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Etiology and incidence of postpartum depression among birthing women in the scenario of pandemics, geopolitical conflicts and natural disasters: a systematic review. 大流行病、地缘政治冲突和自然灾害情况下产妇产后抑郁症的病因和发病率:系统综述。
IF 3.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-12-05 DOI: 10.1080/0167482X.2023.2278016
Lakshmi Pillai, Shayna Srivastava, Akhil Ajin, Sandeep Singh Rana, Darin Mansor Mathkor, Shafiul Haque, Murtaza M Tambuwala, Faraz Ahmad

Postpartum depression (PPD) is classified under postpartum psychiatric disorders and initiates soon after birthing, eliciting neuropsychological and behavioral deficits in mothers and offspring. Globally, PPD is estimated to be associated with 130-190 per 1000 birthing. The severity and incidences of PPD have aggravated in the recent years due to the several unfavorable environmental and geopolitical circumstances. The purpose of this systematic review hence is to explore the contributions of recent circumstances on the pathogenesis and incidence of PPD. The search, selection and retrieval of the articles published during the last three years were systematically performed. The results from the primary studies indicate that unfavorable contemporary socio-geopolitical and environmental circumstances (e.g. Covid-19 pandemic, political conflicts/wars, and natural calamities; such as floods and earthquakes) detrimentally affect PPD etiology. A combination of socio-economic and psychological factors, including perceived lack of support and anxiousness about the future may contribute to drastic aggravation of PPD incidences. Finally, we outline some of the potential treatment regimens (e.g. inter-personal psycho- and art-based therapies) that may prove to be effective in amelioration of PPD-linked symptoms in birthing women, either alone or in complementation with traditional pharmacological interventions. We propose these psychological and art-based intervention strategies may beneficially counteract the negative influences of the unfortunate recent events across multiple cultures, societies and geographical regions.

产后抑郁症(PPD)被归类为产后精神障碍,在分娩后不久即开始发病,会导致母亲和后代出现神经心理和行为障碍。据估计,全球每 1000 例分娩中就有 130-190 例与 PPD 有关。近年来,由于一些不利的环境和地缘政治因素,PPD 的严重程度和发病率有所上升。因此,本系统综述的目的是探讨近期环境对 PPD 发病机制和发病率的影响。我们对过去三年发表的文章进行了系统的搜索、筛选和检索。主要研究结果表明,当代不利的社会地缘政治和环境条件(如 Covid-19 大流行、政治冲突/战争和自然灾害,如洪水和地震)对 PPD 的病因产生了不利影响。社会经济和心理因素的综合作用,包括认为缺乏支持和对未来的焦虑,可能会导致 PPD 发病率急剧上升。最后,我们概述了一些潜在的治疗方案(如人际心理和艺术疗法),这些方案可能被证明对改善分娩妇女与 PPD 相关的症状有效,可以单独使用,也可以与传统的药物干预措施互补使用。我们建议,这些基于心理和艺术的干预策略可以有效抵消近期发生的不幸事件对不同文化、社会和地理区域造成的负面影响。
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引用次数: 0
Reported experienced stress during the COVID-19 pandemic and patient preferences for the consultation of periconception blended lifestyle care: a survey among (pre)pregnant women. 报告在COVID-19大流行期间经历的压力和患者对围孕期混合生活方式护理咨询的偏好:对(前)孕妇的调查
IF 3.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 DOI: 10.1080/0167482X.2023.2243647
M van der Windt, S Schoenmakers, L van Rossem, R P M Steegers-Theunissen

Purpose: To assess experienced stress on different aspects of life and evaluate patient preferences for the consultation of periconception blended lifestyle care, combining face-to-face counseling with eHealth, during the COVID-19 pandemic among (pre)pregnant women. Using this two-fold aim, we were able to analyze the levels of stress among (pre)pregnant women during the COVID-19 pandemic, and to study whether their preferences for the consultation modality of periconception blended lifestyle care was influenced by the levels of stress.

Methods: A quantitative survey among (pre)pregnant women who received blended periconception lifestyle care between March 2020 and December 2021, from the first until the fourth COVID-19 wave in the Netherlands. The questionnaire used a 5-point Likert scale and measured experienced stress and preferred periconception blended lifestyle care modality.

