Pub Date : 2009-01-01DOI: 10.1016/S0004-9514(09)70083-2
Grant Willson
Objective
To review the evidence as to whether early extubation with immediate application of non-invasive ventilation reduces mortality and ventilator-associated pneumonia and improves other outcomes in criticallyill adults receiving invasive ventilation.
Data sources
Medline, Embase, CENTRAL, searched up to April, 2008. This search was supplemented by hand-searching of conference proceeding and citation tracking.
Study selection
Randomised and quasi-randomised controlled trials involving adults with respiratory failure who required invasive ventilation for at least 24 hours in which extubation with immediate application of noninvasive ventilation was compared to continued invasive weaning. Outcome measures were mortality, ventilatorassociated pneumonia, weaning failure, length of stay in intensive care or hospital, total duration of ventilation (invasive and non-invasive), duration of ventilation related to weaning (after randomisation), duration of invasive-only ventilation, adverse events (arrhythmia, reintubation, tracheostomy), and quality of life.
Data extraction
Two reviewers extracted data and discrepancies were resolved by consensus and arbitration. Methodological quality was assessed.
Data synthesis
Of 1368 studies identified by the initial search, 12 studies with a total of 530 patients met the selection criteria and were included in the review. All included studies were of moderate to high quality according to the reviewers’ criteria. Based on the quantitative pooling of the available data from these trials, there was a statistically significant difference in mortality in favour of non-invasive weaning, relative risk 0.55 (95% CI 0.38 to 0.79). Non-invasive weaning also significantly reduced ventilator-associated pneumonia (relative risk 0.29, 95% CI 0.19 to 0.45), length of stay in the intensive care unit (by 6 days, 95% CI 4 to 9) and in the hospital (by 7 days, 95% CI 4 to 11), total duration of ventilation (by 6 days, 95% CI 2 to 9), duration of invasive ventilation (by 8 days, 95% CI 4 to 11), and tracheostomy (relative risk 0.16, 95% CI 0.04 to 0.75). The remaining secondary outcomes did not differ significantly. None of the included studies measured quality of life.
Conclusion
Non-invasive ventilation facilitates weaning and has substantial clinical benefits in adults with respiratory failure who require invasive ventilation.
目的回顾早期拔管并立即应用无创通气是否能降低危重成人接受有创通气的死亡率和呼吸机相关性肺炎,并改善其他结局的证据。数据来源medline, Embase, CENTRAL,检索截止到2008年4月。该检索还辅以手工检索会议记录和引文跟踪。研究选择随机和准随机对照试验,涉及需要有创通气至少24小时的呼吸衰竭成人,其中拔管并立即应用无创通气与持续有创脱机进行比较。结局指标为死亡率、呼吸机相关肺炎、脱机失败、重症监护或住院时间、总通气时间(有创和无创)、脱机相关通气时间(随机化后)、仅有创通气持续时间、不良事件(心律失常、重新插管、气管切开术)和生活质量。数据提取两名审稿人提取数据,差异通过协商一致和仲裁解决。评估方法学质量。在最初检索确定的1368项研究中,有12项研究(共530例患者)符合选择标准,被纳入本综述。根据审稿人的标准,所有纳入的研究均为中等至高质量。基于这些试验中可用数据的定量汇总,非侵入性断奶的死亡率有统计学显著差异,相对危险度为0.55 (95% CI 0.38 ~ 0.79)。无创脱机也显著减少呼吸机相关肺炎(相对危险度0.29,95% CI 0.19 ~ 0.45)、重症监护病房住院时间(减少6天,95% CI 4 ~ 9)和住院时间(减少7天,95% CI 4 ~ 11)、总通气时间(减少6天,95% CI 2 ~ 9)、有创通气时间(减少8天,95% CI 4 ~ 11)和气管造口术(相对危险度0.16,95% CI 0.04 ~ 0.75)。其余次要结局无显著差异。纳入的研究都没有测量生活质量。结论无创通气对需要有创通气的成人呼吸衰竭患者脱机方便,临床获益显著。
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Pub Date : 2009-01-01DOI: 10.1016/S0004-9514(09)70001-7
Mark Elkins , Louise Ada
{"title":"Quality of trials in Australian Journal of Physiotherapy","authors":"Mark Elkins , Louise Ada","doi":"10.1016/S0004-9514(09)70001-7","DOIUrl":"10.1016/S0004-9514(09)70001-7","url":null,"abstract":"","PeriodicalId":50086,"journal":{"name":"Australian Journal of Physiotherapy","volume":"55 4","pages":"Pages 233-234"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0004-9514(09)70001-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28521042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.1016/S0004-9514(09)70003-0
Casey Irvine , Nicholas F. Taylor
Question
Is progressive resistance exercise a safe and effective form of exercise to improve glycaemic control in people with type 2 diabetes?
