Andrzej Badeński, Marta Badeńska, E. Trembecka-Dubel, Ewa Grzywna-Rozenek, E. Kluczewska, M. Szczepańska
Background: Schimke immuno-osseous dysplasia (SIOD, OMIM 242900) is a rare, autosomal recessive, pleiotropic disease caused by mutations in the SMARCAL1 gene. SIOD is characterized by a triad of symptoms, i.e., progressive kidney disease due to focal segmen- tal glomerulosclerosis (FSGS), spondyloepiphyseal dysplasia and T-cell immunodeficiency. Additionally, heterogeneous neurological symptoms are often observed in the course of the syndrome. Case: The authors describe the case of a 14-year-old girl with SIOD, who presented with recurrent neurological symptoms, such as migraine-like headaches, diplopia and seizures. She was born at 34 weeks of pregnancy with hypotrophy (1280 g) and short stature (44 cm). Nephrotic-range proteinuria, the first symptom of the disease, was detected at the age of 4 and a half years. Significant immunodeficiency was also observed. She was finally diagnosed with Schimke immuno-osseous dysplasia on account of two pat- hogenic variants, c.836T>C (p.F279S) and c.2542G>T (p.E848X) identified in the SMARCAL1 gene. Conclusions: This report describes the clinical features and neuroimaging findings of a patient with SIOD. It also presents a possible correlation between neurological events and the Schimke disease, which should be considered during the diagnostic process.
{"title":"Neurological symptoms in Schimke immuno-osseous dysplasia in a 11-year-old girl: a case report","authors":"Andrzej Badeński, Marta Badeńska, E. Trembecka-Dubel, Ewa Grzywna-Rozenek, E. Kluczewska, M. Szczepańska","doi":"10.13112/pc.2021.34","DOIUrl":"https://doi.org/10.13112/pc.2021.34","url":null,"abstract":"Background: Schimke immuno-osseous dysplasia (SIOD, OMIM 242900) is a rare, autosomal recessive, pleiotropic disease caused by mutations in the SMARCAL1 gene. SIOD is characterized by a triad of symptoms, i.e., progressive kidney disease due to focal segmen- tal glomerulosclerosis (FSGS), spondyloepiphyseal dysplasia and T-cell immunodeficiency. Additionally, heterogeneous neurological symptoms are often observed in the course of the syndrome. Case: The authors describe the case of a 14-year-old girl with SIOD, who presented with recurrent neurological symptoms, such as migraine-like headaches, diplopia and seizures. She was born at 34 weeks of pregnancy with hypotrophy (1280 g) and short stature (44 cm). Nephrotic-range proteinuria, the first symptom of the disease, was detected at the age of 4 and a half years. Significant immunodeficiency was also observed. She was finally diagnosed with Schimke immuno-osseous dysplasia on account of two pat- hogenic variants, c.836T>C (p.F279S) and c.2542G>T (p.E848X) identified in the SMARCAL1 gene. Conclusions: This report describes the clinical features and neuroimaging findings of a patient with SIOD. It also presents a possible correlation between neurological events and the Schimke disease, which should be considered during the diagnostic process.","PeriodicalId":49715,"journal":{"name":"Paediatria Croatica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41556757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cross-sectoral cooperation is a complex process involving different systems with their complexities and separate protocols through partnership, sharing responsibilities and benefits. In the developmental system model of early intervention, cross-sectoral coopera- tion implies the connection between the health care system, social welfare and the educational system. In the Republic of Croatia, this type of cooperation has not come to life at the level that would be necessary for the entire system to function adequately. This is why families of children with neurodevelopmental risk and developmental difficulties are often left to fend for themselves and seek support and therapy. Objective: The aim of this paper is to present a model of connecting the health institution, the paediatrician of the health center and the experts of the social care institution that provides early intervention services (EI), and to examine whether this cooperation ac- celerates family involvement in EI support and services. Methods: The collaboration was conducted through secure virtual communication, with paediatricians directing families of chil- dren with a certain deviation from typical development to a social institution, the EI provider, where experts conducted triage by team development assessment. Results: 27 children and their families were included and it was shown that the mentioned cooperation led to the acceleration of obtaining support for the family in an average of 72 days. It also turned out that there was an indirect acceleration of administrative procedures in exercising the right to EI service in 13 days. Conclusion: The results show a positive effect of cross-sectoral cooperation and networking through a system of information ex- change through secured technologies.
