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Predicting intentions towards long-term antidepressant use in the management of people with depression in primary care: A longitudinal survey study 预测基层医疗机构在管理抑郁症患者时长期使用抗抑郁药的意向:纵向调查研究
Pub Date : 2024-02-20 DOI: 10.1101/2024.02.16.24302927
Rachel Dewar-Haggart, Ingrid Muller, Felicity Bishop, Adam Geraghty, Beth Stuart, Tony Kendrick
BackgroundOver the last two decades, antidepressant prescribing in the UK has increased considerably, due to an increased number of people staying on antidepressants for longer. Even when treatment is no longer clinically indicated, qualitative research suggests many people continue due to a fear of depressive relapse or antidepressant withdrawal symptoms. The quantitative effects of peoples’ beliefs and attitudes towards long-term antidepressant use remain relatively unexplored.ObjectivesTo determine the extent to which beliefs and attitudes towards antidepressant treatment predict intentions to stop or continue long-term use; and whether intentions translate into actual discontinuation.MethodsA questionnaire survey formed the main component of an embedded mixed-methods study. Twenty general practices posted questionnaires to adults aged over 18 receiving continuous antidepressant prescriptions for over two years. Outcomes and predictors were determined using an extended model of the Theory of Planned Behaviour, conducting exploratory descriptive and regression analyses. The primary outcome was participants’ intentions to discontinue antidepressants. The secondary outcome of behaviour change was determined by any change in antidepressant dosage at six months.Results277 people were surveyed from 20 practices, with 10 years median antidepressant duration. Mean questionnaire scores for intention and subjective norms towards starting to come off antidepressants were low, and 85% of participants declared that continuing their antidepressant was necessary. Prescribing outcomes retrieved from 175 participants’ medical records six months after they completed the survey found 86% had not changed their antidepressant, 9% reduced the dose, only 1% discontinued their antidepressant, and 4% increased the dose. More favourable attitudes towards stopping, and normative beliefs about depression, were the strongest predictors of intentions to stop long-term antidepressant treatment.ConclusionGiven few intentions to stop taking antidepressants, patients should be made more aware of the importance of ongoing antidepressant monitoring and review from their primary care practitioners. This would promote discussion to support an attitudinal change and initiation of antidepressant tapering where appropriate.
背景在过去二十年中,由于越来越多的人长期服用抗抑郁药物,英国的抗抑郁药物处方量大幅增加。定性研究表明,即使治疗已无临床指征,许多人仍因害怕抑郁症复发或出现抗抑郁药戒断症状而继续服药。目标 确定对抗抑郁治疗的信念和态度在多大程度上可以预测停止或继续长期使用抗抑郁药的意向;以及这种意向是否会转化为实际的停止使用。20家综合诊所向18岁以上、连续两年以上接受抗抑郁药物处方的成年人发放了问卷。研究使用计划行为理论的扩展模型确定了结果和预测因素,并进行了探索性描述和回归分析。主要结果是参与者停用抗抑郁药的意愿。行为改变的次要结果由 6 个月后抗抑郁药用量的任何变化决定。结果 277 人接受了调查,他们来自 20 个医疗机构,抗抑郁治疗时间的中位数为 10 年。对开始停用抗抑郁药的意向和主观规范的问卷平均得分较低,85%的参与者表示有必要继续服用抗抑郁药。调查结束六个月后,从 175 名参与者的医疗记录中获取的处方结果显示,86% 的人没有更换抗抑郁药,9% 的人减少了剂量,只有 1%的人停用了抗抑郁药,4% 的人增加了剂量。结论鉴于患者很少有停止服用抗抑郁药的意愿,因此应让他们更清楚地认识到初级保健医生对抗抑郁药进行持续监测和复查的重要性。这将促进讨论,以支持态度上的转变,并在适当的时候开始减量服用抗抑郁药物。
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引用次数: 0
The association between time-weighted remnant cholesterol and cardiovascular and non-cardiovascular mortality: A population-based cohort study 时间加权残余胆固醇与心血管和非心血管死亡率之间的关系:基于人群的队列研究
Pub Date : 2024-02-09 DOI: 10.1101/2024.02.08.24302507
Lifang Li, Vanessa Chou, Oscar Hou In Chou, Sakshi Roy, Jeffrey Shi Kai Chan, Wing Tak Wong, Tong Liu, Gregory Y.H. Lip, Bernard M.Y. Cheung, Gary Tse, Jiandong Zhou