Design
Systematic review with meta-analysis of randomised controlled trials.
Participants
People with type 2 diabetes mellitus.
Intervention
Progressive resistance exercise.
Outcome measures
The primary outcome was glycaemic control measured as percentage glycosylated haemoglobin (HbA1c). Secondary outcomes were body composition (lean body and fat free mass in kg), and muscle strength (% change in 1RM, dynamometry, change in maximum weight lifted).
Results
The search yielded nine relevant trials that evaluated 372 people with type 2 diabetes. Compared to not exercising, progressive resistance exercise led to small and statistically significant absolute reductions in HbA1c of 0.3% (SMD –0.25, 95% CI –0.47 to –0.03). When compared to aerobic exercise there were no significant differences in HbA1c. Progressive resistance exercise resulted in large improvements in strength when compared to aerobic (SMD 1.44, 95% CI 0.83 to 2.05) or no exercise (SMD 0.95, 95% CI 0.58 to 1.31). There were no significant changes in body composition.
Conclusions
Progressive resistance exercise increases strength and leads to small reductions in glycosylated haemoglobin that are likely to be clinically significant for people with type 2 diabetes. Progressive resistance exercise is a feasible option in the management of glycaemia for this population.
渐进式抵抗运动是一种安全有效的改善2型糖尿病患者血糖控制的运动形式吗?设计采用随机对照试验的荟萃分析进行系统评价。参与者为2型糖尿病患者。干预:进行性抗阻运动。主要终点是血糖控制,以糖化血红蛋白百分比(HbA1c)衡量。次要结果是身体组成(以kg为单位的瘦体和无脂肪质量)和肌肉力量(1RM变化百分比、动力测量、最大举起重量变化)。研究人员对372名2型糖尿病患者进行了9项相关试验。与不运动相比,渐进式阻力运动导致HbA1c绝对降低0.3% (SMD -0.25, 95% CI -0.47至-0.03)。与有氧运动相比,HbA1c无显著差异。与有氧运动(SMD = 1.44, 95% CI = 0.83 - 2.05)或不运动(SMD = 0.95, 95% CI = 0.58 - 1.31)相比,渐进式阻力运动显著改善了力量。身体成分没有明显变化。进行性阻力运动增加力量,导致糖化血红蛋白的少量减少,这对2型糖尿病患者可能具有临床意义。进行性抗阻运动是这一人群血糖管理的可行选择。
{"title":"Progressive resistance exercise improves glycaemic control in people with type 2 diabetes mellitus: a systematic review","authors":"Casey Irvine , Nicholas F. Taylor","doi":"10.1016/S0004-9514(09)70003-0","DOIUrl":"10.1016/S0004-9514(09)70003-0","url":null,"abstract":"<div><h3>Question</h3><p>Is progressive resistance exercise a safe and effective form of exercise to improve glycaemic control in people with type 2 diabetes?</p></div><div><h3>Design</h3><p>Systematic review with meta-analysis of randomised controlled trials.</p></div><div><h3>Participants</h3><p>People with type 2 diabetes mellitus.</p></div><div><h3>Intervention</h3><p>Progressive resistance exercise.</p></div><div><h3>Outcome measures</h3><p>The primary outcome was glycaemic control measured as percentage glycosylated haemoglobin (HbA1c). Secondary outcomes were body composition (lean body and fat free mass in kg), and muscle strength (% change in 1RM, dynamometry, change in maximum weight lifted).</p></div><div><h3>Results</h3><p>The search yielded nine relevant trials that evaluated 372 people with type 2 diabetes. Compared to not exercising, progressive resistance exercise led to small and statistically significant absolute reductions in HbA1c of 0.3% (SMD –0.25, 95% CI –0.47 to –0.03). When compared to aerobic exercise there were no significant differences in HbA1c. Progressive resistance exercise resulted in large improvements in strength when compared to aerobic (SMD 1.44, 95% CI 0.83 to 2.05) or no exercise (SMD 0.95, 95% CI 0.58 to 1.31). There were no significant changes in body composition.</p></div><div><h3>Conclusions</h3><p>Progressive resistance exercise increases strength and leads to small reductions in glycosylated haemoglobin that are likely to be clinically significant for people with type 2 diabetes. Progressive resistance exercise is a feasible option in the management of glycaemia for this population.</p></div>","PeriodicalId":50086,"journal":{"name":"Australian Journal of Physiotherapy","volume":"55 4","pages":"Pages 237-246"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0004-9514(09)70003-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28521043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.1016/S0004-9514(09)70014-5
