (%TWL) after 1-year follow-up. Secondary outcomes consisted of cumulative %TWL, complications (with a focus on ring-related complications), and resolution of medical-associated problems. We included 50 patients of whom 44 were female. Mean pre-conversion BMI was 37.6 kg/m2. All patients have reached the 1-year follow-up point, however 10 were lost to follow-up. After 1-year mean TWL was 17.8% while mean cumulative TWL, calculated from primary SG, was 32%. A total of 10 complications occurred in 8 patients within 30 days, 6 of which were ≤ CD3a and 4 ≥ CD3b. One MiniMizer was removed for complaints of severe dysphagia. Of the 35 medical-associated problems present at screening 5 remained unchanged(14.2%), 15 improved(42.9%) and 15 achieved remission(42.9%). Our series of 50 patients undergoing conversion from SG to RaRYGB is adequate and successful regarding additional weight loss 1 year after conversion, cumulative weight loss, complication rate and achievement of improvement or remission of medical-associated problems.
袖带胃切除术(SG)后体重复发、临床反应不理想和功能紊乱(如反流)等问题可能需要进行转换手术。对于反流问题,改用 Roux-en-Y 胃旁路术(RYGB)被认为是有效的方法。关于临床反应不理想的治疗方法,选择何种技术仍是一个争论的话题。本研究旨在评估从 SG 转为环形增强 RYGB(RaRYGB)的安全性和有效性。研究纳入了2016年1月至2022年1月期间进行的所有腹腔镜SG至RaRYGB转换手术。主要结果是随访一年后的总减重百分比(%TWL)。次要结果包括累计总减重百分比、并发症(重点是环相关并发症)以及医疗相关问题的解决情况。我们共纳入了 50 名患者,其中 44 人为女性。转换前的平均体重指数为 37.6 kg/m2。所有患者均接受了为期 1 年的随访,但有 10 名患者失去了随访机会。1 年后的平均 TWL 为 17.8%,而从主要 SG 计算得出的平均累积 TWL 为 32%。8 名患者在 30 天内共发生了 10 例并发症,其中 6 例≤CD3a,4 例≥CD3b。一名 MiniMizer 患者因主诉严重吞咽困难而被移除。在筛查时存在的 35 个医疗相关问题中,5 个保持不变(14.2%),15 个有所改善(42.9%),15 个达到缓解(42.9%)。我们对 50 名从 SG 转为 RaRYGB 的患者进行了系列研究,在转为 RaRYGB 1 年后的额外体重减轻、累计体重减轻、并发症发生率以及医疗相关问题的改善或缓解方面,我们的研究是充分和成功的。
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引用次数: 0
Postoperative early laboratory changes and follow-up process of patients underwent hyperthermic intrathoracic chemotherapy 胸腔内热化疗患者术后早期实验室变化及随访过程
IF 1.9 3区 医学 Q2 SURGERY Pub Date : 2024-09-19 DOI: 10.1186/s12893-024-02565-2
Sercan Aydin, Seda Kahraman Aydin, Hasan Yavuz, Ayse Gul Ergonul, Tevfik Ilker Akcam, Kutsal Turhan, Alpaslan Cakan, Ufuk Cagirici
The aim of combining hyperthermic intrathoracic chemotherapy (HITHOC) with surgery is to achieve local control in patients with pleural malignancies. Liver and kidney dysfunction resulting from this procedure have been reported in the literature. The objective of the study is to examine whether the laboratory abnormalities observed during the initial period persist until day 30. The study conducted a retrospective analysis of the blood glucose levels, renal function markers, and hepatic function markers of 30 patients who underwent pleurectomy-decortication and HITHOC for pleural mesothelioma from January 2010 to April 2022. The measurements were taken in the postoperative period on the first four and 30th days. The study analyzed the initial and final laboratory results caused by the procedure. Out of the total of 30 patients, 29, 28, 14, and 12 patients had elevated glucose levels on the first four days after the surgery, respectively. There was no association between glucose abnormalities and preoperative-postoperative diabetes mellitus. A minority of patients experienced atypical alterations in kidney and liver functions during the initial postoperative period. There was no apparent relationship between the renal and hepatic functions in the early and late periods after the surgery. Although there were fluctuations in glucose levels and renal and hepatic functions in the early period after surgery, there were no persistent alterations in these parameters by day 30. Elevated glucose levels during the early period were not associated with the development of newly diagnosed diabetes mellitus after surgery. The findings of our study provide evidence that HITHOC is a favorable and well-tolerated treatment option for mesothelioma.