Results: 984 women (response rate: 55.2%) filled out the questionnaire. Experienced stress during the COVID-19 pandemic was relatively low and stable over time. The highest percentage of respondents (31.2%) reported to have experienced stress on fertility and pregnancy. 40.4% (309/764) of the respondents indicated that face-to-face consultations could be replaced by digital consultation. Additionally, the mean experienced stress did not differ between the patients who preferred a video consultation (2.60 ± 1.1), or a telephone consultation (2.57 ± 1.2), either a video or telephone consultation (2.54 ± 1.3), still preferred a face-to-face consultation (2.41 ± 1.4) (p = .83).

Conclusions: Our findings indicate willingness for wide implementation of telemedicine within health care delivery, and reorganizing of periconception blended lifestyle care toward personalized and value-based health care.

目的:评估新冠肺炎大流行期间(预)孕妇对生活不同方面的压力,并评估患者对结合面对面咨询和eHealth的围产期混合生活方式护理咨询的偏好。利用这一双重目标,我们能够分析新冠肺炎大流行期间(怀孕前)孕妇的压力水平,并研究她们对围产期混合生活方式护理的咨询模式的偏好是否受到压力水平的影响。方法:对2020年3月至2021年12月期间在荷兰第一波至第四波新冠肺炎期间接受混合概念周生活方式护理的(预)孕妇进行定量调查。该问卷采用5分Likert量表,测量了体验压力和首选的概念周围混合生活方式护理模式。结果:984名女性(回答率:55.2%)填写了问卷。新冠肺炎大流行期间经历的压力相对较低,并随着时间的推移保持稳定。据报告,有生育和怀孕压力的受访者比例最高(31.2%)。40.4%(309/764)的受访者表示,面对面咨询可以被数字咨询取代。此外,喜欢视频咨询的患者的平均压力没有差异(2.60 ± 1.1),或电话咨询(2.57 ± 1.2),视频或电话咨询(2.54 ± 1.3),仍然倾向于面对面咨询(2.41 ± 1.4)(p=.83)。结论:我们的研究结果表明,我们愿意在医疗保健提供中广泛实施远程医疗,并将概念周围的混合生活方式护理重组为个性化和基于价值的医疗保健。
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引用次数: 0
Understanding cyberchondria in pregnant women: longitudinal assessment of risk factors, triggers, and outcomes. 了解孕妇的网络忧郁症:风险因素、诱因和结果的纵向评估。
IF 3.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-10-06 DOI: 10.1080/0167482X.2023.2265050
Matea Šoštarić, Una Mikac, Nataša Jokić-Begić

Pregnancy often triggers anxiety and health concerns in women, leading many to search for health information online. Excessive, compulsive, and repetitive online health research, accompanied by heightened anxiety, can result in cyberchondria. This study aimed to explore the risk factors, triggers, and outcomes of cyberchondria in pregnant women. A total of 149 participants completed an online questionnaire longitudinally across three stages of pregnancy: early (14-19 weeks), mid (24-29 weeks), and late pregnancy (34-39 weeks). The findings revealed that health anxiety and the cognitive component of anxiety sensitivity are risk factors for cyberchondria during pregnancy. Pregnancy concerns related to motherhood emerged as triggers for cyberchondria. While a connection between cyberchondria and fear of birth was observed, fear of birth did not appear to be a direct outcome of cyberchondria. These results highlight the importance of addressing health anxiety, cognitive anxiety sensitivity and motherhood concerns in prenatal care and support interventions. Understanding the factors contributing to cyberchondria in pregnant women can assist healthcare professionals in providing targeted support and resources to mitigate excessive online health searching behaviors and alleviate anxiety during pregnancy.

怀孕往往会引发女性的焦虑和健康问题,导致许多人在网上搜索健康信息。过度、强迫和重复的在线健康研究,伴随着焦虑加剧,可能会导致网络忧郁症。本研究旨在探讨孕妇患网络忧郁症的风险因素、诱因和结果。共有149名参与者在怀孕的三个阶段纵向完成了一份在线问卷:早期(14-19 周),中期(24-29 周)和妊娠晚期(34-39 周)。研究结果表明,健康焦虑和焦虑敏感性的认知成分是妊娠期网络软骨症的危险因素。与母亲身份相关的怀孕问题成为引发网络忧郁症的诱因。虽然观察到网络疑病与出生恐惧之间存在联系,但出生恐惧似乎不是网络疑病的直接结果。这些结果强调了在产前护理和支持干预中解决健康焦虑、认知焦虑敏感性和母亲问题的重要性。了解导致孕妇网络忧郁症的因素可以帮助医疗保健专业人员提供有针对性的支持和资源,以缓解过度的在线健康搜索行为,缓解怀孕期间的焦虑。
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引用次数: 0
Reflections on the group dynamic in a group cognitive behavioral therapy intervention for young adult women with moderate to severe dysmenorrhea: a qualitative analysis. 对中重度痛经年轻成年女性群体动态认知行为治疗干预的思考:一项定性分析。
IF 3.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-10-06 DOI: 10.1080/0167482X.2023.2264486
Laura C Seidman, Ariel B Handy, Catherine R Temme, Shelly F Greenfield, Laura A Payne

