Pub Date : 2024-09-15DOI: 10.1101/2024.09.14.24312929
Manel Fa-Binefa, Albert Fontanellas-Fes, Gemma Gonzalez Lucena, Alberto Gines Cespedosa, Carlo Gamba
Background: Scientific publications by editorial board members in their own journals raise questions about potential biases in the peer-review process. This study investigates the prevalence of self-publishing in high-impact factor foot and ankle focused journals. Methods: A review was performed of the highest impact factor foot and ankle focused journals: Foot and Ankle International, Foot and Ankle Surgery y Journal of Foot and Ankle Surgery. In January 2023, the editorial board members were identified, and their names, roles, academic backgrounds, and regions were obtained. For each board member, the number of total published articles listed in PubMed and those for each corresponding journal over their entire history, during the last 5 years and during the last 3 years were compiled. Descriptive statistics analyses were performed using IBM SPSS Statistics v26.0. Results: The study included 196 editorial board members from the 3 selected journals. Editorial board members have published 1694 articles in their own journals (9.17% of all the articles published in those 3 journals). Editorial board members published 23.4% (SD 23.6) of their overall production in their affiliated journals. Of that production, 39.0% (SD 38.6) have been published in the last 5 years, considering this 5-year period as the baseline for their role on the editorial board in question. Some 10% of editorial board members have published more than 50% of their scientific production in their own affiliated journal in the last 5 years. European editors (51%) have published more in their own journal over the last 5-year period than North Americans (29%) (p<0.001). Being a surgeon is related to greater publication rates in one own affiliated journal when compared to other specialist profiles (p=0.003). Conclusion: The publication scientific articles by editorial board members as authors in journals with which they are affiliated is a present-day phenomenon in the highest impact factor journals with a focus on the foot & ankle. Knowledge of this data could be the key to understanding the prevalence of this phenomenon, and lead to making this data more accessible.
{"title":"Do editorial board members publish in their own journal? Review of editorial board members as authors in the main foot and ankle journals","authors":"Manel Fa-Binefa, Albert Fontanellas-Fes, Gemma Gonzalez Lucena, Alberto Gines Cespedosa, Carlo Gamba","doi":"10.1101/2024.09.14.24312929","DOIUrl":"https://doi.org/10.1101/2024.09.14.24312929","url":null,"abstract":"Background: Scientific publications by editorial board members in their own journals raise questions about potential biases in the peer-review process. This study investigates the prevalence of self-publishing in high-impact factor foot and ankle focused journals.\u0000Methods: A review was performed of the highest impact factor foot and ankle focused journals: Foot and Ankle International, Foot and Ankle Surgery y Journal of Foot and Ankle Surgery. In January 2023, the editorial board members were identified, and their names, roles, academic backgrounds, and regions were obtained. For each board member, the number of total published articles listed in PubMed and those for each corresponding journal over their entire history, during the last 5 years and during the last 3 years were compiled. Descriptive statistics analyses were performed using IBM SPSS Statistics v26.0. Results: The study included 196 editorial board members from the 3 selected journals. Editorial board members have published 1694 articles in their own journals (9.17% of all the articles published in those 3 journals). Editorial board members published 23.4% (SD 23.6) of their overall production in their affiliated journals. Of that production, 39.0% (SD 38.6) have been published in the last 5 years, considering this 5-year period as the baseline for their role on the editorial board in question. Some 10% of editorial board members have published more than 50% of their scientific production in their own affiliated journal in the last 5 years. European editors (51%) have published more in their own journal over the last 5-year period than North Americans (29%) (p<0.001). Being a surgeon is related to greater publication rates in one own affiliated journal when compared to other specialist profiles (p=0.003). Conclusion: The publication scientific articles by editorial board members as authors in journals with which they are affiliated is a present-day phenomenon in the highest impact factor journals with a focus on the foot & ankle. Knowledge of this data could be the key to understanding the prevalence of this phenomenon, and lead to making this data more accessible.","PeriodicalId":501263,"journal":{"name":"medRxiv - Orthopedics","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-09DOI: 10.1101/2024.09.08.24313289
Emily Miller, Timothy Lowe, Hongtian Zhu, Woowon Lee, Pablo Argote, Danielle Dresdner, James Kelly, Rachel Frank, Eric McCarty, Jonathan Bravman, Daniel Stokes, Nancy Emery, Corey Neu
