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Low-cost simulation model for ultrasound-guided punch biopsy and puncture: Construction manual and photo examples. 超声引导下打孔活检和穿刺的低成本模拟模型:构造手册和图片示例。
IF 3.1 3区 医学 Q1 ACOUSTICS Pub Date : 2025-02-01 Epub Date: 2024-03-21 DOI: 10.1055/a-2292-0530
Theresa Lüdke, Alexander Paliege, Anne Kluge, Falk-Tony Olesch, Gregor Hilger, Thomas Beleites, Max Kemper

Purpose: Ultrasound-guided puncture and punch biopsy pose a particular challenge in ultrasound examination training. These techniques should be learned and performed several times using a simulation model that is as realistic as possible before being applied to patients. While the use of agar-agar-based models is extensively documented in the literature, there is a discernible gap in publications specifically addressing their use in punch biopsy and puncture. The aim was to develop a cost-effective model for the simulation of ultrasound-guided interventions.

Materials and methods: The developed simulation model is based on the vegetable gelatine agar-agar. The agar-agar powder is boiled in water and colored. Various objects are added to the mass. Blueberries, olives, tomatoes, and cornichons imitate solid structures. Liquid-filled balloons are used to simulate cystic structures. Adding stones can make the exercises more difficult due to hyperechoic reflexes with distal shadowing.

Results: With the model, ultrasound-guided puncture and punch biopsies could be successfully simulated, and ultrasound images can be generated for this purpose. The cost of a single model is about 2 euros. Production takes less than 2 hours, including cooling. The pure processing time is 30 minutes. The durability of the models is limited by mold, which occurs after 5 days when stored at room temperature and after 5 weeks in the refrigerator.

Conclusion: It was shown that it is possible to produce an inexpensive agar-agar-based ultrasound model in a short time and with easily available ingredients to learn ultrasound-guided puncture and punch biopsies.