Stephanie Valentin
{"title":"Cincinnati Orthopaedic Disability Index in canines","authors":"Stephanie Valentin","doi":"10.1016/S0004-9514(09)70014-5","DOIUrl":"10.1016/S0004-9514(09)70014-5","url":null,"abstract":"","PeriodicalId":50086,"journal":{"name":"Australian Journal of Physiotherapy","volume":"55 4","pages":"Page 288"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0004-9514(09)70014-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28522543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.1016/S0004-9514(09)70044-3
Julie C. Reeve
Question
Does the instillation of normal saline before suctioning reduce the incidence of ventilator-associated pneumonia in intubated and ventilated adults?
Design
Randomised, controlled trial with blinded outcome assessment.
Setting
The medical/surgical intensive care unit of a tertiary oncology hospital in Brazil.
Participants
Adults expected to require at least 72 hours of mechanical ventilation via an endotracheal or tracheostomy tube. Previous ventilation within the past month and contraindications to bronchoscopy were exclusion criteria. Randomisation of 262 participants allotted 130 to the intervention group and 132 to a control group.
Interventions
Closed tracheal suction systems with heat and moisture exchangers were used with both groups and were changed regularly. All patients were nursed with backrest elevation to 45 degrees. Medical or nursing staff, who were blinded to group allocations, requested suctioning when any of the following occurred: visible or audible secretions, ventilator-patient asynchrony, and increased peak inspiratory pressures or decreased tidal volumes attributed to secretions. Respiratory therapists performed the suctioning according to a standardised procedure that included preoxygenation. The therapists instilled 8 mL of normal saline prior to suctioning in the intervention group only.
Outcome measures
The primary outcome was the incidence of ventilator-associated pneumonia (VAP). If VAP was suspected because of radiographic evidence plus either fever, leukocytosis, or purulent secretions, a bronchoscopy with standardised lavage was performed. VAP was considered confirmed if the bacterial density of the lavage fluid exceeded 1000 colony-forming units/mL. Secondary outcome measures included time to VAP, duration of mechanical ventilation, length of stay and mortality in the intensive care unit, unscheduled ventilation circuitry changes due to secretions, and number of suctions per day.
Results
All participants completed the study. Significantly fewer participants in the saline group developed VAP (14/130) than in the control group (31/132), relative risk reduction 0.54 (95% CI 0.18 to 0.74). This indicates that one patient will avoid developing VAP for every 8 patients in which saline instillation is used. Significant benefits of saline instillation were also seen in the incidence of VAP (9 vs 21 per 1000 days of mechanical ventilation, p = 0.01) and in the time to first VAP (p = 0.02). The groups did not differ significantly on the remaining secondary outcomes.
Conclusion
Instillation of normal saline before tracheal suctioning decreases the incidence of VAP in mechanically ventilated adults.