Background: Anterior cruciate ligament (ACL) injuries are prevalent musculoskeletal conditions often resulting in long-term degenerative outcomes such as osteoarthritis (OA). Despite surgical advances in ACL reconstruction, a significant number of patients develop OA within ten years post-surgery, providing a patient population that may present early markers of cartilage degeneration detectable using noninvasive imaging. Purpose: This study aims to investigate the temporal evolution of cartilage strain and relaxometry post-ACL reconstruction using displacement under applied loading MRI and quantitative MRI. Specifically, we examined the correlations between MRI metrics and pain, as well as knee loading patterns during gait, to identify early candidate markers of cartilage degeneration. Materials and Methods: Twenty-five participants (female/male = 15/10; average age = 25.6 yrs) undergoing ACL reconstruction were enrolled in a prospective longitudinal cohort study between 2022 and 2023. MRI scans were conducted at 6- and 12-months post-surgery, assessing T2, T2*, and T1ρ relaxometry values, and intratissue cartilage strain. Changes in pain were evaluated using standard outcome scores, and gait analysis assessed the knee adduction moment (KAM). Regressions were performed to evaluate relationships between MRI metrics in cartilage contact regions, patient-reported pain, and knee loading metrics. Results: Increases in axial and transverse strains in the tibial cartilage were significantly correlated with increased pain, while decreases in shear strain were associated with increased pain. Changes in strain metrics were also significantly related to KAM at12 months. Conclusions: Changes in cartilage strain and relaxometry are related to heightened pain and altered knee loading patterns, indicating potential early markers of osteoarthritis progression. These findings underscore the importance of using advanced MRI for early monitoring in ACL-reconstructed patients to optimize treatment outcomes, while also highlighting KAM as a modifiable intervention through gait retraining that may positively impact the evolution of cartilage health and patient pain.
{"title":"Evolving cartilage strain with pain progression and gait: a longitudinal study post-ACL reconstruction at six and twelve months","authors":"Emily Miller, Timothy Lowe, Hongtian Zhu, Woowon Lee, Pablo Argote, Danielle Dresdner, James Kelly, Rachel Frank, Eric McCarty, Jonathan Bravman, Daniel Stokes, Nancy Emery, Corey Neu","doi":"10.1101/2024.09.08.24313289","DOIUrl":"https://doi.org/10.1101/2024.09.08.24313289","url":null,"abstract":"Background: Anterior cruciate ligament (ACL) injuries are prevalent musculoskeletal conditions often resulting in long-term degenerative outcomes such as osteoarthritis (OA). Despite surgical advances in ACL reconstruction, a significant number of patients develop OA within ten years post-surgery, providing a patient population that may present early markers of cartilage degeneration detectable using noninvasive imaging. Purpose: This study aims to investigate the temporal evolution of cartilage strain and relaxometry post-ACL reconstruction using displacement under applied loading MRI and quantitative MRI. Specifically, we examined the correlations between MRI metrics and pain, as well as knee loading patterns during gait, to identify early candidate markers of cartilage degeneration. Materials and Methods: Twenty-five participants (female/male = 15/10; average age = 25.6 yrs) undergoing ACL reconstruction were enrolled in a prospective longitudinal cohort study between 2022 and 2023. MRI scans were conducted at 6- and 12-months post-surgery, assessing T2, T2*, and T1ρ relaxometry values, and intratissue cartilage strain. Changes in pain were evaluated using standard outcome scores, and gait analysis assessed the knee adduction moment (KAM). Regressions were performed to evaluate relationships between MRI metrics in cartilage contact regions, patient-reported pain, and knee loading metrics. Results: Increases in axial and transverse strains in the tibial cartilage were significantly correlated with increased pain, while decreases in shear strain were associated with increased pain. Changes in strain metrics were also significantly related to KAM at12 months. Conclusions: Changes in cartilage strain and relaxometry are related to heightened pain and altered knee loading patterns, indicating potential early markers of osteoarthritis progression. These findings underscore the importance of using advanced MRI for early monitoring in ACL-reconstructed patients to optimize treatment outcomes, while also highlighting KAM as a modifiable intervention through gait retraining that may positively impact the evolution of cartilage health and patient pain.","PeriodicalId":501263,"journal":{"name":"medRxiv - Orthopedics","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142207046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-05DOI: 10.1101/2024.09.03.24312969
Michael J. Jurynec, Elena Nosyreva, David Thompson, Crystal Munoz, Kendra A. Novak, Derek J. Matheson, Nikolas H. Kazmers, Ruhma Syeda
The synovial joints senses and responds to a multitude of physical forces to maintain joint homeostasis. Disruption of joint homeostasis results in development of osteoarthritis (OA), a disease characterized by loss of joint space, degeneration of articular cartilage, remodeling of bone and other joint tissues, low-grade inflammation, and pain. How changes in mechanosensing in the joint contribute to OA susceptibility remains elusive. PIEZO1 is a major mechanosensitive cation channel in the joint directly regulated by mechanical stimulus. To test whether altered PIEZO1 channel activity causes increased OA susceptibility, we determined whether variants affecting PIEZO1 are associated with dominant inheritance of age-associated familial OA. We identified four rare coding variants affecting PIEZO1 that are associated with familial hand OA. Single channel analyses demonstrated that all four PIEZO1 mutant channels act in a dominant-negative manner to reduce the open probability of the channel in response to pressure. Furthermore, we show that a GWAS mutation in PIEZO1 associated with reduced joint replacement results in increased channel activity when compared with WT and the mutants. Our data support the hypothesis that reduced PIEZO1 activity confers susceptibility to age-associated OA whereas increased PIEZO1 activity may be associated with reduced OA susceptibility.