目的 超声引导穿刺和打孔活检是超声检查培训中的一项特殊挑战。在使用尽可能逼真的模拟模型对患者进行操作之前,应先学习并多次操作这些技术。虽然文献中广泛记载了琼脂-琼脂模型的使用,但专门针对其在打孔活检和穿刺中的使用的文献明显不足。我们的目的是开发一种具有成本效益的模型,用于模拟超声引导下的介入治疗。材料和方法 所开发的模拟模型以植物明胶琼脂琼脂为基础。琼脂糖粉末在水中煮沸并着色。在粉末中加入各种物体。蓝莓、橄榄、西红柿和玉米粒都是固体结构。充满液体的气球用来模拟囊性结构。加入结石会使练习更加困难,因为会出现高回声反射和远端阴影。结果 使用该模型可成功模拟超声引导下的穿刺和打孔活检,并为此生成超声图像。单个模型的成本约为 2 欧元。包括冷却在内,制作时间不到 2 小时。纯加工时间为 30 分钟。模型的耐久性受到霉菌的限制,在室内空气中存放 5 天后会发霉,在冰箱中存放 5 周后会发霉。结论 研究表明,可以在短时间内利用容易获得的原料制作出一种廉价的琼脂-琼脂超声模型,用于学习超声引导穿刺和打孔活检。目的 超声引导下穿刺和穿刺活检是超声检查培训中的一项特殊挑战。在病人身上使用这些技术之前,最好使用逼真的模拟模型进行学习。迄今为止,使用模型来教授超声引导下穿刺活检和穿刺的方法还鲜有报道。我们的目的是制作一个具有成本效益的模型,用于模拟超声引导下的介入治疗。材料和方法 所开发的模拟模型以植物明胶为基础。明胶粉在水中煮沸并着色。模型成型后,可在其中加入各种物体。固体结构可以用蓝莓、橄榄和西红柿来模拟。充满液体的气球可以模拟囊性结构。加入石头可以增加练习的难度。结果 利用所述模型,可以成功模拟超声引导穿刺和打孔活检,并为此生成超声图像。一个模拟模型的成本约为 2 欧元。制作时间约为 3 小时,包括冷却时间。纯工作时间为 30 分钟。冷却后,模型可立即使用。在室内空气中存放 5 天后会发霉,在冰箱中存放 5 周后会发霉。结论 现已证明,在琼脂琼脂的基础上,可以用容易获得的材料在短时间内制作出一种廉价的超 声波模型,用于学习超声引导穿刺和打孔活检。
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引用次数: 0
Standardized measurement of the piriformis muscle and the proximal portion of the sacral nerve roots using transvaginal ultrasound. 经阴道超声对梨状肌和骶神经根近端进行标准化测量。
IF 3.1 3区 医学 Q1 ACOUSTICS Pub Date : 2025-01-21 DOI: 10.1055/a-2521-9321
Gábor Szabó, Attila Bokor, Veronika Fancsovits, Ezgi Darici Kurt, Theresa Hudelist, Gernot Hudelist
<p><strong>Objective: </strong>To identify the sonomorphological appearance and to measure the thickness of the piriformis muscle (PM) and the proximal portion of the sacral nerve roots S1-S3 in healthy premenopausal women.</p><p><strong>Materials and methods: </strong>This prospective multicentric observational study included a consecutive series of women undergoing transvaginal sonography (TVS) at two tertiary gynecological referral centers. Standardized assessment of the pelvic organs was performed followed by an attempt to visualize the right and left PM and sacral nerve roots S1-S3 at their origin in proximity to the sacral neuroforamen. Visualization rates, diameters of the muscle and nerve thickness and the time needed to identify the PM were recorded.</p><p><strong>Results: </strong>305 patients were included in the study. In 293 women (96.1%) PM was identified bilaterally. The median diameter of the right PM was 18.3mm and 18.4mm on the left side. S1 nerve roots were succesfully identified bilaterally in 224 (73.4%) patients. Their right and left median diameters were 4.8mm. Both S2 nerves were succesfully identified in 215 (70.5%) patients. Their median diameter were 4.3mm on both sides. S3 nerve roots were succesfully identified in 203 (66.6%) patients. Their median diameter were 3.2mm on both sides.</p><p><strong>Conclusion: </strong>We describe methods which allow consistent and rapid identification of the PM and the S1-S3 sacral nerve roots using TVS. Visualization of the PM and the proximal portion of the sacral plexus may be useful regarding identification of pathological changes in PM thickness and could help to distinguish perineural cysts from other gynecological pathologies. Ziel: Die Beschreibung der sonomorphologischen Merkmale als auch die standardisierte Messung des Durchmessers des Musculus piriformis (PM) und der proximalen Anteile der Sakralnervenwurzel (SNW) S1-S3 bei prämenopausalen Frauen.</p><p><strong>Material und methoden: </strong>Diese prospektive Beobachtungsstudie umfasste konsekutiv untersuchte Patientinnen an zwei tertiären gynäkologischen Referenzzentren. Nach standardisierter Beurteilung der Beckenorgane wurde versucht beide PM, deren Durchmesser und die proximalen Anteile der SNW S1-S3 an ihrem Ursprung in der Nähe des Sakralneuroforamens transvaginalsonografisch (TVS) darzustellen. Ergebnisse: Von 305 wurden bei 293 (96,1%) Patientinnen der PM beidseitig detektiert. Der mediane Durchmesser des rechten PM betrug 18,3 mm und des linken PM lag bei 18,4 mm. Die S1-Nervenwurzel (NW) wurde beidseitig bei 224/305 (73,4%) Patientinnen erfolgreich identifiziert. Der mediane Durchmesser der S1-NW betrug an beiden Seiten 4,8 mm. Beide S2-NW wurden bei 215/305 (70,5%) Patientinnen erfolgreich identifiziert. Der mediane Durchmesser der S2-NW betrug 4,3 mm an beiden Seiten. Schließlich wurden bei 203/305 (66,6%) Patientinnen S3-NW erfolgreich identifiziert. Der mediane Durchmesser der S3-NW betrug 3,2 mm an beiden Sei
目的:探讨健康绝经前妇女梨状肌(PM)和骶神经根近端S1-S3的形态特征及厚度。材料和方法:这项前瞻性多中心观察性研究包括在两个三级妇科转诊中心连续接受阴道超声检查(TVS)的妇女。对盆腔器官进行标准化评估,然后尝试在靠近骶神经孔的位置观察左右PM和骶神经根S1-S3的起源。记录可视化率、肌肉直径和神经厚度以及识别PM所需的时间。结果:305例患者纳入研究。293名女性(96.1%)双侧确诊PM。右侧PM中位直径18.3mm,左侧PM中位直径18.4mm。224例(73.4%)患者成功识别双侧S1神经根。左、右中位直径4.8mm。215例(70.5%)患者成功识别出2条S2神经。双侧中位直径为4.3mm。203例(66.6%)患者成功识别S3神经根。两侧中位直径3.2mm。结论:我们描述了使用TVS对PM和S1-S3骶神经根进行一致和快速识别的方法。PM和骶神经丛近端部的可视化可能有助于识别PM厚度的病理变化,并有助于将神经周围囊肿与其他妇科疾病区分开来。Ziel: Die Beschreibung der sononomorphologischen Merkmale也auch Die standardisierte Messung des Durchmessers des musriformis (PM)和der proximalen Anteile der Sakralnervenwurzel (SNW) S1-S3 bei prämenopausalen Frauen。材料和方法:临床前瞻性beobachtungsstudy, unfasste konsekutitiv . patientinen and zwei tertiären gynäkologischen Referenzzentren。每个标准鉴别器Beurteilung der Beckenorgane wurde versuder PM, deren Durchmesser和die近端antele der SNW S1-S3和ihrem Ursprung der Nähe des sakralal神经孔经阴道超声检查(TVS) darzusten。医学进展:Von 305 wurden bei 293 (96,1%) patientinen der PM beidseitig detektiert。中间的Durchmesser的rechten PM在18.3 mm之间,链接PM在18.4 mm之间。Die S1-Nervenwurzel (NW) wurde beidseitig bei 224/305 (73,4%) patientinen erfolgrerich identifiiert。中位Durchmesser为S1-NW,前后为4,8 mm。Beide S2-NW wurden bei 215/305(70.5%)。中间的Durchmesser Der S2-NW在4,3 mm之间,在Seiten之间。Schließlich wurden bei 203/305 (66.6%) Patientinnen S3-NW erfolgreich identifiziert。中间的Durchmesser Der S3-NW在3.2 mm之间,在Seiten之间。研究:PM- dicke过敏症的诊断与诊断möglich mit obigegebenen Referenzwerten der PM- dicke。Die SNW S1-S3 können beder Mehrheit der Patientinnen mittelels TVS and ihrem unsprung identifiziert werden。神经神经丛前肢病变与近端骶神经丛前肢病变的鉴别诊断与病理分析Veränderungen
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引用次数: 0
The reliability and validity of superb microvascular imaging as a potential disease activity marker in rheumatoid arthritis. 超级微血管成像作为类风湿关节炎潜在疾病活动标志物的可靠性和有效性。
IF 3.1 3区 医学 Q1 ACOUSTICS Pub Date : 2025-01-17 DOI: 10.1055/a-2463-8297
Esin Kurtulus Ozturk, Saffet Ozturk, Ayse Bahar Kelesoglu Dincer

