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Managing Allergic Nickel Dermatitis in Occupational Settings: A Case Report. 处理职业环境中的过敏性镍皮炎:病例报告。
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-21 DOI: 10.23749/mdl.v115i3.15931
Rui André Mendes Ribeiro, Vanessa Teófilo, Salomé Moreira, Paulo Pinho, Pedro Norton, Teresa Pereira

Contact dermatitis is a common cutaneous inflammatory condition, triggered by exposure to irritant substances or allergens. Nickel is the most prevalent allergen, a metal widely used in accessories, furniture, office materials, food and in industry, with multiple exposure pathways, making it difficult to assess which exposure is causing allergic dermatitis. Here, we report a case of an administrative worker with chronic hand eczema, limited to the radial metacarpophalangeal region of the left hand, caused by occupational exposure to nickel, confirmed by nickel deposition test on the hand and a positive test with a metallic stapler used at her workplace.

接触性皮炎是一种常见的皮肤炎症,由接触刺激性物质或过敏原引发。镍是最常见的过敏原,它是一种广泛用于饰品、家具、办公材料、食品和工业的金属,有多种接触途径,因此很难评估哪种接触会导致过敏性皮炎。在此,我们报告了一例因职业性接触镍而导致慢性手部湿疹的行政工作者,该湿疹局限于左手的桡侧掌指关节区域,经手部镍沉积测试和工作场所使用的金属订书机测试呈阳性证实。
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引用次数: 0
Benzene Exposure in Workers From a Waste Oil Regeneration Plant During Ordinary Activities by Air and Biological Monitoring. 通过空气和生物监测,了解废油再生厂工人在日常活动中的苯暴露情况。
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-21 DOI: 10.23749/mdl.v115i3.15863
Laura Campo, Luca Boniardi, Luca Olgiati, Elisa Polledri, Rosa Mercadante, Silvia Fustinoni

Background: In the regeneration of waste oil, a strategical technological process for the European Union circular economy action plan, exhausted oils are regenerated to produce high performing oil bases. Aim of this work was to assess the exposure to benzene in plant workers during ordinary activities.

Methods: 59 workers, potentially exposed to benzene, and 9 administrative workers from an Italian plant were monitored for the whole work shift with personal air samplers; urinary benzene (BEN-U) and S-phenyl mercapturic acid (SPMA) were measured by mass spectrometry methods in end-shift urine samples. Different job tasks were identified among workers.

Results: Median (minimum-maximum) airborne exposures to benzene were <0.9 (<0.9-6.3) and <0.9 (<0.9-0.9) µg/m3, BEN-U and SPMA levels were 0.094 (<0.015-3.095) µg/L and 0.15 (<0.10-9.67) µg/g crt and 0.086 (0.034-0.712) µg/L and <0.10 (<0.10-3.19) µg/g creatinine in workers and administrative workers, respectively. No differences were found among job tasks and between workers and administrative workers, while higher levels were found in smokers than in non-smokers. For all job tasks, the exposure to benzene was always below occupational limit values.

Conclusions: This study has investigated for the first time the exposure to benzene of workers employed in the re-refining of exhaust oil. The results showed that normal production activities in regenerating used oils do not pose a risk of exposure to benzene in workers.

背景:废油再生是欧盟循环经济行动计划的一项战略性技术工艺,在废油再生过程中,废油被再生为高性能油基。方法:使用个人空气采样器对意大利一家工厂的 59 名可能接触苯的工人和 9 名行政人员进行全班监测;通过质谱法测量班末尿样中的尿苯(BEN-U)和 S-苯基巯基酸(SPMA)。在工人中确定了不同的工作任务:结果:空气中苯暴露量的中位数(最小值-最大值)为 0:这项研究首次调查了废油再提炼工人的苯接触情况。结果表明,废油再生的正常生产活动不会对工人造成接触苯的风险。
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引用次数: 0
Comparing Exposure to Psychosocial Risks: Face-to-Face Work vs. Telework. 社会心理风险暴露比较:面对面工作与远程工作。
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-21 DOI: 10.23749/mdl.v115i3.15265
Angela Gomez-Dominguez, Pedro Ferrer-Rosende, Laura Esteve-Matali, Clara Llorens-Serrano, Sergio Salas-Nicás, Albert Navarro-Giné

Background: In recent years, substantial changes have occurred in the work organization and arrangements. One of the main ones has been the popularization of teleworking among non-manual workers. This paper aims to assess the exposure of psychosocial risks among non-manual Spanish wage-earners, depending on the working modality (mainly telework, combining teleworking with onsite work, or onsite work).