Background: Remnant cholesterol (RC) have been suggested as a significant mediator of atherosclerotic cardiovascular diseases. However, the relationship between RC with cause-specific mortality in long-term remained uncertain. This study aimed to investigate the association between time-weighted RC and cause-specific mortality outcomes. Methods: This retrospective population-based study enrolled patients attending family medicine clinics in Hong Kong between 1st January 2000, to 31st December 2003 with at least three RC testing results during follow-up. The time-weighted RC was calculated by the products of the sums of two consecutive measurements and the time interval divided by the total time. The primary outcomes were all-cause mortality and cause-specific mortality outcomes. Cox regression and marginal effective plots were applied to identify associations between time-weighted RC and mortality.Results: A cohort of 75,342 patients (39.69% males, mean age: 61.3 years old) with at least three valid RC test were included. During up to 19 years of follow-up, in the multivariate model adjusted for demographics, comorbidities, medications, and time-weighted laboratory results, time-weighted RC was associated with all-cause mortality (Hazard ratio [HR]: 1.41; 95% Confidence Interval [CI]: 1.35-1.48) but not RC (HR: 0.99; 95% CI: 0.89-1.10). Time-weighted RC was also associated with increased risks of cardiovascular-related mortality (HR: 1.40; 95% CI: 1.27-1.54), cancer-related mortality (HR: 1.59; 95% CI: 1.43-1.77), and respiratory-related mortality (HR: 1.33; 95% CI: 1.20-1.47). The exploratory analysis of the cause of death demonstrated that time-weighted RC was associated with Ischaemic heart disease, cerebrovascular-related and pneumonia. Conclusions: Time-weighted RC was independently associated with all-cause mortality and cause-specific mortality outcomes amongst the general population. Keywords: Cause-specific mortality, Low-density lipoprotein, Very-low-density lipoprotein, Intermediate-density lipoprotein, Remnant cholesterol, Atherosclerosis, Cardiovascular disease
背景:残余胆固醇(RC)被认为是动脉粥样硬化性心血管疾病的重要介质。然而,RC 与特定病因死亡率之间的长期关系仍不确定。本研究旨在调查时间加权 RC 与特定病因死亡率结果之间的关系。研究方法这项以人群为基础的回顾性研究收集了 2000 年 1 月 1 日至 2003 年 12 月 31 日期间在香港家庭医学诊所就诊、随访期间至少有三次 RC 检测结果的患者。时间加权 RC 由两次连续测量结果之和与时间间隔的乘积除以总时间计算得出。主要结果为全因死亡率和病因特异性死亡率。采用 Cox 回归和边际有效图来确定时间加权 RC 与死亡率之间的关系:共纳入了至少进行过三次有效 RC 测试的 75342 名患者(39.69% 为男性,平均年龄为 61.3 岁)。在长达 19 年的随访期间,在调整了人口统计学、合并症、药物和时间加权实验室结果的多变量模型中,时间加权 RC 与全因死亡率相关(危险比 [HR]:1.41;95% 置信区间 [CI]:1.35-1.48),但与 RC 无关(HR:0.99;95% CI:0.89-1.10)。时间加权 RC 还与心血管相关死亡率(HR:1.40;95% CI:1.27-1.54)、癌症相关死亡率(HR:1.59;95% CI:1.43-1.77)和呼吸系统相关死亡率(HR:1.33;95% CI:1.20-1.47)的风险增加有关。对死因的探索性分析表明,时间加权 RC 与缺血性心脏病、脑血管相关疾病和肺炎有关。结论在普通人群中,时间加权 RC 与全因死亡率和特定死因死亡率结果有独立关联。关键词特定病因死亡率 低密度脂蛋白 极低密度脂蛋白 中密度脂蛋白 剩余胆固醇 动脉粥样硬化 心血管疾病
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引用次数: 0
Effects of intervention stage completion in an integrated behavioral health and primary care randomized pragmatic intervention trial 行为健康和初级保健综合随机务实干预试验中干预阶段完成的影响
Pub Date : 2024-02-08 DOI: 10.1101/2024.02.07.24302481
Kari A. Stephens, Constance van Eeghen, Zihan Zheng, Tracy Anastas, Kris Pui Kwan Ma, Maria G. Prado, Jessica Clifton, Gail Rose, Daniel Mullin, Kwun C. G. Chan, Rodger Kessler
Purpose A pragmatic, cluster-randomized controlled trial of a comprehensive practice-level, multi-staged practice transformation intervention aimed to increase behavioral health integration in primary care practices and improve patient outcomes. We examined association between the completion of intervention stages and patient outcomes across a heterogenous national sample of primary care practices.