A recent group cognitive behavioral therapy (gCBT) intervention for dysmenorrhea conducted by our team demonstrated feasibility, acceptability, and preliminary efficacy at reducing menstrual pain. This study aimed to use qualitative analyses to explore participants' reflections about the intervention's group dynamic. Participants included 20 young women ages 18-24 years with average menstrual pain of 8.0 (SD = 1.1) on a 0-10 (0 = none, 10 = worst pain possible) numeric rating scale. Semi-structured individual and group interviews were conducted after the intervention. Researchers then conducted deductive, iterative thematic analysis using a template analysis approach. Two themes were generated: benefit and logistics. The benefit theme included two sub-themes: (1) camaraderie (an emotional, psychological, or social connection between participants); and (2) sharing (information, advice, or experiences). The logistics theme highlighted how the structure of the group influenced the dynamic and was divided into two sub-themes according to the time frame being described: (1) reactions (participants' experiences with how the group dynamic was facilitated); and (2) future (how the group structure could be improved). Results of this study contribute to the growing body of literature related to gCBT for pain conditions. Future research is needed to optimize the group dynamic and evaluate its specific therapeutic role in the treatment.

我们团队最近进行的一项针对痛经的群体认知行为疗法(gCBT)干预证明了在减轻月经疼痛方面的可行性、可接受性和初步疗效。本研究旨在使用定性分析来探索参与者对干预的群体动态的反思。参与者包括20名18-24岁的年轻女性 在0-10(0)年平均月经疼痛8.0(SD=1.1) = 无,10 = 最严重的疼痛可能)数字评定量表。干预后进行半结构化的个人和小组访谈。然后,研究人员使用模板分析方法进行演绎、迭代的主题分析。产生了两个主题:效益和后勤。福利主题包括两个子主题:(1)同志情谊(参与者之间的情感、心理或社会联系);以及(2)分享(信息、建议或经验)。物流主题强调了群体的结构如何影响动态,并根据所描述的时间框架分为两个子主题:(1)反应(参与者对如何促进群体动态的体验);以及(2)未来(如何改进集团结构)。这项研究的结果为越来越多的关于gCBT治疗疼痛的文献做出了贡献。未来的研究需要优化群体动态,并评估其在治疗中的具体治疗作用。
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引用次数: 0
Association between adverse childhood experience and unintended pregnancy among Japanese women: a large-scale cross-sectional study. 日本妇女不良童年经历与意外怀孕之间的关系:一项大规模的横断面研究。
IF 3.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-10-26 DOI: 10.1080/0167482X.2023.2274295
Yoshiaki Kanamori, Yuki Miyamoto, Utako Sawada, Mako Iida, Takahiro Tabuchi, Daisuke Nishi

Unintended pregnancy (UP) can negatively impact the health of mothers, children, and families. While Adverse Childhood Experiences (ACEs) are increasingly known to affect sexual health, the influence on pregnancy intention is not fully understood. This study examines the relationship between ACEs and UP and explores other related factors, using 5049 pregnant and postpartum women data from the Japan COVID-19 and Society Internet Survey (JACSIS). We measured participants' pregnancy intentions, ACEs, family functioning, and social network size. Logistic regression analysis provided odds ratios and 95% confidence intervals (CI). The prevalence of UP was approximately 16.5% (n = 893). Cumulative ACEs were consistently associated with UP, even after adjusting for intermediate variables in adulthood. The odds ratio for UP with a single ACE was 1.00 (CI: 0.82-1.21) but rose significantly with multiple ACEs: 1.39 (CI: 1.10-1.76) with double, 1.38 (CI: 1.02-2.86) with triple, and 1.81 (CI: 1.37-2.39) with more. Additionally, bad family functioning and lack of social networks emerged as contributors to UP. In conclusion, this study showed that ACEs are potentially correlated with UP. A deeper understanding of the transition from childhood experiences to UP is important for health interventions, necessitating further investigation.