Rheumatoid arthritis (RA) is a systemic autoimmune disease of unknown etiology that causes progressive and destructive inflammation in the joints. Superb microvascular imaging (SMI) is a new ultrasound technique that allows visualization of slow blood flow in synovitis. This study aimed to report on the clinical value and utility of the SMI technique and its grading for monitoring RA by determining the correlation with clinical disease activity scores (DAS 28) and power Doppler ultrasound (PDUS).All RA patients with clinically apparent synovitis were assessed using DAS 28. Synovitis was investigated with PDUS and SMI and each joint was graded semi-quantitatively. All assessments were carried out at baseline and repeated at least at the 4-month follow-up. Correlations between scores were investigated using Spearman's correlation.60 RA patients with 552 affected joints were recruited. Clinical and sonographic scores were significantly improved at follow-up (p<0.001). SMI showed significantly more joint count and flow signal scores than clinical examination and PDUS. Moderate correlations were found between the SMI score and clinical scores (p<0.001, 0.586 for SMI score vs. DAS 28-CRP, p=0.001, 0.432 for SMI vs. DAS 28-ESR). There were also stronger correlations between the SMI score and PDUS score at both baseline and follow-up (p<0.001, r = 0.817, 0.842 respectively).SMI provides greater utility and ability to detect synovial vascularity and to monitor disease activity than PDUS. A new activity scoring system based on SMI and clinical objective findings is required to improve reliability and validity.

