Pub Date : 2025-03-01DOI: 10.1053/j.semdp.2024.01.006
Horacio Maluf
Mark Wick made a wide range of contributions to the field of mediastinal pathology. Early papers amplified the spectrum of neuroendocrine carcinomas of the thymus and brought attention to the aggressive nature of this tumor, also highlighting the occurrence of coexisting carcinoid tumor and small cell carcinoma of this organ. The controversial issue of thymoma classification was addressed in several papers and editorial comments, while also reporting a case of metastatic thymoma. A series of thymic carcinomas as well a report on the unusual clear cell variant bear his name as one of the authors. He summarized the topic of mediastinal cyst in a review published in 2005. Sarcomas arising in mediastinal germ cell tumors were also within the purview of his interests, with a publication of series of seven cases. He reviewed the topic of inflammatory myofibroblastic tumor of the heart and added a case to the existing literature. Two books dedicated to different aspect of mediastinal pathology also carry his name in the front cover in association with Drs Taazelar in one and Marchevsky in the other.
{"title":"Mark Wick contributions to pathology of the mediastinum","authors":"Horacio Maluf","doi":"10.1053/j.semdp.2024.01.006","DOIUrl":"10.1053/j.semdp.2024.01.006","url":null,"abstract":"<div><div><span><span><span>Mark Wick made a wide range of contributions to the field of mediastinal pathology. Early papers amplified the spectrum of neuroendocrine carcinomas<span><span> of the thymus and brought attention to the aggressive nature of this tumor, also highlighting the occurrence of coexisting </span>carcinoid tumor and </span></span>small cell carcinoma<span> of this organ. The controversial issue of thymoma<span> classification was addressed in several papers and editorial comments, while also reporting a case of metastatic thymoma. A series of thymic carcinomas<span> as well a report on the unusual clear cell variant bear his name as one of the authors. He summarized the topic of mediastinal cyst in a review published in 2005. </span></span></span></span>Sarcomas arising in </span>mediastinal germ cell tumors<span> were also within the purview of his interests, with a publication of series of seven cases. He reviewed the topic of inflammatory myofibroblastic tumor of the heart and added a case to the existing literature. Two books dedicated to different aspect of mediastinal pathology also carry his name in the front cover in association with Drs Taazelar in one and Marchevsky in the other.</span></div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 2","pages":"Article 150835"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139373855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1053/j.semdp.2024.01.007
C. Alexis Noble , Chinmoy Bhate , Buu T. Duong , Allison R. Cruse , Robert T. Brodell , Riley C. Hanus
The unenlightened clinician may submit a skin specimen to the lab and expect an “answer.” The experienced clinician knows that in performing skin biopsies, it is critical to select the most appropriate: 1) anatomic location for the biopsy1,2; 2) type of biopsy1,2; 3) depth and breadth of the biopsy; and 4) medium for hematoxylin and eosin staining (formalin) or direct immunofluorescence (Michel's Transport Medium or normal saline).2 Demographic information, anatomic location, clinical context, and differential diagnosis are all critical components of a properly completed requisition form.3, 4, 5 Proper biopsy design and appropriate grossing of the tissue at the bedside should be added to this list. In this article, we review the basics of gross pathologic examination and then provide four examples to demonstrate that optimal clinical-pathologic correlation requires the clinician consider the needs of the pathologist when tissue is presented to the lab.
{"title":"Clinical-pathologic correlation: The impact of grossing at the bedside","authors":"C. Alexis Noble , Chinmoy Bhate , Buu T. Duong , Allison R. Cruse , Robert T. Brodell , Riley C. Hanus","doi":"10.1053/j.semdp.2024.01.007","DOIUrl":"10.1053/j.semdp.2024.01.007","url":null,"abstract":"<div><div><span>The unenlightened clinician may submit a skin specimen to the lab and expect an “answer.” The experienced clinician knows that in performing skin biopsies, it is critical to select the most appropriate: 1) anatomic location for the biopsy</span><span><span><sup>1</sup></span></span><sup>,</sup><span><span><sup>2</sup></span></span>; 2) type of biopsy<span><span><sup>1</sup></span></span><sup>,</sup><span><span><sup>2</sup></span></span><span><span>; 3) depth and breadth of the biopsy; and 4) medium for hematoxylin and </span>eosin<span> staining (formalin) or direct immunofluorescence (Michel's Transport Medium or normal saline).</span></span><span><span><sup>2</sup></span></span> Demographic information, anatomic location, clinical context, and differential diagnosis are all critical components of a properly completed requisition form.<span><span>3</span></span>, <span><span>4</span></span>, <span><span>5</span></span><span> Proper biopsy design and appropriate grossing of the tissue at the bedside should be added to this list. In this article, we review the basics of gross pathologic examination and then provide four examples to demonstrate that optimal clinical-pathologic correlation requires the clinician consider the needs of the pathologist when tissue is presented to the lab.</span></div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 2","pages":"Article 150836"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139373870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1053/j.semdp.2024.11.002
Toan Bui , Laura M. Rezac , C. Alexis Noble , Ariel R. Velasquez-Evers , Robert T. Brodell
Background
Targetoid hemosiderotic hemangioma (THH), also known as hobnail lymphatic malformation (HLL) or hobnail hemangioma, is an uncommon, acquired vascular lesion with a dynamic presentation and an unclear etiology. It predominantly affects adults with an age range from 9 to 78 years and has no gender predilection. The lesion is thought to arise from trauma, leading to micro-shunts between small lesional capillaries and adjacent lymphatic vessels.