滑膜关节能感知并应对多种物理力，以维持关节的平衡。骨关节炎（OA）是一种以关节间隙丧失、关节软骨退化、骨和其他关节组织重塑、低度炎症和疼痛为特征的疾病。关节内机械感应的变化如何导致对 OA 的易感性，目前仍是一个谜。PIEZO1 是关节中直接受机械刺激调控的主要机械敏感阳离子通道。为了检验 PIEZO1 通道活性的改变是否会导致 OA 易感性的增加，我们确定了影响 PIEZO1 的变异是否与年龄相关家族性 OA 的显性遗传有关。我们发现了四个影响 PIEZO1 的罕见编码变异与家族性手部 OA 有关。单通道分析表明，所有四个 PIEZO1 突变通道都以显性阴性方式发挥作用，降低通道对压力的开放概率。此外，我们还发现，与 WT 和突变体相比，PIEZO1 的 GWAS 突变与关节置换减少有关，会导致通道活性增加。我们的数据支持这样的假设，即 PIEZO1 活性降低会导致老年性 OA 易感性，而 PIEZO1 活性增加可能与 OA 易感性降低有关。
{"title":"PIEZO1 variants that reduce open channel probability are associated with familial osteoarthritis","authors":"Michael J. Jurynec, Elena Nosyreva, David Thompson, Crystal Munoz, Kendra A. Novak, Derek J. Matheson, Nikolas H. Kazmers, Ruhma Syeda","doi":"10.1101/2024.09.03.24312969","DOIUrl":"https://doi.org/10.1101/2024.09.03.24312969","url":null,"abstract":"The synovial joints senses and responds to a multitude of physical forces to maintain joint homeostasis. Disruption of joint homeostasis results in development of osteoarthritis (OA), a disease characterized by loss of joint space, degeneration of articular cartilage, remodeling of bone and other joint tissues, low-grade inflammation, and pain. How changes in mechanosensing in the joint contribute to OA susceptibility remains elusive. PIEZO1 is a major mechanosensitive cation channel in the joint directly regulated by mechanical stimulus. To test whether altered PIEZO1 channel activity causes increased OA susceptibility, we determined whether variants affecting <em>PIEZO1</em> are associated with dominant inheritance of age-associated familial OA. We identified four rare coding variants affecting <em>PIEZO1</em> that are associated with familial hand OA. Single channel analyses demonstrated that all four PIEZO1 mutant channels act in a dominant-negative manner to reduce the open probability of the channel in response to pressure. Furthermore, we show that a GWAS mutation in <em>PIEZO1</em> associated with reduced joint replacement results in increased channel activity when compared with WT and the mutants. Our data support the hypothesis that reduced PIEZO1 activity confers susceptibility to age-associated OA whereas increased PIEZO1 activity may be associated with reduced OA susceptibility.","PeriodicalId":501263,"journal":{"name":"medRxiv - Orthopedics","volume":"453 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-28DOI: 10.1101/2024.08.28.24312687
Joaquin Gonzalez Aroca, Laura Vergara Merino, Camila Escobar Liquitay, Humberto Farias A, Jorge Olivares Arancibia, Alvaro Puelles
ntroduction: Musculoskeletal disorders (MSDs) represent a significant global health burden, leading to substantial disability and socioeconomic impact. With the rise of artificial intelligence (AI), particularly large language models-driven conversational agents (chatbots), there is potential to enhance the management of MSDs. However, the application of AI-powered chatbots in this population has not been comprehensively synthesized. Objective: To explore the current and potential use of AI-powered chatbots in the management of MSDs. The review will map out the targeted diseases, the purposes of chatbot interventions, the clinical tools or frameworks utilized in training these systems, and the evaluated outcomes in clinical settings. Methods: This scoping review will follow the PRISMA-ScR guidelines, with a comprehensive search across multiple databases including Medline (Ovid MEDLINE), Embase (Ovid), ISI Web of Science (wos; clarivate) and ClinicalTrials.gov. Studies involving adults with MSDs, regardless of publication status, language, or year, will be included. The scoping review will exclude studies using non-AI chatbots or human health coaches. Data extraction and synthesis will focus on demographic characteristics, chatbot methods, outcomes, and thematic analysis.
