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The relationship between febrile seizure and hematological parameters in children 儿童热性惊厥与血液学参数之间的关系
Pub Date : 2023-12-08 DOI: 10.30569/adiyamansaglik.1334775
Rojan Ipek, H. Almış, I. Bucak, Sumeyye Erdogan
Aim: The aim of this study was to investigate whether hematological parameters play a significant role in the relationship between hematological parameters and seizure occurrence in children with febrile seizures (FS) by comparing them to a healthy control group with no fever or seizures.Materials and Methods: One-hundred forty-one patients diagnosed with FS and with available a complete blood count results and a control group of 143 children were finally enrolled.Results: The study group consisted of 141 patients, 57 girls (40.4%) and 84 boys (59.6%) (M/F=1.4). Mean age at the time of first FS was 22.89 ± 13.95 months. Ninety-two (65.2%) of the study group were diagnosed with simple FS, 32 (22.7%) with complex FS, and 17 (12.1%) with febrile status epilepticus (FSE). Conclusion: Since our neutrophil, lymphocyte, eosinophil, and mean platelet volume (MPV) results were statistically significant in patients with FS, it is thought that these markers may represent potential predictive parameters in that condition.
目的:本研究旨在通过将发热性癫痫发作(FS)患儿与无发热或癫痫发作的健康对照组进行比较,探讨血液学参数是否在血液学参数与癫痫发作之间的关系中发挥重要作用:材料与方法:最终招募了 141 名确诊为发热性惊厥且有全血细胞计数结果的患者,以及 143 名儿童组成的对照组:研究组共有 141 名患者,其中女孩 57 名(占 40.4%),男孩 84 名(占 59.6%)(男/女=1.4)。首次接受 FS 时的平均年龄为 22.89±13.95 个月。研究组中有 92 人(65.2%)被诊断为单纯性 FS,32 人(22.7%)被诊断为复杂性 FS,17 人(12.1%)被诊断为发热性癫痫(FSE)。结论由于我们的中性粒细胞、淋巴细胞、嗜酸性粒细胞和平均血小板体积(MPV)结果在FS患者中具有统计学意义,因此认为这些标记物可能代表了该病症的潜在预测参数。
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引用次数: 0
Retrospective evaluation of newborns with germinal matrix hemorrhage after preterm delivery 对早产后胚芽基质出血新生儿的回顾性评估
Pub Date : 2023-12-06 DOI: 10.30569/adiyamansaglik.1314039
Ali Özen, Selahattin Akar
Amaç: Bu çalışmada germinal matriks kanaması olan hastaların klinik seyri ve tedavi sonuçlarını değerlendirmek amaçlanmıştır.Gereç ve Yöntem: Ocak 2018 – Mart 2020 tarihleri arasında germinal matriks kanaması olan hastalar retrospektif olarak incelenmiştir. Bulgular: Toplam 66 hasta germinal matriks kanaması nedeni ile takip edildi. Hastaların 34’ü kadın, 32’si erkekti. On sekiz hastanın evre-1, 22 hastanın evre-2, 16 hastanın evre-3 ve 10 hastanın evre-4 kanaması vardı. Yirmi altı hastaya ventriküler tap yapıldı. On üç hastaya eksternal ventriküler drenaj takıldı. Bir hastaya ventriküler rezervuar ve bir hastaya ventrikülosubgaleal şant takıldı. Takiplerinde sekiz hastaya ventriküloperitoneal şant takıldı. Otuz altı hasta exitus oldu. Yirmi beş hasta taburcu edildi. Beş hasta dış merkeze sevk edildi. Sonuç: Preterm doğum sonrası germinal matriks kanamaları sık görülmekte ve asemptomatik olabilmektedir. Hastaların transfontanel ultrasonografi ile değerlendirilmeleri erken tanı ve tedavi olanağı sağlamaktadır. Bu hastaların tedavileri konusunda ortak bir algoritma henüz bulunmamaktadır.
研究目的本研究旨在评估生殖基质出血患者的临床过程和治疗效果:对2018年1月至2020年3月期间的胚芽基质出血患者进行回顾性研究。结果共有 66 名生殖基质出血患者接受了随访。其中 34 名患者为女性,32 名患者为男性。18名患者为1期,22名患者为2期,16名患者为3期,10名患者为4期。26 名患者接受了心室穿刺。13 名患者接受了心室外引流术。一名患者接受了脑室贮液器,一名患者接受了脑室腹腔分流术。8 名患者在随访期间接受了脑室腹腔分流术。36 名患者进行了出口手术。25 名患者出院。五名患者被转诊至外部中心。结论早产后胚芽基质出血很常见,而且可能没有症状。通过经皮层超声波检查对患者进行评估,可提供早期诊断和治疗。目前还没有治疗这些患者的通用算法。
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引用次数: 0
Serebral palsili çocuğu olan annelerde bruksizm ve temporomandibular rahatsızlığın değerlendirilmesi 评估脑瘫母亲的磨牙症和颞下颌关节紊乱症
Pub Date : 2023-12-06 DOI: 10.30569/adiyamansaglik.1373778
Ö. Dursun, Erhan Di̇ncer, İbrahim Hakkı Sağol
Aim: The aim of this study was to assess bruxism and temporomandibular disorder in mothers of children with cerebral palsy (CP).Materials and Methods: 18 mothers of children with CP and 18 mothers of healthy children were included in study. The pressure pain threshold of the masticatory muscles and the upper trapezius were measured with a digital dynamometer. Maximum mouth opening was assessed with a digital caliper. Bruxism was evaluated by a non-instrumental method. Sleep quality, depression, neck disability, and temporomandibular disorder were evaluated with the Pittsburgh Sleep Quality Index, Beck Depression Index, Neck Disability Index, and Fonseca Questionnaire.Results: Pain thresholds were lower (p<0.05), sleep disturbance, depression, neck disability, and temporomandibular disorder were higher in the mothers of children with CP (p<0.05). Conclusion: Our study showed that bruxism and temporomandibular disorder are highly observed in mothers of children with CP.
