Pub Date : 2024-03-30DOI: 10.53022/oarjls.2024.7.1.0024
Laila A. Ibrahim, Muna Salem M. Solyman, Marwa M. El Omami, Abeer H. Amer, Abdalla I. Mohamed
Neocidol, containing Diazinon, stands as a prevalent compound in the fields of plant protection and insect control for public health. Despite its historical prominence, Neocidol, classified as a non-systemic organophosphate, exerts its effects by inhibiting cholinesterase, a pivotal enzyme in nerve transmission. In light of the widespread use of Neocidol in Libya and the absence of local studies, this research endeavors to assess its impact on blood parameters and the biochemistry of female white mice. The study involves prolonged tests wherein a sublethal concentration of 15 µl Neocidol per kg of body weight is introduced through the mice's drinking water. Toxicity assessments reveal noteworthy distinctions in various blood parameters between treated and untreated mice. Treated mice exhibit elevated leukocyte and erythrocyte values, coupled with diminished MCHC and MCV values. While blood chemistry results generally align between the control and treatment groups, an exception is observed in the form of heightened Alk-phosphatase values in treated mice. In summary, despite Neocidol's historical favorability in agricultural and public health pest control, this study underscores emerging criticisms concerning its identified health and environmental implications.
{"title":"The Impact of Neocidol on Hematological Parameters in Swiss Albino Mice","authors":"Laila A. Ibrahim, Muna Salem M. Solyman, Marwa M. El Omami, Abeer H. Amer, Abdalla I. Mohamed","doi":"10.53022/oarjls.2024.7.1.0024","DOIUrl":"https://doi.org/10.53022/oarjls.2024.7.1.0024","url":null,"abstract":"Neocidol, containing Diazinon, stands as a prevalent compound in the fields of plant protection and insect control for public health. Despite its historical prominence, Neocidol, classified as a non-systemic organophosphate, exerts its effects by inhibiting cholinesterase, a pivotal enzyme in nerve transmission. In light of the widespread use of Neocidol in Libya and the absence of local studies, this research endeavors to assess its impact on blood parameters and the biochemistry of female white mice. The study involves prolonged tests wherein a sublethal concentration of 15 µl Neocidol per kg of body weight is introduced through the mice's drinking water. Toxicity assessments reveal noteworthy distinctions in various blood parameters between treated and untreated mice. Treated mice exhibit elevated leukocyte and erythrocyte values, coupled with diminished MCHC and MCV values. While blood chemistry results generally align between the control and treatment groups, an exception is observed in the form of heightened Alk-phosphatase values in treated mice. In summary, despite Neocidol's historical favorability in agricultural and public health pest control, this study underscores emerging criticisms concerning its identified health and environmental implications.","PeriodicalId":497826,"journal":{"name":"Open access research journal of life sciences","volume":"12 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140361638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.53022/oarjls.2024.7.1.0026
Ehizogie Paul Adeghe, Chioma Anthonia Okolo, Olumuyiwa Tolulope Ojeyinka
Predictive analytics, empowered by machine learning, has emerged as a transformative force in healthcare, offering unparalleled opportunities for enhancing patient outcomes. The primary focus is on understanding the implications, applications, and challenges associated with the use of machine learning algorithms in predicting patient health outcomes. The paper begins by establishing the context with an overview of predictive analytics in healthcare and its evolution. Emphasis is placed on the critical role of patient health outcomes in pharmacy practice. The review explores the current landscape of predictive analytics in pharmacy practice, detailing traditional approaches, their limitations, and the advantages that machine learning brings to the forefront. An in-depth examination of applications follows, focusing on areas such as medication adherence prediction, disease progression modeling, and personalized medication regimens. Real-world case studies and success stories illustrate the practical impact of machine learning on patient outcomes. Addressing the importance of data sources, the paper discusses the diverse types of data employed in predictive analytics, ranging from electronic health records to patient-generated data and wearables. Ethical and privacy concerns are thoroughly explored, emphasizing the need for responsible data usage. The implications for pharmacists and healthcare providers are discussed, highlighting the evolving role of pharmacists in predictive analytics and the potential benefits and challenges for healthcare providers. The conclusion summarizes key findings and issues a call to action, encouraging further research and adoption of machine learning in pharmacy practice to harness its potential for improving patient outcomes.