{"title":"Promoting cross-sectoral cooperation in the early intervention model","authors":"Tena Matijaš, D. Bulić","doi":"10.13112/pc.2021.30","DOIUrl":"https://doi.org/10.13112/pc.2021.30","url":null,"abstract":"Cross-sectoral cooperation is a complex process involving different systems with their complexities and separate protocols through partnership, sharing responsibilities and benefits. In the developmental system model of early intervention, cross-sectoral coopera- tion implies the connection between the health care system, social welfare and the educational system. In the Republic of Croatia, this type of cooperation has not come to life at the level that would be necessary for the entire system to function adequately. This is why families of children with neurodevelopmental risk and developmental difficulties are often left to fend for themselves and seek support and therapy. Objective: The aim of this paper is to present a model of connecting the health institution, the paediatrician of the health center and the experts of the social care institution that provides early intervention services (EI), and to examine whether this cooperation ac- celerates family involvement in EI support and services. Methods: The collaboration was conducted through secure virtual communication, with paediatricians directing families of chil- dren with a certain deviation from typical development to a social institution, the EI provider, where experts conducted triage by team development assessment. Results: 27 children and their families were included and it was shown that the mentioned cooperation led to the acceleration of obtaining support for the family in an average of 72 days. It also turned out that there was an indirect acceleration of administrative procedures in exercising the right to EI service in 13 days. Conclusion: The results show a positive effect of cross-sectoral cooperation and networking through a system of information ex- change through secured technologies.","PeriodicalId":49715,"journal":{"name":"Paediatria Croatica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47368835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Tomac, S. Puseljic, Martina Kos, S. Dorner, Romana Pavišić Kezan, J. Wagner
This study presents a retrospective data analysis of 101 postnatally detected cases of Down syndrome, routinely diagnosed among 1879 postnatal investigations performed during a 15-year period (2005-2020) at a single tertiary centre. All patients with features of Down syndrome were examined at the Department of Paediatrics, Osijek University Hospital Centre. Karyotyping was performed at the Laboratory of Medical Genetics, Faculty of Medicine in Osijek. Among 101 Down syndrome patients, 55% patients were male and 45% were female patients. Trisomy 21 as the most common karyotype was found in 95%, Robertsonian translocation in 4% and mosaic form in 1% of Down syndrome patients. The average age of the mothers was 33 years. Congenital heart defects were present in 38/89 (42.7%) patients. There was no marked decrease in the prevalence of live birth Down syndrome in eastern Croatia over the 15-year period. The usage of prenatal diagnosis was low, so women’s, as well as physicians’ knowledge and attitudes towards the prenatal diagnosis of Down syndrome should be evaluated.