胸腔内热化疗(HITHOC)与手术相结合的目的是使胸膜恶性肿瘤患者的病情得到局部控制。有文献报道,这种手术会导致肝肾功能障碍。本研究的目的是探讨初期观察到的实验室异常是否会持续到第30天。研究对2010年1月至2022年4月期间因胸膜间皮瘤接受胸膜切除术和HITHOC的30名患者的血糖水平、肾功能指标和肝功能指标进行了回顾性分析。测量是在术后第 4 天和第 30 天进行的。研究分析了手术导致的初始和最终实验室结果。在总共 30 名患者中,分别有 29 名、28 名、14 名和 12 名患者在术后头四天血糖水平升高。血糖异常与术前术后糖尿病之间没有关联。少数患者在术后初期出现肝肾功能非典型改变。术后早期和晚期的肝肾功能没有明显的关系。虽然术后早期的血糖水平和肝肾功能有所波动,但到第 30 天时,这些参数没有出现持续性改变。早期血糖水平升高与术后新诊断糖尿病的发生无关。我们的研究结果证明,HITHOC 是治疗间皮瘤的一种良好且耐受性良好的治疗方案。
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引用次数: 0
Orthostatic intolerance during early mobilization following thoracoscopic lung resection: a prospective observational study 胸腔镜肺切除术后早期活动时的直立性不耐受:一项前瞻性观察研究
IF 1.9 3区 医学 Q2 SURGERY Pub Date : 2024-09-16 DOI: 10.1186/s12893-024-02556-3
Hongjie Yi, Wenfeng Tang, Ying Shen, Li Tan, Fanshu Zeng, Siqi Yang
Early postoperative mobilization is important for enhanced recovery but can be hindered by orthostatic intolerance. However, study on postoperative orthostatic intolerance in thoracoscopic lung resection is limited. Thus, this investigation aims to examine the prevalence and variables contributing to orthostatic intolerance on the first day following thoracoscopic lung cancer resection. A prospective observational study was conducted from February 01 to May 05, 2023, at the First Affiliated Hospital of Chongqing Medical University. Typically, 215 subjects subjected to thoracoscopic lung resection were enrolled in this study. Their general information, disease, and treatment information were collected, and the occurrence of orthostatic intolerance was recorded. Typically, 64 patients (29.77%) demonstrated orthostatic intolerance during early mobilization, and 43.75% failed to walk. The prevalence of nausea, dizziness, and impaired vision was 60.94%, 92.19%, and 25.00%, respectively, and no patient experienced syncope. The factors shown to be independently linked with orthostatic intolerance were being female (OR = 2.98, 1.53 to 5.82) and high pain level during sitting (OR = 2.69, 1.79 to 4.04). Individuals with orthostatic intolerance had a longer postoperative hospital stay with a mean of 5.42 days against 4.25 days (p = 0.003). Orthostatic intolerance was prevalent following thoracoscopic lung cancer resection and affected patients’ capability to mobilize and prolonged postoperative hospitalization. Being female and having high pain levels during sitting were identified as independent factors for orthostatic intolerance. This suggests that more emphasis should be given to risky patients, and for these groups, we may optimize pain management to adjust the risk of emerging orthostatic intolerance, facilitating early mobilization and early postoperative rehabilitation.
