Objective
Compare prevalence and profile of post-intensive care patient (P-PICS) and family/caregiver (F-PICS) syndrome in two cohorts (COVID and non-COVID) and analyse risk factors for P-PICS.
Design
Prospective, observational cohort (March 2018- 2023), follow-up at three months and one year.
Setting
14-bed polyvalent Intensive Care Unit (ICU), Level II Hospital.
Patients or participants
265 patients and 209 relatives. Inclusion criteria patients: age > 18 years, mechanical ventilation > 48 hours, ICU stay > 5 days, delirium, septic shock, acute respiratory distress syndrome, cardiac arrest. Inclusion criteria family: those who attended.
Interventions
Follow-up 3 months and 1 year after hospital discharge.
Main variables of interest
Patients; sociodemographic, clinical, evolutive, physical, psychological and cognitive alterations, dependency degree and quality of life. Main caregivers: mental state and physical overload.
Results
64.9% PICS-P, no differences between groups. COVID patients more physical alterations than non-COVID (p = 0.028). These more functional deterioration (p = 0.005), poorer quality of life (p = 0.003), higher nutritional alterations (p = 0.004) and cognitive deterioration (p< 0.001). 19.1% PICS-F, more frequent in relatives of non-COVID patients (17.6% vs. 5.5%; p = 0.013). Independent predictors of PICS-P: first years of the study (OR: 0.484), higher comorbidity (OR: 1.158), delirium (OR: 2.935), several reasons for being included (OR: 3.171) and midazolam (OR: 4.265).
Conclusions
Prevalence PICS-P and PICS-F between both cohorts was similar. Main factors associated with the development of SPCI-P were: higher comorbidity, delirium, midazolam, inclusion for more than one reason and during the first years.