Pub Date : 2024-01-01DOI: 10.33545/26646862.2024.v6.i1a.41
Shwetha Sr, Paul Richards M, Suchitra D
{"title":"Analytical method for simultaneous estimation of metformin and Dapagliflozin by RP HPLC method","authors":"Shwetha Sr, Paul Richards M, Suchitra D","doi":"10.33545/26646862.2024.v6.i1a.41","DOIUrl":"https://doi.org/10.33545/26646862.2024.v6.i1a.41","url":null,"abstract":"","PeriodicalId":499224,"journal":{"name":"International Journal of Pharmaceutical Research and Development","volume":"31 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140519795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.33545/26646862.2024.v6.i1a.38
Vedant A Chaudhari, Nikita R Dhumal, Prajwal V Chavhan, Sujata G Dhanake, Amit R Jadhav, Sagar A Sarode, Parag R Patil
{"title":"Overview of novel transdermal drug delivery system","authors":"Vedant A Chaudhari, Nikita R Dhumal, Prajwal V Chavhan, Sujata G Dhanake, Amit R Jadhav, Sagar A Sarode, Parag R Patil","doi":"10.33545/26646862.2024.v6.i1a.38","DOIUrl":"https://doi.org/10.33545/26646862.2024.v6.i1a.38","url":null,"abstract":"","PeriodicalId":499224,"journal":{"name":"International Journal of Pharmaceutical Research and Development","volume":"37 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140522131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.33545/26646862.2024.v6.i1a.42
Arun Kumar Sah, Paul Richards M, BA Vishwanath
{"title":"Stability indicating method development and validation for the determination of piperaquine tetraphosphate and dihydro artemisinin by RP HPLC","authors":"Arun Kumar Sah, Paul Richards M, BA Vishwanath","doi":"10.33545/26646862.2024.v6.i1a.42","DOIUrl":"https://doi.org/10.33545/26646862.2024.v6.i1a.42","url":null,"abstract":"","PeriodicalId":499224,"journal":{"name":"International Journal of Pharmaceutical Research and Development","volume":"19 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140518495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.33545/26646862.2024.v6.i1a.43
Pradip Kumar Yadav, Paul Richards M, BA Vishwanath
{"title":"Analytical method for determination of Lenvatinib in pharmaceutical and bulk dosage form by using RP-HPLC Method","authors":"Pradip Kumar Yadav, Paul Richards M, BA Vishwanath","doi":"10.33545/26646862.2024.v6.i1a.43","DOIUrl":"https://doi.org/10.33545/26646862.2024.v6.i1a.43","url":null,"abstract":"","PeriodicalId":499224,"journal":{"name":"International Journal of Pharmaceutical Research and Development","volume":"28 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140516841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.33545/26646862.2024.v6.i1a.39
Aarti Chandra, Bhagyashree Agrawal, Dheeraj Kumar Ahirwar, Leena Yadav
{"title":"Anti-gram-positive and anti-gram-negative pathogen-killing potential of some novel Quinoxaline compounds","authors":"Aarti Chandra, Bhagyashree Agrawal, Dheeraj Kumar Ahirwar, Leena Yadav","doi":"10.33545/26646862.2024.v6.i1a.39","DOIUrl":"https://doi.org/10.33545/26646862.2024.v6.i1a.39","url":null,"abstract":"","PeriodicalId":499224,"journal":{"name":"International Journal of Pharmaceutical Research and Development","volume":"32 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140527104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.33545/26646862.2024.v6.i1a.40
Aarti Chandra, Bhagyashree Agrawal, Dheeraj Kumar Ahirwar, Leena Yadav
{"title":"Quinoxaline: Synthetic and pharmacological perspectives","authors":"Aarti Chandra, Bhagyashree Agrawal, Dheeraj Kumar Ahirwar, Leena Yadav","doi":"10.33545/26646862.2024.v6.i1a.40","DOIUrl":"https://doi.org/10.33545/26646862.2024.v6.i1a.40","url":null,"abstract":"","PeriodicalId":499224,"journal":{"name":"International Journal of Pharmaceutical Research and Development","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140520342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human hair exhibits additional capabilities since it is associated with aesthetic, cultural, sexual, and attractiveness characteristics in addition to its protective role. Although not a critical organ, hair has a significant impact on appearance and is a sign of health, youth, and strength. Alopecia patients have hair loss on their heads as well as occasionally other parts of their bodies. The chronically inflammatory disorder harms the hair follicles. Although it can result in skin irritation and physical problems owing to the loss of eyelashes and eyebrows, it is neither painful nor life-threatening. The actual cause and subsequent course of the development of alopecia, an autoimmune disease brought on by a synthesis of inherited and environmental variables, are unknown. In India, over 150 million people under the age of 20 suffer from hair loss, which translates to 9 out of 10 Indians experiencing hereditary hair loss at some point in their life. Every day, between 100 and 150 hair strands fall out, which is entirely natural and of no consequence. A number of causes, including ageing, pollution, and extreme stress, can hasten hair loss and, in some circumstances, result in severe hair loss. Temporary hair loss can also be a side effect of menopause or pregnancy. In Indians, men were more likely than women to develop alopecia areata, and 88% of those under the age of 40 were affected. While men or boys with earlier onset of severe alopecia were more likely to have it, women or girls with childhood onset were more likely to have it. In this review paper, we discuss alopecia, its pathophysiology, nanotechnology-based drug delivery systems, and quality of life issues related to alopecia.