术后早期活动对促进康复非常重要,但可能会因正压性不耐受而受到阻碍。然而,关于胸腔镜肺切除术后正压性不耐受的研究非常有限。因此,本研究旨在探讨胸腔镜肺癌切除术后第一天导致正压性不耐受的发生率和变量。一项前瞻性观察研究于 2023 年 2 月 1 日至 5 月 5 日在重庆医科大学附属第一医院进行。本研究共纳入 215 名接受过胸腔镜肺切除术的受试者。研究人员收集了他们的一般信息、疾病和治疗信息,并记录了发生直立性不耐受的情况。通常情况下,64 名患者(29.77%)在早期活动时表现出正压性不耐受,43.75% 的患者无法行走。恶心、头晕和视力受损的发生率分别为 60.94%、92.19% 和 25.00%,没有患者出现晕厥。结果显示,女性(OR = 2.98,1.53 至 5.82)和坐着时疼痛程度高(OR = 2.69,1.79 至 4.04)是与正性静力性不耐受独立相关的因素。有直立性不耐受的患者术后住院时间更长,平均为 5.42 天,而非 4.25 天(P = 0.003)。胸腔镜肺癌切除术后,患者普遍会出现直立性不耐受,这影响了患者的活动能力,延长了术后住院时间。女性和坐位时疼痛程度较高被认为是导致直立性不耐受的独立因素。这表明,我们应更加重视高风险患者,对于这些患者,我们可以优化疼痛管理,以调整出现直立性不耐受的风险,促进早期活动和早期术后康复。
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引用次数: 0
Indocyanine green fluorescence in the evaluation of post-resection pancreatic remnant perfusion after a pancreaticoduodenectomy: a clinical study protocol 吲哚菁绿荧光评估胰十二指肠切除术后胰腺残余灌注:临床研究方案
IF 1.9 3区 医学 Q2 SURGERY Pub Date : 2024-09-14 DOI: 10.1186/s12893-024-02559-0
Štěpán-Ota Schütz, Michael Rousek, Pavel Záruba, Tereza Husárová, Radek Pohnán
Pancreaticoduodenectomy is associated with an incidence of postoperative complications of approximately 41%. One of the most severe complications is a postoperative pancreatic fistula. The exact cause of postoperative fistula development is still unknown, but it appears to be multifactorial. Proper perfusion of pancreatic remnant is essential for the healing of pancreaticojejunostomy. To date, there is no method to reliably evaluate the vascular supply of the remnant. One of the methods for the assessment of organ perfusion is the indocyanine green fluorescence. This study aims to determine if indocyanine green fluorescence is a reliable method to measure the perfusion of the post-resection pancreatic remnant. The secondary outcome is to determine if intraoperative evaluation of the vascular supply of the post-resection remnant may predict the increased risk of postoperative pancreatic fistula development. This study is designed as a prospective, observational study. All consecutive patients undergoing open or robotic pancreaticoduodenectomies at our department during the 1st May 2024-31st December 2026 period will be enrolled. The exclusion criteria are an allergy to indocyanine green and refusal by the patient. The adequacy of the vascular supply of the post-resection pancreatic remnant will be intraoperatively evaluated using a fluorescence detector. Patients will be divided into two groups: Those with high risk of pancreatic fistula development and those with low risk. The incidence of pancreatic fistulas in both groups is to be compared. Postoperative data including morbidity, mortality, hospital stay, intensive care unit stay and postoperative fistula development will be collected. If an intraoperative assessment of the perfusion of post-resection pancreatic remnant using indocyanine green is proven to be a suitable method to estimate the increased risk of the pancreatic fistula, the list of the existing known risk factors could be expanded. In the most high-risk patients the modification of the surgical procedure could be considered. Number: NCT06198400 ClinicalTrials.Gov. Date 08.01.2024.