{"title":"Role of Artificial Intelligence-Powered Conversational Agents (Chatbots) in Musculoskeletal Disorders: A Scoping Review Protocol","authors":"Joaquin Gonzalez Aroca, Laura Vergara Merino, Camila Escobar Liquitay, Humberto Farias A, Jorge Olivares Arancibia, Alvaro Puelles","doi":"10.1101/2024.08.28.24312687","DOIUrl":"https://doi.org/10.1101/2024.08.28.24312687","url":null,"abstract":"ntroduction: Musculoskeletal disorders (MSDs) represent a significant global health burden, leading to substantial disability and socioeconomic impact. With the rise of artificial intelligence (AI), particularly large language models-driven conversational agents (chatbots), there is potential to enhance the management of MSDs. However, the application of AI-powered chatbots in this population has not been comprehensively synthesized. Objective: To explore the current and potential use of AI-powered chatbots in the management of MSDs. The review will map out the targeted diseases, the purposes of chatbot interventions, the clinical tools or frameworks utilized in training these systems, and the evaluated outcomes in clinical settings. Methods: This scoping review will follow the PRISMA-ScR guidelines, with a comprehensive search across multiple databases including Medline (Ovid MEDLINE), Embase (Ovid), ISI Web of Science (wos; clarivate) and ClinicalTrials.gov. Studies involving adults with MSDs, regardless of publication status, language, or year, will be included. The scoping review will exclude studies using non-AI chatbots or human health coaches. Data extraction and synthesis will focus on demographic characteristics, chatbot methods, outcomes, and thematic analysis.","PeriodicalId":501263,"journal":{"name":"medRxiv - Orthopedics","volume":"407 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142207057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-26DOI: 10.1101/2024.08.25.24312205
Corey Scholes, Carl Holder, Christopher Vertullo, Matthew Lawrence Broadhead
Purpose: The relationship between remoteness of patient residence and post-surgical outcomes, such as early implant revision, has yet to be examined. The aim of this study was to assess whether the incidence of all-cause revision at up to 2 years following primary hip or knee total joint arthroplasty varies with the remoteness of a person's place of residence at the time of the primary procedure. Methods: An analysis was performed of data from the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) from 1 Sept 1999 to 31 Dec 2022. The Modified Monash Model (2015) of remoteness classification was used to categorise patient residence and hospital location into metro-regional (MM 1-2) and rural-remote (MM 3-7). All-cause revision within the two-year period after surgery for primary total knee arthroplasty (TKA) and primary total hip arthroplasty (THA) for osteoarthritis as the primary diagnosis was selected as the primary outcome. A directed-acyclic graph approach was used to prioritise covariates for inclusion in a Cox proportional hazards regression model. Cumulative percent revision (CPR) rates with 95% confidence intervals was reported with hazard ratios between subgroups of residential and hospital remoteness. Results: The two-year CPR for primary TKA ranged from 1.8% (95% CI 1.7 - 1.9) to 2.2% (95% CI 1.8 - 2.7). Patients residing in rural-remote areas who travelled to a metro-regional hospital displayed a significantly higher rate of revision following TKA compared to patients that were treated at a rural-remote hospital (HR: 1.11, 95% CI 1.05 - 1.18, P = 0.001) within two-year follow-up of the primary procedure. Patients residing in rural-remote areas that stayed in these areas for their operation displayed a significantly reduced revision rate compared to metro-regional patients that stayed in-area for their joint replacement (HR=0.90, 95%CI 0.85 - 0.95, P <0.001). Infection was the dominant reason for TKA revision for patients in the follow-up period. No discernible differences in revision risk were observed between patient and hospital combinations for primary total hip replacement. Conclusions: Travel distance, but not remoteness of a patient's place of residence may be associated with cumulative risk of early revision (within 2 years) of primary TKA, particularly in regional/remote patients travelling out of area, but not for patients undergoing THA. Further work linking service utilisation prior to a revision procedure is required to clarify whether differences in revision between remoteness and travel distances are due to variability in the clinical threshold for offering revision arthroplasty between regional and metropolitan surgeons or improved outcomes of the primary procedure.