{"title":"A review of the use of machine learning in predictive analytics for patient health outcomes in pharmacy practice","authors":"Ehizogie Paul Adeghe, Chioma Anthonia Okolo, Olumuyiwa Tolulope Ojeyinka","doi":"10.53022/oarjls.2024.7.1.0026","DOIUrl":"https://doi.org/10.53022/oarjls.2024.7.1.0026","url":null,"abstract":"Predictive analytics, empowered by machine learning, has emerged as a transformative force in healthcare, offering unparalleled opportunities for enhancing patient outcomes. The primary focus is on understanding the implications, applications, and challenges associated with the use of machine learning algorithms in predicting patient health outcomes. The paper begins by establishing the context with an overview of predictive analytics in healthcare and its evolution. Emphasis is placed on the critical role of patient health outcomes in pharmacy practice. The review explores the current landscape of predictive analytics in pharmacy practice, detailing traditional approaches, their limitations, and the advantages that machine learning brings to the forefront. An in-depth examination of applications follows, focusing on areas such as medication adherence prediction, disease progression modeling, and personalized medication regimens. Real-world case studies and success stories illustrate the practical impact of machine learning on patient outcomes. Addressing the importance of data sources, the paper discusses the diverse types of data employed in predictive analytics, ranging from electronic health records to patient-generated data and wearables. Ethical and privacy concerns are thoroughly explored, emphasizing the need for responsible data usage. The implications for pharmacists and healthcare providers are discussed, highlighting the evolving role of pharmacists in predictive analytics and the potential benefits and challenges for healthcare providers. The conclusion summarizes key findings and issues a call to action, encouraging further research and adoption of machine learning in pharmacy practice to harness its potential for improving patient outcomes.","PeriodicalId":497826,"journal":{"name":"Open access research journal of life sciences","volume":"37 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.53022/oarjls.2024.7.1.0023
Carlos Henrique Marchiori, Klebert de Paula Malheiros
They do not have a popular name, at least among non-native people. They are occasionally referred to as crickets, although they are not Grylloidea, but Stenopelmatoidea. Easily identifiable by the convex body in lateral view, shiny, glabrous integument, and with both apterous sexes. The anterior thigh has a lobe with spines. During the day they remain hidden under logs or stones, leaf litter, or in burrows dug by themselves. Buthidae are found throughout Brazil and makeup around 60% of national species. This family includes the genus Tityus Koch, 1966 (Scorpiones, Buthidae), the most dangerous. The species that exist in Brazil are divided into four families. This note reports for the first time the genus Lutosa Walker, 1869 in the Central-West Region, State of Goiás, Brazil, and the first report of the entire process of locust predation in the world.