胰十二指肠切除术的术后并发症发生率约为 41%。术后胰瘘是最严重的并发症之一。术后瘘管形成的确切原因尚不清楚,但似乎是多因素造成的。胰腺残余物的适当灌注对胰腺空肠吻合术的愈合至关重要。迄今为止,还没有一种方法能可靠地评估残余胰腺的血管供应情况。吲哚菁绿荧光法是评估器官灌注的方法之一。本研究旨在确定吲哚菁绿荧光是否是测量胰腺切除术后残余胰腺灌注的可靠方法。次要研究结果是确定术中对切除后残留胰腺血管供应的评估是否可以预测术后胰瘘发生风险的增加。本研究是一项前瞻性观察研究。所有在 2024 年 5 月 1 日至 2026 年 12 月 31 日期间在我科接受开腹或机器人胰十二指肠切除术的连续患者都将被纳入研究范围。排除标准为对吲哚菁绿过敏和患者拒绝。术中将使用荧光检测器评估切除后胰腺残余的血管供应是否充足。患者将分为两组:胰瘘高风险组和低风险组。两组患者的胰瘘发生率将进行比较。将收集术后数据,包括发病率、死亡率、住院时间、重症监护室住院时间和术后瘘管发展情况。如果使用吲哚菁绿术中评估切除术后胰腺残余的灌注情况被证明是估计胰瘘风险增加的合适方法,那么现有的已知风险因素清单就可以扩大。对于风险最高的患者,可以考虑修改手术方法。编号NCT06198400 ClinicalTrials.Gov. Date 08.01.2024.
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引用次数: 0
Assessing the accuracy of the revised Cardiac Risk Index compared to the American Society of Anaesthesiologists physical status classification in predicting Pulmonary and Cardiac complications among non-cardiothoracic surgery patients at Muhimbili National Hospital: a prospective cohort study 评估经修订的心脏风险指数与美国麻醉医师协会身体状况分类法在预测穆欣比利国立医院非心胸手术患者肺部和心脏并发症方面的准确性:一项前瞻性队列研究
IF 1.9 3区 医学 Q2 SURGERY Pub Date : 2024-09-14 DOI: 10.1186/s12893-024-02536-7
Elias Makoye Chrisant, Ramadhan Hassani Khamisi, Frank Muhamba, Ally Hamis Mwanga, Hervé Tshikomba Mbuyamba
The Revised Cardiac Risk Index (RCRI) and the American Society of Anaesthesiologists (ASA-PS) classification system are two commonly used tools for preoperative risk assessment. This study aimed to assess the accuracy of RCRI compared to the ASA-PS classification system in preoperative risk assessment for pulmonary and cardiac problems among non-cardiothoracic surgery patients admitted at Muhimbili National Hospital (MNH). This was a prospective cohort study design conducted from August 2022 to April 2023 among 184 patients of 18 years and above admitted at MNH for elective non-cardiothoracic surgery. Data Analysis was conducted using STATA software version 16. Means and standard deviations were used to summarize continuous data. Frequencies and percentages were used to summarize categorical data. The logistic regression and ROC curve analysis were used to determine the correlation between variables. The majority of patients (43.3%) had an RCRI score of 1 point, and 39.9% were classified as ASA class 1. Patients in ASA classes 3 and 4 had higher odds of developing cardiac and pulmonary complications (AUC = 0.75 and 0.77, respectively). Patients with an RCRI score of 2 or ≥ 3 points were also more likely to experience cardiac and pulmonary complications (AUC = 0.73 and 0.72, respectively). There was no significant difference in the predictive ability of the two tools. Both RCRI and ASA-PS classification systems were equally effective in predicting these complications. Both the RCRI and the ASA-PS classification system demonstrated good predictive ability for cardiac and pulmonary complications among patients undergoing non-cardiothoracic surgery.