Methods: Based on an online survey conducted between April and May 2021, a cross-sectional study was carried out among n=11,519 members of a trade union where Psychosocial Risks (PSR) were measured through COPSOQ Questionnaire Scales. All analyses were performed stratifying by sex.

Results: Women who combine telework and face-to-face work (aPR: 1.21; 95%CI 1.07-1.37) and men who mainly telework (aPR: 1.26; 95%CI 1.11-1.43) and that combine (aPR: 1.27; 95%CI 1.11-1.45) are more exposed to quantitative demands than men and women who do not telework. On the other hand, women who telework, either entirely (aPR: 0.89; 95%CI 0.82-0.97) or combining (aPR: 0.89; 95%CI 0.81-0.98), are less exposed to emotional demands than women who do not telework, and the same occurs among men who mainly telework (aPR: 0.84; 95%CI 0.76-0.92). Telework and horizontal or vertical social support are not associated, except for supervisor support among males, nor with work-life conflict.

Conclusions: Except for quantitative demands, employees who combine telework and face-to-face work are less exposed to psychosocial risks than those who mainly telework or work face-to-face only. More studies with a gender and class perspective are needed in this area.

背景:近年来,工作组织和安排发生了巨大变化。其中一个主要变化就是远程工作在非体力劳动者中的普及。本文旨在评估西班牙非体力劳动者因工作方式(主要是远程工作、远程工作与现场工作相结合或现场工作)不同而面临的社会心理风险:基于 2021 年 4 月至 5 月间进行的在线调查,对 11 519 名工会会员进行了横断面研究,通过 COPSOQ 问卷量表测量了社会心理风险(PSR)。所有分析均按性别进行分层:结果:与不从事远程工作的男性和女性相比,同时从事远程工作和面对面工作的女性(aPR:1.21;95%CI:1.07-1.37)和主要从事远程工作的男性(aPR:1.26;95%CI:1.11-1.43)以及同时从事远程工作和面对面工作的男性(aPR:1.27;95%CI:1.11-1.45)更容易受到量化需求的影响。另一方面,完全远程工作(aPR:0.89;95%CI 0.82-0.97)或合并远程工作(aPR:0.89;95%CI 0.81-0.98)的女性比不进行远程工作的女性面临的情感需求更少,同样的情况也出现在主要进行远程工作的男性中(aPR:0.84;95%CI 0.76-0.92)。远程办公与横向或纵向的社会支持(男性的上司支持除外)以及工作与生活的冲突没有关联:结论:除数量要求外,远程工作与面对面工作相结合的员工所面临的社会心理风险低于那些主要从事远程工作或仅从事面对面工作的员工。在这一领域,需要从性别和阶级的角度进行更多的研究。
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引用次数: 0
Occupational Physicians' Management of Workers With Multiple Sclerosis in Italy: Results From a Survey. 意大利职业医师对多发性硬化症患者的管理:调查结果
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-21 DOI: 10.23749/mdl.v115i3.16038
Bruna Maria Rondinone, Giuliana Buresti, Sergio Iavicoli, Paolo Durando, Mario Alberto Battaglia, Guglielmo Dini, Alfredo Montecucco, Alborz Rahmani, Nicoletta Debarbieri, Paolo Bandiera, Michela Ponzio, Tommaso Manacorda, Elena Pignattelli, Matilde Inglese, Benedetta Persechino

Background: This study, conducted on a sample of Italian occupational physicians (OPs), aimed to gather data regarding professional activity and their needs in managing workers with multiple sclerosis.

Methods: A convenience sample of OPs recruited by e-mail invitation to the list of Italian Society of Occupational Medicine members was considered. A total of 220 OPs participated between July and October 2022. An ad hoc questionnaire was developed based on previous survey experiences. It investigated, among others, the characteristics of OP respondents, the evaluation of fitness for work issues, and the OP training and updating needs on multiple sclerosis and work.

Results: Ninety-one percent of OPs had to assess the fitness for work of workers with multiple sclerosis during their activity. Sixty-four percent experienced particular difficulties in issuing a fitness for work judgment. Regarding the level of knowledge on multiple sclerosis, 54% judged it sufficient. The "Assessment of fitness for work for the specific task" and the "Role of the OPs in identifying reasonable accommodations" were the most interesting training topics regarding MS management in work contexts chosen by the respondents.

