Pub Date : 2024-04-01DOI: 10.1016/j.jviscsurg.2024.02.002
Mathilde Aubert , Etienne Buscail , Emilie Duchalais , Antoine Cazelles , Maxime Collard , Diane Charleux-Muller , Florence Jeune , Alexandre Nuzzo , Alexandra Pellegrin , Luca Theuil , Amandine Toutain , Bertrand Trilling , Laurent Siproudhis , Guillaume Meurette , Jérémie H. Lefevre , Léon Maggiori , Diane Mege , sous l’égide de la Société nationale française de coloproctologie (SNFCP) et de la Société française de chirurgie digestive (SFCD)
Aim
Digestive stoma are frequently performed. The last French guidelines have been published twenty years ago. Our aim was to update French clinical practice guidelines for the perioperative management of digestive stoma and stoma-related complications.
Methods
A systematic literature review of French and English articles published between January 2000 and May 2022 was performed. Only digestive stoma for fecal evacuation in adults were considered. Stoma in children, urinary stoma, digestive stoma for enteral nutrition, and rare stoma (Koch, perineal) were not included.
Results
Guidelines include the surgical landmarks to create digestive stoma (ideal location, mucocutaneous anastomosis, utility of support rods, use of prophylactic mesh), the perioperative clinical practice guidelines (patient education, preoperative ostomy site marking, postoperative equipment, prescriptions, and follow-up), the management of early stoma-related complications (difficulties for nursing, high output, stoma necrosis, retraction, abscess and peristomal skin complications), and the management of late stoma-related complications (stoma prolapse, parastomal hernia, stoma stenosis, late stoma retraction). A level of evidence was assigned to each statement.
Conclusion
These guidelines will be very useful in clinical practice, and allow to delete some outdated dogma.
{"title":"Management of adult intestinal stomas: The 2023 French guidelines","authors":"Mathilde Aubert , Etienne Buscail , Emilie Duchalais , Antoine Cazelles , Maxime Collard , Diane Charleux-Muller , Florence Jeune , Alexandre Nuzzo , Alexandra Pellegrin , Luca Theuil , Amandine Toutain , Bertrand Trilling , Laurent Siproudhis , Guillaume Meurette , Jérémie H. Lefevre , Léon Maggiori , Diane Mege , sous l’égide de la Société nationale française de coloproctologie (SNFCP) et de la Société française de chirurgie digestive (SFCD)","doi":"10.1016/j.jviscsurg.2024.02.002","DOIUrl":"10.1016/j.jviscsurg.2024.02.002","url":null,"abstract":"<div><h3>Aim</h3><p>Digestive stoma are frequently performed. The last French guidelines have been published twenty years ago. Our aim was to update French clinical practice guidelines for the perioperative management of digestive stoma and stoma-related complications.</p></div><div><h3>Methods</h3><p>A systematic literature review of French and English articles published between January 2000 and May 2022 was performed. Only digestive stoma for fecal evacuation in adults were considered. Stoma in children, urinary stoma, digestive stoma for enteral nutrition, and rare stoma (Koch, perineal) were not included.</p></div><div><h3>Results</h3><p>Guidelines include the surgical landmarks to create digestive stoma (ideal location, mucocutaneous anastomosis, utility of support rods, use of prophylactic mesh), the perioperative clinical practice guidelines (patient education, preoperative ostomy site marking, postoperative equipment, prescriptions, and follow-up), the management of early stoma-related complications (difficulties for nursing, high output, stoma necrosis, retraction, abscess and peristomal skin complications), and the management of late stoma-related complications (stoma prolapse, parastomal hernia, stoma stenosis, late stoma retraction). A level of evidence was assigned to each statement.</p></div><div><h3>Conclusion</h3><p>These guidelines will be very useful in clinical practice, and allow to delete some outdated dogma.</p></div>","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1016/j.jviscsurg.2023.11.008
Jérôme Brunet, Clément Billaquois, Hugo Viellard, Franck Courari
Following a reminder on the quantities of carbon emitted in the healthcare sector, and casting a spotlight on those directly related to architecture, the authors of this article will develop three large-scale themes, the objective being to render hospital construction sustainable. 1. Energy consumption and how to reduce it. 2. “Low-carbon” construction and how building designers can limit emissions by the choice of construction materials. 3. The “resilience” of some constructions, their capacity to stave off obsolescence. As a conclusion, the authors present one of the most recent projects of the Brunet Saunier & Associates architecture agency: the Saint-Ouen university hospital, Grand Paris Nord. This project is illustrative of these preoccupations and demonstrates the possibility of meeting the challenges of sustainable development by means of simple and durable architecture.