目的 对一项综合实践层面、多阶段实践转型干预措施进行务实、分组随机对照试验,旨在加强初级医疗实践中的行为健康整合,改善患者预后。我们研究了全国不同基层医疗机构样本中干预阶段的完成情况与患者治疗效果之间的关系。
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引用次数: 0
Telephone training to improve ECG quality in remote screening for atrial fibrillation 电话培训提高心房颤动远程筛查的心电图质量
Pub Date : 2024-02-08 DOI: 10.1101/2024.02.08.24302493
Kethaki Prathivadi Bhayankaram, Jonathan Mant, James Brimicombe, Andrew Dymond, Kate Williams, Peter H. Charlton, SAFER authorship group
Background and Aims Self-recorded, single-lead ECGs are increasingly used to diagnose arrhythmias. However, they can be of variable quality, which can affect the reliability of interpretation. In this analysis of ECGs collected in atrial fibrillation screening studies, our aims were to: (i) determine the quality of ECGs when recorded unsupervised (at home); and (ii) investigate whether telephone training improved ECG quality.
背景和目的 自录单导联心电图越来越多地被用于诊断心律失常。然而,这些心电图的质量可能参差不齐,从而影响判读的可靠性。在对心房颤动筛查研究中收集的心电图进行的分析中,我们的目标是(i) 确定在无人监督的情况下(在家)记录的心电图的质量;(ii) 调查电话培训是否能提高心电图的质量。
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引用次数: 0
Impact of a team-based versus individual clinician-focused training approach on primary healthcare professionals’ intention to have serious illness conversations with patients: a theory informed process evaluation of a cluster randomized trial 以团队为基础的培训方法与以临床医生个人为重点的培训方法对初级医疗保健专业人员与患者进行重病谈话的意向的影响:一项分组随机试验的理论过程评估
Pub Date : 2024-02-07 DOI: 10.1101/2024.02.05.24302368
Lucas Gomes Souza, Patrick Archambault, Dalil Asmaou Bouba, Suélène Georgina Dofara, Sabrina Guay-Bélanger, Sergio Cortez Ghio, Souleymane Gadio, LeAnn Michaels, Jean-Sébastien Paquette, Shigeko (Seiko) Izumi, Annette M. Totten, France Légaré, The Meta-LARC ACP Cluster Randomized Trial team
Background Cluster Randomized Trials (cRTs) conducted in real-world settings face complex challenges due to diverse practices and populations. Process evaluations alongside cRTs can help explain their results by exploring possible causal mechanisms as the trial proceeds.
背景 在真实世界环境中开展的分组随机试验(cRTs)由于实践和人群的多样性而面临着复杂的挑战。与 cRT 同时进行的过程评估可以在试验过程中探索可能的因果机制,从而帮助解释试验结果。
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引用次数: 0
Patterns of Herbal Medicine Use in a General Outpatient Clinic in Nigeria- A Cross-sectional Study 尼日利亚普通门诊使用草药的模式--横断面研究
Pub Date : 2024-01-31 DOI: 10.1101/2024.01.30.24302041
Afisulahi Abiodun Maiyegun, Mark D Akangoziri, Bukar A Grema, Yahkub B Mutalub, Farida B Ibrahim, AbdulRauf S Ibraheem
Background: Herbal medicine use remains an important part of primary care and the World Health Organization has mandated member countries to conduct research into this and other forms of traditional medicine. However, research into traditional medicine remains scanty, even in the developing where it is often a major health option. Objective: to determine the prevalence, types and sources of herbal medicine used among the study population.MethodsThree hundred and forty-one questionnaires were administered to adult patients attending the general outpatient clinic of a tertiary hospital in Northern Nigeria. The data was collected and analysed using EPI INFO version 7.2.5.0 software. ResultsThe prevalence of herbal medicine use was 85.34%; the commonest herbs were moringa (59.8%), black seed (36.8%), and olive oil (34.4%); and the commonest source of the herbs were herbal practitioners and herbal medicine vendors (79.04%). Herbal medicine use was associated with religion (P= 0.0005) and residential area (P= 0.01). Only 18.12 % of participants ever discussed herbal medicine use with their doctors.Conclusion: herbal medicine use remains high even among patients attending outpatient clinics in tertiary hospitals in Nigeria. However, health workers are often not the source of herbal medicine and patients rarely disclose its use to them.