目的:类风湿性关节炎(RA)是一种病因不明的全身性自身免疫性疾病,会导致关节出现进行性和破坏性炎症。超微血管成像(SMI)是一种新型超声技术,可观察滑膜炎的缓慢血流。本研究旨在通过确定 SMI 技术与临床疾病活动评分(DAS 28)和动力多普勒超声(PDUS)的相关性,报告 SMI 技术及其分级在监测 RA 方面的临床价值和实用性:方法: 使用 DAS 28 对所有临床表现为滑膜炎的 RA 患者进行评估。用 PDUS 和 SMI 检查滑膜炎,并对每个关节进行半定量分级。所有评估均在基线时进行,并在至少 4 个月的随访中重复进行。采用斯皮尔曼相关性分析了各评分之间的相关性:结果:共招募了 60 名 RA 患者,他们有 552 个受影响的关节。随访期间,临床和声像图评分均有明显改善(p 结论:SMI 提供了更高的实用性和能力:与 PDUS 相比,SMI 在检测滑膜血管和监测疾病活动性方面具有更高的实用性和能力。需要一种基于 SMI 和临床客观检查结果的新活动度评分系统来提高可靠性和有效性。
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引用次数: 0
Sonography of Salivary Gland Tumors and Disorders. 唾液腺肿瘤和疾病的超声检查。
IF 3.1 3区 医学 Q1 ACOUSTICS Pub Date : 2025-01-17 DOI: 10.1055/a-2481-7248
Felix Johnson, Alessandro Bozzato, Naglaa Mansour, Konstantinos Mantsopoulos, Georgios Psychogios, Pamela Zengel, Benedikt Hofauer

Diseases of the salivary glands are as common as they are diverse and can have different causes. Clinicians can differentiate salivary gland changes based on chronic systemic diseases, congenital and vascular malformations, and benign and malignant tumors. Acute infectious pathologies can also arise as a result of obstructive pathologies. A large number of diseases with similar clinical presentations have to be differentiated. Due to the improved resolution of ultrasound technology over the last 20 years, it is now used as the first imaging modality to examine salivary gland pathologies. It allows a quick, dynamic, and non-invasive examination of the salivary glands and the soft tissue of the neck. In order to accurately diagnose and treat patients, a very good knowledge of these diseases and their appearance on sonography is required.