{"title":"Eco-friendly hospital architecture","authors":"Jérôme Brunet, Clément Billaquois, Hugo Viellard, Franck Courari","doi":"10.1016/j.jviscsurg.2023.11.008","DOIUrl":"10.1016/j.jviscsurg.2023.11.008","url":null,"abstract":"<div><p>Following a reminder on the quantities of carbon emitted in the healthcare sector, and casting a spotlight on those directly related to architecture, the authors of this article will develop three large-scale themes, the objective being to render hospital construction sustainable. 1. Energy consumption and how to reduce it. 2. “Low-carbon” construction and how building designers can limit emissions by the choice of construction materials. 3. The “resilience” of some constructions, their capacity to stave off obsolescence. As a conclusion, the authors present one of the most recent projects of the Brunet Saunier & Associates architecture agency: the Saint-Ouen university hospital, Grand Paris Nord. This project is illustrative of these preoccupations and demonstrates the possibility of meeting the challenges of sustainable development by means of simple and durable architecture.</p></div>","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139555628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1016/j.jviscsurg.2023.02.006
E. Dohner , F. Kierdorf , P. Moreno , R. Langer , M. Zuber , R. Fahrner
Aim of the study
In histologically non-inflamed but clinically suspect appendices, changes described as neurogenic appendicopathy with fibrous or fibrolipomatous obliterations can be observed. The purpose of this study was to analyse the incidence of these entities of the appendix in a longitudinal patient cohort.
Patients and methods
This is a retrospective single-centre study of 457 patients undergoing laparoscopic appendectomy from 2017 to 2020 due to suspected acute appendicitis.
Results
In 72 patients (15.8%) with clinically suspected acute appendicitis, the appendix showed no distinct signs of acute inflammation during the procedure. In 43 patients, histological analysis revealed neurogenic appendicopathy or fibrous and fibrolipomatous obliteration. Female gender (P = 0.088), younger age (P < 0.0001), longer pain duration (P < 0.0001) and repetitive pain episodes were more frequent in these patients than in those with acute appendicitis. Inflammation markers were also decreased in the group of patients with neurogenic appendicopathy (leukocytes 9.8 ± 3.5 vs. 13.0 ± 4.5 G/L and C-reactive protein 38.7 ± 60.7 vs. 59.4 ± 70.5 mg/L).
Conclusion
Neurogenic appendicopathy with fibrous/fibrolipomatous obliteration is a differential diagnosis of acute appendicitis that can only be confirmed by pathology. Female gender, young age, prolonged duration with repetitive episodes of pain, and relatively low inflammatory markers are evocative of this diagnosis.