Conclusions: The interest in the work inclusion and job retention of people with disability, particularly the aspects linked to the Identification and implementation of reasonable accommodations, will require integration with the occupational safety and health protection system and will undoubtedly impact the OP's activities.

研究背景本研究以意大利职业医师(OPs)为样本,旨在收集有关多发性硬化症患者管理方面的职业活动及其需求的数据:方法:通过电子邮件邀请意大利职业医学会会员名单中的职业医师进行抽样调查。2022年7月至10月期间,共有220名职业医师参与。根据以往的调查经验制定了一份特别问卷。除其他外,问卷还调查了多发性硬化症患者的特征、工作适应性评估、多发性硬化症和工作方面的培训和更新需求:结果:91%的手术医生在工作中需要评估多发性硬化症患者的工作适应性。64%的操作员在做出是否适合工作的判断时遇到了特殊困难。关于多发性硬化症的知识水平,54% 的人认为足够。受访者最感兴趣的培训主题是 "特定任务的工作适应性评估 "和 "操作人员在确定合理便利措施中的作用":结论:对残疾人工作融入和工作保留的关注,特别是与合理便利措施的确定和实施相关的方面,需要与职业安全和健康保护系统相结合,这无疑会对业务官员的活动产生影响。
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引用次数: 0
Job Retention by People With Disabilities: A Qualitative Study of the Perspectives of People With Multiple Sclerosis. 残疾人保留工作:多发性硬化症患者视角的定性研究》。
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-21 DOI: 10.23749/mdl.v115i3.15947
Michela Ponzio, Elena Pignattelli, Anna Verri, Erica Grange, Benedetta Persechino, Bruno Kusznir Vitturi, Paolo Bandiera, Tommaso Manacorda, Matilde Inglese, Paolo Durando, Mario Alberto Battaglia

Background: Multiple sclerosis (MS), because of its early age at onset, greatly impacts the working lives of those affected by it in ways linked to different factors, both professional and personal. It has been observed that only a small percentage (20-40%) of workers with MS retain their jobs after the diagnosis. When identifying factors determining job retention or loss in this setting, it is essential to consider the direct perspectives of people with MS (PwMS).

Methods: A qualitative study, based on the conduction of two focus groups, was conducted to explore the personal experiences of PwMS who work.

Results: The results show that there are numerous factors, both positive and negative, that can influence these people's ability to retain their jobs. The climate established in the workplace and the relationship between workers with MS and their colleagues were fundamentally important aspects, as was knowledge of the disease at the level of public opinion.

Conclusions: Managing work is a complex undertaking for people with a disabling condition like MS. There needs to be greater awareness of the employment rights of PwMS. Improving these knowledge-based aspects could undoubtedly improve the quality of the working lives of PwM.

背景:多发性硬化症(MS)由于发病年龄较早,对患者的工作生活造成了很大影响,这些影响与不同的因素有关,既有职业因素,也有个人因素。据观察,只有一小部分(20%-40%)多发性硬化症患者在确诊后能够保住工作。在确定这种情况下决定保留或失去工作的因素时,必须考虑多发性硬化症患者(PwMS)的直接观点:方法:在开展两个焦点小组的基础上,进行了一项定性研究,以探讨工作中的多发性硬化症患者的个人经历:结果:研究结果表明,有许多积极和消极的因素会影响这些人保住工作的能力。工作场所的氛围以及多发性硬化症患者与同事之间的关系是最重要的因素,公众舆论对该疾病的了解也是如此:对于像多发性硬化症这样的致残性疾病患者来说,工作管理是一项复杂的工作。需要提高对多发性硬化症患者就业权利的认识。改善这些基于知识的方面无疑可以提高 PwM 的工作生活质量。
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引用次数: 0
The Digital Economy and Hybrid Work Call for a Review of Compensation Criteria for Musculoskeletal Disorders. 数字经济和混合型工作要求对肌肉骨骼疾病的赔偿标准进行审查。
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-21 DOI: 10.23749/mdl.v115i3.16072
Yves Roquelaure, Julie Bodin, Florence Cros, Alexis Descatha, Marc Fadel