唾液腺疾病是常见的,因为它们是多种多样的,可以有不同的原因。临床医生可以根据慢性全身性疾病、先天性和血管畸形、良性和恶性肿瘤来区分唾液腺的变化。急性感染性病变也可由阻塞性病变引起。大量临床表现相似的疾病必须加以鉴别。由于超声技术在过去20年中分辨率的提高,它现在被用作检查唾液腺病理的第一成像方式。它允许对唾液腺和颈部软组织进行快速、动态和非侵入性检查。为了准确诊断和治疗患者,需要对这些疾病及其超声表现有很好的了解。
{"title":"Sonography of Salivary Gland Tumors and Disorders.","authors":"Felix Johnson, Alessandro Bozzato, Naglaa Mansour, Konstantinos Mantsopoulos, Georgios Psychogios, Pamela Zengel, Benedikt Hofauer","doi":"10.1055/a-2481-7248","DOIUrl":"https://doi.org/10.1055/a-2481-7248","url":null,"abstract":"<p><p>Diseases of the salivary glands are as common as they are diverse and can have different causes. Clinicians can differentiate salivary gland changes based on chronic systemic diseases, congenital and vascular malformations, and benign and malignant tumors. Acute infectious pathologies can also arise as a result of obstructive pathologies. A large number of diseases with similar clinical presentations have to be differentiated. Due to the improved resolution of ultrasound technology over the last 20 years, it is now used as the first imaging modality to examine salivary gland pathologies. It allows a quick, dynamic, and non-invasive examination of the salivary glands and the soft tissue of the neck. In order to accurately diagnose and treat patients, a very good knowledge of these diseases and their appearance on sonography is required.</p>","PeriodicalId":49400,"journal":{"name":"Ultraschall in Der Medizin","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Best Practice Guidelines - DEGUM Recommendations on Breast Ultrasound. 最佳实践指南-乳腺超声DEGUM建议。
IF 3.1 3区 医学 Q1 ACOUSTICS Pub Date : 2025-01-14 DOI: 10.1055/a-2481-6610
Claudia Maria Vogel-Minea, Werner Bader, Jens-Uwe Blohmer, Volker Duda, Christian Eichler, Eva Fallenberg, André Farrokh, Michael Golatta, Ines Gruber, Bernhard-Joachim Hackelöer, Jörg Heil, Helmut Madjar, Ellen Marzotko, Eberhard Merz, Alexander Mundinger, Markus Müller-Schimpfle, Ralf Ohlinger, Uwe Peisker, Ruediger Schulz-Wendtland, Fritz Kw Schäfer, Christine Solbach, Mathias Warm, Dirk Watermann, Sebastian Wojcinaki, Markus Hahn

Breast ultrasound has been established for many years as an important method in addition to mammography for clarifying breast findings. The goal of the Best Practice Guidelines Part III of the DEGUM breast ultrasound working group is to provide colleagues working in senology with information regarding the specific medical indications for breast ultrasound in addition to the current ultrasound criteria and assessment categories published in part I and the additional and optional sonographic diagnostic methods described in part II. The value of breast ultrasound for specific indications including follow-up, evaluation of breast implants, diagnostic workup of dense breast tissue, diagnostic workup during pregnancy and lactation, and the diagnostic workup of breast findings in men is discussed. Each section after the general information section contains a description of specific pathologies followed by a short summary and DEGUM recommendations for the particular indications. The latest S3 guidelines and AGO guidelines were taken into consideration.

乳腺超声作为除乳房x光检查外的一种重要检查方法已经确立多年。DEGUM乳腺超声工作组最佳实践指南第三部分的目标是,除了第一部分中公布的当前超声标准和评估类别以及第二部分中描述的附加和可选超声诊断方法之外,为从事老年学工作的同事提供有关乳腺超声具体医学指征的信息。本文讨论了乳腺超声在随访、乳房植入物评价、乳腺致密组织诊断检查、孕期和哺乳期诊断检查以及男性乳腺表现诊断检查等具体适应症中的价值。一般信息部分后的每个部分都包含特定病理的描述,然后是简短的总结和DEGUM对特定适应症的建议。考虑了最新的S3指南和AGO指南。
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引用次数: 0
Best Practice Guidelines - DEGUM Recommendations on Breast Ultrasound. 最佳实践指南-乳腺超声DEGUM建议。
IF 3.1 3区 医学 Q1 ACOUSTICS Pub Date : 2025-01-14 DOI: 10.1055/a-2487-5111
Claudia M Vogel-Minea, Werner Bader, Jens-Uwe Blohmer, Volker Duda, Christian Eichler, Eva Fallenberg, André Farrokh, Michael Golatta, Ines Gruber, Bernhard-Joachim Hackelöer, Jörg Heil, Helmut Madjar, Ellen Marzotko, Eberhard Merz, Alexander Mundinger, Markus Müller-Schimpfle, Ralf Ohlinger, Uwe Peisker, Ruediger Schulz-Wendtland, Fritz K W Schäfer, Christine Solbach, Mathias Warm, Dirk Watermann, Sebastian Wojcinaki, Markus Hahn