{"title":"Neurogenic appendicopathy: A rare differential diagnosis of acute appendicitis","authors":"E. Dohner , F. Kierdorf , P. Moreno , R. Langer , M. Zuber , R. Fahrner","doi":"10.1016/j.jviscsurg.2023.02.006","DOIUrl":"10.1016/j.jviscsurg.2023.02.006","url":null,"abstract":"<div><h3>Aim of the study</h3><p>In histologically non-inflamed but clinically suspect appendices, changes described as neurogenic appendicopathy with fibrous or fibrolipomatous obliterations can be observed. The purpose of this study was to analyse the incidence of these entities of the appendix in a longitudinal patient cohort.</p></div><div><h3>Patients and methods</h3><p>This is a retrospective single-centre study of 457 patients undergoing laparoscopic appendectomy<span> from 2017 to 2020 due to suspected acute appendicitis.</span></p></div><div><h3>Results</h3><p>In 72 patients (15.8%) with clinically suspected acute appendicitis, the appendix showed no distinct signs of acute inflammation during the procedure. In 43 patients, histological analysis revealed neurogenic appendicopathy or fibrous and fibrolipomatous obliteration. Female gender (<em>P</em> <!-->=<!--> <!-->0.088), younger age (<em>P</em> <!--><<!--> <!-->0.0001), longer pain duration (<em>P</em> <!--><<!--> <!-->0.0001) and repetitive pain episodes were more frequent in these patients than in those with acute appendicitis. Inflammation markers were also decreased in the group of patients with neurogenic appendicopathy (leukocytes 9.8<!--> <!-->±<!--> <!-->3.5 vs. 13.0<!--> <!-->±<!--> <!-->4.5 G/L and C-reactive protein 38.7<!--> <!-->±<!--> <!-->60.7 vs. 59.4<!--> <!-->±<!--> <!-->70.5<!--> <!-->mg/L).</p></div><div><h3>Conclusion</h3><p>Neurogenic appendicopathy with fibrous/fibrolipomatous obliteration is a differential diagnosis of acute appendicitis that can only be confirmed by pathology. Female gender, young age, prolonged duration with repetitive episodes of pain, and relatively low inflammatory markers are evocative of this diagnosis.</p></div>","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10774062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The histological examination (HE) of all cholecystectomy specimens removed for cholelithiasis is a widespread practice to rule out unrecognized gallbladder cancer. (GBC). But this dogmatic practice has been called into question by recent published data. The aim of this literature review was to answer two questions: (1) can HE be omitted in specific cases; (2) under what conditions is a selective strategy indicated?
Methods
A review of the literature was carried out that included selected multicenter studies, registry studies, or meta-analyses. A reliable technique for the surgeon's macroscopic examination of the specimen would allow the selection of dubious cases for HE. The cost-effectiveness of selective HE was discussed. The PICO methodology (population, intervention, comparator, outcome) was used in the selection of articles that compared routine and selective histological examination.
Results
If cases from countries with a high prevalence of gallbladder cancer are excluded and in the absence of high-risk situations (advanced age, female gender, calcified or porcelain gallbladder, acute cholecystitis, polyps, abnormalities noted intra-operatively), the macroscopic examination of the gallbladder in the operating room has a reliability approaching 100% in the majority of published studies. This would make it possible to omit systematic HE without compromising the diagnosis and prognosis of patients with unsuspected GBC and with a very favorable cost-effectiveness ratio.
Conclusion
Through a selection of patients at very low risk of incidentally-discovered cancer and a routine macroscopic examination of the opened gallbladder, the strategy of selective HE could prove useful in both clinical and economic terms.
导言对所有因胆石症而切除的胆囊切除术标本进行组织学检查(HE)是一种普遍的做法,以排除未被发现的胆囊癌。(GBC)。但最近发表的数据对这种教条式的做法提出了质疑。本文献综述旨在回答两个问题:(1) 在特定病例中是否可以省略 HE;(2) 在什么情况下需要采取选择性策略。外科医生对标本进行宏观检查的可靠技术将有助于选择可疑病例进行 HE。讨论了选择性 HE 的成本效益。结果如果排除来自胆囊癌高发国家的病例,并且不存在高风险情况(高龄、女性、胆囊钙化或瓷化、急性胆囊炎、息肉、术中发现异常),那么在大多数已发表的研究中,手术室胆囊宏观检查的可靠性接近 100%。结论通过选择偶然发现癌症风险极低的患者并对打开的胆囊进行常规宏观检查,选择性胆囊切除术的策略在临床和经济方面都能证明是有用的。
