Pub Date : 2022-11-24DOI: 10.1186/s00015-022-00423-y
J. Vanardois, A. Lahfid, P. Trap, B. Lacroix, F. Roger, L. Guillou-Frottier, D. Marquer, J. Paquette, J. Melleton
{"title":"Thermal evolution of a Variscan syn-orogenic intracontinental basin (Servoz basin, Western Alps): RSCM geothermometry and geochronology","authors":"J. Vanardois, A. Lahfid, P. Trap, B. Lacroix, F. Roger, L. Guillou-Frottier, D. Marquer, J. Paquette, J. Melleton","doi":"10.1186/s00015-022-00423-y","DOIUrl":"https://doi.org/10.1186/s00015-022-00423-y","url":null,"abstract":"","PeriodicalId":49456,"journal":{"name":"Swiss Journal of Geosciences","volume":" ","pages":"1-24"},"PeriodicalIF":3.1,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47286126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-22DOI: 10.1186/s00015-022-00421-0
A. Pictet, P. Kürsteiner, K. Tschanz, Amane Tajika
{"title":"Record of a dense succession of drowning phases in the Alpstein mountains, north-eastern Switzerland: part I—the Lower Cretaceous Tierwis Formation (latest Hauterivian to latest Barremian)","authors":"A. Pictet, P. Kürsteiner, K. Tschanz, Amane Tajika","doi":"10.1186/s00015-022-00421-0","DOIUrl":"https://doi.org/10.1186/s00015-022-00421-0","url":null,"abstract":"","PeriodicalId":49456,"journal":{"name":"Swiss Journal of Geosciences","volume":"115 1","pages":"1-31"},"PeriodicalIF":3.1,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45920963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-18DOI: 10.1186/s00015-022-00420-1
M. Ruiz, U. Schaltegger, S. Gaynor, M. Chiaradia, J. Abrecht, Christian Gisler, F. Giovanoli, M. Wiederkehr
{"title":"Reassessing the intrusive tempo and magma genesis of the late Variscan Aar batholith: U–Pb geochronology, trace element and initial Hf isotope composition of zircon","authors":"M. Ruiz, U. Schaltegger, S. Gaynor, M. Chiaradia, J. Abrecht, Christian Gisler, F. Giovanoli, M. Wiederkehr","doi":"10.1186/s00015-022-00420-1","DOIUrl":"https://doi.org/10.1186/s00015-022-00420-1","url":null,"abstract":"","PeriodicalId":49456,"journal":{"name":"Swiss Journal of Geosciences","volume":" ","pages":"1-24"},"PeriodicalIF":3.1,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47719786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-07DOI: 10.1186/s00015-022-00419-8
A. Michard, S. Schmid, A. Lahfid, M. Ballèvre, P. Manzotti, C. Chopin, S. Iaccarino, Davide Dana
{"title":"The Maira-Sampeyre and Val Grana Allochthons (south Western Alps): review and new data on the tectonometamorphic evolution of the Briançonnais distal margin","authors":"A. Michard, S. Schmid, A. Lahfid, M. Ballèvre, P. Manzotti, C. Chopin, S. Iaccarino, Davide Dana","doi":"10.1186/s00015-022-00419-8","DOIUrl":"https://doi.org/10.1186/s00015-022-00419-8","url":null,"abstract":"","PeriodicalId":49456,"journal":{"name":"Swiss Journal of Geosciences","volume":"115 1","pages":"1-43"},"PeriodicalIF":3.1,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45230466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Pancreatic ductal adenocarcinoma (PDAC) is a malignant cancer and chemotherapy ineffectively treats PDAC, leading to the requirement for alternative tumor-targeted treatment. Human amniotic fluid mesenchymal stem cells (hAFMSCs) have been revealed to suppress tumor growth in various cancers and they are a strong candidate for treating PDAC.
Methods: To evaluate the effects of hAFMSCs on human pancreatic carcinoma cells (PANC1, AsPC1 and BxPC3 cell lines) and the possible mechanism involved, an in vitro cell coculture system was used. A PANC1 orthotopic xenograft mouse model was established and hAFMSCs were injected intravenously at 4 weeks post-xenograft.
Results: An in vitro coculture assay showed that hAFMSCs inhibited PANC1 cell proliferation by inducing S phase cell cycle arrest and increased cell apoptosis in a time-dependent manner. In PANC1 cells, hAFMSCs caused the downregulation of Cyclin A and Cyclin B1 as well as the upregulation of p21 (CDKN1A) at 24 h post coculture. The upregulation of pro-apoptotic factors Caspase-3/-8 and Bax at 24 h post coculture reduced the migration and invasion ability of PANC1 cells through inhibiting the epithelial-mesenchymal transition (EMT) process. In a PANC1 orthotopic xenograft mouse model, a single injection of hAFMSCs showed significant tumor growth inhibition with evidence of the modulation of cell cycle and pro-apoptotic regulatory genes and various genes involved in matrix metallopeptidase 7 (MMP7) signaling-triggered EMT process. Histopathological staining showed lower Ki67 levels in tumors from hAFMSCs-treated mice.
Conclusions: Our data demonstrated that hAFMSCs strongly inhibit PDAC cell proliferation, tumor growth and invasion, possibly by altering cell cycle arrest and MMP7 signaling-triggered EMT.