{"title":"A Precis of the alopecia (Hair loss) associated with therapies based on nanotechnology and its impact on quality of Life (QoL)","authors":"Yash Srivastav, Akhandnath Prajapati, Jaya Singh, Rajdeep Gupta, Madhaw Kumar","doi":"10.33545/26646862.2023.v5.i2a.33","DOIUrl":"https://doi.org/10.33545/26646862.2023.v5.i2a.33","url":null,"abstract":"Human hair exhibits additional capabilities since it is associated with aesthetic, cultural, sexual, and attractiveness characteristics in addition to its protective role. Although not a critical organ, hair has a significant impact on appearance and is a sign of health, youth, and strength. Alopecia patients have hair loss on their heads as well as occasionally other parts of their bodies. The chronically inflammatory disorder harms the hair follicles. Although it can result in skin irritation and physical problems owing to the loss of eyelashes and eyebrows, it is neither painful nor life-threatening. The actual cause and subsequent course of the development of alopecia, an autoimmune disease brought on by a synthesis of inherited and environmental variables, are unknown. In India, over 150 million people under the age of 20 suffer from hair loss, which translates to 9 out of 10 Indians experiencing hereditary hair loss at some point in their life. Every day, between 100 and 150 hair strands fall out, which is entirely natural and of no consequence. A number of causes, including ageing, pollution, and extreme stress, can hasten hair loss and, in some circumstances, result in severe hair loss. Temporary hair loss can also be a side effect of menopause or pregnancy. In Indians, men were more likely than women to develop alopecia areata, and 88% of those under the age of 40 were affected. While men or boys with earlier onset of severe alopecia were more likely to have it, women or girls with childhood onset were more likely to have it. In this review paper, we discuss alopecia, its pathophysiology, nanotechnology-based drug delivery systems, and quality of life issues related to alopecia.","PeriodicalId":499224,"journal":{"name":"International Journal of Pharmaceutical Research and Development","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135446015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.33545/26646862.2023.v5.i1a.32
Gloria Timipre Okou Owonaro, A Peter Eniojukan, F Joshua, Timipre F Okou
The use of drugs by the majority of Nigerian athletes to improve their performance for personal gain and to relieve discomfort is alarmingly on the rise. This study was conducted to examine the knowledge and attitudes toward doping among Nigerian athletes. At the national camps for wrestling, weightlifting, and athletics held in preparation for the 2019 12th African Games in Morocco, information on demographics, knowledge, and attitudes of usage of performance-enhancing drugs was gathered through the administration of a well-structured questionnaire. 122 respondents were selected using a stratified sample procedure. The study's data were analyzed using SPSS to produce ANOVA and t-test procedures. Findings revealed that the knowledge of athletes in the studied population about performance-enhancing drugs was inadequate. According to the participant's attitude towards doping, the findings revealed a grand mean of 2.68 (SD=1.37) which indicated a negative attitude towards performance-enhancing drugs in sports. Furthermore, the study findings revealed that there was an association between age group and doping knowledge, but no correlation between knowledge and gender. To ensure the reduction in the use of drugs to enhance performance in sports, it was recommended that intentional efforts should be made by the stakeholders to design a doping awareness campaign to educate athletes on the dangers of doping with a guarantee that such a campaign is efficiently implemented.