{"title":"Is systematic histological examination of the cholecystectomy specimen always necessary?","authors":"Karem Slim , Flora Badon , Camille Darcha , Jean-Marc Regimbeau","doi":"10.1016/j.jviscsurg.2023.11.011","DOIUrl":"10.1016/j.jviscsurg.2023.11.011","url":null,"abstract":"<div><h3>Introduction</h3><p>The histological examination (HE) of all cholecystectomy specimens removed for cholelithiasis is a widespread practice to rule out unrecognized gallbladder cancer. (GBC). But this dogmatic practice has been called into question by recent published data. The aim of this literature review was to answer two questions: (1) can HE be omitted in specific cases; (2) under what conditions is a selective strategy indicated?</p></div><div><h3>Methods</h3><p>A review of the literature was carried out that included selected multicenter studies, registry studies, or meta-analyses. A reliable technique for the surgeon's macroscopic examination of the specimen would allow the selection of dubious cases for HE. The cost-effectiveness of selective HE was discussed. The PICO methodology (population, intervention, comparator, outcome) was used in the selection of articles that compared routine and selective histological examination.</p></div><div><h3>Results</h3><p>If cases from countries with a high prevalence of gallbladder cancer are excluded and in the absence of high-risk situations (advanced age, female gender, calcified or porcelain gallbladder, acute cholecystitis, polyps, abnormalities noted intra-operatively), the macroscopic examination of the gallbladder in the operating room has a reliability approaching 100% in the majority of published studies. This would make it possible to omit systematic HE without compromising the diagnosis and prognosis of patients with unsuspected GBC and with a very favorable cost-effectiveness ratio.</p></div><div><h3>Conclusion</h3><p>Through a selection of patients at very low risk of incidentally-discovered cancer and a routine macroscopic examination of the opened gallbladder, the strategy of selective HE could prove useful in both clinical and economic terms.</p></div>","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138684092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1016/j.jviscsurg.2023.12.005
Ymer Durmishi, Floren Kavaja
Gastric band migration, for which abscess of the subcutaneous port is an alarm signal, can in some cases be asymptomatic. Therapeutic options for withdrawal of the migrated band include colonoscopy (if the band is located at the level of the ileo-caecal valve), laparoscopy and mini-laparotomy.
{"title":"Asymptomatic gastric band migration","authors":"Ymer Durmishi, Floren Kavaja","doi":"10.1016/j.jviscsurg.2023.12.005","DOIUrl":"10.1016/j.jviscsurg.2023.12.005","url":null,"abstract":"<div><p>Gastric band migration, for which abscess of the subcutaneous port<span> is an alarm signal, can in some cases be asymptomatic. Therapeutic options for withdrawal of the migrated band include colonoscopy (if the band is located at the level of the ileo-caecal valve), laparoscopy and mini-laparotomy.</span></p></div>","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iatrogenic ureteral injury (IUI) is a rare but formidable complication of any abdominal or pelvic surgery. The aim of this study was to describe the epidemiology of IUI in colorectal surgery in the Basse-Normandie region over the period 2004–2022, as well as to review the literature on the management of this complication.
Materials and methods
This multicenter retrospective analysis of clinical data (medical records and operative reports) concerned 22 patients (13 men and 9 women) who suffered an IUI during colorectal surgery between 2004 and 2022. Ureteral resections for oncological purposes and endoluminal instrumental injuries (post-ureteroscopy) were excluded from the study. We also carried out a review of the literature concerning the incidence of IUI in colorectal surgery.
Results
The incidence of IUI was 0.27% over the study period (22 ureteral injuries out of 8129 colorectal procedures). Colorectal cancer and sigmoid diverticulitis were the dominant surgical indications (85% of cases). Proctectomy and left colectomy were the most performed resection procedures (75% of cases). Surgery was scheduled in 68% of cases. The approach was open laparotomy in 59% and laparoscopy in 41% of cases. The IUI involved the left ureter in 63% of cases and the pelvic ureter in 77% of cases. Conservative endoscopic treatment by insertion of a double-J catheter stent had a success rate of 87.5%. Surgical repairs consisting of re-implantation techniques and uretero-ureteral anastomosis had a success rate of 75%. The nephrectomy rate was 13.6% (3/22) and the mortality rate 9% (2/22). A literature review identified sixteen studies, where the incidence of IUI varied from 0.1 to 4.5%.
