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When Occupational Cancer Recognition Falters. 当职业癌症的认识动摇。
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-04-17 DOI: 10.23749/mdl.v116i2.16997
Giorgio Assennato, Chiara De Giampaulis

There are differences between epidemiology and legal medicine in addressing the problem of under-reporting occupational cancers. Epidemiology focuses on systematically gathering data and identifying patterns of under-reporting, which is not deemed to pose ethical dilemmas, as its goal is to improve public health outcomes. Conversely, legal medicine investigates individual cases and ensures compliance with legal standards, presenting more complex ethical challenges. Considering workers' frustrations when dealing with unrecognized occupational diseases is essential. These workers experience significant physical and emotional distress and should not have to face a complicated compensation claims process. There is a need for ethical approaches that support workers in navigating their rightful claims for compensation, not challenging their mental and emotional well-being.

流行病学和法律医学在处理少报职业癌症问题方面存在差异。流行病学的重点是系统地收集数据和确定漏报的模式,这并不被视为构成道德困境,因为其目标是改善公共卫生结果。相反,法律医学调查个案并确保遵守法律标准,提出了更复杂的伦理挑战。在处理未被确认的职业病时,考虑工人的挫折感是必要的。这些工人经历了严重的身体和精神上的痛苦,不应该面对复杂的赔偿索赔过程。我们需要一种合乎道德的方法,支持工人正确地提出赔偿要求,而不是挑战他们的精神和情感健康。
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引用次数: 0
Beyond the Balance Sheet: The Human Cost of Neglecting Occupational Health. 超越资产负债表:忽视职业健康的人力成本。
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-04-17 DOI: 10.23749/mdl.v116i2.17057
Antonio Mutti
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引用次数: 0
Presenteeism and Its Associated Factors Among Teachers. 教师出勤及其相关因素。
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-04-17 DOI: 10.23749/mdl.v116i2.16010
Hend Serya, Abdel-Hady El-Gilany

Background: Teaching is a mentally and physically demanding profession, often performed under challenging and stressful conditions. In Egypt, the lack of school resources, low teacher salaries, poor organizational climate, and high work pressures represent just a few challenges faced by the educational system. These difficulties can adversely affect teachers' health, leading to negative outcomes such as presenteeism. Despite this, no studies have assessed presenteeism among Egyptian teachers. Therefore, this study aimed to estimate the prevalence of presenteeism and identify associated factors among public school teachers.

Methods: A cross-sectional study was conducted involving 373 teachers using an interview-administered questionnaire to gather information on their sociodemographic, occupational, and medical characteristics, along with their Stanford Presenteeism Scale scores and responses to the Job Content Questionnaire.

Results: The prevalence of presenteeism among the teachers studied over the last 12 months was 70.8%. Of these, 74.6% had lower presenteeism scores, reflecting diminished performance in work activities. Key independent predictors of presenteeism included being a female teacher, having additional jobs, experiencing musculoskeletal and/or respiratory health issues, facing high job demands, and possessing low job control. The Adjusted Odds Ratios (AOR) for these factors were 4.1, 5.1, 3.1, 11.7, and 11.7, respectively.

Conclusion: Presenteeism is highly prevalent among public school teachers in Egypt. Therefore, teachers with significant predictors of presenteeism should be given increased attention.

背景:教学是一项对身心都要求很高的职业,经常在充满挑战和压力的条件下进行。在埃及,学校资源缺乏、教师工资低、组织氛围差和工作压力大只是教育系统面临的一些挑战。这些困难会对教师的健康产生不利影响,导致诸如出勤等负面结果。尽管如此,还没有研究评估埃及教师的出勤率。因此,本研究旨在评估公立学校教师的出勤率,并找出相关因素。方法:采用访谈式问卷对373名教师进行了横断面研究,收集了他们的社会人口学、职业和医学特征信息,以及他们的斯坦福出勤量表得分和对工作内容问卷的回答。结果:近12个月受访教师出勤率为70.8%。其中,74.6%的人出勤得分较低,反映出他们在工作活动中的表现有所下降。出勤的主要独立预测因素包括:女教师、有额外工作、有肌肉骨骼和/或呼吸系统健康问题、面临高工作要求、工作控制力低。这些因素的调整优势比(AOR)分别为4.1、5.1、3.1、11.7和11.7。结论:出勤现象在埃及公立学校教师中非常普遍。因此,具有显著出勤预测因子的教师应给予更多的关注。
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引用次数: 0
Welding Fumes Exposure and the Risk of Head and Neck and Gastrointestinal Cancer: A Systematic Review and Meta-Analysis. 焊接烟雾暴露与头颈部和胃肠道癌症的风险:一项系统综述和荟萃分析。
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-04-17 DOI: 10.23749/mdl.v116i2.16092
Andrei Cosmin Siea, Giulia Collatuzzo, Maha Hamdani, Paolo Boffetta