吸痰前滴注生理盐水是否能降低插管和通气成人呼吸机相关性肺炎的发生率?设计随机对照试验,采用盲法结局评估。巴西一家三级肿瘤医院的内科/外科重症监护病房。成人受试者预计需要通过气管内或气管造口管进行至少72小时的机械通气。排除标准为过去一个月内的通气史和支气管镜禁忌症。262名参与者的随机化,其中130人被分配到干预组,132人被分配到对照组。干预措施两组均采用带热交换器和湿气交换器的闭式气管吸引系统,并定期更换。所有患者均护理靠背抬高至45度。对分组分组不知情的医务人员或护理人员,当出现以下任何情况时要求进行吸痰:可见或可听到分泌物,呼吸机与患者不同步,由分泌物引起的呼吸峰值压力增加或潮气量减少。呼吸治疗师根据包括预充氧在内的标准化程序进行吸痰。仅干预组在抽吸前灌注生理盐水8ml。主要结局指标为呼吸机相关性肺炎(VAP)的发生率。如果由于影像学证据加上发热、白细胞增多或化脓性分泌物而怀疑VAP,则行支气管镜检查并进行标准化灌洗。如果灌洗液的细菌密度超过1000菌落形成单位/mL,则认为确认了VAP。次要结局指标包括到达VAP的时间、机械通气持续时间、在重症监护病房的住院时间和死亡率、因分泌物引起的计划外通气回路改变和每天吸痰次数。所有参与者均完成了研究。生理盐水组发生VAP的参与者(14/130)明显少于对照组(31/132),相对风险降低0.54 (95% CI 0.18 ~ 0.74)。这表明,每8例使用生理盐水的患者中,就有1例患者可以避免发生VAP。生理盐水灌注在VAP发生率(每1000天机械通气9 vs 21, p = 0.01)和到达第一次VAP的时间(p = 0.02)方面也有显著的益处。两组在其余次要结果上没有显著差异。结论气管吸痰前灌注生理盐水可降低成人机械通气患者VAP的发生率。
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Pub Date : 2009-01-01DOI: 10.1016/S0004-9514(09)70063-7
Eleanor Lee-Bognar
Question
Does neuromuscular electrical stimulation improve lower urinary tract dysfunction in people with multiple sclerosis (MS), when given in addition to pelvic floor exercises and electromyographic biofeedback?
Design
Randomised, controlled trial with concealed allocation and blinded assessment of some outcomes.
Setting
Twelve health-care facilities in Northern Ireland.
Participants
Adults with MS with no hospital admissions in the preceding 3 months. They were required to have lower urinary tract dysfunction (involuntary leakage, > 8 voids per day, nocturia, or voiding dysfunction) but not to score more than 7.5 on the Expanded Disability Status Scale (EDSS) from 0 (normal) to 10 (death due to MS). Symptomatic prolapse, prostatic hyperplasia, infection and contraindications to electrical stimulation were exclusion criteria. Randomisation of 74 participants allotted 37 to each of two groups.
Interventions
Both groups were taught skills and strategies to prevent incontinence and trained in pelvic floor muscle exercises. Both groups were taught to perform the exercises with electrical stimulation via a hand-held unit with a vaginal or anal probe. The treatment group received active stimulation while the control group received sham stimulation. Both groups performed the exercises daily for 9 weeks. The exercises were reviewed with electromyographic biofeedback at a weekly clinic visit.
Outcome measures
The primary outcome was the number of leakage episodes per day as monitored by diary. Secondary outcome measures included gain in pad weight after use, voiding measures, symptom questionnaires, and assessment of pelvic floor muscle function using the Oxford classification and EMG. All outcomes were measured at 9, 16, and 24 weeks.
Results
In each group, 36 participants completed the study. At 9 weeks, the treatment group had significantly less incontinence, with 0.8 fewer episodes per day (95% CI 0.1 to 1.4) and 89 g lighter pads (95% CI 8 to 171) than the control group. The treatment group also had significantly larger voids, by 47 ml (95% CI 1 to 93), and significantly smaller post-void residual volumes. Symptoms were also rated as significantly less bothersome. At 24 weeks, however, pad weight was the only objective outcome that remained statistically significant. Nevertheless, patients in the treatment group still rated their symptoms as significantly less bothersome on two questionnaires.
Conclusion
For people with MS, the addition of electrical stimulation to a program of pelvic floor muscle training and EMG biofeedback induces several improvements in lower urinary tract dysfunction. Although some improvements were temporary, symptoms remained less bothersome for 24 weeks.