{"title":"Epidemiological, cytogenetic and clinical characteristics of children with Down syndrome in eastern Croatia – fifteen-year postnatal experience","authors":"V. Tomac, S. Puseljic, Martina Kos, S. Dorner, Romana Pavišić Kezan, J. Wagner","doi":"10.13112/pc.2021.11","DOIUrl":"https://doi.org/10.13112/pc.2021.11","url":null,"abstract":"This study presents a retrospective data analysis of 101 postnatally detected cases of Down syndrome, routinely diagnosed among 1879 postnatal investigations performed during a 15-year period (2005-2020) at a single tertiary centre. All patients with features of Down syndrome were examined at the Department of Paediatrics, Osijek University Hospital Centre. Karyotyping was performed at the Laboratory of Medical Genetics, Faculty of Medicine in Osijek. Among 101 Down syndrome patients, 55% patients were male and 45% were female patients. Trisomy 21 as the most common karyotype was found in 95%, Robertsonian translocation in 4% and mosaic form in 1% of Down syndrome patients. The average age of the mothers was 33 years. Congenital heart defects were present in 38/89 (42.7%) patients. There was no marked decrease in the prevalence of live birth Down syndrome in eastern Croatia over the 15-year period. The usage of prenatal diagnosis was low, so women’s, as well as physicians’ knowledge and attitudes towards the prenatal diagnosis of Down syndrome should be evaluated.","PeriodicalId":49715,"journal":{"name":"Paediatria Croatica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46442537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validation and standardisation of the Croatian version of ASQ-3 for children aged 3 to 5 years","authors":"T. Velki, Ksenija Romstein","doi":"10.13112/pc.2021.15","DOIUrl":"https://doi.org/10.13112/pc.2021.15","url":null,"abstract":"","PeriodicalId":49715,"journal":{"name":"Paediatria Croatica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66774448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Septic thrombophlebitis of the portal venous system, also known as pylephlebitis, is a rare clinical condition with nonspecific clinical presentation, in which imaging has a crucial role in its prompt diagnosis. We report a case of a 13-year-old male who presented with fever, jaundice and hepatomegaly. Ultrasound and computed tomography revealed portal vein thrombosis, hepatomegaly, splenomegaly, and mild ascites. No primary focus of infection, underlying thrombophilia or malignancy was identified, and broad-spec-trum antibiotic therapy and anticoagulation were initiated, resulting in clinical improvement and partial recanalization of the portal vein. Clinical and imaging follow-up should be maintained to exclude the development of portal hypertension.
{"title":"Septic thrombophlebitis of the portal vein – a case report","authors":"J. Louro, B. Teixeira, E. Santos Silva","doi":"10.13112/pc.2021.16","DOIUrl":"https://doi.org/10.13112/pc.2021.16","url":null,"abstract":"Septic thrombophlebitis of the portal venous system, also known as pylephlebitis, is a rare clinical condition with nonspecific clinical presentation, in which imaging has a crucial role in its prompt diagnosis. We report a case of a 13-year-old male who presented with fever, jaundice and hepatomegaly. Ultrasound and computed tomography revealed portal vein thrombosis, hepatomegaly, splenomegaly, and mild ascites. No primary focus of infection, underlying thrombophilia or malignancy was identified, and broad-spec-trum antibiotic therapy and anticoagulation were initiated, resulting in clinical improvement and partial recanalization of the portal vein. Clinical and imaging follow-up should be maintained to exclude the development of portal hypertension.","PeriodicalId":49715,"journal":{"name":"Paediatria Croatica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41924765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marina Stilinović, I. Sabolić, D. Papeš, M. Pasini, Dora Škrljak-Šoša, T. Luetić
{"title":"Patient- and family-centred care – satisfaction with care as an indicator of health care quality","authors":"Marina Stilinović, I. Sabolić, D. Papeš, M. Pasini, Dora Škrljak-Šoša, T. Luetić","doi":"10.13112/pc.2021.14","DOIUrl":"https://doi.org/10.13112/pc.2021.14","url":null,"abstract":"","PeriodicalId":49715,"journal":{"name":"Paediatria Croatica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41776882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Kehler, T. Kezele, Ariana Fužinac-Smojver, Tamara Kauzlarić-Živković
The aim of the study was to investigate serum vitamin D level in undergraduate students of health studies and its relationship with the frequency of vitamin D rich food consumption, sun exposure, study-related fatigue, headache and psychopathological status, and the relationship of the latter three parameters with the type of physical activity. A blood level of 25-hydroxyvitamin D (25(OH)D), Migraine Disability Assessment (MIDAS), Pediatric Quality of Life Inventory Multidimensional Fatigue Scale, Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM), nutrition and physical activity were surveyed in randomly chosen students. Study results showed that 49% of students had 25(OH)D insufficiency/deficiency. The MIDAS values were higher in the insufficient/ deficient group (p=0.035) and were associated with hours of weekly cardio exercises (r=-0.48, p=0.031). CORE-OM and total fatigue correlated with 25(OH)D (r=-0.59, p=0.024; r=0.51, p=0.023). Students with sufficient 25(OH)D had a significantly higher vitamin D intake by consuming sardines in their monthly nutrition (p=0.048). 25(OH)D correlated with the amount of monthly consumed sardines (r=0.59, p=0.006) in general. Our results provide initial evidence that an appropriate lifestyle along with proper physical activity, especially cardio exercise, and vitamin D rich nutrition is important to reduce fatigue, headaches and psychological distress. our study is that all these studies analysed vitamin D status in groups of adolescents (12-18 years).