Background: The association between welding fumes and cancers other than lung cancer remains undefined. We conducted a systematic review and meta-analysis on occupational exposure to welding fumes and the risk of head and neck cancer (HN, comprising oral, pharynx, and larynx) and gastrointestinal cancer (GI, comprising esophagus, stomach, colorectal, liver, and pancreas).

Methods: A systematic search was performed in PubMed, Scopus, and Embase using PRISMA guidelines. Cohort studies on occupational exposure to welding fumes were identified. Study quality was assessed through the CASP score. Data were analyzed in random-effects models to calculate the relative risks (RR) and 95% confidence intervals (CI) of HN and GI cancer overall and stratified by cancer site.

Results: Seven independent studies with data on oral, pharynx, larynx, esophagus, stomach, colorectal, liver, or pancreas cancer were identified. We observed the following associations: HN RR=1.10 (95% CI 1.00-1.22); GI RR= 1.03 (95% CI 0.97-1.10); oral and pharynx RR=1.06 (95%, CI 0.93-1.20, eleven risk estimates); larynx RR=1.17 (95%, CI 1.01-1.37, nine risk estimates); esophagus RR=0.98 (95%, CI 0.83-1.15, three risk estimates); stomach RR= 1.10 (95%, CI 1.02-1.19, five risk estimates); colorectal RR=0.99 (95%, CI 0.85-1.15, seven risk estimates); liver RR=1.23 (95%, CI 0.79-1.90, five risk estimates); and pancreas cancer RR=1.05 (95%, CI 0.94-1.16, three risk estimates).

Conclusions: We observed an association between occupational exposure to welding fumes and larynx and stomach cancer. No association was found for other HN or GI cancers. Our study stresses the need to investigate the risk of cancers other than lung following occupational exposure to welding fumes.

背景:除肺癌外,焊接烟雾与癌症之间的关系尚不清楚。我们对职业暴露于焊接烟雾与头颈癌(HN,包括口腔癌、咽喉癌)和胃肠道癌(GI,包括食道癌、胃癌、结肠直肠癌、肝癌和胰腺癌)的风险进行了系统回顾和荟萃分析。方法:采用PRISMA指南在PubMed、Scopus和Embase中进行系统检索。确定了职业性接触焊接烟雾的队列研究。通过CASP评分评估研究质量。采用随机效应模型对数据进行分析,计算HN和GI癌症的总体相对危险度(RR)和95%置信区间(CI),并按癌症部位分层。结果:7项独立研究的数据涉及口腔癌、咽喉癌、食道癌、胃癌、结直肠癌、肝癌或胰腺癌。我们观察到以下相关性:HN RR=1.10 (95% CI 1.00-1.22);Gi rr = 1.03 (95% ci 0.97-1.10);口腔和咽部RR=1.06 (95%, CI 0.93-1.20, 11个风险估计);喉部RR=1.17 (95%, CI 1.01-1.37, 9个风险估计);食道RR=0.98 (95%, CI 0.83-1.15, 3个风险估计);胃RR= 1.10 (95%, CI 1.02-1.19, 5个风险估计);结直肠RR=0.99 (95%, CI 0.85-1.15, 7个风险估计);肝脏RR=1.23 (95%, CI 0.79-1.90, 5个风险估计);胰腺癌RR=1.05 (95%, CI 0.94-1.16,三个风险估计)。结论:我们观察到职业接触焊接烟雾与喉癌和胃癌之间的联系。与其他HN或GI癌症没有关联。我们的研究强调有必要调查职业接触焊接烟雾后患肺癌以外的癌症的风险。
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引用次数: 0
Assessment of a Systematic Screening of Occupational Exposures in Malignant Hemopathies in the Rhone-Alpes Area: Prolymphome Study. 罗纳-阿尔卑斯地区恶性血液病职业暴露系统筛查评估:淋巴瘤前研究。
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-04-17 DOI: 10.23749/mdl.v116i2.16270
Olivia Pérol, Rejane Remion, Barbara Charbotel, Béatrice Fervers