意外怀孕(UP)会对母亲、孩子和家庭的健康产生负面影响。虽然越来越多的人知道儿童不良经历会影响性健康,但对怀孕意向的影响尚不完全清楚。本研究利用日本新冠肺炎和社会互联网调查(JACSIS)的5049名孕妇和产后妇女数据,研究了ACE与UP之间的关系,并探讨了其他相关因素。我们测量了参与者的怀孕意向、ACE、家庭功能和社交网络规模。Logistic回归分析提供了优势比和95%置信区间(CI)。UP的患病率约为16.5%(n = 893)。即使在成年期调整了中间变量后,累积ACE也始终与UP相关。单一ACE的UP比值比为1.00(CI:0.82-12.1),但多个ACE的比值比显著上升:双ACE为1.39(CI:1.10-1.76),三ACE为1.38(CI:1.02-2.86),多ACE为1.81(CI:1.37-2.39)。此外,不良的家庭功能和缺乏社交网络成为UP的原因。总之,这项研究表明ACE与UP有潜在的相关性。更深入地了解从童年经历到UP的转变对健康干预很重要,需要进一步调查。
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引用次数: 0
Analyzing the dynamic measurement of growth and development in children born after the transplantation of poor quality blastocyst embryos: a propensity matching study. 劣质囊胚移植后出生儿童生长发育动态测量分析:倾向匹配研究。
IF 3.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-11-29 DOI: 10.1080/0167482X.2023.2284100
Chunmei Yu, Lijing Bai, Wanchao Zhang, Lin Feng, Xiaoyu Wang, Li Chen, Lingmin Hu

Objective: This study aimed to observe the dynamic measurement of growth and development in children (0-3 years) after transplantation of low-quality frozen-thawed single blastocysts.

Methods: This was a retrospective cohort study conducted from January 2016 to December 2019 at a single center. The follow-up data of the children were obtained from the Jiangsu Province Maternal and Child Database. A total of 350 singleton live births were included. Based on the blastocyst score, the live births were divided into good-quality blastocyst embryo (GQE) group (315 live births) and poor-quality blastocyst embryo (PQE) group (35 live births). To improve statistical efficiency and control for potential confounding factors, singletons conceived from PQEs were matched with a 3:1 ratio according to couple ages, BMI, occupation and women AMH levels. Ultimately, 32 children in the PQE group and 95 children (with one missing data) in the GQE group were included in the final analysis.

Results: After matching for parents' age, BMI, occupation and maternal serum AMH level, there was no significant difference in growth and development of children between the PQE group and GQE group. However, the E2 level on trigger days, the rate of 2PN oocyte, and blastocyst formation rate in the PQE group were significantly lower than in the GQE group (p < .05). The number of embryo transfers (ETs) in the PQE group was higher than in the GQE group (p < .0001). The rate of cesarean section in the PQE group was significantly higher than in the GQE group (p < .05). The height (at 3 months) and head circumference (at 12 months) in the PQE group were lower than in the GQE group (p < .05).

Conclusions: Transplantation of PQEs did not affect the growth and development of offspring (0-3 years) compared to good-quality blastocysts. However, the oocyte and embryo development potential was lower in the PQE group than in the GQE group. These results provide clinical reference that the transfer of PQE could be acceptable for patients with only PQE embryos.