{"title":"Stay or go? Outcomes of lower limb arthroplasty in patients travelling away from home for surgery: A cross-sectional analysis of the AOANJRR comparing patient residence and hospital remoteness","authors":"Corey Scholes, Carl Holder, Christopher Vertullo, Matthew Lawrence Broadhead","doi":"10.1101/2024.08.25.24312205","DOIUrl":"https://doi.org/10.1101/2024.08.25.24312205","url":null,"abstract":"Purpose: The relationship between remoteness of patient residence and post-surgical outcomes, such as early implant revision, has yet to be examined. The aim of this study was to assess whether the incidence of all-cause revision at up to 2 years following primary hip or knee total joint arthroplasty varies with the remoteness of a person's place of residence at the time of the primary procedure. Methods: An analysis was performed of data from the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) from 1 Sept 1999 to 31 Dec 2022. The Modified Monash Model (2015) of remoteness classification was used to categorise patient residence and hospital location into metro-regional (MM 1-2) and rural-remote (MM 3-7). All-cause revision within the two-year period after surgery for primary total knee arthroplasty (TKA) and primary total hip arthroplasty (THA) for osteoarthritis as the primary diagnosis was selected as the primary outcome. A directed-acyclic graph approach was used to prioritise covariates for inclusion in a Cox proportional hazards regression model. Cumulative percent revision (CPR) rates with 95% confidence intervals was reported with hazard ratios between subgroups of residential and hospital remoteness. Results: The two-year CPR for primary TKA ranged from 1.8% (95% CI 1.7 - 1.9) to 2.2% (95% CI 1.8 - 2.7). Patients residing in rural-remote areas who travelled to a metro-regional hospital displayed a significantly higher rate of revision following TKA compared to patients that were treated at a rural-remote hospital (HR: 1.11, 95% CI 1.05 - 1.18, P = 0.001) within two-year follow-up of the primary procedure. Patients residing in rural-remote areas that stayed in these areas for their operation displayed a significantly reduced revision rate compared to metro-regional patients that stayed in-area for their joint replacement (HR=0.90, 95%CI 0.85 - 0.95, P <0.001). Infection was the dominant reason for TKA revision for patients in the follow-up period. No discernible differences in revision risk were observed between patient and hospital combinations for primary total hip replacement. Conclusions: Travel distance, but not remoteness of a patient's place of residence may be associated with cumulative risk of early revision (within 2 years) of primary TKA, particularly in regional/remote patients travelling out of area, but not for patients undergoing THA. Further work linking service utilisation prior to a revision procedure is required to clarify whether differences in revision between remoteness and travel distances are due to variability in the clinical threshold for offering revision arthroplasty between regional and metropolitan surgeons or improved outcomes of the primary procedure.","PeriodicalId":501263,"journal":{"name":"medRxiv - Orthopedics","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142207048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-20DOI: 10.1101/2024.08.13.24311955
shuaishuai hu, Duzheng Zhang, Ruijun Cong
There is limited research on the association between 25-hydroxyvitamin D levels and meniscus injury. This study investigated serum 25-hydroxyvitamin D (25-OHD) in meniscus injury patients and its association with other bioinorganic chemistry of micronutrients, and immune cells numbers from January 2023 to December 2023. A total of 198 participants were recruited between the age of 18 and 89 years. Participants with renal or liver failure, or any other chronic conditions, who were taking medications that might affect the metabolism of vitamin D, were not included in the study. In this study, we categorized serum 25(OH)D concentrations as follows: ≤30ngm/dl was categorized as insufficient, and >30ngm/dl was deemed sufficient. Among the 198 participants, 82% (n=162) were serum 25(OH)D deficient, while only 18% (n=36) participants were serum 25(OH)D sufficient. No significant difference observed in vitamin D deficiency among difference age, BMI, sex, blood pressure, inflammatory cell numbers, and other vitamins compared to the vitamin D sufficient group. Moreover, the serum 25(OH)D concentrations were negatively related to the severity of meniscus injury based on MRI examination. In conclusion, severe vitamin D deficiency is more common in patients with meniscus injury and may play a significant role in their prognosis.