Background: Several studies have highlighted the role of environmental exposures in malignant hemopathies etiology. Some patients with malignant hemopathies can be compensated as occupational diseases. The Prolymphome research aimed to assess a systematic screening of occupational exposures in patients with lymphoma or myeloma treated in three hospitals in the Rhône-Alpes region.

Methods: Patients received a self-administered questionnaire to fill in at home to collect their job history and potential occupational exposures to carcinogens. A physician assessed the questionnaire to determine if a dedicated consultation was required and the possibility of claiming compensation. Patients were systematically assisted by a social worker for administrative procedures.

Results: In 12 months, 754 patients were enrolled in the study, and 361 (48%) returned the questionnaire. A specialized consultation was proposed for 123 patients, and 98 patients attended the consultation. Overall, a compensation claim was proposed to 18 patients: 11 have been occupationally exposed to pesticides and seven to trichloroethylene.

Conclusions: Our results confirmed the feasibility of the systematic screening procedure. Barriers were observed at every step of the process, and it underlined that patients are rarely  nformed about occupational exposures. As the prevalence of occupational exposures in malignant hemopathies remains scarce, a systematic targeted screening could be relevant in this population.

背景:一些研究强调了环境暴露在恶性血液病病因学中的作用。部分恶性血液病患者可作为职业病进行补偿。prolymphoome研究旨在评估在Rhône-Alpes地区三家医院治疗的淋巴瘤或骨髓瘤患者的系统性职业暴露筛查。方法:患者在家自行填写工作经历和潜在致癌物暴露情况调查问卷。医生评估问卷,以确定是否需要专门的咨询和索赔的可能性。一名社会工作者系统地协助病人办理行政手续。结果:在12个月的时间里,754例患者入组研究,361例(48%)患者回复了问卷。123例患者提出专科会诊,98例患者参加会诊。总体而言,向18名患者提出了赔偿要求:11名患者因职业原因暴露于农药,7名患者暴露于三氯乙烯。结论:我们的结果证实了系统筛选程序的可行性。在过程的每一步都观察到障碍,并强调患者很少被告知职业暴露。由于恶性血液病职业暴露的患病率仍然很少,因此系统的靶向筛查可能与这一人群相关。
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引用次数: 0
Workplace Violence in Tertiary Hospitals: Unraveling Its Detrimental Effects on Healthcare Workers' Job Engagement. 三级医院工作场所暴力:揭示其对医护人员工作投入的不利影响。
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-04-17 DOI: 10.23749/mdl.v116i2.16271
Habip Balsak, Mehmet Özel

Background: Workplace (WPW) violence is a significant issue among healthcare workers (HCWs) in hospitals and negatively impacts the healthcare workforce. WPW can have more severe consequences, especially in tertiary hospitals with a concentrated, specialised workforce. In this regard, the study aimed to identify the dynamics of workplace violence exposure among HCWs in a tertiary hospital. It also investigated its impact on job engagement.

Methods: The study was designed as a descriptive cross-sectional study conducted between June and September 2023. The study involved 3,526 HCWs at a tertiary hospital in Turkey, all invited, with 390 participating. The study examined healthcare workers' ability to handle WPV. It also examined their exposure to violence, their perception of safety against violence at work, and their engagement in their jobs.

Results: Exposure to WPV among HCWs included in the study significantly predicts job engagement, with a negative relationship (β: -0.473). Additionally, as HCWs' skills in managing WPV increase, job engagement also increases (β: -0.279). Among younger and less experienced HCWs, WPV exposure and job engagement scores were significantly lower (p<0.05).