神经肌肉电刺激是否能改善多发性硬化症(MS)患者的下尿路功能障碍,在盆底运动和肌电生物反馈的基础上进行?随机对照试验,隐匿分配,对部分结果进行盲法评估。在北爱尔兰设立了12个保健设施。参与者:前3个月内未住院的成年MS患者。他们被要求有下尿路功能障碍(不自主渗漏,>每天排空8次,夜尿症或排尿功能障碍),但在扩展残疾状态量表(EDSS)中得分不超过7.5分,从0分(正常)到10分(死于多发性硬化症)。排除标准为症状性脱垂、前列腺增生、感染和电刺激禁忌症。74名参与者随机分为两组,每组37人。干预措施:两组患者均接受了预防尿失禁的技巧和策略培训,并进行了盆底肌肉锻炼。两组人都被教导通过带有阴道或肛门探针的手持装置进行电刺激练习。治疗组采用主动刺激,对照组采用假刺激。两组每天都进行锻炼,持续9周。在每周一次的诊所访问中,用肌电图生物反馈来评估这些练习。主要结果是通过日记监测每天的渗漏次数。次要结果测量包括使用后尿垫重量增加、排尿测量、症状问卷调查以及使用牛津分类和肌电图评估盆底肌功能。在第9周、第16周和第24周测量所有结果。结果每组36人完成研究。在第9周时,治疗组的尿失禁明显减少,每天少0.8次(95% CI 0.1至1.4),尿垫轻89 g (95% CI 8至171)。治疗组的空腔也明显增大,增加了47 ml (95% CI 1 ~ 93),空腔后残留体积也明显减小。症状也被评为明显不那么麻烦。然而,在24周时,尿垫重量是唯一具有统计学意义的客观结果。然而,在两份调查问卷中,治疗组的患者仍然认为他们的症状明显不那么麻烦。结论:对于多发性硬化症患者,在盆底肌肉训练和肌电图生物反馈的基础上增加电刺激可改善下尿路功能障碍。虽然有些改善是暂时的,但症状在24周内仍然不那么麻烦。
{"title":"Electrical stimulation is a useful adjunct in the management of urinary incontinence in people with multiple sclerosis","authors":"Eleanor Lee-Bognar","doi":"10.1016/S0004-9514(09)70063-7","DOIUrl":"10.1016/S0004-9514(09)70063-7","url":null,"abstract":"<div><h3>Question</h3><p>Does neuromuscular electrical stimulation improve lower urinary tract dysfunction in people with multiple sclerosis (MS), when given in addition to pelvic floor exercises and electromyographic biofeedback?</p></div><div><h3>Design</h3><p>Randomised, controlled trial with concealed allocation and blinded assessment of some outcomes.</p></div><div><h3>Setting</h3><p>Twelve health-care facilities in Northern Ireland.</p></div><div><h3>Participants</h3><p>Adults with MS with no hospital admissions in the preceding 3 months. They were required to have lower urinary tract dysfunction (involuntary leakage, > 8 voids per day, nocturia, or voiding dysfunction) but not to score more than 7.5 on the Expanded Disability Status Scale (EDSS) from 0 (normal) to 10 (death due to MS). Symptomatic prolapse, prostatic hyperplasia, infection and contraindications to electrical stimulation were exclusion criteria. Randomisation of 74 participants allotted 37 to each of two groups.</p></div><div><h3>Interventions</h3><p>Both groups were taught skills and strategies to prevent incontinence and trained in pelvic floor muscle exercises. Both groups were taught to perform the exercises with electrical stimulation via a hand-held unit with a vaginal or anal probe. The treatment group received active stimulation while the control group received sham stimulation. Both groups performed the exercises daily for 9 weeks. The exercises were reviewed with electromyographic biofeedback at a weekly clinic visit.</p></div><div><h3>Outcome measures</h3><p>The primary outcome was the number of leakage episodes per day as monitored by diary. Secondary outcome measures included gain in pad weight after use, voiding measures, symptom questionnaires, and assessment of pelvic floor muscle function using the Oxford classification and EMG. All outcomes were measured at 9, 16, and 24 weeks.</p></div><div><h3>Results</h3><p>In each group, 36 participants completed the study. At 9 weeks, the treatment group had significantly less incontinence, with 0.8 fewer episodes per day (95% CI 0.1 to 1.4) and 89 g lighter pads (95% CI 8 to 171) than the control group. The treatment group also had significantly larger voids, by 47 ml (95% CI 1 to 93), and significantly smaller post-void residual volumes. Symptoms were also rated as significantly less bothersome. At 24 weeks, however, pad weight was the only objective outcome that remained statistically significant. Nevertheless, patients in the treatment group still rated their symptoms as significantly less bothersome on two questionnaires.</p></div><div><h3>Conclusion</h3><p>For people with MS, the addition of electrical stimulation to a program of pelvic floor muscle training and EMG biofeedback induces several improvements in lower urinary tract dysfunction. Although some improvements were temporary, symptoms remained less bothersome for 24 weeks.</p></div>","PeriodicalId":50086,"journal":{"name":"Australian Journal of Physiotherapy","volume":"55 1","pages":"Page 62"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0004-9514(09)70063-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27993069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.1016/S0004-9514(09)70064-9
Sandeep Gupta
Question
Do treadmill training and resistance training improve the functional performance of patients with peripheral arterial disease (PAD)?