Breast ultrasound has been established for many years as an important method in addition to mammography for clarifying breast findings. The goal of the Best Practice Guidelines Part III of the DEGUM breast ultrasound working group is to provide colleagues working in senology with information regarding the specific medical indications for breast ultrasound in addition to the current ultrasound criteria and assessment categories published in part I and the additional and optional sonographic diagnostic methods described in part II. The value of breast ultrasound for specific indications including follow-up, evaluation of breast implants, diagnostic workup of dense breast tissue, diagnostic workup during pregnancy and lactation, and the diagnostic workup of breast findings in men is discussed. Each section after the general information section contains a description of specific pathologies, followed by a short summary and DEGUM recommendations for the particular indications. The latest S3 guidelines and AGO guidelines were taken into consideration.

乳腺超声作为除乳房x光检查外的一种重要检查方法已经确立多年。DEGUM乳腺超声工作组最佳实践指南第三部分的目标是,除了第一部分中公布的当前超声标准和评估类别以及第二部分中描述的附加和可选超声诊断方法之外,为从事老年学工作的同事提供有关乳腺超声具体医学指征的信息。本文讨论了乳腺超声在随访、乳房植入物评价、乳腺致密组织诊断检查、孕期和哺乳期诊断检查以及男性乳腺表现诊断检查等具体适应症中的价值。一般信息部分后的每个部分都包含特定病理的描述,然后是简短的总结和DEGUM对特定适应症的建议。考虑了最新的S3指南和AGO指南。
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引用次数: 0
Bilateral persistent sciatic arteries with right sciatic artery aneurysm thrombosis and distal embolization: A case report. 双侧持续性坐骨神经动脉伴右侧坐骨神经动脉瘤血栓形成和远端栓塞:病例报告。
IF 3.1 3区 医学 Q1 ACOUSTICS Pub Date : 2025-01-10 DOI: 10.1055/a-2444-2843
Yanzhou Liu, Wensheng Yue, Duo Huang
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引用次数: 0
Endosonography in head and neck imaging and surgery. 内窥镜在头颈部成像和手术中的应用。
IF 3.1 3区 医学 Q1 ACOUSTICS Pub Date : 2024-12-20 DOI: 10.1055/a-2451-9373
Marie Brandt, Martin Garset-Zamani, Alessandro Bozzato, Johannes M Weimer, Christoph Arens, Christoph F Dietrich, Tobias Todsen, Julian Künzel

This CME article explores the evolving role of endosonography in otorhinolaryngology and head and neck surgery. Endosonography offers significant potential to improve imaging inside the upper respiratory tract, particularly with advancements in probe technology and imaging resolution. The article will describe the sonoanatomy of the oral cavity, pharynx, and larynx and the selection of probes and scanning techniques used for the various anatomical sites. Transoral ultrasound can be used to improve the diagnosis of salivary gland diseases, oropharyngeal abscesses, and ultrasound-guided puncture and biopsy. Endoscopic endolaryngeal ultrasound is used especially for diagnosing small laryngeal cancer and determining infiltration status. The article highlights the role of endosonography in managing oncologic diseases, especially in oral tongue carcinoma, where it aids in surgical planning by assessing the depth of invasion. In cases of HPV-positive carcinoma of unknown primary, high-frequency endosonography is crucial for detecting small tumors in the oropharyngeal region. In summary, the article advocates the broader integration of endosonography in clinical practice, highlighting its potential to enhance diagnostic accuracy and improve patient outcomes in head and neck oncology.