关于 25- 羟基维生素 D 水平与半月板损伤之间关系的研究十分有限。本研究调查了 2023 年 1 月至 2023 年 12 月期间半月板损伤患者的血清 25- 羟维生素 D（25-OHD）及其与其他生物无机化学微量元素和免疫细胞数量的关系。共招募了 198 名年龄在 18 至 89 岁之间的参与者。患有肾功能衰竭、肝功能衰竭或任何其他慢性疾病的参与者，以及正在服用可能影响维生素 D 代谢的药物的参与者未被纳入研究。在这项研究中，我们将血清 25(OH)D 浓度分为以下几类：≤30ngm/dl为不足，>30ngm/dl为充足。在 198 名参与者中，82%（n=162）的人血清中 25（OH）D 不足，而只有 18%（n=36）的人血清中 25（OH）D 充足。与维生素 D 充足组相比，年龄、体重指数、性别、血压、炎症细胞数量和其他维生素的缺乏情况没有明显差异。此外，根据核磁共振成像检查，血清 25（OH）D 浓度与半月板损伤的严重程度呈负相关。总之，维生素 D 严重缺乏在半月板损伤患者中更为常见，并可能对其预后产生重要影响。
{"title":"A Single Center Observational Study on 25-hydroxyvitamin D levels in Meniscus Injury Patients","authors":"shuaishuai hu, Duzheng Zhang, Ruijun Cong","doi":"10.1101/2024.08.13.24311955","DOIUrl":"https://doi.org/10.1101/2024.08.13.24311955","url":null,"abstract":"There is limited research on the association between 25-hydroxyvitamin D levels and meniscus injury. This study investigated serum 25-hydroxyvitamin D (25-OHD) in meniscus injury patients and its association with other bioinorganic chemistry of micronutrients, and immune cells numbers from January 2023 to December 2023. A total of 198 participants were recruited between the age of 18 and 89 years. Participants with renal or liver failure, or any other chronic conditions, who were taking medications that might affect the metabolism of vitamin D, were not included in the study. In this study, we categorized serum 25(OH)D concentrations as follows: ≤30ngm/dl was categorized as insufficient, and >30ngm/dl was deemed sufficient. Among the 198 participants, 82% (n=162) were serum 25(OH)D deficient, while only 18% (n=36) participants were serum 25(OH)D sufficient. No significant difference observed in vitamin D deficiency among difference age, BMI, sex, blood pressure, inflammatory cell numbers, and other vitamins compared to the vitamin D sufficient group. Moreover, the serum 25(OH)D concentrations were negatively related to the severity of meniscus injury based on MRI examination. In conclusion, severe vitamin D deficiency is more common in patients with meniscus injury and may play a significant role in their prognosis.","PeriodicalId":501263,"journal":{"name":"medRxiv - Orthopedics","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142207055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-20DOI: 10.1101/2024.08.19.24312206
Cooper Moody, Corey Scholes, Manaal Fatima, Kevin Eng, Graeme Brown, Richard S Page
Background: Despite technical and material improvements in rotator cuff repair (RCR) clinical and radiological failure remains common. Following suture fixation, tension and footprint compression decrease from time zero. A novel suture (Dynacord, Depuy Synthes) has been designed to shorten when submerged in liquid to maintain tension and increase repair construct security. Methods: A retrospective cohort analysis was performed on the PRULO (Patient Reported Outcomes in Upper Limb Surgery) registry for 12 months follow up after RCR using this suture regarding all cause failure, rates of common complications, Quick Disability of the Arm, Shoulder and Hand (QuickDASH), and Western Ontario Rotator Cuff Index (WORC). Summary statistics were generated for patient characteristics and patient-reported outcome measures (PROMs) analysed using multiple imputation and a linear model to assess changes over 12 months follow up. Results: A cohort of 236 cases was included for analysis. Complication rates and functional improvements were comparable to literature on similar sutures. At 12 months follow up, all-cause failure occurred in 12% of cases, and mean scores for QuickDASH decreased by 37 and WORC increased by 44, both of which surpass the minimum clinically important difference. Our observed rates of complications are as follows: Infection 2.1%, stiffness/capsulitis 11% and retear 12%. Conclusion: The novel suture demonstrated favourable safety and efficacy profiles, with outcomes comparable to those published for commonly used sutures. This study through an IDEAL 2a framework for surgical innovation highlights this suture as safe, effective in mitigating common failure mechanisms and having satisfactory outcomes in RCR.