目的:观察0 ~ 3岁儿童低质量冻融单囊胚移植后生长发育的动态变化。方法:这是一项回顾性队列研究,于2016年1月至2019年12月在单中心进行。儿童的随访数据来源于江苏省母婴数据库。共包括350名单胎活产婴儿。根据囊胚评分分为优质囊胚组(GQE) 315例和劣质囊胚组(PQE) 35例。为了提高统计效率和控制潜在的混杂因素,根据夫妇年龄、BMI、职业和女性AMH水平,以3:1的比例匹配PQEs的单胎。最终,PQE组32名儿童和GQE组95名儿童(其中1名数据缺失)被纳入最终分析。结果:经父母年龄、BMI、职业、母亲血清AMH水平匹配后,PQE组与GQE组患儿生长发育无显著差异。然而,触发日E2水平、2PN卵母细胞率和囊胚形成率PQE组显著低于GQE组(p p p p p)。结论:与优质囊胚相比,PQE组对子代(0-3岁)的生长发育没有影响。然而,PQE组的卵母细胞和胚胎发育潜力低于GQE组。这些结果为PQE胚胎移植在只有PQE胚胎的患者中是可以接受的提供了临床参考。
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引用次数: 0
Mother-to-infant bonding mediates the effects of depressive and anxious postpartum symptoms on parenting stress. 母婴关系介导产后抑郁和焦虑症状对育儿压力的影响。
IF 3.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-10-14 DOI: 10.1080/0167482X.2023.2264487
Chiara Pazzagli, Livia Buratta, Elena Coletti, Claudia Mazzeschi

A number of studies have suggested close associations between maternal postpartum mental health (depressive and anxious symptoms), mother-infant bonding, and parenting stress. However, the relationship between maternal bonding and parenting stresshas hardly been explored in published literature. This cross-sectional study explored whether maternal bonding could mediate the effect of postpartum maternal mental health on parenting stress. This study assessed maternal bonding (MPAS), depressive and anxious symptoms (EPDS; STAI), and parenting stress (PSI) at 3 months postpartum in a community sample of 105 women (M (SD) = 32.60 (4.18) years old). Spearman's correlation analyses showed moderate to high correlations between these factors. The three mediation models run showed that mother's MPAS partially mitigates the effects of EPDS (b = 0.71; SE = 0.217; 95% CI = 0.290/1.136) and STAI State (b = 0.39; SE = 0.113; 95% CI = 0.178/0.625) on PSI, and totally mediated the relationship between STAI Trait and PSI (b = 0.59; SE = 0.155; 95% CI = 0.303/0.912). Maternal bonding resulted to be a relevant factor in the association between maternal mental health and parenting stress. This highlights the importance of interventions focusing on mother-infant relationship to reduce parenting stress and prevent developmental difficulties in children.

许多研究表明,母亲产后心理健康(抑郁和焦虑症状)、母婴关系和育儿压力之间存在密切联系。然而,在已发表的文献中,几乎没有探讨过母亲关系和养育压力之间的关系。这项横断面研究探讨了母亲关系是否可以调节产后母亲心理健康对育儿压力的影响。本研究评估了105名女性(M(SD)=32.60(4.18)岁)的社区样本中产后3个月的母亲关系(MPAS)、抑郁和焦虑症状(EPDS;STAI)和育儿压力(PSI)。Spearman的相关分析显示,这些因素之间存在中度到高度的相关性。运行的三个中介模型表明,母亲的MPAS部分减轻了EPDS的影响(b = 0.71;SE = 0.217;95%CI=0.290/1.136)和STAI状态(b = 0.39;SE = 0.113;95%可信区间=0.178/0.625),并且完全介导了STAI特性与PSI之间的关系(b = 0.59;SE = 0.155;95%可信区间为0.303/0.912)。母亲关系是母亲心理健康与养育压力之间的相关因素。这突出了以母婴关系为重点的干预措施对减轻育儿压力和防止儿童发育困难的重要性。
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引用次数: 0
Experiences of communication in women with endometriosis: perceived validation and invalidation in different contexts, and associations with health-related quality of life. 子宫内膜异位症妇女的沟通经验:在不同背景下感知的有效性和无效性,以及与健康相关的生活质量的关系。
IF 3.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-10-03 DOI: 10.1080/0167482X.2023.2264483
Hanna Grundström, Linnéa Engman, Elin Rimhagen, Clara Söderstierna, Ida Flink

Endometriosis, a chronic gynecological disease affecting approximately 10% of women of reproductive age, has a significant impact on physical and mental health. This cross-sectional study aimed to explore experiences of validating and invalidating communication in three contexts (with healthcare providers, employers, and family/friends), and whether this may predict health-related quality of life (HRQoL) in women with endometriosis. Data was collected through a digital survey distributed to women with self-reported endometriosis in Sweden. The survey included measures of validating and invalidating communication, depressive symptoms, anxiety, and HRQoL. A total of 427 women participated. The results indicated that women experienced varying levels of validating and invalidating communication in different contexts, with close family/friends providing the highest level of validation, and healthcare providers the lowest. Furthermore, a combined construct of high levels of validation and low levels of invalidation from healthcare providers and from close family and friends were significant predictors of HRQoL. These findings highlight the importance of supportive communication and understanding from healthcare providers and close social networks in promoting the well-being of women with endometriosis. Future research should further explore the impact of validating communication within healthcare settings and develop interventions to improve communication and support for women with endometriosis.