这篇CME文章探讨了超声在耳鼻喉科和头颈部外科中不断发展的作用。特别是随着探针技术和成像分辨率的进步,超声在改善上呼吸道内部成像方面提供了巨大的潜力。本文将介绍口腔、咽、喉的超声解剖,以及在不同解剖部位使用的探头和扫描技术的选择。经口超声可提高对唾液腺疾病、口咽脓肿的诊断,超声引导下穿刺活检。内镜下咽内超声特别适用于小喉癌的诊断和浸润情况的确定。这篇文章强调了超声在治疗肿瘤疾病中的作用,特别是在口腔舌癌中,它通过评估浸润深度来帮助手术计划。在原发不明的hpv阳性癌病例中,高频超声对于检测口咽区域的小肿瘤至关重要。总之,本文提倡在临床实践中更广泛地整合超声检查,强调其在提高头颈部肿瘤诊断准确性和改善患者预后方面的潜力。
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引用次数: 0
Relationship between prenatal ultrasound signs and genetic abnormalities for fetal malformations of cortical development. 胎儿皮质发育畸形的产前超声征象与遗传异常的关系。
IF 3.1 3区 医学 Q1 ACOUSTICS Pub Date : 2024-12-19 DOI: 10.1055/a-2467-3362
JunYa Chen, Rong Zhu, Hong Pan, YiNan Ma, Ying Zhu, LiLi Liu, XinLin Hou, Karina Krajden Haratz

To explore the relationship between ultrasound signs of suspected fetal malformation of cortical development (MCD) and genetic MCD.The retrospective study involved fetuses with one of the following 10 neurosonography (NSG) signs: (A) abnormal development of the Sylvian fissure; (B) delayed achievement of cortical milestones; (C) premature or aberrant appearance of sulcation; (D) irregular border of the ventricular wall or irregular shape of the ventricle; (E) abnormal shape or orientation of the sulci; (F) hemispheric asymmetry; (G) non-continuous cerebral cortex; (H) intraparenchymal echogenic nodules; (I) persistent ganglionic eminence (GE) or GE cavitation; (J) abnormal cortical lamination.95 fetuses were included in the study. Chromosomal microarray (CMA) combined with exome sequencing (ES) was available in 40 fetuses, CMA was abnormal in nine and ES in 22. Sign C (7/7, 100%), sign H (2/2, 100%), sign A (18/19, 94.7%), and sign B (12/13, 92.3%) were the signs leading to the highest probability of genetic MCD. The incidence of genetic MCD for sign E, sign I, and sign D was 66.7-73.7%. Only one or none of the fetuses with sign J, sign F, or sign G underwent CMA+ES. The signs in the fetuses with FGFR3, CCND2, FLNA, or TSC2 mutations had the expected features. The other fetuses with different gene mutations showed several non-specific NSG signs.Several reliable signs for genetic MCD can be detected by NSG, and the probability varies with different signs. Most signs are not associated with a specific gene. Therefore, CMA combined with ES is preferred.

