Journal of Spinal Disorders & Techniques最新文献

Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections globally and is one of the most commonly reported infections in the United States. There is a need to develop new therapeutics due to drug resistance and the failure of current treatments to clear persistent infections. Structures of potential C. trachomatis rational drug-discovery targets, including C. trachomatis inorganic pyrophosphatase (CtPPase), have been determined by the Seattle Structural Genomics Center for Infectious Disease. Inorganic pyrophosphatase hydrolyzes inorganic pyrophosphate during metabolism. Furthermore, bacterial inorganic pyrophosphatases have shown promise for therapeutic discovery. Here, a 2.2 Å resolution X-ray structure of CtPPase is reported. The crystal structure of CtPPase reveals shared structural features that may facilitate the repurposing of inhibitors identified for bacterial inorganic pyrophosphatases as starting points for new therapeutics for C. trachomatis.

Study design: We designed a retrospective study on preoperative tracheal stretch exercise (TSE) before anterior cervical spine surgery. The changes in vital signs before and during the surgery and the postoperative clinical outcome were recorded and compared with none treated patients.

Objective: The aim of this study was to evaluate whether the preoperative TSE is beneficial to the anterior cervical spine surgery and clinical outcome.

Summary of background data: Anterior approach to the cervical spine surgery requires prolonged retraction of the trachea and esophagus. Although the surgery can be managed to complete, related potential complications may occur.

Methods: This is a retrospective study on 128 patients scheduled for anterior cervical spine surgery. Patients in the stretched group received preoperative TSE for 3 consecutive days before surgery, whereas the control group did not. During the preoperative exercise and the surgery, the changes in the vital signs were recorded and compared with the control group. The visual analogue scale, neck disability index (NDI), and the Clinical Symptom Score of the Japanese Orthopaedic Association (JOA) were also compared at different follow-up intervals, including 1, 3, and 6 months postoperation.

Results: The changes in blood pressure, heart rate, and respiratory and swallowing rates during the first exercise are significantly greater than those during the last exercise (P<0.05). During the surgery, changes in the vital signs in the exercise patients are also significantly smaller than those in control patients (P<0.05), excluding the blood oxygen saturation. The significant differences were also observed with the postoperative NDI and JOA scores between the exercise and control group at 6 months (P<0.05).

Conclusions: Proper and systematic preoperative TSE has great significance for the success of anterior cervical spine surgery.

Study design: A retrospective historical cohort design.

Objective: To determine what effect the addition of intrawound vancomycin powder to the prophylactic regimen of posterior instrumented spinal arthrodesis procedures has had on acute surgical site infections (SSIs).

Summary of background data: SSIs are known complications in instrumented spinal arthrodesis procedures, and are predominately caused by Staphylococcus aureus. Recent reports have suggested that placing vancomycin powder into the surgical wound before closure prevents SSIs in spinal surgery. Risk factors for SSIs in the setting of intrawound vancomycin powder use have not been previously reported on.

Materials and methods: SSI rates after 342 posterior instrumented spinal arthrodeses (October 2008-September 2011) in which intrawound vancomycin powder was used in addition to the standard antimicrobial prophylaxis (Vanco cohort) were compared with 341 posterior instrumented spinal arthrodeses (April 2005-October 2008) in which no vancomycin powder was added (non-Vanco cohort). Both 2 sample t test and χ test (Fisher where appropriate) were used for group comparisons. A subanalysis of the Vanco cohort was undertaken to identify risk factors for SSIs despite intrawound vancomycin use.

Results: There was a significant reduction in the number of acute staphylococcal SSIs in the Vanco cohort (1.1%) compared with the non-Vanco cohort (3.8%; P=0.029). Deep staphylococcal infections decreased to 0 compared with 7 in the non-Vanco cohort (2.1%; P=0.008). Deep methicillin-resistant S. aureus infections decreased to 0 compared with 5 in the non-Vanco cohort (1.5%; P=0.031). A subanalysis of the Vanco cohort identified that being discharged to an inpatient rehabilitation or skilled nursing facility was associated with developing a SSI.