Findings
IUI occurring during colorectal surgery is a rare occurrence but remain a formidable complication. No means of prevention has proven its effectiveness to date, but guidance devices using illuminated ureteral catheters or dyes seem to constitute a promising approach. Injuries to the left pelvic ureter are the most common, and the majority can be treated endoscopically if diagnosed early.
{"title":"Iatrogenic ureteral injury: What should the digestive surgeon know?","authors":"Abdelaziz Souli , Arnaud Alves , Xavier Tillou , Benjamin Menahem","doi":"10.1016/j.jviscsurg.2023.04.001","DOIUrl":"10.1016/j.jviscsurg.2023.04.001","url":null,"abstract":"<div><h3>Purpose of the study</h3><p>Iatrogenic ureteral injury (IUI) is a rare but formidable complication of any abdominal or pelvic surgery. The aim of this study was to describe the epidemiology of IUI in colorectal surgery in the Basse-Normandie region over the period 2004–2022, as well as to review the literature on the management of this complication.</p></div><div><h3>Materials and methods</h3><p>This multicenter retrospective analysis of clinical data (medical records and operative reports) concerned 22 patients (13 men and 9 women) who suffered an IUI during colorectal surgery between 2004 and 2022. Ureteral resections for oncological purposes and endoluminal instrumental injuries (post-ureteroscopy) were excluded from the study. We also carried out a review of the literature concerning the incidence of IUI in colorectal surgery.</p></div><div><h3>Results</h3><p>The incidence of IUI was 0.27% over the study period (22 ureteral injuries out of 8129 colorectal procedures). Colorectal cancer and sigmoid diverticulitis were the dominant surgical indications (85% of cases). Proctectomy and left colectomy were the most performed resection procedures (75% of cases). Surgery was scheduled in 68% of cases. The approach was open laparotomy in 59% and laparoscopy in 41% of cases. The IUI involved the left ureter in 63% of cases and the pelvic ureter in 77% of cases. Conservative endoscopic treatment by insertion of a double-J catheter stent had a success rate of 87.5%. Surgical repairs consisting of re-implantation techniques and uretero-ureteral anastomosis had a success rate of 75%. The nephrectomy rate was 13.6% (3/22) and the mortality rate 9% (2/22). A literature review identified sixteen studies, where the incidence of IUI varied from 0.1 to 4.5%.</p></div><div><h3>Findings</h3><p>IUI occurring during colorectal surgery is a rare occurrence but remain a formidable complication. No means of prevention has proven its effectiveness to date, but guidance devices using illuminated ureteral catheters or dyes seem to constitute a promising approach. Injuries to the left pelvic ureter are the most common, and the majority can be treated endoscopically if diagnosed early.</p></div>","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139502108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1016/j.jviscsurg.2023.11.003
Antoine Poirier, Amélie Delens, Thomas Serradori
Rapunzel syndrome is a rare disorder characterized by a trichobezoar in the gastroduodenal tract caused by trichophagia. Diagnosis was confirmed by upper endoscopy and treatment was surgical.
{"title":"A case of Rapunzel syndrome","authors":"Antoine Poirier, Amélie Delens, Thomas Serradori","doi":"10.1016/j.jviscsurg.2023.11.003","DOIUrl":"10.1016/j.jviscsurg.2023.11.003","url":null,"abstract":"<div><p><span><span>Rapunzel syndrome is a rare disorder characterized by a </span>trichobezoar in the gastroduodenal tract caused by trichophagia. Diagnosis was confirmed by upper </span>endoscopy<span> and treatment was surgical.</span></p></div>","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1016/j.jviscsurg.2023.07.002
Pr. Antoine Brouquet , Quentin Denost
{"title":"Can shared medical decision-making help to solve the complex equation involved in the choice of optimal treatment for low rectal cancer?","authors":"Pr. Antoine Brouquet , Quentin Denost","doi":"10.1016/j.jviscsurg.2023.07.002","DOIUrl":"10.1016/j.jviscsurg.2023.07.002","url":null,"abstract":"","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}