Methods
This review article examines the clinical, histologic, and immunohistochemical characteristics of THH, and explores its differential diagnoses, including Kaposi's sarcoma, solitary angiokeratoma, retiform hemangioendothelioma, and Dabska tumor.
Results
THH presents clinically as asymptomatic, well-circumscribed lesions with a central red-blue and/or brown papule surrounded by a peripheral ecchymotic ring, giving a "bull's-eye" or targetoid appearance. Histologically, THH exhibits dilated vascular channels lined by hobnail endothelial cells, red blood cell extravasation, hemosiderin deposition, and mild lymphohistiocytic infiltrates. Immunohistochemistry is positive for D2-40, a lymphatic endothelial marker.
Conclusions
Heightened awareness of the clinical appearance of these solitary targetoid lesions is important. Without clinical-pathologic correlation, the branching telangiectatic vessels and purpura seen in THH could suggest more concerning vascular lesions like Kaposi sarcoma.
{"title":"Targetoid hemosiderotic hemangioma: A review article","authors":"Toan Bui , Laura M. Rezac , C. Alexis Noble , Ariel R. Velasquez-Evers , Robert T. Brodell","doi":"10.1053/j.semdp.2024.11.002","DOIUrl":"10.1053/j.semdp.2024.11.002","url":null,"abstract":"<div><h3>Background</h3><div>Targetoid hemosiderotic hemangioma (THH), also known as hobnail lymphatic malformation (HLL) or hobnail hemangioma, is an uncommon, acquired vascular lesion with a dynamic presentation and an unclear etiology. It predominantly affects adults with an age range from 9 to 78 years and has no gender predilection. The lesion is thought to arise from trauma, leading to micro-shunts between small lesional capillaries and adjacent lymphatic vessels.</div></div><div><h3>Methods</h3><div>This review article examines the clinical, histologic, and immunohistochemical characteristics of THH, and explores its differential diagnoses, including Kaposi's sarcoma, solitary angiokeratoma, retiform hemangioendothelioma, and Dabska tumor.</div></div><div><h3>Results</h3><div>THH presents clinically as asymptomatic, well-circumscribed lesions with a central red-blue and/or brown papule surrounded by a peripheral ecchymotic ring, giving a \"bull's-eye\" or targetoid appearance. Histologically, THH exhibits dilated vascular channels lined by hobnail endothelial cells, red blood cell extravasation, hemosiderin deposition, and mild lymphohistiocytic infiltrates. Immunohistochemistry is positive for D2-40, a lymphatic endothelial marker.</div></div><div><h3>Conclusions</h3><div>Heightened awareness of the clinical appearance of these solitary targetoid lesions is important. Without clinical-pathologic correlation, the branching telangiectatic vessels and purpura seen in THH could suggest more concerning vascular lesions like Kaposi sarcoma.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 2","pages":"Article 150869"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1053/S0740-2570(25)00023-1
{"title":"TABLE OF CONTENTS (p/u from previous issue w/updates)","authors":"","doi":"10.1053/S0740-2570(25)00023-1","DOIUrl":"10.1053/S0740-2570(25)00023-1","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 2","pages":"Article 150887"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1053/j.semdp.2024.01.005
Saul Suster
The curriculum vitae of Dr. Mark R. Wick contains 57 peer-reviewed publications, 3 editorials, 6 book chapters and a whole book dedicated to diseases of the lung and pleura. It is remarkable that such productivity should represent only a small portion of the overall output of Dr. Wick, which includes (at last count) 341 original peer-review publications, 119 invited review articles, 93 book chapters, 42 editorials, 3 society-related position papers, 18 books and 2 interactive video disks. Yet, his contributions to the literature in pulmonary and pleural pathology have been significant and influential and have established for him a national and international reputation as one of the leading experts in pulmonary pathology. Herein, it is my privilege to recount the various publications contributed by Dr. Wick to this topic, which span the gamut from transplant pathology to neoplastic diseases of the lung and pleura.