Conclusions: WPV, common among health workers, is an essential factor that reduces work engagement. Identifying and controlling the dynamics of WPV is critical to enhancing job engagement among healthcare workers and preventing related adverse outcomes.

背景:工作场所(WPW)暴力是医院医护人员(HCWs)中的一个重要问题,并对医护人员产生负面影响。WPW可能产生更严重的后果,特别是在拥有集中的专业工作人员的三级医院。在这方面,该研究旨在确定三级医院卫生保健员在工作场所遭受暴力的动态情况。它还调查了它对工作投入的影响。方法:本研究设计为描述性横断面研究,于2023年6月至9月进行。该研究涉及土耳其一家三级医院的3,526名卫生保健员,所有人都受到邀请,其中390人参与了研究。该研究检查了卫生保健工作者处理WPV的能力。调查还调查了他们遭受暴力的情况、他们对工作中不受暴力侵害的安全感以及他们对工作的投入程度。结果:参与研究的医护人员对工作投入有显著的预测作用,呈负相关(β: -0.473)。此外,随着医护人员管理WPV技能的提高,工作敬业度也会增加(β: -0.279)。在年轻和经验不足的卫生工作者中,WPV暴露和工作敬业度得分明显较低(结论:WPV在卫生工作者中很常见,是降低工作敬业度的重要因素。识别和控制WPV的动态对于提高卫生保健工作者的工作参与度和预防相关的不良后果至关重要。
{"title":"Workplace Violence in Tertiary Hospitals: Unraveling Its Detrimental Effects on Healthcare Workers' Job Engagement.","authors":"Habip Balsak, Mehmet Özel","doi":"10.23749/mdl.v116i2.16271","DOIUrl":"10.23749/mdl.v116i2.16271","url":null,"abstract":"<p><strong>Background: </strong>Workplace (WPW) violence is a significant issue among healthcare workers (HCWs) in hospitals and negatively impacts the healthcare workforce. WPW can have more severe consequences, especially in tertiary hospitals with a concentrated, specialised workforce. In this regard, the study aimed to identify the dynamics of workplace violence exposure among HCWs in a tertiary hospital. It also investigated its impact on job engagement.</p><p><strong>Methods: </strong>The study was designed as a descriptive cross-sectional study conducted between June and September 2023. The study involved 3,526 HCWs at a tertiary hospital in Turkey, all invited, with 390 participating. The study examined healthcare workers' ability to handle WPV. It also examined their exposure to violence, their perception of safety against violence at work, and their engagement in their jobs.</p><p><strong>Results: </strong>Exposure to WPV among HCWs included in the study significantly predicts job engagement, with a negative relationship (β: -0.473). Additionally, as HCWs' skills in managing WPV increase, job engagement also increases (β: -0.279). Among younger and less experienced HCWs, WPV exposure and job engagement scores were significantly lower (p<0.05).</p><p><strong>Conclusions: </strong>WPV, common among health workers, is an essential factor that reduces work engagement. Identifying and controlling the dynamics of WPV is critical to enhancing job engagement among healthcare workers and preventing related adverse outcomes.</p>","PeriodicalId":49833,"journal":{"name":"Medicina Del Lavoro","volume":"116 2","pages":"16271"},"PeriodicalIF":2.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the Impact of Asthma: A Cross-Sectional Study in Workers Undergoing Therapy. 评估哮喘的影响:接受治疗的工人的横断面研究。
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-04-17 DOI: 10.23749/mdl.v116i2.15786
Amira Omrane, Latifa Krayem, Imen Touil, Raja Romdhani, Yosra Brahem, Leila Boussoffara, Jalel Knani, Taoufik Khalfallah, Nadia Boudawara

Background: This study aimed to investigate the impact of asthma on work productivity among adults receiving asthma therapy.

Methods: A cross-sectional study involving 101 asthmatic patients treated at the Pulmonology Department of University Hospital in Mahdia (Tunisia) who had been employed for at least six months was conducted over the course of a year. Recruited patients were asked to complete a self-administered questionnaire that consisted of the Simplified Medication Adherence Questionnaire (SMAQ), the Work Productivity and Activity Impairment (WPAI), and the Pichot questionnaire.