{"title":"Low incidence of adverse events or construct failure of a novel high-strength No.2 round suture in rotator cuff repair: An IDEAL Stage 2a assessment retrospective cohort analysis","authors":"Cooper Moody, Corey Scholes, Manaal Fatima, Kevin Eng, Graeme Brown, Richard S Page","doi":"10.1101/2024.08.19.24312206","DOIUrl":"https://doi.org/10.1101/2024.08.19.24312206","url":null,"abstract":"Background: Despite technical and material improvements in rotator cuff repair (RCR) clinical and radiological failure remains common. Following suture fixation, tension and footprint compression decrease from time zero. A novel suture (Dynacord, Depuy Synthes) has been designed to shorten when submerged in liquid to maintain tension and increase repair construct security. Methods: A retrospective cohort analysis was performed on the PRULO (Patient Reported Outcomes in Upper Limb Surgery) registry for 12 months follow up after RCR using this suture regarding all cause failure, rates of common complications, Quick Disability of the Arm, Shoulder and Hand (QuickDASH), and Western Ontario Rotator Cuff Index (WORC). Summary statistics were generated for patient characteristics and patient-reported outcome measures (PROMs) analysed using multiple imputation and a linear model to assess changes over 12 months follow up. Results: A cohort of 236 cases was included for analysis. Complication rates and functional improvements were comparable to literature on similar sutures. At 12 months follow up, all-cause failure occurred in 12% of cases, and mean scores for QuickDASH decreased by 37 and WORC increased by 44, both of which surpass the minimum clinically important difference. Our observed rates of complications are as follows: Infection 2.1%, stiffness/capsulitis 11% and retear 12%. Conclusion: The novel suture demonstrated favourable safety and efficacy profiles, with outcomes comparable to those published for commonly used sutures. This study through an IDEAL 2a framework for surgical innovation highlights this suture as safe, effective in mitigating common failure mechanisms and having satisfactory outcomes in RCR.","PeriodicalId":501263,"journal":{"name":"medRxiv - Orthopedics","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142207049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-20DOI: 10.1101/2024.08.20.24312094
Mehrdad Davoudi, Firooz Salami, Robert Reisig, Katharina Susanne Gather, Sebastian Wolf
Abstract Duchenne gait, characterized by an ipsilateral trunk lean towards the affected stance limb, compensates for weak hip abductor muscles, notably the gluteus medius (GM). This study aims to investigate how electromyographic (EMG) cluster analysis of GM contributes to a better understanding of Duchenne gait in patients with cerebral palsy (CP). We analyzed retrospective gait data from 845 patients with CP and 65 typically developed individuals. EMG activity of GM in envelope format were collected and examined with gait kinematics and kinetics parameters in frontal plane and hip abductor strength, and hip abduction passive range of motion. Six key EMG envelope features during ten gait phases were extracted and normalized. A hybrid K-means-PSO clustering algorithm was employed, followed by hierarchical clustering. The identified clusters were characterized by having a low (cluster_1), medium (cluster_2), and high (cluster_3) activity of GM during loading response. The patients in cluster_1 also exhibited pathological gait characteristics, including increased trunk lateral lean and weak hip abductor, which are associated with Duchenne gait. The patients in this cluster were subclustered according to their response to the intervention: SUB_1 with a significant improvement in trunk obliquity, pelvic obliquity, and hip abduction after intervention, and SUB_2 without such improvement. Comparing pre-treatment EMG and clinical exam of the sub_clusters, SUB_1 had significantly higher activity of GM during 50-87% of the gait cycle with a greater passive range of hip abduction compared to SUB_2. This study established a relationship between EMG of GM and frontal plane gait abnormalities in patients with CP, highlighting potential improvement in Duchenne gait with prolonged GM activity during swing after the intervention.
{"title":"Gluteus Medius Muscle Activation Patterns during Gait with Cerebral Palsy (CP): A hierarchical clustering analysis","authors":"Mehrdad Davoudi, Firooz Salami, Robert Reisig, Katharina Susanne Gather, Sebastian Wolf","doi":"10.1101/2024.08.20.24312094","DOIUrl":"https://doi.org/10.1101/2024.08.20.24312094","url":null,"abstract":"Abstract Duchenne gait, characterized by an ipsilateral trunk lean towards the affected stance limb, compensates for weak hip abductor muscles, notably the gluteus medius (GM). This study aims to investigate how electromyographic (EMG) cluster analysis of GM contributes to a better understanding of Duchenne gait in patients with cerebral palsy (CP). We analyzed retrospective gait data from 845 patients with CP and 65 typically developed individuals. EMG activity of GM in envelope format were collected and examined with gait kinematics and kinetics parameters in frontal plane and hip abductor strength, and hip abduction passive range of motion.\u0000Six key EMG envelope features during ten gait phases were extracted and normalized. A hybrid K-means-PSO clustering algorithm was employed, followed by hierarchical clustering. The identified clusters were characterized by having a low (cluster_1), medium (cluster_2), and high (cluster_3) activity of GM during loading response. The patients in cluster_1 also exhibited pathological gait characteristics, including increased trunk lateral lean and weak hip abductor, which are associated with Duchenne gait. The patients in this cluster were subclustered according to their response to the intervention: SUB_1 with a significant improvement in trunk obliquity, pelvic obliquity, and hip abduction after intervention, and SUB_2 without such improvement. Comparing pre-treatment EMG and clinical exam of the sub_clusters, SUB_1 had significantly higher activity of GM during 50-87% of the gait cycle with a greater passive range of hip abduction compared to SUB_2. This study established a relationship between EMG of GM and frontal plane gait abnormalities in patients with CP, highlighting potential improvement in Duchenne gait with prolonged GM activity during swing after the intervention.","PeriodicalId":501263,"journal":{"name":"medRxiv - Orthopedics","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-11DOI: 10.1101/2024.07.11.24310261