{"title":"Description of predatory behavior of the genus Lutosa walker, 1869 (Orthoptera: Anostostomatidae: Lutosinae) in Brazil","authors":"Carlos Henrique Marchiori, Klebert de Paula Malheiros","doi":"10.53022/oarjls.2024.7.1.0023","DOIUrl":"https://doi.org/10.53022/oarjls.2024.7.1.0023","url":null,"abstract":"They do not have a popular name, at least among non-native people. They are occasionally referred to as crickets, although they are not Grylloidea, but Stenopelmatoidea. Easily identifiable by the convex body in lateral view, shiny, glabrous integument, and with both apterous sexes. The anterior thigh has a lobe with spines. During the day they remain hidden under logs or stones, leaf litter, or in burrows dug by themselves. Buthidae are found throughout Brazil and makeup around 60% of national species. This family includes the genus Tityus Koch, 1966 (Scorpiones, Buthidae), the most dangerous. The species that exist in Brazil are divided into four families. This note reports for the first time the genus Lutosa Walker, 1869 in the Central-West Region, State of Goiás, Brazil, and the first report of the entire process of locust predation in the world.","PeriodicalId":497826,"journal":{"name":"Open access research journal of life sciences","volume":"43 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.53022/oarjls.2024.7.1.0025
SIMÕES, R.S.Q
Human papillomavirus (HPV) induces the most common sexually transmitted disease and has been classified in the Alphapapillomavirus genus, Papillomaviridae family. They are non‒enveloped viruses presenting a closed circular double‒stranded non‒segmented DNA genome of approximately 8 kb that infect the anogenital epithelium causing cervical cancer, anal and penis cancer. There are viral groups based on their oncogenic activity as high‒risk types, low‒risk types and types of undetermined‒risk. mRNA vaccines are being evaluated in people with HPV-related cancers. This study described how mRNA cancer vaccines work and their applications recruiting several strategies for HPV cancer immunotherapy. Several biopharmaceuticals are developing mRNA vaccines encoding neoepitopes that can induce immune responses against target tumors. One trial is testing a personalized mRNA vaccine in combination with an immune checkpoint inhibitor in patients with advanced head and neck cancer. The production of therapeutic mRNA proteins for development of vaccine cancer have been manufactured by upstream and downstream methods. Several stages are processed in bioreactors using input and output parameters to measure the quality control of purified substance. Thus, novel technologies using different mRNA delivery system can be able to be integrated in clinical trials of HPV16 tumor-derived antigens associated cervical intraepithelial lesions of different stages until head and neck squamous cell carcinoma, oropharyngeal and cervical cancers.
{"title":"mRNA vaccines in cancer clinical trials: HPV16 tumor-derived antigens (e6 and e7 oncoproteins) associated with head and neck squamous cell carcinoma (HNSCC), oropharyngeal and cervical cancers","authors":"SIMÕES, R.S.Q","doi":"10.53022/oarjls.2024.7.1.0025","DOIUrl":"https://doi.org/10.53022/oarjls.2024.7.1.0025","url":null,"abstract":"Human papillomavirus (HPV) induces the most common sexually transmitted disease and has been classified in the Alphapapillomavirus genus, Papillomaviridae family. They are non‒enveloped viruses presenting a closed circular double‒stranded non‒segmented DNA genome of approximately 8 kb that infect the anogenital epithelium causing cervical cancer, anal and penis cancer. There are viral groups based on their oncogenic activity as high‒risk types, low‒risk types and types of undetermined‒risk. mRNA vaccines are being evaluated in people with HPV-related cancers. This study described how mRNA cancer vaccines work and their applications recruiting several strategies for HPV cancer immunotherapy. Several biopharmaceuticals are developing mRNA vaccines encoding neoepitopes that can induce immune responses against target tumors. One trial is testing a personalized mRNA vaccine in combination with an immune checkpoint inhibitor in patients with advanced head and neck cancer. The production of therapeutic mRNA proteins for development of vaccine cancer have been manufactured by upstream and downstream methods. Several stages are processed in bioreactors using input and output parameters to measure the quality control of purified substance. Thus, novel technologies using different mRNA delivery system can be able to be integrated in clinical trials of HPV16 tumor-derived antigens associated cervical intraepithelial lesions of different stages until head and neck squamous cell carcinoma, oropharyngeal and cervical cancers.","PeriodicalId":497826,"journal":{"name":"Open access research journal of life sciences","volume":"44 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.53022/oarjls.2024.7.1.0021
Peter, Onuche, Adamu, Michael Kudyo, Ortese, Celestina Tartor
This paper makes use of Two-way Analysis of Variance approach to check whether significant difference exists in the weight of an infant as it relates to gravida and maternal age or not. Five hundred and thirty-three (533) samples on the weight of an infant, maternal age and gravida sourced from Family Support Programme (FSP) Makurdi Benue State, Nigeria was used. Maternal age was divided into five (14-19, 20-25, 26-31, 32-37 and 38-43); the level of gravida (number of pregnancies) considered are gravida one (1), gravida two (2), gravida three (3) and gravida four (number of pregnancies greater than or equal to four). The results revealed that significant difference exist between the maternal age as it relates to the weight of an infant since the p_value of 0.0001 is less than 0.05 alpha level of significance. Significant difference was also seen in gravida since the p_value of 0.0001 is less than 0.05 alpha level of significance. As a result of significant difference observed in both maternal age and gravida, multiple mean comparison was carried out to identify the mean weight that actually differs. It was discovered that the mean weight of an infant in gravida four (4) is different from that of gravida one (1) and two (2), in addition, gravida 3 and 1 were statistically significant. Maternal age one (14-19) was also found to be different from every other age group.