Results: The study's participants had a sex ratio of 0.51 and a mean age of 44.1±13.2 years. Exposure to aerocontaminants was high among 64.4% of patients. The majority of the patients were treated with inhaled corticosteroids (ICS) and long-acting beta-agonists (LABA) (54.4%), and nearly half were classified as having moderate asthma. Our findings revealed significant challenges faced by these patients, with 62.4% experiencing poorly controlled or uncontrolled asthma. Additionally, 69.3% were non-adherent to treatment, and 71.3% reported worsening symptoms while at work. They worked an average of 38.3±16.4 hours per week. The impact of general health status on work productivity was measured at 3.3±2.5. Absenteeism and presenteeism rates were 4.2% and 33.1%, respectively, resulting in a productivity loss of 30.4%. Activity impairment was associated with factors such as gender, alcohol consumption, and uncontrolled asthma.

Conclusion: Addressing asthma control, working conditions, and mental health emerges as essential strategies to enhance workplace productivity. When evaluating the effectiveness of interventions among active asthmatic patients, presenteeism, absenteeism, and productivity loss should be considered.

背景:本研究旨在探讨哮喘对接受哮喘治疗的成人工作效率的影响。方法:一项横断面研究涉及101例在马赫迪亚(突尼斯)大学医院肺病科治疗的哮喘患者,这些患者在一年的时间里至少工作了6个月。招募的患者被要求完成一份自我管理的问卷,包括简化药物依从性问卷(SMAQ)、工作效率和活动障碍(WPAI)和Pichot问卷。结果:研究参与者的性别比例为0.51,平均年龄为44.1±13.2岁。64.4%的患者暴露于空气污染物中。大多数患者接受吸入皮质类固醇(ICS)和长效β激动剂(LABA)治疗(54.4%),近一半患者被归类为中度哮喘。我们的研究结果揭示了这些患者面临的重大挑战,62.4%的患者患有控制不良或未控制的哮喘。此外,69.3%的人对治疗没有依从性,71.3%的人报告在工作时症状恶化。他们平均每周工作38.3±16.4小时。一般健康状况对工作效率的影响为3.3±2.5。旷工率和出勤率分别为4.2%和33.1%,导致生产率损失30.4%。活动障碍与性别、饮酒和未控制的哮喘等因素有关。结论:解决哮喘控制、工作条件和心理健康问题是提高工作场所生产力的基本策略。在评估活动性哮喘患者干预措施的有效性时,应考虑出勤、旷工和生产力损失。
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引用次数: 0
Celebrating the Legacy of a Century of Scientific Research Published by La Medicina del Lavoro. 庆祝一个世纪的科学研究遗产由La Medicina del Lavoro出版。
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-21 DOI: 10.23749/mdl.v116i1.16774
Antonio Mutti
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引用次数: 0
Forward-Thinking: How a Century Ago Protecting Women and Children in the Workplace Laid the Groundwork for Gender Medicine and Decent Work. 前瞻性思考:一个世纪前在工作场所保护妇女和儿童如何为性别医学和体面工作奠定基础。
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-21 DOI: 10.23749/mdl.v116i1.16787
Michele Augusto Riva, Maria Emilia Paladino

Dr. Livia Lollini, a physician and an early pioneer in women's occupational health, authored a paper published as the lead article in the inaugural issue of La Medicina del Lavoro, which adopted its current title in 1925. Her work, La protezione della donna e del fanciullo sul lavoro (The Protection of Women and Children at Work), constitutes one of her contributions to labor protections for women and children in early 20th-century Italy. Born into a family distinguished by socialist and feminist ideals, she completed her medical education in 1913. Subsequently, she served as an assistant at the Clinica del Lavoro in Milan, where she addressed various issues related to occupational health. Drawing from international labor laws, Dr. Lollini critiqued the inadequate enforcement of existing legislation in Italy and emphasized the notable disparities in maternity protections. Her analysis highlighted the need to safeguard women's health at the workplace and called for systemic reforms, including implementing regular medical examinations, female labor inspectors, and industrial nursing services. Her work, grounded in gender-sensitive approaches to occupational health, continues to resonate with contemporary principles of gender medicine. Although substantial advancements in labor legislation have been realized, many of the challenges she addressed-such as child labor, maternity rights, and workplace safety-remain central to global discussions surrounding decent work and equitable labor practices.