{"title":"Correlates of doping among athletes in Nigeria","authors":"Gloria Timipre Okou Owonaro, A Peter Eniojukan, F Joshua, Timipre F Okou","doi":"10.33545/26646862.2023.v5.i1a.32","DOIUrl":"https://doi.org/10.33545/26646862.2023.v5.i1a.32","url":null,"abstract":"The use of drugs by the majority of Nigerian athletes to improve their performance for personal gain and to relieve discomfort is alarmingly on the rise. This study was conducted to examine the knowledge and attitudes toward doping among Nigerian athletes. At the national camps for wrestling, weightlifting, and athletics held in preparation for the 2019 12th African Games in Morocco, information on demographics, knowledge, and attitudes of usage of performance-enhancing drugs was gathered through the administration of a well-structured questionnaire. 122 respondents were selected using a stratified sample procedure. The study's data were analyzed using SPSS to produce ANOVA and t-test procedures. Findings revealed that the knowledge of athletes in the studied population about performance-enhancing drugs was inadequate. According to the participant's attitude towards doping, the findings revealed a grand mean of 2.68 (SD=1.37) which indicated a negative attitude towards performance-enhancing drugs in sports. Furthermore, the study findings revealed that there was an association between age group and doping knowledge, but no correlation between knowledge and gender. To ensure the reduction in the use of drugs to enhance performance in sports, it was recommended that intentional efforts should be made by the stakeholders to design a doping awareness campaign to educate athletes on the dangers of doping with a guarantee that such a campaign is efficiently implemented.","PeriodicalId":499224,"journal":{"name":"International Journal of Pharmaceutical Research and Development","volume":"160 37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135058093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.33545/26646862.2023.v5.i2a.34
Ravi Prakash, Raj Kumar, RB Singh
The Corona virus (COVID-19) has quickly spread across the globe and becoming a pandemic. This disease has a variable impact in different countries depending on their cultural norms, mitigation efforts and health infrastructure. In India, a majority of people upon Traditional Indian Medicine to treat human maladies due to less-cost, easier availability and without any side-effect. These medicines are made by herbal plants. This study aims to assess the Indian herbal plants in the pursuit of potential COVID-19 inhibitors using in silico approaches. We have considered 18 extracted compounds of 11 different species of these plants. Our calculated lipophilicity, aqueous solubility and binding affinity of the extracted compounds suggest that the inhibition potentials in the order; harsingar > aloe vera > giloy > turmeric > neem > ashwagandha >ginger>red onion > tulsi> cannabis > black pepper. On comparing the binding affinity with hydroxychloroquine, we note that the inhibition potentials of the extracts of harsingar, aloe vera and giloy are very promising. Therefore, we believe that these findings will open further possibilities and accelerate the works towards finding an antidote for this malady.
{"title":"An In silico study on the Inhibition of Corona virus disease (COVID-19) Protease by the extract of Indian herbal plants","authors":"Ravi Prakash, Raj Kumar, RB Singh","doi":"10.33545/26646862.2023.v5.i2a.34","DOIUrl":"https://doi.org/10.33545/26646862.2023.v5.i2a.34","url":null,"abstract":"The Corona virus (COVID-19) has quickly spread across the globe and becoming a pandemic. This disease has a variable impact in different countries depending on their cultural norms, mitigation efforts and health infrastructure. In India, a majority of people upon Traditional Indian Medicine to treat human maladies due to less-cost, easier availability and without any side-effect. These medicines are made by herbal plants. This study aims to assess the Indian herbal plants in the pursuit of potential COVID-19 inhibitors using in silico approaches. We have considered 18 extracted compounds of 11 different species of these plants. Our calculated lipophilicity, aqueous solubility and binding affinity of the extracted compounds suggest that the inhibition potentials in the order; harsingar > aloe vera > giloy > turmeric > neem > ashwagandha >ginger>red onion > tulsi> cannabis > black pepper. On comparing the binding affinity with hydroxychloroquine, we note that the inhibition potentials of the extracts of harsingar, aloe vera and giloy are very promising. Therefore, we believe that these findings will open further possibilities and accelerate the works towards finding an antidote for this malady.","PeriodicalId":499224,"journal":{"name":"International Journal of Pharmaceutical Research and Development","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135594527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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