Conclusions: Intrawound vancomycin powder use has decreased the rate of acute staphylococcal SSIs in our posterior instrumented spine arthrodesis surgeries. Patients who are discharged to skilled nursing or rehabilitation facilities are at an increased risk for developing SSIs despite intrawound vancomycin use.

Study design: A single-center retrospective cohort study.

Objective: To evaluate the ability of the Estimation of Physiologic Ability and Surgical Stress (E-PASS) system to predict postoperative risk in patients scheduled for spinal surgery.

Summary of background data: The E-PASS system is a surgical audit to predict postoperative morbidity and mortality in general surgery. It is currently not applied in patients with spinal disorders.

Methods: The E-PASS system is comprised of a preoperative risk score (PRS), a surgical stress score (SSS), and a comprehensive risk score (CRS). The latter reflects both the PRS and SSS. We calculated the E-PASS scores for 275 consecutive patients who underwent spinal surgery and evaluated the relationship between the incidence of postoperative complications and each score of the E-PASS system and their ability to predict postoperative morbidity.

Results: Postoperative complications developed in 31 patients (11.3%). All E-PASS scores were significantly higher in patients with postoperative complications and they were linearly correlated with the overall incidence of postoperative complications. In particular, PRS was correlated with complications at nonsurgical sites and SSS with surgical site complications. The area under the receiver operating characteristic curve (AUC) for PRS and SSS was higher in patients with complications at nonsurgical and surgical sites, respectively. The AUC for CRS exhibited good predictive power for both types of complication.

Conclusions: The E-PASS system correctly predicted morbidity. The predictive ability of CRS was good for overall morbidity. The E-PASS system is useful for the accurate prediction of the risk for in-hospital morbidity in individual patients scheduled for spinal surgery.

Study design: A prospective controlled study.

Objective: The aim of this study was to compare the safety and efficacy of the zero-profile device with that of an anterior cervical plate and cage in patients undergoing anterior cervical discectomy and fusion (ACDF).

Summary of background data: A series of studies have indicated that anterior instruments produce good clinical results during ACDF. However, common implants are associated with a high rate of postoperative complications. A cervical stand-alone cage with integrated fixation for zero-profile segmental stabilization has been developed to solve this problem.

Materials and methods: A total of 46 patients with cervical radiculopathy or myelopathy were randomly treated with an anterior plate and a cage or a new zero-profile implant between September 2009 and April 2010. Patients were followed for 2 years. The operation time, blood loss, exposure to radiation, the Japan Department of Orthopedics Association (JOA) score, pain Visual Analogue Score (VAS), and dysphagia score were recorded.

Results: The operation was completed successfully in 46 patients. Twenty-three patients received an anterior plate and cage (control group) and 23 patients received the new zero-profile implant (test group). Analysis of postoperative data at all protocol-defined intervals demonstrated improvement in all clinical outcomes for both the groups when compared with the corresponding preoperative data. No significant difference in VAS and JOA score was found in the 2 treatment groups. The test group had a greater reduction in dysphagia at all follow-up intervals, compared with the control group. No adjacent segment degeneration was found in the test group, whereas 4 patients in the control group developed degeneration in adjacent segments (P=0.045). Both the groups had no adverse events associated with the implant or implant surgery.

Conclusions: The Zero-P implant is a viable alternative to ACDF in patients with persistently symptomatic, single-level cervical disk disease. The procedure requires more technical requirements than traditional plates.

Study design: Prospective study.

Objective: To study the clinical efficacy of tapered rods in posterior cervicothoracic instrumentation.

Summary of background data: The cervicothoracic spine is a junctional area with complex biomechanics. A variety of disorders affect this region, rendering it unstable. Numerous posterior constructs have been evaluated by in vitro biomechanical studies. There are no data available on the clinical efficacy of a screw-rod system utilizing tapered (dual-diameter) rods. This is the first study analyzing the efficacy of this system in clinical scenarios in the short term.