Livia Lollini博士是一名医生,也是女性职业健康的早期先驱,她在《Lavoro医学》创刊号上发表了一篇论文,作为主要文章,该杂志于1925年采用了现在的标题。她的作品《保护工作中的妇女和儿童》(La protezione della donna e del fantasullo sul lavoro)是她对20世纪初意大利妇女和儿童劳动保护的贡献之一。她出生在一个以社会主义和女权主义理想著称的家庭,1913年完成了医学教育。随后,她在米兰的Lavoro诊所担任助理,处理与职业健康有关的各种问题。根据国际劳动法,洛里尼博士批评了意大利现有立法执行不力的问题,并强调了在保护产妇方面存在的显著差异。她的分析强调有必要保障妇女在工作场所的健康,并呼吁进行系统性改革,包括实施定期体检、女性劳动监察员和工业护理服务。她的工作基于对职业健康的性别敏感方法,继续与当代性别医学原则产生共鸣。尽管在劳工立法方面已经取得了实质性进展,但她提出的许多挑战——如童工、产妇权利和工作场所安全——仍然是围绕体面工作和平等劳动实践的全球讨论的核心。
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引用次数: 0
Occupational Diesel Exposure and Brain Tumors: A Systematic Review and Meta-Analysis. 职业性柴油机暴露与脑肿瘤:系统回顾与荟萃分析。
IF 2 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-21 DOI: 10.23749/mdl.v116i1.16357
Michele Sassano, Giulia Collatuzzo, Federica Teglia, Paolo Boffetta

Diesel exhaust (DE) is recognized as a carcinogen for the lungs, although evidence linking it to adult brain tumors is limited. We aimed to systematically review the evidence regarding the association between occupational DE exposure and adult brain and other central nervous system (CNS) tumors. A systematic literature review was conducted to identify cohort studies on occupational DE exposure and the risk of adult cancers other than lung cancer. We meta-analyzed relative risks (RRs) and 95% confidence intervals (CIs) for brain or CNS tumors using the DerSimonian and Laird random-effects model. Fourteen studies were included in the meta-analysis. The results showed no in-creased risk of brain or CNS tumors among workers exposed to DE (RR: 0.99; 95% CI: 0.91, 1.07). Findings were consistent when analyzing studies based on incidence (RR: 0.96; 95% CI: 0.90, 1.03; six studies) and mortality (RR: 1.09; 95% CI: 0.87, 1.37; nine studies) separately, as well as in subgroup analyses based on sex, publication year, geographic region, and study quality score. No evidence of publication bias was found (p=0.244). The findings of our meta-analysis suggest that occupational DE exposure is not associated with adult brain or CNS tumors. Given the limitations of the included studies, these results should be interpreted with caution.

柴油废气(DE)被认为是肺部的致癌物,尽管将其与成人脑瘤联系起来的证据有限。我们的目的是系统地回顾关于职业性DE暴露与成人脑部和其他中枢神经系统(CNS)肿瘤之间关系的证据。我们进行了一项系统的文献综述,以确定职业性DE暴露与肺癌以外的成人癌症风险的队列研究。我们使用DerSimonian和Laird随机效应模型对脑或中枢神经系统肿瘤的相对风险(RRs)和95%置信区间(CIs)进行meta分析。荟萃分析包括14项研究。结果显示,暴露于DE的工人患脑部或中枢神经系统肿瘤的风险没有增加(RR: 0.99;95% ci: 0.91, 1.07)。当分析基于发病率的研究时,结果是一致的(RR: 0.96;95% ci: 0.90, 1.03;6项研究)和死亡率(RR: 1.09;95% ci: 0.87, 1.37;9项研究),以及基于性别、出版年份、地理区域和研究质量评分的亚组分析。未发现发表偏倚的证据(p=0.244)。我们的荟萃分析结果表明,职业性DE暴露与成人脑部或中枢神经系统肿瘤无关。考虑到纳入研究的局限性,这些结果应谨慎解释。
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引用次数: 0
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Medicina Del Lavoro
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