{"title":"Human amniotic fluid mesenchymal stem cells attenuate pancreatic cancer cell proliferation and tumor growth in an orthotopic xenograft mouse model.","authors":"Ying-Cheng Chen, Ying-Wei Lan, Shiaw-Min Huang, Chih-Ching Yen, Wei Chen, Wan-Ju Wu, Theresa Staniczek, Kowit-Yu Chong, Chuan-Mu Chen","doi":"10.1186/s13287-022-02910-3","DOIUrl":"10.1186/s13287-022-02910-3","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic ductal adenocarcinoma (PDAC) is a malignant cancer and chemotherapy ineffectively treats PDAC, leading to the requirement for alternative tumor-targeted treatment. Human amniotic fluid mesenchymal stem cells (hAFMSCs) have been revealed to suppress tumor growth in various cancers and they are a strong candidate for treating PDAC.</p><p><strong>Methods: </strong>To evaluate the effects of hAFMSCs on human pancreatic carcinoma cells (PANC1, AsPC1 and BxPC3 cell lines) and the possible mechanism involved, an in vitro cell coculture system was used. A PANC1 orthotopic xenograft mouse model was established and hAFMSCs were injected intravenously at 4 weeks post-xenograft.</p><p><strong>Results: </strong>An in vitro coculture assay showed that hAFMSCs inhibited PANC1 cell proliferation by inducing S phase cell cycle arrest and increased cell apoptosis in a time-dependent manner. In PANC1 cells, hAFMSCs caused the downregulation of Cyclin A and Cyclin B1 as well as the upregulation of p21 (CDKN1A) at 24 h post coculture. The upregulation of pro-apoptotic factors Caspase-3/-8 and Bax at 24 h post coculture reduced the migration and invasion ability of PANC1 cells through inhibiting the epithelial-mesenchymal transition (EMT) process. In a PANC1 orthotopic xenograft mouse model, a single injection of hAFMSCs showed significant tumor growth inhibition with evidence of the modulation of cell cycle and pro-apoptotic regulatory genes and various genes involved in matrix metallopeptidase 7 (MMP7) signaling-triggered EMT process. Histopathological staining showed lower Ki67 levels in tumors from hAFMSCs-treated mice.</p><p><strong>Conclusions: </strong>Our data demonstrated that hAFMSCs strongly inhibit PDAC cell proliferation, tumor growth and invasion, possibly by altering cell cycle arrest and MMP7 signaling-triggered EMT.</p>","PeriodicalId":49456,"journal":{"name":"Swiss Journal of Geosciences","volume":"101 1","pages":"235"},"PeriodicalIF":2.7,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73536457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-12DOI: 10.1186/s00015-022-00418-9
K. A. Stevens, Scott Ernst, D. Marty
{"title":"Coupling length: a generalized gleno-acetabular distance measurement for interpreting the size and gait of quadrupedal trackmakers","authors":"K. A. Stevens, Scott Ernst, D. Marty","doi":"10.1186/s00015-022-00418-9","DOIUrl":"https://doi.org/10.1186/s00015-022-00418-9","url":null,"abstract":"","PeriodicalId":49456,"journal":{"name":"Swiss Journal of Geosciences","volume":"115 1","pages":"1-27"},"PeriodicalIF":3.1,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42027794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-10DOI: 10.1186/s00015-022-00416-x
P. Mojon, E. Kaenel
{"title":"New paleontological and biostratigraphical data (calcareous nannofossils, ostracods, brachiopods), correlations and lithostratigraphic units in the Urgonian facies (latest Hauterivian-Barremian) of the Swiss and French Jura Mountains: the Falaises Member and the Saars Formation (former “Gorges de l’","authors":"P. Mojon, E. Kaenel","doi":"10.1186/s00015-022-00416-x","DOIUrl":"https://doi.org/10.1186/s00015-022-00416-x","url":null,"abstract":"","PeriodicalId":49456,"journal":{"name":"Swiss Journal of Geosciences","volume":" ","pages":"1-43"},"PeriodicalIF":3.1,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46358972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-03DOI: 10.1186/s00015-022-00407-y
M. Haas, Davide Carraro, D. Ventra, M. Plötze, Antoine de Haller, A. Moscariello
{"title":"Integrated stratigraphic, sedimentological and petrographical evaluation for CERN’s Future Circular Collider subsurface infrastructure (Geneva Basin, Switzerland-France)","authors":"M. Haas, Davide Carraro, D. Ventra, M. Plötze, Antoine de Haller, A. Moscariello","doi":"10.1186/s00015-022-00407-y","DOIUrl":"https://doi.org/10.1186/s00015-022-00407-y","url":null,"abstract":"","PeriodicalId":49456,"journal":{"name":"Swiss Journal of Geosciences","volume":" ","pages":"1-43"},"PeriodicalIF":3.1,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48047574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-22DOI: 10.1186/s00015-022-00417-w
G. Georgalis, T. Scheyer
{"title":"Crushed but not lost: a colubriform snake (Serpentes) from the Miocene Swiss Molasse, identified through the use of micro-CT scanning technology","authors":"G. Georgalis, T. Scheyer","doi":"10.1186/s00015-022-00417-w","DOIUrl":"https://doi.org/10.1186/s00015-022-00417-w","url":null,"abstract":"","PeriodicalId":49456,"journal":{"name":"Swiss Journal of Geosciences","volume":"115 1","pages":"1-9"},"PeriodicalIF":3.1,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45609902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-15DOI: 10.1186/s00015-022-00415-y
E. Kempf, Jörg Hermann, J. Connolly
{"title":"Serpentinite dehydration at low pressures","authors":"E. Kempf, Jörg Hermann, J. Connolly","doi":"10.1186/s00015-022-00415-y","DOIUrl":"https://doi.org/10.1186/s00015-022-00415-y","url":null,"abstract":"","PeriodicalId":49456,"journal":{"name":"Swiss Journal of Geosciences","volume":"115 1","pages":"1-30"},"PeriodicalIF":3.1,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47953555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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