背景:草药的使用仍然是初级保健的重要组成部分,世界卫生组织已授权成员国对草药和其他形式的传统医药进行研究。然而,对传统医学的研究仍然很少,即使是在传统医学通常是主要保健选择的发展中国家也是如此。方法:对尼日利亚北部一家三级医院普通门诊的成年患者发放了 341 份调查问卷。使用 EPI INFO 7.2.5.0 版软件收集和分析数据。结果草药使用率为 85.34%;最常见的草药是辣木(59.8%)、黑种子(36.8%)和橄榄油(34.4%);最常见的草药来源是草药医师和草药商贩(79.04%)。草药的使用与宗教信仰(P= 0.0005)和居住地区(P= 0.01)有关。结论:即使在尼日利亚三级医院门诊就诊的患者中,草药的使用率仍然很高。然而,医护人员往往不是草药的来源,患者也很少向他们透露草药的使用情况。
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引用次数: 0
Characteristics of Walk-In Clinic Physicians and Patients in Ontario, Canada: A Cross-Sectional Study 加拿大安大略省随访诊所医生和患者的特征:横断面研究
Pub Date : 2024-01-17 DOI: 10.1101/2024.01.16.24301360
Lauren Lapointe-Shaw, Christine Salahub, Peter C. Austin, Li Bai, Sundeep Banwatt, Simon Berthelot, R. Sacha Bhatia, Cherryl Bird, Laura Desveaux, Tara Kiran, Aisha Lofters, Malcolm Maclure, Danielle Martin, Kerry A. McBrien, Rita K. McCracken, J. Michael Paterson, Bahram Rahman, Jennifer Shuldiner, Mina Tadrous, Braeden A. Terpou, Niels Thakkar, Ruoxi Wang, Noah M. Ivers
Objective We aimed to describe family physicians who primarily practice in a walk-in clinic setting and compare them to family physicians who provide longitudinal care.
目标 我们旨在描述主要在随到随诊诊所执业的家庭医生的情况,并将他们与提供纵向护理的家庭医生进行比较。
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引用次数: 0
Implementation of Evidence-Based Medicine in Primary Care Through the Use of Encounter Shared Decision Making Tools: The ShareEBM Pragmatic Trial 通过使用会诊共同决策工具在初级保健中实施循证医学:ShareEBM 实用试验
Pub Date : 2023-12-21 DOI: 10.1101/2023.12.19.23300235
Annie LeBlanc, Megan E Branda, Jason Egginton, Jonathan Inselman, Sara Dick, Janet Schuerman, Jill Kemper, Nilay Shah, Victor Montori
BACKGROUND: While decision aids have been proven effective to facilitate patient-centered discussion about evidence-based health information in practice and enable shared decision making (SDM), a chasm remains between the promise and the use of these SDM tools in practice. AIMS: To promote evidence-based patient-centered care in primary care by using encounter SDM tools for medication management of chronic conditions. METHODS: We conducted a mixed methods study centered around a practice-based, multi-centered pragmatic randomized trial comparing active implementation (active) to passive dissemination (passive) of a web-based toolkit, ShareEBM, to facilitate the uptake in primary care of four SDM tools designed for use during clinical encounters. These tools supported collaborative decisions about medications for chronic conditions. ShareEBM included activities and tactics to increase the likelihood that encounter SDM tools will be routinized in practice. Study team members worked closely with practices in the active arm to actively integrate and promote the use of SDM tools; passive arm practices received no support from the study team. The embedded qualitative evaluation included clinician phone interviews (n=10) and site observations (n=5) for active practices, and exit focus groups for all practices (n=11). RESULTS: Eleven practices and 62 clinicians participated in the study. Clinicians in the active arm used SDM tools in 621 encounters (Mean [SD]: 21 [25] encounters per clinician, range: 0-93) compared to 680 in the passive arm (Mean [SD]: 20 [40] encounters per clinician, range: 0-156, p=0.4). Six of 29 (21%) clinicians in the active arm and 14 of 33 (42%) in the passive arm did not use any tools (p=0.1). Clinicians' views covered four major themes: general views of using encounter SDM tools, perceived impact on patients, strategies used, and how encounter SDM tools are incorporated into practice flow. CONCLUSION: Neither active nor passive implementation of a toolkit improved the uptake and use of encounter SDM tools in primary care. Overcoming clinician reluctance to consider using encounter SDM tools, their seamless integration into the electronic and practice workflows, and ongoing feedback about the quality of their use during encounters appear necessary to implement their use in primary care practices.