Work-related musculoskeletal disorders (WRMSD) pose a significant occupational health challenge in Europe. The digitization of the economy substantially reshaped the nature and organization of work. The proliferation of hybrid working, characterized by a combination of office-based and remote work, has been accelerated by the COVID-19 pandemic. This review covers hybrid forms of work, their impact on WRMSDs, and the potential implications for WRMSD compensation. Approximately 30-40% of the European workforce could potentially transition to hybrid forms of work. Hybrid work arrangements can result in prolonged static postures of the trunk, neck, and upper limbs without adequate breaks, thereby increasing the risk of neck and lower back pain. As teleworking and hybrid working become more prevalent, an increase in non-specific WRMSDs is anticipated among the working population. In many countries, claims for WRMSDs necessitate a formal diagnosis by a healthcare professional. However, cases of non-specific WRMSDs, such as cervicalgia or chronic shoulder pain, - commonly observed in sedentary workers engaged in predominantly low-intensity, prolonged static work amid visually and cognitively demanding tasks - often do not meet the criteria for compensation as occupational diseases. The compensation system and/or the criteria for compensation must be adapted to accommodate the rise of telework, necessitating evolving criteria for compensation that address both medical and risk exposure considerations.

在欧洲,与工作相关的肌肉骨骼疾病(WRMSD)对职业健康构成了重大挑战。经济的数字化极大地改变了工作的性质和组织形式。COVID-19大流行加速了以办公室工作和远程工作相结合为特征的混合工作方式的普及。本综述涉及混合工作形式、其对 WRMSD 的影响以及对 WRMSD 补偿的潜在影响。大约 30-40% 的欧洲劳动力有可能过渡到混合工作形式。混合工作安排会导致躯干、颈部和上肢长时间处于静态姿势,没有适当的休息时间,从而增加颈部和下背部疼痛的风险。随着远程工作和混合工作越来越普遍,预计工作人群中的非特异性 WRMSD 会增加。在许多国家,WRMSD 的索赔必须由医疗保健专业人员进行正式诊断。然而,非特异性 WRMSDs(如颈椎痛或慢性肩痛)--通常见于主要从事低强度、长时间静态工作的久坐工人,以及视觉和认知要求较高的任务--往往不符合职业病赔偿标准。必须对补偿制度和/或补偿标准进行调整,以适应远程工作的兴起,这就需要不断发展补偿标准,既要考虑医疗因素,又要考虑风险暴露因素。
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引用次数: 0
Artificial Intelligence and Occupational Health and Safety, Benefits and Drawbacks. 人工智能与职业健康和安全,利与弊。
IF 2.7 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-04-24 DOI: 10.23749/mdl.v115i2.15835
Mohamed El-Helaly

This paper discusses the impact of artificial intelligence (AI) on occupational health and safety. Although the integration of AI into the field of occupational health and safety is still in its early stages, it has numerous applications in the workplace. Some of these applications offer numerous benefits for the health and safety of workers, such as continuous monitoring of workers' health and safety and the workplace environment through wearable devices and sensors. However, AI might have negative impacts in the workplace, such as ethical worries and data privacy concerns. To maximize the benefits and minimize the drawbacks of AI in the workplace, certain measures should be applied, such as training for both employers and employees and setting policies and guidelines regulating the integration of AI in the workplace.

本文讨论了人工智能(AI)对职业健康与安全的影响。虽然人工智能与职业健康和安全领域的结合仍处于早期阶段,但它在工作场所有许多应用。其中一些应用为工人的健康和安全带来了诸多益处,例如通过可穿戴设备和传感器对工人的健康和安全以及工作场所环境进行持续监测。然而,人工智能可能会给工作场所带来负面影响,如道德担忧和数据隐私问题。为了最大限度地发挥人工智能在工作场所的益处,减少其弊端,应采取一些措施,如对雇主和雇员进行培训,制定政策和指导方针,规范人工智能在工作场所的应用。
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引用次数: 0
Exposure Assessment and Monitoring of Antiblastic Drugs Preparation in Health Care Settings: A Systematic Review. 医疗机构中抗原药物配制的暴露评估和监测:系统回顾
IF 2.4 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-04-24 DOI: 10.23749/mdl.v115i2.15609
Francesca Borghi, Carolina Zellino, Arianna Zago, Giovanni De Vito, Rocco Loris Del Vecchio, Andrea Cattaneo, Andrea Spinazzè, Domenico Maria Cavallo