摘要本研究旨在探讨健康专业本科学生血清维生素D水平与摄入富含维生素D的食物频率、日晒、学习疲劳、头痛和精神病理状态的关系，以及后三项参数与体育活动类型的关系。随机抽取学生进行25-羟基维生素D (25(OH)D)血药浓度、偏头痛残疾评估(MIDAS)、儿童生活质量量表多维疲劳量表、常规评估-结果测量临床结果(CORE-OM)、营养和身体活动的调查。研究结果显示，49%的学生有25(OH)D不足/缺乏。MIDAS值在缺乏/缺乏组较高(p=0.035)，并且与每周有氧运动小时数相关(r=-0.48, p=0.031)。CORE-OM和总疲劳与25(OH)D相关(r=-0.59, p=0.024;r = 0.51, p = 0.023)。25(OH)D充足的学生在每月营养摄入沙丁鱼后，维生素D摄入量显著增加(p=0.048)。总体而言，25(OH)D与每月沙丁鱼食用量相关(r=0.59, p=0.006)。我们的研究结果提供了初步证据，表明适当的生活方式，适当的体育锻炼，尤其是有氧运动，以及富含维生素D的营养对减少疲劳、头痛和心理困扰很重要。我们的研究是，所有这些研究都分析了青少年群体(12-18岁)的维生素D状况。
{"title":"Association of vitamin D insufficiency and low physical activity with fatigue, headaches and psychological distress in college students, North-Mediterranean Croatia – a pilot study","authors":"T. Kehler, T. Kezele, Ariana Fužinac-Smojver, Tamara Kauzlarić-Živković","doi":"10.13112/pc.2021.10","DOIUrl":"https://doi.org/10.13112/pc.2021.10","url":null,"abstract":"The aim of the study was to investigate serum vitamin D level in undergraduate students of health studies and its relationship with the frequency of vitamin D rich food consumption, sun exposure, study-related fatigue, headache and psychopathological status, and the relationship of the latter three parameters with the type of physical activity. A blood level of 25-hydroxyvitamin D (25(OH)D), Migraine Disability Assessment (MIDAS), Pediatric Quality of Life Inventory Multidimensional Fatigue Scale, Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM), nutrition and physical activity were surveyed in randomly chosen students. Study results showed that 49% of students had 25(OH)D insufficiency/deficiency. The MIDAS values were higher in the insufficient/ deficient group (p=0.035) and were associated with hours of weekly cardio exercises (r=-0.48, p=0.031). CORE-OM and total fatigue correlated with 25(OH)D (r=-0.59, p=0.024; r=0.51, p=0.023). Students with sufficient 25(OH)D had a significantly higher vitamin D intake by consuming sardines in their monthly nutrition (p=0.048). 25(OH)D correlated with the amount of monthly consumed sardines (r=0.59, p=0.006) in general. Our results provide initial evidence that an appropriate lifestyle along with proper physical activity, especially cardio exercise, and vitamin D rich nutrition is important to reduce fatigue, headaches and psychological distress. our study is that all these studies analysed vitamin D status in groups of adolescents (12-18 years).","PeriodicalId":49715,"journal":{"name":"Paediatria Croatica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44014353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are still urgent medical issues in developing countries and in some communities of high-income countries. The aim of our study was to evaluate plasma cytokine concentrations in children with RHD and their correlation with antibody concentrations to viruses of the Herpesviridae family. Sixty-two patients with RHD aged 8 to 17 years were included in the study. The concentrations of TNF-α, IL-4, IL-8, IL-10 and IFN-γ were evaluated; IgG and IgM antibodies to cytomegalovirus (CMV), herpes simplex virus (HSV) groups I-II and Epstein-Barr virus (EBV) in serum were determined by ELISA meth-od. A significant increase of cytokine concentrations (TNF-α, IL-8, IL-4 and IL-10) was recorded in RHD patients. Antibodies to intracel-lular Herpesviridae family viruses were detected in all children with RHD. Children with RHD were significantly