{"title":"Gravida and maternal age group effect on the weight of an infant","authors":"Peter, Onuche, Adamu, Michael Kudyo, Ortese, Celestina Tartor","doi":"10.53022/oarjls.2024.7.1.0021","DOIUrl":"https://doi.org/10.53022/oarjls.2024.7.1.0021","url":null,"abstract":"This paper makes use of Two-way Analysis of Variance approach to check whether significant difference exists in the weight of an infant as it relates to gravida and maternal age or not. Five hundred and thirty-three (533) samples on the weight of an infant, maternal age and gravida sourced from Family Support Programme (FSP) Makurdi Benue State, Nigeria was used. Maternal age was divided into five (14-19, 20-25, 26-31, 32-37 and 38-43); the level of gravida (number of pregnancies) considered are gravida one (1), gravida two (2), gravida three (3) and gravida four (number of pregnancies greater than or equal to four). The results revealed that significant difference exist between the maternal age as it relates to the weight of an infant since the p_value of 0.0001 is less than 0.05 alpha level of significance. Significant difference was also seen in gravida since the p_value of 0.0001 is less than 0.05 alpha level of significance. As a result of significant difference observed in both maternal age and gravida, multiple mean comparison was carried out to identify the mean weight that actually differs. It was discovered that the mean weight of an infant in gravida four (4) is different from that of gravida one (1) and two (2), in addition, gravida 3 and 1 were statistically significant. Maternal age one (14-19) was also found to be different from every other age group.","PeriodicalId":497826,"journal":{"name":"Open access research journal of life sciences","volume":"40 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.53022/oarjls.2024.7.1.0074
S. Senthilmurugan, R. Prinitha, S. Miltonprabu
The unprecedented usage of BUV-328 (Benzotriazole Ultraviolet Stabilizer) in many biological and environmental matrices is of acute environmental importance because of its toxicity even at low concentrations. To better understand the protective function of DiMC on the liver tissues of zebrafish exposed to sublethal concentration of BUV-328 was assessed in the present investigation. Adult zebrafish were exposed to BUV-328 at sublethal concentrations of 55µg/l. The responses were assessed in the liver tissues at 28 days and another group was supplemented with DiMC to investigate its ameliorative potential against BUV-328 induced hepatotoxicity. Biochemical markers of oxidative stress, histopathological changes, and antioxidant enzymes were measured in the exposed groups. The outcomes of our present study revealed that BUV-328 exposure upregulated the oxidative stress markers and diminished the activities of the antioxidant enzymes, altered the biochemical constituents in liver. Histopathological abrasions such as hypertrophy, cellular and nuclear enlargement, cytoplasmic and nuclear degeneration, necrosis with pyknotic nuclei, lipid and cytoplasmic vacuolization and nuclear displacement to the periphery were found to be increased in BUV-328 exposure group. The oxidative, biochemical and histological alterations induced by BUV-328 were almost recuperated in DiMC supplemented group which signifies its protective influence against BUV-328 incited hepatotoxicity.