探讨胎儿皮质发育畸形(MCD)超声征象与遗传性MCD的关系。回顾性研究涉及具有以下10种神经超声(NSG)体征之一的胎儿:(A)脊髓裂发育异常;(B)皮质发育里程碑延迟实现;(C)过早出现或异常出现;(D)心室壁边界不规则或心室形状不规则;(E)沟的形状或方向异常;(F)半球不对称;(G)不连续大脑皮层;(H)实质内回声结节;(1)持续性神经节隆起(GE)或神经节空洞;(J)皮质层压异常。95名胎儿参与了这项研究。染色体微阵列(CMA)联合外显子组测序(ES)检测40例胎儿,CMA异常9例,ES异常22例。C征(7/7,100%)、H征(2/2,100%)、A征(18/19,94.7%)、B征(12/13,92.3%)是导致遗传性MCD概率最高的标志。E号、I号和D号的遗传性MCD发生率为66.7-73.7%。在J、F或G征的胎儿中,只有一个或没有发生CMA+ES。FGFR3、CCND2、FLNA或TSC2突变胎儿的体征具有预期的特征。其他不同基因突变的胎儿表现出几种非特异性NSG体征。NSG可以检测到遗传性MCD的几种可靠信号,不同信号的概率不同。大多数症状与特定基因无关。因此,CMA结合ES是首选。
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引用次数: 0
Fallopian tube catheterization under 3D vaginal ultrasound guidance followed by highly selective hysterosalpingo-foam sonography: an outpatient procedure. 在三维阴道超声引导下进行输卵管导管插入术,然后进行高选择性子宫输卵管造影:门诊手术。
IF 3.1 3区 医学 Q1 ACOUSTICS Pub Date : 2024-12-18 DOI: 10.1055/a-2384-4254
Yaakov Melcer, Marina Pekar-Zlotin, Michal Youngster, Itai Gat, Ron Maymon

To describe the feasibility of our preliminary outpatient fallopian tube catheterization procedure under 3D vaginal ultrasound (US) guidance followed by highly selective hysterosalpingo-foam sonography (HyFoSy) in infertile women diagnosed with proximal tubal obstruction.A prospective trial was conducted from October 2022 to December 2023. 3D vaginal US was used to establish the precise location of the tip of the selective salpingography catheter at the tubal ostium. A roadrunner was used to cannulate the occluded portion of the fallopian tube. After tubal cannulation, ExEm foam was injected under direct US guidance to confirm tubal recanalization and its passage through the fallopian tubes.During the study period, a total of 14 women with proximal tubal occlusion underwent this procedure. Tubal patency was achieved in 92.8% of cases. No immediate and remote complications were observed. To date, 3 (21.4%) of the patients conceived after tubal catheterization and 1 had a live birth.Outpatient fallopian tube catheterization under 3D vaginal US guidance, followed by selective HyFoSy, can be successfully implemented for the diagnosis and treatment of patients with proximal tubal occlusion. The 3D modality allows volume capture of the required acquisition and subsequent post-imaging analysis, thus permitting further examination and study. Additional experience is needed to determine the feasibility of this innovative procedure and to identify the patient subgroups that would benefit the most from this approach.

目的:描述我们在三维阴道超声(US)引导下,通过高选择性子宫输卵管造影(HyFoSy)对确诊为近端输卵管阻塞的不孕妇女进行输卵管导管术的初步门诊可行性:2022年10月至2023年12月进行了一项前瞻性试验。使用三维阴道 US 确定选择性输卵管造影导管顶端在输卵管输卵管口的精确位置。使用 "跑马灯 "对输卵管闭塞部分进行插管。输卵管插管后,在 US 直接引导下注入 ExEm 泡沫,以确认输卵管再通及其通过输卵管的情况:在研究期间,共有 14 名输卵管近端闭塞的妇女接受了这一手术。92.8%的患者获得了输卵管通畅。未发现直接或远期并发症。迄今为止,有 3 名(21.4%)患者在输卵管导管术后受孕,其中 1 名活产儿:结论:在三维阴道 US 引导下进行门诊输卵管导管术,然后进行选择性 HyFoSy,可成功诊断和治疗近端输卵管闭塞患者。三维模式可实现所需采集的容积捕捉,以及随后的成像后分析,以便进行进一步检查和研究。我们还需要更多的经验来巩固这一创新手术的可行性,并确定哪些患者亚群最受益于这种方法。
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Ultraschall in Der Medizin
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