Materials and methods: All consecutive patients with cervicothoracic junctional pathologies undergoing surgical treatment by posterior instrumentation utilizing tapered rods, between April 2007 and April 2012 were included in the study. The tapered rod tapers from a diameter of 5.5-3.5 mm to accommodate thoracic pedicle screws and lateral mass screws/pedicle screws of cervical spine, respectively. The cases were periodically followed up. Postoperative radiographs and computed tomography scans were analyzed.

Results: There were 14 cases, 11 males and 3 females. The etiology was tuberculosis in 7 cases, neoplasm in 5, and 1 each of trauma and deformity. Three patients required combined anterior and posterior surgeries and remaining 10 were managed by posterior-only procedures. The average follow-up was 28 months. Three patients died (surgically unrelated reasons) and 1 was lost to follow-up. Excluding 2 patients with neoplastic and traumatic etiologies, patients with neurological deficit had significant improvement. One patient had postoperative cerebrospinal fluid leak which was recognized and corrected subsequently. No biomechanical failure occurred in any of the patients. No intraoperative complications were noted.

Conclusions: This study demonstrates that tapered rods are an excellent and a viable option to connect screws to stabilize cervicothoracic junction in the short term. This study complements the biomechanical studies previously reported.

Study design: This was a prospective, randomized control pilot study.

Objective: The aim of this study was to determine whether continuous monitoring and adjustment of the endotracheal tube cuff pressure (ETTCP) to 15 mm Hg during ACSS would alter the incidence of postoperative dysphagia.

Summary of background data: Postoperative dysphagia is a recognized potential complication of anterior cervical spine surgery (ACSS). Recent findings on preventive measures suggest that certain intraoperative practices may minimize this complication.

Methods: Fifty patients undergoing ACSS, arthroplasty, or fusion, completed routine lateral cervical preoperative plain films and questionnaires [Dysphagia Disability Index (DDI), Bazaz-Yoo Dysphagia Score (BYDS), and Short Form (36) Health Survey]. Patients were randomized into 2 groups: treatment group with ETTCP maintained at 15 mm Hg and control group with cuff pressure monitored without manipulation. Radiographs and questionnaires were obtained at 24 hours, 6 weeks, and 3 and 6 months postsurgery to assess soft tissue thickness and rates of dysphagia.

Results: There were no significant differences between the groups in the soft tissue thickness or questionnaire scores at any timepoint (P>0.05). Within-group analysis revealed treatment and control groups had a significantly higher 24-hour postoperative soft tissue thickness and questionnaire scores compared with follow-up measurements (P<0.05). In the pooled group (n=50), the 24-hour postoperative DDI, BYDS, and soft tissue thickness were significantly higher compared with all other timepoints (P<0.01). DDI scores ≥10 related to dysphagia were in 59% of patients at 24 hours, 35% at 6 weeks, 24% at 3 months, and 18% at 6 months.

Conclusions: This study suggests decreased ETTCP has no effect on the prevalence of dysphagia. The incidence of dysphagia decreases over time and normalizes by 6 months postsurgery.

Study design: A meta-analysis.

Objective: We performed this meta-analysis to evaluate the association between overweight and lumbar disease.

Summary of background data: An extensive English language literature retrieval regarding the association between overweight and the risk of lumbar disease was conducted on Public Medline and Excerpta Medica Database until May 2014.

Methods: Meta-analysis for all the included literatures was performed by STATA 11.0 to summarize test performance with forest plots after heterogeneity test. Moreover, subgroup and sensitivity analyses were performed to examine the potential candidate effect factors. Afterward, the likelihood of publication bias was assessed by constructing funnel plots and performing Begg rank correlation test and Egger linear regression method.

Results: A total of 5 studies satisfied the predefined eligibility criteria, including 1749 cases with lumbar disk diseases and 1885 controls. Altogether, overweight was associated with increased risk of lumbar disease [odds ratio (OR)=1.45; 95% confidence interval (CI), 1.27, 1.66; P<0.001]. Moreover, subgroup analysis proved that overweight was a predominant factor in development of lumbar disease compared with age and sex. Although significant publication bias was observed in our meta-analysis, we proved high credibility of meta-analysis result using trim and fill method (OR=1.27; 95% CI, 1.06, 1.53).