{"title":"Prospective hepatotoxic effect of UV-328 and its affirmable rescue by Dimethoxy curcumin in Zebrafish","authors":"S. Senthilmurugan, R. Prinitha, S. Miltonprabu","doi":"10.53022/oarjls.2024.7.1.0074","DOIUrl":"https://doi.org/10.53022/oarjls.2024.7.1.0074","url":null,"abstract":"The unprecedented usage of BUV-328 (Benzotriazole Ultraviolet Stabilizer) in many biological and environmental matrices is of acute environmental importance because of its toxicity even at low concentrations. To better understand the protective function of DiMC on the liver tissues of zebrafish exposed to sublethal concentration of BUV-328 was assessed in the present investigation. Adult zebrafish were exposed to BUV-328 at sublethal concentrations of 55µg/l. The responses were assessed in the liver tissues at 28 days and another group was supplemented with DiMC to investigate its ameliorative potential against BUV-328 induced hepatotoxicity. Biochemical markers of oxidative stress, histopathological changes, and antioxidant enzymes were measured in the exposed groups. The outcomes of our present study revealed that BUV-328 exposure upregulated the oxidative stress markers and diminished the activities of the antioxidant enzymes, altered the biochemical constituents in liver. Histopathological abrasions such as hypertrophy, cellular and nuclear enlargement, cytoplasmic and nuclear degeneration, necrosis with pyknotic nuclei, lipid and cytoplasmic vacuolization and nuclear displacement to the periphery were found to be increased in BUV-328 exposure group. The oxidative, biochemical and histological alterations induced by BUV-328 were almost recuperated in DiMC supplemented group which signifies its protective influence against BUV-328 incited hepatotoxicity.","PeriodicalId":497826,"journal":{"name":"Open access research journal of life sciences","volume":"44 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.53022/oarjls.2024.7.1.0073
Kalyani Kondapalli, Anand Kumar Y, Murthy P.N.V.N
Rosiglitazone HCl, a member of thiazolidinedione class of antidiabetic agent, improves glycemic control by improving insulin sensitivity. The maximum solubility of rosiglitazone was found at pH 1.2 and solubility decreases up to pH 4.0. At a pH 6.0 and higher pH, solubility reduces drastically. Suitable solid dispersion systems of rosiglitazone with maltodextrin and poloxamer were prepared by solvent evaporation and kneading methods at 1:1 and 1:3 drug: carrier. Drug content, saturation solubility, FTIR, XRD, DSC and In-vitro dissolution were studied. The drug content was uniform, solubility of the drug increased linearly as a function of the carrier concentration and method. The FTIR studies suggest possible interaction at molecular level further justified by XRD and DSC studies. The dissolution study suggests, the increase in drug release was dependent on type of method of preparation. The DP60 and DE60 values were significantly higher (P<0.05) in solid dispersion systems prepared by kneading method when compared to pure rosiglitazone, physical mixture and solvent evaporation method. The dissolution follows first order model and obeyed Hixson- Crowell’s cube root law.