Design
Randomised, controlled trial with blinded outcome assessment and stratification for symptoms of intermittent claudication (IC).
Setting
Tertiary hospital in the USA.
Participants
Participants with an ankle brachial index of 0.95 or less were recruited from vascular clinics and the community. Key exclusion criteria were critical limb ischaemia, foot ulcers, amputation, inability to attend or perform the interventions, and usual exercise comparable to the study regimens. Randomisation of 156 participants allotted 51 to treadmill training, 52 to resistance training and 53 to a control group.
Interventions
The treadmill group performed supervised treadmill exercise 3 times per week for 6 months. Participants aimed to increase to 40 minutes by week 8, after which the speed or grade of the treadmill was progressed. Participants with IC were encouraged to exercise to near maximal leg symptoms. Asymptomatic participants exercised at a perceived exertion of 12 to 14 on the Borg scale. The resistance group also performed supervised exercise 3 times per week for 6 months, including 3 sets of 8 repetitions of resisted lower limb exercises. External resistance was maintained above 50% of 1 repetition maximum and perceived exertion at 12 to 14. The control group attended 11 sessions that were designed to provide contact with a health professional but not to change behaviour.
Outcome measures
The primary outcomes were the change in the six-minute walk test (6MWT) and the short physical performance battery (SPPB) at 6 months. The SPPB assesses walking speed, balance, and sit-to-stand performance. Secondary outcome measures were treadmill endurance, lower limb strength, endothelial function measured non-invasively at the brachial artery, habitual physical activity measured over 7 days via an accelerometer, a walking impairment questionnaire (WIQ), and the SF-36 quality of life questionnaire.
Results
Compared to control, treadmill training significantly improved 6MW distance (by 36 m, 95% CI 15 to 57), total treadmill time (by 3.4 min, 95% CI 2 to 4.8), pain-free treadmill time (by 1.6 min, 95% CI 0.3 to 2.9), endothelial function, and the Distance domain of the WIQ. Compared to control, resistance training significantly improved total treadmill time (by 1.9 min, 95% CI 0.5 to 3.3), knee extension strength (by 80 N, 95% CI 37 to 124), and the Distance and Stair Climbing domains of the WIQ. Both regimens produced significant, 7.5-point improvements in the Physical Functioning domain of the SF-36.