背景:虽然决策辅助工具已被证明能有效促进以患者为中心讨论实践中的循证健康信息,并实现共同决策(SDM),但这些 SDM 工具的承诺与实际应用之间仍存在差距。目的:通过在慢性病用药管理中使用 SDM 工具,在初级保健中推广以患者为中心的循证护理。方法:我们开展了一项混合方法研究,以基于实践的多中心实用随机试验为中心,比较主动实施(主动)和被动传播(被动)基于网络的工具包 ShareEBM,以促进基层医疗机构对设计用于临床会诊的四种 SDM 工具的吸收。这些工具支持慢性病用药的合作决策。ShareEBM 包括各种活动和策略,以提高临床会诊 SDM 工具在实践中常规化的可能性。研究小组成员与主动行动组的实践紧密合作,积极整合并推广 SDM 工具的使用;被动行动组的实践没有得到研究小组的支持。嵌入式定性评估包括针对积极实践的临床医生电话访谈(10 人)和现场观察(5 人),以及针对所有实践的退出焦点小组(11 人)。结果:11 家诊所和 62 名临床医生参与了研究。主动组的临床医生在 621 次诊疗中使用了 SDM 工具(平均值[SD]:每位临床医生 21 [25] 次,范围:0-93),而被动组的临床医生在 680 次诊疗中使用了 SDM 工具(平均值[SD]:每位临床医生 20 [40] 次,范围:0-156,P=0.4)。主动组 29 名临床医生中有 6 名(21%)未使用任何工具,被动组 33 名临床医生中有 14 名(42%)未使用任何工具(P=0.1)。临床医生的观点涵盖四大主题:对使用会诊 SDM 工具的总体看法、对患者的影响、使用的策略以及如何将会诊 SDM 工具纳入实践流程。结论:无论是主动还是被动实施工具包,都不能提高基层医疗机构对遭遇式 SDM 工具的吸收和使用。要在初级医疗实践中使用会诊 SDM 工具,必须克服临床医生不愿意考虑使用会诊 SDM 工具的问题,将其无缝集成到电子和实践工作流程中,并在会诊过程中持续反馈使用质量。
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引用次数: 0
Assessing the usability of the new automated medication dispensation device for patients and the adherence dashboard for real-time medication monitoring for healthcare providers: a study protocol 评估新型自动配药设备对患者的实用性以及对医疗服务提供者进行实时药物监测的依从性仪表板:研究方案
Pub Date : 2023-12-17 DOI: 10.1101/2023.12.16.23300074
Tejal Patel, Christoph Laeer, Hamed Darabi, Maxime Lachance, Michelle Anawati, Marie-Hélène Chomienne
Background Non-adherence to prescribed medication regimens can lead to suboptimal control of chronic health conditions and increased hospitalizations. Older adults may find it particularly challenging to self-manage medications due to physical and cognitive limitations resulting in medication non-adherence. While automated medication dispensing technologies may offer a solution for medication self-management among older adults, these technologies must demonstrate usability before effectiveness can be investigated and products made available for widespread use.
背景 不遵医嘱用药会导致慢性病控制不佳,增加住院率。由于身体和认知能力的限制,老年人可能会发现自我管理药物尤其具有挑战性,从而导致不坚持用药。虽然自动配药技术可以为老年人的药物自我管理提供一种解决方案,但这些技术必须先证明其可用性,然后才能对其有效性进行调查,并提供产品供广泛使用。
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引用次数: 0
A Clinical Audit on Longer-Term Stroke Management as A Specific Service in A Primary Care Setting: Assessing Adherence of Service and Clinical Parameters 对基层医疗机构特定服务中的长期卒中管理进行临床审计:评估服务的依从性和临床参数
Pub Date : 2023-12-14 DOI: 10.1101/2023.12.12.23299871
Gadaffi Mostapha, Noor Azah Abd Aziz, Mohd Fairuz Ali
Background Primary-care long-term stroke care service offers comprehensive management at the community level. A clinical audit was carried out to assess the services of this clinic as compared to the established standardized criteria for longer-term stroke care.
背景 基层医疗机构的长期中风护理服务在社区层面提供全面的管理。我们开展了一项临床审核,以评估该诊所的服务是否符合既定的中风长期护理标准化标准。
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引用次数: 0
期刊
medRxiv - Primary Care Research
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