{"title":"Studies on enhancement of solubility and dissolution properties of rosiglitazone hydrochloride by solid dispersion technique","authors":"Kalyani Kondapalli, Anand Kumar Y, Murthy P.N.V.N","doi":"10.53022/oarjls.2024.7.1.0073","DOIUrl":"https://doi.org/10.53022/oarjls.2024.7.1.0073","url":null,"abstract":"Rosiglitazone HCl, a member of thiazolidinedione class of antidiabetic agent, improves glycemic control by improving insulin sensitivity. The maximum solubility of rosiglitazone was found at pH 1.2 and solubility decreases up to pH 4.0. At a pH 6.0 and higher pH, solubility reduces drastically. Suitable solid dispersion systems of rosiglitazone with maltodextrin and poloxamer were prepared by solvent evaporation and kneading methods at 1:1 and 1:3 drug: carrier. Drug content, saturation solubility, FTIR, XRD, DSC and In-vitro dissolution were studied. The drug content was uniform, solubility of the drug increased linearly as a function of the carrier concentration and method. The FTIR studies suggest possible interaction at molecular level further justified by XRD and DSC studies. The dissolution study suggests, the increase in drug release was dependent on type of method of preparation. The DP60 and DE60 values were significantly higher (P<0.05) in solid dispersion systems prepared by kneading method when compared to pure rosiglitazone, physical mixture and solvent evaporation method. The dissolution follows first order model and obeyed Hixson- Crowell’s cube root law.","PeriodicalId":497826,"journal":{"name":"Open access research journal of life sciences","volume":"127 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Based on Biopharmaceutics Classification System (BCS), nimesulide is a class II drug, characterized by low solubility and high permeability. Thus, its dissolution represents a limiting step in the drug absorption process which directly affects the bioavailability of the drug. Oral Dispersible tablets (ODTs) of nimesulide overcome the problem related to dissolution by enhancing the rate of dissolution by decreasing the disintegration time and making it easy to administer to patients who refuse to swallow a tablet. In the present study, different formulations of nimesulide were prepared to vary the concentration of superdisintegrants: crospovidone, croscarmellose sodium, sodium starch glycolate along with other excipients: PVP K-30, Aerosil, Mannitol, and Magnesium stearate by direct compression method. Precompression and post-compression parameters were evaluated and also the effect of different concentrations of superdisintegrants on the release profile of Nimesulide ODT was studied. The final data revealed that a combination of 10% crospovidone and 8.33% SSG i.e. formulation B4 was found best combination with the lowest dispersion time of 40 seconds, lowest disintegration time of 19.16 seconds, and lowest wetting time of 15 seconds as compared to other formulations. All other studied parameters were found to be satisfactory for all ODT formulations for Nimesulide. It was concluded that Nimesulide can be successfully formulated as oral dispersible tablets using various superdisintegrants in different concentrations by direct compression method. The optimized batch can be subjected to real-time and accelerated stability studies to determine the shelf life for commercial use.
{"title":"Formulation and evaluation of oral dispersible tablet of nimesulide by direct compression method","authors":"None Rabindra Kumar Rokaya, None Kedar Prasad Sah, None Stuti Shrestha, None Reshma KC, None Sonam Thakur, None Nimesh Kumar Singh, None Chandrakala Sah","doi":"10.53022/oarjls.2023.6.2.0059","DOIUrl":"https://doi.org/10.53022/oarjls.2023.6.2.0059","url":null,"abstract":"Based on Biopharmaceutics Classification System (BCS), nimesulide is a class II drug, characterized by low solubility and high permeability. Thus, its dissolution represents a limiting step in the drug absorption process which directly affects the bioavailability of the drug. Oral Dispersible tablets (ODTs) of nimesulide overcome the problem related to dissolution by enhancing the rate of dissolution by decreasing the disintegration time and making it easy to administer to patients who refuse to swallow a tablet. In the present study, different formulations of nimesulide were prepared to vary the concentration of superdisintegrants: crospovidone, croscarmellose sodium, sodium starch glycolate along with other excipients: PVP K-30, Aerosil, Mannitol, and Magnesium stearate by direct compression method. Precompression and post-compression parameters were evaluated and also the effect of different concentrations of superdisintegrants on the release profile of Nimesulide ODT was studied. The final data revealed that a combination of 10% crospovidone and 8.33% SSG i.e. formulation B4 was found best combination with the lowest dispersion time of 40 seconds, lowest disintegration time of 19.16 seconds, and lowest wetting time of 15 seconds as compared to other formulations. All other studied parameters were found to be satisfactory for all ODT formulations for Nimesulide. It was concluded that Nimesulide can be successfully formulated as oral dispersible tablets using various superdisintegrants in different concentrations by direct compression method. The optimized batch can be subjected to real-time and accelerated stability studies to determine the shelf life for commercial use.","PeriodicalId":497826,"journal":{"name":"Open access research journal of life sciences","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136132825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Bismarck model is a great model that has been used in other countries as a reference. It provides coverage for all, and it is a more-simple model than the American healthcare system. Coverage is required regardless of someone's income, and it has a higher life expectancy because of the early preventative care provided. The Bismarck model was implemented in 1875 and has worked for Germany and Japan. San Diego County would benefit from this Bismarck model because it has proven to have positive outcomes for its citizens. The objective of this paper is to implement the Bismarck model in San Diego County.