Several antiblastic drugs (ADs) are classified as carcinogenic, mutagenic, and/or toxic for reproduction. Despite established guidelines and safe handling technologies, ADs contamination of the work environments could occur in healthcare settings, leading to potential exposure of healthcare staff. This systematic review aims to investigate the main techniques and practices for assessing ADs occupational exposure in healthcare settings. The reviewed studies unveil that workplace contamination by ADs appears to be a still-topical problem in healthcare settings. These issues are linked to difficulties in guaranteeing: (i) the adherence to standardized protocols when dealing with ADs, (ii) the effective use of personal protective equipment by operators involved in the administration or management of ADs, (iii) a comprehensive training of the healthcare personnel, and (iv) a thorough health surveillance of exposed workers. A "multi-parametric" approach emerges as a desirable strategy for exposure assessment. In parallel, exposure assessment should coincide with the introduction of novel technologies aimed at minimizing exposure (i.e., risk management). Assessment must consider various departments and health operators susceptible to ADs contamination, with a focus extended beyond worst-case scenarios, also considering activities like surface cleaning and logistical tasks related to ADs management. A comprehensive approach in ADs risk assessment enables the evaluation of distinct substance behaviors and subsequent exposure routes, affording a more holistic understanding of potential risks.

有几种抗肿瘤药物(ADs)被归类为致癌、诱变和/或生殖毒性药物。尽管有既定的指导原则和安全处理技术,但在医疗机构中仍可能发生工作环境中的ADs污染,从而导致医护人员的潜在暴露。本系统综述旨在调查医疗机构中评估反式脂肪酸职业暴露的主要技术和实践。综述的研究结果表明,在医疗机构中,工作场所的反式脂肪酸污染似乎仍然是一个棘手的问题。这些问题与难以保证以下几点有关:(i) 在处理反式脂肪酸时遵守标准化规程,(ii) 参与反式脂肪酸管理的操作人员有效使用个人防护设备,(iii) 对医护人员进行全面培训,以及 (iv) 对暴露于反式脂肪酸的工作人员进行全面的健康监测。"多参数 "方法是暴露评估的理想策略。与此同时,暴露评估应与旨在尽量减少暴露的新技术(即风险管理)的引进同步进行。评估必须考虑易受反式脂肪酸污染的各个部门和卫生操作人员,重点不仅放在最坏情况下,还要考虑与反式脂肪酸管理相关的表面清洁和后勤任务等活动。采用综合方法进行反式脂肪酸风险评估,可对不同的物质行为和随后的接触途径进行评估,从而更全面地了解潜在风险。
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引用次数: 0
Occupational Risk for Coronary Artery Disease in Shift Workers - A Systematic Review. 轮班工人患冠状动脉疾病的职业风险--系统回顾。
IF 2.7 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-04-24 DOI: 10.23749/mdl.v115i2.15532
Gabriele D'Ettorre, Prisco Piscitelli, Vincenza Pellicani, Roberta Tornese, Giancarlo Ceccarelli, Gabriella D'Ettorre, Giuseppe La Torre

Background: Coronary artery disease (CAD) prevention in shift workers (SWs) poses a significant challenge worldwide, as CAD remains a major cause of mortality and disability. In the past, SWs were found at higher risk of CAD than non-s SWs. Nevertheless, the pathogenic mechanism between shift work and CAD to date is unclear. This systematic review aims to enhance understanding of the risk of CAD occurrence in SWs.

Methods: A systematic literature review was conducted from January 2013 to December 2023. MEDLINE/Pubmed databases were used initially, and additional relevant studies were searched from references. Shift work was defined as any schedule outside traditional shifts, including the night shift.

Results: Fifteen pertinent papers were categorized into risk assessment or risk management. Findings demonstrated an increased risk of CAD among SWs compared to non-SWs, with an increased CAD risk observed for both shift work and night shift work.

Discussion: Duration-response associations indicate that greater shift exposure is linked to higher CAD risk. SWs incur an increased risk of CAD through the atherosclerotic process. As shift work duration increases as the risk of atherosclerosis is higher, workers demonstrate a higher prevalence and severity of coronary artery plaques.

Conclusions: The evidence-based results underscore the increased risk of CAD in SWs and are sufficient for proposing guidelines aimed at reducing the risk of CAD in SWs and at managing people with CAD in return to work characterized by disrupted circadian rhythms.