Conclusion
Treadmill and resistance training have different benefits for people with peripheral arterial disease, but both improve qualit
跑步机训练和阻力训练能改善外周动脉疾病(PAD)患者的功能表现吗?随机对照试验,对间歇性跛行(IC)症状进行盲法结局评估和分层。美国三级医院。踝关节肱指数为0.95或更低的参与者从血管诊所和社区招募。主要排除标准为严重肢体缺血、足部溃疡、截肢、无法参加或执行干预措施以及与研究方案相当的日常运动。156名参与者随机分配,51人进行跑步机训练,52人进行阻力训练,53人作为对照组。干预措施:跑步机组每周进行3次有监督的跑步机锻炼,持续6个月。参与者的目标是在第8周增加到40分钟,之后增加跑步机的速度或等级。IC患者被鼓励进行接近最大腿部症状的运动。无症状的参与者在博格量表上的感知运动为12到14。抵抗组每周进行3次有监督的运动,持续6个月,包括3组8次重复的下肢抵抗运动。外部阻力维持在1次重复最大值的50%以上,并在12至14时感觉到劳累。对照组参加了11次会议,旨在提供与健康专业人员的联系,但不改变行为。主要结果是6个月时6分钟步行测试(6MWT)和短物理性能电池(SPPB)的变化。SPPB评估行走速度、平衡和坐立表现。次要结果测量是跑步机耐力、下肢力量、无创肱动脉内皮功能测量、7天内通过加速度计测量的习惯性身体活动、行走障碍问卷(WIQ)和SF-36生活质量问卷。结果与对照组相比,跑步机训练显著改善了6MW距离(36 m, 95% CI 15 ~ 57)、总跑步时间(3.4 min, 95% CI 2 ~ 4.8)、无痛跑步时间(1.6 min, 95% CI 0.3 ~ 2.9)、内皮功能和WIQ的距离域。与对照组相比,阻力训练显著改善了跑步机总时间(1.9分钟,95% CI 0.5至3.3),膝关节伸展强度(80 N, 95% CI 37至124),以及WIQ的距离和爬楼梯范围。两种方案在SF-36的生理功能领域都产生了显著的7.5分的改善。结论跑步机和阻力训练对外周动脉疾病患者的疗效不同,但均能提高患者的生活质量。
{"title":"Endurance and strength training have different benefits for people with peripheral arterial disease, but both improve quality of life","authors":"Sandeep Gupta","doi":"10.1016/S0004-9514(09)70064-9","DOIUrl":"10.1016/S0004-9514(09)70064-9","url":null,"abstract":"<div><h3>Question</h3><p>Do treadmill training and resistance training improve the functional performance of patients with peripheral arterial disease (PAD)?</p></div><div><h3>Design</h3><p>Randomised, controlled trial with blinded outcome assessment and stratification for symptoms of intermittent claudication (IC).</p></div><div><h3>Setting</h3><p>Tertiary hospital in the USA.</p></div><div><h3>Participants</h3><p>Participants with an ankle brachial index of 0.95 or less were recruited from vascular clinics and the community. Key exclusion criteria were critical limb ischaemia, foot ulcers, amputation, inability to attend or perform the interventions, and usual exercise comparable to the study regimens. Randomisation of 156 participants allotted 51 to treadmill training, 52 to resistance training and 53 to a control group.</p></div><div><h3>Interventions</h3><p>The treadmill group performed supervised treadmill exercise 3 times per week for 6 months. Participants aimed to increase to 40 minutes by week 8, after which the speed or grade of the treadmill was progressed. Participants with IC were encouraged to exercise to near maximal leg symptoms. Asymptomatic participants exercised at a perceived exertion of 12 to 14 on the Borg scale. The resistance group also performed supervised exercise 3 times per week for 6 months, including 3 sets of 8 repetitions of resisted lower limb exercises. External resistance was maintained above 50% of 1 repetition maximum and perceived exertion at 12 to 14. The control group attended 11 sessions that were designed to provide contact with a health professional but not to change behaviour.</p></div><div><h3>Outcome measures</h3><p>The primary outcomes were the change in the six-minute walk test (6MWT) and the short physical performance battery (SPPB) at 6 months. The SPPB assesses walking speed, balance, and sit-to-stand performance. Secondary outcome measures were treadmill endurance, lower limb strength, endothelial function measured non-invasively at the brachial artery, habitual physical activity measured over 7 days via an accelerometer, a walking impairment questionnaire (WIQ), and the SF-36 quality of life questionnaire.</p></div><div><h3>Results</h3><p>Compared to control, treadmill training significantly improved 6MW distance (by 36 m, 95% CI 15 to 57), total treadmill time (by 3.4 min, 95% CI 2 to 4.8), pain-free treadmill time (by 1.6 min, 95% CI 0.3 to 2.9), endothelial function, and the Distance domain of the WIQ. Compared to control, resistance training significantly improved total treadmill time (by 1.9 min, 95% CI 0.5 to 3.3), knee extension strength (by 80 N, 95% CI 37 to 124), and the Distance and Stair Climbing domains of the WIQ. Both regimens produced significant, 7.5-point improvements in the Physical Functioning domain of the SF-36.</p></div><div><h3>Conclusion</h3><p>Treadmill and resistance training have different benefits for people with peripheral arterial disease, but both improve qualit","PeriodicalId":50086,"journal":{"name":"Australian Journal of Physiotherapy","volume":"55 1","pages":"Page 63"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0004-9514(09)70064-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27993070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}