目的:本研究旨在评估脑瘫(CP)儿童母亲的磨牙症和颞下颌关节紊乱。用数字测力计测量咀嚼肌和上斜方肌的压痛阈值。最大张口度用数字卡尺进行评估。磨牙症采用非仪器方法进行评估。采用匹兹堡睡眠质量指数、贝克抑郁指数、颈部残疾指数和丰塞卡问卷对睡眠质量、抑郁、颈部残疾和颞下颌关节紊乱进行了评估:结果:CP患儿母亲的疼痛阈值较低(P<0.05),睡眠障碍、抑郁、颈部残疾和颞下颌关节紊乱程度较高(P<0.05)。结论我们的研究表明,患有磨牙症和颞下颌关节紊乱症的儿童的母亲中,磨牙症和颞下颌关节紊乱症的发病率较高。
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引用次数: 0
Sezaryen yapılan Türk ve göçmen hastalarda anestezi sonuçlarının karşılaştırılması 比较土耳其和移民剖腹产患者的麻醉效果
Pub Date : 2023-12-06 DOI: 10.30569/adiyamansaglik.1297358
Ayşe Gül Ferlengez, Abdurrahman Tünay
Aim: Our study aims to compare anesthesia complications between immigrant and Turkish patients thus better knowledge to clinicians and anesthetists for the management of cesarean operative delivery among different race obstetric populations.Materials and Methods: Between 06.2018-08.2018, cesarean anesthesia forms were examined retrospectively. Age, gestational week, indication of surgery, anesthesia method applied, complications in mother (hypotension, bradycardia, bleeding, emesis) recorded. Results: 143 Turkish and 145 immigrant patients were recruited for our study. ASA II score, emergency cesarean (CS) rate, emesis incidence, hypotension rate of patients were statistically higher in immigrant patients than in Turkish patients (p<0.05). There was statically no significant difference found between the two groups of patients on behalf of bradycardia.Conclusion: We highlight the barriers to emergency cesarean section operations in the un-monitored obstetric population, so it is vital to raise awareness of both obstetricians and anesthesiologists on this issue.
目的:我们的研究旨在比较移民和土耳其患者的麻醉并发症,从而让临床医生和麻醉师更好地了解不同种族产科人群剖宫产手术的管理:对2018年6月至2018年8月期间的剖宫产麻醉表格进行回顾性研究。记录年龄、孕周、手术指征、麻醉方法、产妇并发症(低血压、心动过缓、出血、呃逆)。结果:本研究共招募了 143 名土耳其患者和 145 名移民患者。从统计学角度看,移民患者的 ASA II 评分、紧急剖宫产(CS)率、呃逆发生率、低血压发生率均高于土耳其患者(P<0.05)。两组患者在心动过缓方面没有明显差异:我们强调了在无监护的产科人群中进行紧急剖宫产手术的障碍,因此提高产科医生和麻醉师对这一问题的认识至关重要。
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引用次数: 0
Türkiye’deki kanser hastalarında kalıtsal PALB2 gen varyantlarının yeni nesil dizileme yöntemiyle araştırılması 利用新一代测序方法调查土耳其癌症患者的遗传性 PALB2 基因变异
Pub Date : 2023-12-04 DOI: 10.30569/adiyamansaglik.1378620
Ş. Tunçer, Seda Kilic Erciyas, Özge ŞÜKRÜOĞLU ERDOĞAN, Betül Çeli̇k, Zübeyde YALNIZ KAYIM, Büşra KURT GÜLTAŞLAR
Aim: The study aimed to investigate germline PALB2 gene variants in 1056 cancer patients in Türkiye, selected based on the National Comprehensive Cancer Network guidelines for genetic/familial high-risk assessment related to breast, ovarian, and pancreatic cancer.Materials and Methods: The next-generation sequencing analysis of genomic DNA was performed using a Sophia Hereditary Cancer Solutions Panel for PALB2 gene mutation screening.Results: The PALB2 genetic variants were detected in 48 patients, including 20 patients with pathogenic or likely pathogenic variants and 28 patients with variants of uncertain significance. The most common PALB2 mutations were the frameshift mutations c.557dupA p.(Asn186Lysfs*4) and c.509_510del p.(Arg170Ilefs*14), found in 0.57% and 0.28% of patients, respectively. Conclusion: The findings of the study emphasize the importance of PALB2 gene analysis for breast cancer predisposition in Türkiye.
目的:该研究旨在调查土耳其1056名癌症患者的种系PALB2基因变异情况,这些患者是根据美国国家综合癌症网络(National Comprehensive Cancer Network)关于乳腺癌、卵巢癌和胰腺癌遗传/家族高风险评估指南筛选出来的:使用索菲亚遗传性癌症解决方案面板对基因组DNA进行新一代测序分析,以筛查PALB2基因突变:结果:在48名患者中检测到了PALB2基因变异,其中20名患者存在致病或可能致病的变异,28名患者存在意义不确定的变异。最常见的 PALB2 基因突变是帧移位突变 c.557dupA p.(Asn186Lysfs*4) 和 c.509_510del p.(Arg170Ilefs*14) ,分别在 0.57% 和 0.28% 的患者中发现。结论研究结果强调了在土耳其进行 PALB2 基因分析对乳腺癌易感性的重要性。
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引用次数: 0
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