背景:轮班工人(SWs)的冠状动脉疾病(CAD)预防是全球面临的一项重大挑战,因为 CAD 仍然是导致死亡和残疾的主要原因。过去,人们发现轮班工人比非轮班工人患 CAD 的风险更高。然而,轮班工作与 CAD 之间的致病机制至今仍不清楚。本系统性综述旨在加深对社工发生 CAD 风险的了解:方法:对 2013 年 1 月至 2023 年 12 月期间的文献进行了系统性回顾。首先使用 MEDLINE/Pubmed 数据库,然后从参考文献中搜索其他相关研究。轮班工作定义为传统轮班以外的任何时间安排,包括夜班:15篇相关论文分为风险评估和风险管理两类。研究结果表明,与非轮班工作者相比,轮班工作者患 CAD 的风险更高,轮班工作和夜班工作都会增加患 CAD 的风险:讨论:持续时间-反应关联表明,轮班工作时间越长,患 CAD 的风险越高。轮班工作者通过动脉粥样硬化过程增加了患 CAD 的风险。随着轮班工作时间的延长,动脉粥样硬化的风险越高,工人冠状动脉斑块的发病率和严重程度也越高:以证据为基础的研究结果表明,轮班工人罹患冠状动脉粥样硬化症的风险增加,足以提出旨在降低轮班工人罹患冠状动脉粥样硬化症风险的指导原则,以及在昼夜节律紊乱的情况下管理重返工作岗位的冠状动脉粥样硬化症患者。
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引用次数: 0
Risk of Skin Cancer in Workers Exposed to Diesel Exhaust: A Systematic Review and Meta-Analysis of Cohort Studies. 接触柴油机废气的工人患皮肤癌的风险:对队列研究的系统回顾和荟萃分析》。
IF 2.7 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-04-24 DOI: 10.23749/mdl.v115i2.15569
Marika D'Agostini, Giulia Collatuzzo, Federica Teglia, Paolo Boffetta

Background: Our objective was to study the association between occupational exposure to diesel exhaust (DE) and skin cancer.

Methods: A systematic review following STROBE guidelines and PECOS criteria was conducted to identify cohort studies describing the association between occupational DE exposure and the risk of skin cancer. We extracted 12 independent risk estimates for melanoma skin cancer (MSC), 8 for non-melanoma skin cancer (NMSC), and 3 for skin cancer not otherwise specified (SC-NOS). Random effects meta-analyses were performed, site-specific and stratified by geographic region and quality score. 95% confidence intervals (CI) were reported. Between-study heterogeneity and potential publication bias were investigated.

Results: There was no overall evidence of an increased risk of MSC [RR=0.90, 95% CI: 0.73-1.11; I2=92.86%, 95% CI: 82.83-97.03%], NMSC [RR=1.04, 95% CI: 0.88-1.23; I2=60.79%, 95% CI: 0-87.34%] or SC-NOS [RR=0.72, 95% CI: 0.54-0.97; I2=26.60%, 95% CI: 0-94.87%] in workers exposed to DE. No difference between low-quality and high-quality studies was found. A stratified analysis by geographical region did not reveal any significant differences. There was no evidence of publication bias.

Conclusions: No evidence of an association between skin cancer and occupational DE exposure was found. Residual confounding and other sources of bias cannot be ruled out.

背景:我们的目的是研究职业暴露于柴油废气(DE)与皮肤癌之间的关系:我们的目标是研究职业暴露于柴油废气(DE)与皮肤癌之间的关系:我们按照 STROBE 指南和 PECOS 标准进行了系统回顾,以确定描述职业性柴油机废气暴露与皮肤癌风险之间关系的队列研究。我们提取了 12 项黑色素瘤皮肤癌 (MSC) 的独立风险估计值、8 项非黑色素瘤皮肤癌 (NMSC) 的独立风险估计值和 3 项非特定皮肤癌 (SC-NOS) 的独立风险估计值。进行了随机效应荟萃分析,针对特定部位,并按地理区域和质量评分进行了分层。报告了 95% 的置信区间 (CI)。对研究之间的异质性和潜在的出版偏差进行了调查:没有总体证据表明暴露于 DE 的工人患 MSC [RR=0.90,95% CI:0.73-1.11;I2=92.86%,95% CI:82.83-97.03%]、NMSC [RR=1.04,95% CI:0.88-1.23;I2=60.79%,95% CI:0-87.34%] 或 SC-NOS [RR=0.72,95% CI:0.54-0.97;I2=26.60%,95% CI:0-94.87%]的风险增加。低质量研究与高质量研究之间没有差异。按地理区域进行的分层分析未发现任何显著差异。没有证据表明存在发表偏倚:没有证据表明皮肤癌与职业性 DE 暴露有关。不能排除残余混杂因素和其他偏倚来源。
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引用次数: 0
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Medicina Del Lavoro
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