more likely to have IgG HSV I-II antibodies, and IgG and IgM EBV antibodies compared to controls (p<0.05). The concentration of IgM antibody to CMV showed positive correlation with TNF-α; the concentration of IgG antibody to EBV showed negative correlation with TNF-α; and the concentration of IgG and IgM antibodies to EBV showed positive correlation with IL-10 levels. Considering positive correlation of IL-10 concentration with IgG and IgM antibody concentrations to EBV, and the significance of IL-10 in the progression of RHD, the possible predisposing role of EBV in the progression of RHD can be postulated, which needs further study.
{"title":"The correlation between cytokine concentrations and IgG/IgM antibodies to viruses of the Herpesviridae family in children with rheumatic heart disease","authors":"O. Boyarchuk","doi":"10.13112/pc.2021.9","DOIUrl":"https://doi.org/10.13112/pc.2021.9","url":null,"abstract":"Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are still urgent medical issues in developing countries and in some communities of high-income countries. The aim of our study was to evaluate plasma cytokine concentrations in children with RHD and their correlation with antibody concentrations to viruses of the Herpesviridae family. Sixty-two patients with RHD aged 8 to 17 years were included in the study. The concentrations of TNF-α, IL-4, IL-8, IL-10 and IFN-γ were evaluated; IgG and IgM antibodies to cytomegalovirus (CMV), herpes simplex virus (HSV) groups I-II and Epstein-Barr virus (EBV) in serum were determined by ELISA meth-od. A significant increase of cytokine concentrations (TNF-α, IL-8, IL-4 and IL-10) was recorded in RHD patients. Antibodies to intracel-lular Herpesviridae family viruses were detected in all children with RHD. Children with RHD were significantly more likely to have IgG HSV I-II antibodies, and IgG and IgM EBV antibodies compared to controls (p<0.05). The concentration of IgM antibody to CMV showed positive correlation with TNF-α; the concentration of IgG antibody to EBV showed negative correlation with TNF-α; and the concentration of IgG and IgM antibodies to EBV showed positive correlation with IL-10 levels. Considering positive correlation of IL-10 concentration with IgG and IgM antibody concentrations to EBV, and the significance of IL-10 in the progression of RHD, the possible predisposing role of EBV in the progression of RHD can be postulated, which needs further study.","PeriodicalId":49715,"journal":{"name":"Paediatria Croatica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66774536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Paponja, Valentina Rahelić, Nikola Mesarić, T. Žigman, Ana Škaričić, Iva Bilandžija-Kuš, E. Pavić, I. Senečić-čala, M. Peršić, J. Vuković, I. Barić, D. Ramadža
{"title":"Hereditary fructose intolerance – two case reports and literature review","authors":"K. Paponja, Valentina Rahelić, Nikola Mesarić, T. Žigman, Ana Škaričić, Iva Bilandžija-Kuš, E. Pavić, I. Senečić-čala, M. Peršić, J. Vuković, I. Barić, D. Ramadža","doi":"10.13112/PC.2021.6","DOIUrl":"https://doi.org/10.13112/PC.2021.6","url":null,"abstract":"","PeriodicalId":49715,"journal":{"name":"Paediatria Croatica","volume":"65 1","pages":"36-42"},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46140205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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