修订心脏风险指数(RCRI)和美国麻醉医师协会(ASA-PS)分类系统是两种常用的术前风险评估工具。本研究旨在评估 RCRI 与 ASA-PS 分类系统相比,在穆亨比里国立医院(MNH)收治的非心胸手术患者术前肺部和心脏问题风险评估中的准确性。这是一项前瞻性队列研究,研究时间为2022年8月至2023年4月,研究对象为184名在Muhimbili国立医院接受非心胸外科择期手术的18岁及以上患者。数据分析采用 STATA 软件 16 版。平均数和标准差用于总结连续性数据。频率和百分比用于总结分类数据。逻辑回归和 ROC 曲线分析用于确定变量之间的相关性。大多数患者(43.3%)的 RCRI 得分为 1 分,39.9% 的患者被划分为 ASA 1 级。ASA 3 级和 4 级患者出现心脏和肺部并发症的几率更高(AUC 分别为 0.75 和 0.77)。RCRI评分为2分或≥3分的患者也更有可能出现心脏和肺部并发症(AUC分别为0.73和0.72)。两种工具的预测能力没有明显差异。RCRI 和 ASA-PS 分级系统在预测这些并发症方面同样有效。RCRI和ASA-PS分类系统对非心胸手术患者的心脏和肺部并发症都有很好的预测能力。
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引用次数: 0
Hypoparathyroidism after total thyroidectomy: reactive to symptoms supplementation 甲状腺全切除术后甲状旁腺功能减退:对症状补充剂的反应
IF 1.9 3区 医学 Q2 SURGERY Pub Date : 2024-09-14 DOI: 10.1186/s12893-024-02534-9
Maxime Constant, Franck Schillo, Sophie Billet, Bruno Heyd, Alexandre Doussot, Nicolas Bouviez
After total thyroidectomy (TT), postoperative hypoparathyroidism (PH) is the most frequent complication. Yet, management strategies for PH remain disputed. The aim of this study was to evaluate outcomes of a reactive supplementation in case of symptomatic PH. Additionally, risk factors for symptomatic PH and readmission due to PH were analyzed. All consecutive patients who underwent TT or completion from 2017 to 2022 were considered for inclusion. During this period, a reactive to symptom vitamin-calcium supplementation was used. The primary outcome was the occurrence of severe PH after discharge resulting in readmission. Overall, 307 patients were included, of which 98 patients (31.9%) developed symptomatic PH including 43 patients before discharge. Independent risk factors for developing symptomatic PH were age (p = 0.010) and postoperative day 1 (POD1) PTH level (p < 0.001). Overall, 264 patients (86%) did not present PH before discharge and were discharged home. Among them, 55 patients (20.8%) experienced symptomatic PH, requiring readmission in 18 patients. The overall readmission rate owing to symptomatic PH requiring intravenous supplementation despite oral vitamin-calcium supplementation was 6.8% (n = 18). Independent risk factors for symptomatic PH-related readmission were age (p = 0.007) and POD1 PTH level (p < 0.001). Adequate cut-off values for predicting readmission were POD1 albumin-adjusted calcium = 2.1 mmol/l (Sensibility = 0.95, Specificity = 0.30) and POD1 PTH = 11.5 pg/ml (Sensibility = 0.90, Specificity = 0.71). Supplementing only symptomatic patients was safe and efficient. This attitude does not alter on morbidity, mortality or readmission rate which is in line with current literature.
甲状腺全切除术(TT)后,术后甲状旁腺功能减退症(PH)是最常见的并发症。然而,PH的治疗策略仍存在争议。本研究旨在评估有症状的PH患者接受反应性补充治疗的效果。此外,还分析了无症状 PH 和因 PH 再入院的风险因素。所有在 2017 年至 2022 年期间接受过 TT 或完成 TT 的连续患者均被纳入考虑范围。在此期间,采用了反应性对症维生素钙补充剂。主要结果是出院后发生严重 PH 导致再次入院。总共纳入了 307 名患者,其中 98 名患者(31.9%)出现了有症状的 PH,包括出院前的 43 名患者。出现症状性 PH 的独立风险因素是年龄(P = 0.010)和术后第 1 天(POD1)PTH 水平(P < 0.001)。总体而言,264 名患者(86%)在出院前未出现 PH 并出院回家。其中,55 名患者(20.8%)出现有症状的 PH,18 名患者需要再次入院。尽管口服了维生素钙补充剂,但由于出现需要静脉补充的症状性 PH 而再次入院的总比例为 6.8%(n = 18)。年龄(p = 0.007)和 POD1 PTH 水平(p < 0.001)是无症状 PH 相关再入院的独立风险因素。预测再入院的适当临界值为 POD1 白蛋白调整钙 = 2.1 mmol/l(灵敏度 = 0.95,特异性 = 0.30)和 POD1 PTH = 11.5 pg/ml(灵敏度 = 0.90,特异性 = 0.71)。仅对有症状的患者进行补充是安全有效的。这种态度不会改变发病率、死亡率或再入院率,这与当前的文献一致。
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引用次数: 0
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BMC Surgery
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