子宫内膜异位症是一种影响约10%育龄妇女的慢性妇科疾病,对身心健康有重大影响。这项横断面研究旨在探索在三种情况下(与医疗保健提供者、雇主和家人/朋友)验证和无效沟通的经验,以及这是否可以预测子宫内膜异位症女性的健康相关生活质量(HRQoL)。数据是通过一项数字调查收集的,该调查分发给瑞典自我报告患有子宫内膜异位症的女性。该调查包括验证和无效沟通、抑郁症状、焦虑和HRQoL的测量。共有427名妇女参加。结果表明,女性在不同的环境中经历了不同程度的验证和无效沟通,亲密的家人/朋友提供的验证程度最高,医疗保健提供者提供的验证水平最低。此外,来自医疗保健提供者以及亲密的家人和朋友的高水平验证和低水平无效的组合结构是HRQoL的重要预测因素。这些发现强调了来自医疗保健提供者和密切社交网络的支持性沟通和理解在促进子宫内膜异位症女性健康方面的重要性。未来的研究应进一步探索在医疗环境中验证沟通的影响,并制定干预措施,以改善子宫内膜异位症女性的沟通和支持。
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引用次数: 0
Getting off to the best start: the vital role of mother-infant bonding. 最好的开端:母婴亲子关系的重要作用。
IF 3.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-12-26 DOI: 10.1080/0167482X.2023.2297643
Julie A Quinlivan, Mijke Lambregtse-van den Berg
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引用次数: 0
Effectiveness of double ABCX-based psychotherapy for psychological distress among women undergoing in vitro fertilization-embryo transfer: a three-arm randomized controlled trial. 双重abx为基础的心理治疗对体外受精-胚胎移植妇女心理困扰的有效性:一项三组随机对照试验
IF 3.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-12-06 DOI: 10.1080/0167482X.2023.2278015
Dan Chen, Anni Wang, Wen Zhang, Yufang Guo, Shuyu Yao, Xiaoxuan Chen, Jingping Zhang

Objective: This study aimed to evaluate the effectiveness of double ABCX-based psychotherapy for psychological distress during in vitro fertilization-embryo transfer (IVF-ET) among a female group (FG), couple group (CoG) and control group (CG).

Methods: A total of 201 women undergoing their first IVF-ET cycle were randomized into three groups. The 6-session intervention was delivered at each visit to the IVF clinic. The primary outcomes were depression and anxiety, and the secondary outcomes included sleep quality, serum cortisol (nmol/L) levels and the clinical pregnancy rate, which were assessed before and after the intervention.

Results: The group-by-time effects were significant for depression, anxiety, sleep quality and serum cortisol levels, with larger effect sizes in the FG than in the CoG. There was no significant difference in the pregnancy rate among the three groups.

Conclusion: Psychotherapy effectively mitigated psychological distress, suggesting greater effectiveness for couples undergoing IVF couples than for women only. It is structured and easy to use during the IVF treatment cycle.

Trial registration number: https://register.clinicaltrials.gov (NCT03931187, retrospectively registered on April 23, 2019).

目的:探讨双abx心理治疗对女性组(FG)、夫妻组(CoG)和对照组(CG)体外受精-胚胎移植(IVF-ET)过程中心理困扰的治疗效果。方法:201例首次IVF-ET周期的妇女随机分为三组。在每次访问试管婴儿诊所时进行6次干预。干预前后主要指标为抑郁和焦虑,次要指标为睡眠质量、血清皮质醇(nmol/L)水平和临床妊娠率。结果:抑郁、焦虑、睡眠质量和血清皮质醇水平的分组时间效应显著,FG组的效应量大于CoG组。三组妊娠率差异无统计学意义。结论:心理治疗能有效缓解心理困扰,表明接受体外受精的夫妇比仅接受女性治疗的夫妇更有效。它是结构化的,易于在试管婴儿治疗周期中使用。试验注册号:https://register.clinicaltrials.gov (NCT03931187,追溯注册于2019年4月23日)。
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Journal of Psychosomatic Obstetrics & Gynecology
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