Conclusions: We suggest that overweight might increase the risk of lumbar diseases, and weight control should be considered for overweight or obese population to reduce the occurrence and development of lumbar disease.

Background: Interbody fusion represents an efficient surgical treatment in degenerative lumbar disease, achieving satisfying outcome in >90% of cases. Various studies have affirmed the advantages of percutaneous and minimally invasive techniques with regard to minimized damage on soft tissues during surgical procedure, but their efficacy in comparison with the classic open surgical procedures has not yet been demonstrated.

Materials and methods: This is a retrospective study. We compared 30 consecutive patients affected by disk degenerative disease or grade I degenerative spondylolisthesis that were treated with minimally invasive transforaminal lumbar interbody fusion (mini-TLIF) to a group of 34 consecutive patients presenting similar pathologic findings and demographic characteristics that underwent interbody fusion by traditional open approach (open-TLIF). All patients were treated between 2006 and 2010. Patients' mean age was 46 years (min 28-max 56) and 51 years (min 32-max 58), respectively. Mean follow-up was 23 months (min 12-max 38) and 25 months (min 12-max 40), respectively. Clinical evaluation was performed by using Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) questionnaires. Radiographic evaluation was performed on standing and dynamic x-rays before operation and at final follow-up.

Results: There was a statistically significant improvement in clinical scores (VAS and ODI) in both groups. Early postoperative VAS score was significantly lower in the mini-TLIF group. Mean hospital stay and mean blood loss were significantly higher in the open-TLIF group than in the mini-TLIF group (7.4 vs. 4.1 d and 620 vs. 230 mL, respectively). Surgical time length of the procedure was higher in the mini-TLIF group. There were no major neurological complications in any of the patients. At final follow-up, radiographic evaluation showed good implant stability in both groups.

Conclusions: Mini-TLIF is a safe and efficient procedure and, when correctly and carefully performed, can reach good results, similar to those obtained with traditional open surgical techniques, even though it may require a longer surgical time at least during the first stages of the learning curve. Reduced surgical invasiveness, short hospital stay, and limited blood loss represent the major advantages of minimally invasive technique.

Study design: A retrospective clinical study.

Objective: To analyze and evaluate the clinical outcomes of cerebrospinal fluid (CSF) leak after anterior decompression for cervical ossification of the posterior longitudinal ligament (OPLL) with or without dural ossification (DO).

Summary of background data: Anterior decompression can be highly efficacious in the treatment of OPLL. However, in some cases of OPLL, there often exists DO and fusion with the posterior longitudinal ligament, which may increase the chance for CSF leak during an anterior decompression surgery.

Materials and methods: A retrospective analysis was performed on 126 OPLL patients (89 men and 37 women) treated with anterior decompression surgery between January 2008 and January 2012. The mean age at operation was 61 years (ranging from 46 to 72 y) and the average duration of diagnosis was 4.2 years (ranging from 3 d to 7 y). DO was present in 11 patients, of whom 7 developed dural tear or defect. Among the 115 patients without DO, only 4 developed dural tear. Intraoperative dural repair was performed with gelatin foam onlay and fibrin glue seal. Postoperative care for CSF leak involved bed rest, CSF drainage, nutritional support, and antibiotics.

Results: A total of 11 cases associated with dural tear or defect developed postoperative CSF leak (an overall incidence of 8.7%). There was a statistically significant difference (P<0.001) in the incidence of CSF leak between the DO group (63.6%) and the non-DO group (3.5%). While leakage in 3 patients resolved spontaneously within 5 days of surgery, intermittent CSF cysts developed in 8 patients. These were treated with circular pressure bandages, repeated aspiration, and lumbar drainage. All 8 cases resolved 14-30 days after surgery. These 11 patients were followed up for an average of 12.8 months (range of 1 to 36 mo) with an average Japanese Orthopedic Association score of 51.2% and no significant neurological deficit or persistent headaches were recorded.

Conclusions: Patients with DO are at increased risk for dural injury while undergoing anterior decompression for the treatment of OPLL. This is associated with a high incidence of CSF leak. However, the majority of patients with CSF leak could be managed conservatively.