{"title":"Implementing the Bismarck model for dental care in San Diego County","authors":"None Foujan Jabbarzadehkhoei, None Jacqueline Hernandez, None Paniz Sabeghi","doi":"10.53022/oarjls.2023.6.1.0058","DOIUrl":"https://doi.org/10.53022/oarjls.2023.6.1.0058","url":null,"abstract":"The Bismarck model is a great model that has been used in other countries as a reference. It provides coverage for all, and it is a more-simple model than the American healthcare system. Coverage is required regardless of someone's income, and it has a higher life expectancy because of the early preventative care provided. The Bismarck model was implemented in 1875 and has worked for Germany and Japan. San Diego County would benefit from this Bismarck model because it has proven to have positive outcomes for its citizens. The objective of this paper is to implement the Bismarck model in San Diego County.","PeriodicalId":497826,"journal":{"name":"Open access research journal of life sciences","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.53022/oarjls.2023.6.1.0061
None Shalini, None Bhawna Pant
Cheetal deer (Axis axis Erxleben, 1777) is the most abundance species of deer found in Corbett National Park. The Bijrani and Jhirna, two zones of Corbett Park (with abundance of wildlife) are selected for the study of Cheetal. The primary data for this study is mainly based on direct observation by field visits in the study area. The largest group of Cheetal deer was 252 and the highest mean group size was 79.6 found in March 2019 in Jhirna zone. While in Bijrani zone the largest group of Cheetal deer was 172 individual and the highest mean group size was 56.4 found in March 2019. According to this study there is a variation in monthly group size of Cheetal deer and number of groups in both Bijrani and Jhirna zone of Corbett National Park. The group aggregation of Cheetal deer depends upon maximum and minimum temperature, food availability, visibility in park and number of more babies in group (fawning season). In March (spring) there is sufficient food available in the grassland and shrub area (new sprouting grass) so the population of Cheetal deer is found highest and also group size is found largest in Corbett National Park.
{"title":"Monthly variation in group size of cheetal deer (Axis axis Erxleben, 1777) in Jim Corbett National Park Uttarakhand, India","authors":"None Shalini, None Bhawna Pant","doi":"10.53022/oarjls.2023.6.1.0061","DOIUrl":"https://doi.org/10.53022/oarjls.2023.6.1.0061","url":null,"abstract":"Cheetal deer (Axis axis Erxleben, 1777) is the most abundance species of deer found in Corbett National Park. The Bijrani and Jhirna, two zones of Corbett Park (with abundance of wildlife) are selected for the study of Cheetal. The primary data for this study is mainly based on direct observation by field visits in the study area. The largest group of Cheetal deer was 252 and the highest mean group size was 79.6 found in March 2019 in Jhirna zone. While in Bijrani zone the largest group of Cheetal deer was 172 individual and the highest mean group size was 56.4 found in March 2019. According to this study there is a variation in monthly group size of Cheetal deer and number of groups in both Bijrani and Jhirna zone of Corbett National Park. The group aggregation of Cheetal deer depends upon maximum and minimum temperature, food availability, visibility in park and number of more babies in group (fawning season). In March (spring) there is sufficient food available in the grassland and shrub area (new sprouting grass) so the population of Cheetal deer is found highest and also group size is found largest in Corbett National Park.","PeriodicalId":497826,"journal":{"name":"Open access research journal of life sciences","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136344507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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