{"title":"Contributions of Dr. Wick to the pathology of diseases of the lung and pleura","authors":"Saul Suster","doi":"10.1053/j.semdp.2024.01.005","DOIUrl":"10.1053/j.semdp.2024.01.005","url":null,"abstract":"<div><div>The curriculum vitae of Dr. Mark R. Wick contains 57 peer-reviewed publications, 3 editorials, 6 book chapters and a whole book dedicated to diseases of the lung and pleura. It is remarkable that such productivity should represent only a small portion of the overall output of Dr. Wick, which includes (at last count) 341 original peer-review publications, 119 invited review articles, 93 book chapters, 42 editorials, 3 society-related position papers, 18 books and 2 interactive video disks. Yet, his contributions to the literature in pulmonary and pleural pathology have been significant and influential and have established for him a national and international reputation as one of the leading experts in pulmonary pathology. Herein, it is my privilege to recount the various publications contributed by Dr. Wick to this topic, which span the gamut from transplant pathology to neoplastic diseases of the lung and pleura.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 2","pages":"Article 150834"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139373856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.semdp.2025.150895
Justin A. Bishop
{"title":"Festschrift for Drs. Wick and Santa Cruz","authors":"Justin A. Bishop","doi":"10.1016/j.semdp.2025.150895","DOIUrl":"10.1016/j.semdp.2025.150895","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 2","pages":"Article 150895"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-21DOI: 10.1053/j.semdp.2025.02.002
Baris Boyraz, Syed A. Hoda
In the second part of this two-part review series, we revisit Chapter X of the seminal textbook Problems in Breast Pathology written by Dr. John G. Azzopardi and discuss breast malignancies which may be underdiagnosed. We include the two major lesions covered in Dr. Azzopardi's textbook: ductal carcinoma in situ and lobular carcinoma in situ. Furthermore, we discuss microinvasive carcinoma, residual invasive carcinoma status-post neoadjuvant treatment and carcinomas with certain morphologic features which may lead to underdiagnosis. While discussing these lesions, we highlight problems raised by Dr. Azzopardi and discuss both their morphologic features as well as ancillary tools developed since then to aid reaching the diagnosis.
在这个由两部分组成的回顾系列的第二部分，我们将重温由John G. Azzopardi博士撰写的开创性教科书《乳腺病理学问题》的第十章，并讨论可能未被诊断的乳腺恶性肿瘤。我们包括Azzopardi博士的教科书中涵盖的两个主要病变：导管原位癌和小叶原位癌。此外，我们还讨论了微创癌、新辅助治疗后残留浸润癌的状态以及具有某些可能导致漏诊的形态学特征的癌。在讨论这些病变时，我们强调Azzopardi博士提出的问题，并讨论了它们的形态学特征以及自那时以来开发的辅助工具，以帮助达到诊断。
{"title":"Underdiagnosis of breast malignancy: Azzopardi's Problems in Breast Pathology revisited, part II","authors":"Baris Boyraz, Syed A. Hoda","doi":"10.1053/j.semdp.2025.02.002","DOIUrl":"10.1053/j.semdp.2025.02.002","url":null,"abstract":"<div><div>In the second part of this two-part review series, we revisit Chapter X of the seminal textbook <em>Problems in Breast Pathology</em> written by Dr. John G. Azzopardi and discuss breast malignancies which may be underdiagnosed. We include the two major lesions covered in Dr. Azzopardi's textbook: ductal carcinoma <em>in situ</em> and lobular carcinoma <em>in situ</em>. Furthermore, we discuss microinvasive carcinoma, residual invasive carcinoma status-post neoadjuvant treatment and carcinomas with certain morphologic features which may lead to underdiagnosis. While discussing these lesions, we highlight problems raised by Dr. Azzopardi and discuss both their morphologic features as well as ancillary tools developed since then to aid reaching the diagnosis.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 4","pages":"Article 150875"},"PeriodicalIF":2.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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