Rusul Yonis, Daniel Perry, James S Bowness
Background: Ultrasound imaging plays a pivotal role in the diagnosis and monitoring of developmental dysplasia of the hip (DDH). However, this step requires a formal referral to the radiology department for an ultrasound by an expert radiologist or sonographer. This process can delay diagnosis and treatment initiation due to long wait times caused by the high demand on NHS services. In recent years, there has been a growing interest in leveraging artificial intelligence (AI) in ultrasound imaging. AI has potential to assist in image acquisition and interpretation, to inform clinical decision-making. Further benefits may include improved accuracy, efficiency, and consistency in diagnosis, ultimately leading to better patient outcomes. This scoping review aims to review the evidence for AI to support ultrasound detection of DDH, including reviewing the methodologies employed, the accuracy and utility of algorithms, challenges and opportunities for clinical translation, and requirements for future research. Methods: We will conduct a comprehensive search of the literature using multiple databases, including ACM Digital Library, EMBASE, OVID MEDLINE, PUBMED, COCHRANE Library, CINAHL, and IEEE Explore. These databases cover a wide range of academic disciplines, including computer science, and medical sciences, ensuring thorough coverage of relevant studies related to artificial intelligence (AI) in ultrasound for developmental dysplasia of the hip (DDH). In addition, we will explore the International Committee of Medical Journal Editors (ICMJE) approved clinical trial registries and the World Health Organization (WHO) clinical trials registry to identify ongoing or completed studies in this field. This will capture relevant research that may not yet be published in peer-reviewed journals. To supplement the research databases, we will search the websites of international societies in relevant fields, such as the British Society of Children's Orthopaedic Surgery (BSCOS) and Paediatric Orthopaedic Society of North America (POSNA). As AI has a strong commercial interest, we will review product information and publicly available evidence from EXO Imaging (https://www.exo.inc), a commercial company with a known interest in this field and an established AI aided US device. Discussion: This scoping review represents the first comprehensive attempt to gather the available evidence on the application of AI in ultrasound imaging for the diagnosis of DDH. By systematically reviewing and synthesizing a diverse range of studies, we aim to provide an overview of the current state of the art in this emerging field, identify gaps in the literature, and inform future research.
{"title":"Artificial Intelligence Aided Ultrasound Detection of DDH: A Scoping Review Protocol","authors":"Rusul Yonis, Daniel Perry, James S Bowness","doi":"10.1101/2024.07.11.24310261","DOIUrl":"https://doi.org/10.1101/2024.07.11.24310261","url":null,"abstract":"Background:\u0000Ultrasound imaging plays a pivotal role in the diagnosis and monitoring of developmental dysplasia of the hip (DDH). However, this step requires a formal referral to the radiology department for an ultrasound by an expert radiologist or sonographer. This process can delay diagnosis and treatment initiation due to long wait times caused by the high demand on NHS services.\u0000In recent years, there has been a growing interest in leveraging artificial intelligence (AI) in ultrasound imaging. AI has potential to assist in image acquisition and interpretation, to inform clinical decision-making. Further benefits may include improved accuracy, efficiency, and consistency in diagnosis, ultimately leading to better patient outcomes.\u0000This scoping review aims to review the evidence for AI to support ultrasound detection of DDH, including reviewing the methodologies employed, the accuracy and utility of algorithms, challenges and opportunities for clinical translation, and requirements for future research.\u0000Methods:\u0000We will conduct a comprehensive search of the literature using multiple databases, including ACM Digital Library, EMBASE, OVID MEDLINE, PUBMED, COCHRANE Library, CINAHL, and IEEE Explore. These databases cover a wide range of academic disciplines, including computer science, and medical sciences, ensuring thorough coverage of relevant studies related to artificial intelligence (AI) in ultrasound for developmental dysplasia of the hip (DDH).\u0000In addition, we will explore the International Committee of Medical Journal Editors (ICMJE) approved clinical trial registries and the World Health Organization (WHO) clinical trials registry to identify ongoing or completed studies in this field. This will capture relevant research that may not yet be published in peer-reviewed journals.\u0000To supplement the research databases, we will search the websites of international societies in relevant fields, such as the British Society of Children's Orthopaedic Surgery (BSCOS) and Paediatric Orthopaedic Society of North America (POSNA). As AI has a strong commercial interest, we will review product information and publicly available evidence from EXO Imaging (https://www.exo.inc), a commercial company with a known interest in this field and an established AI aided US device. Discussion:\u0000This scoping review represents the first comprehensive attempt to gather the available evidence on the application of AI in ultrasound imaging for the diagnosis of DDH. By systematically reviewing and synthesizing a diverse range of studies, we aim to provide an overview of the current state of the art in this emerging field, identify gaps in the literature, and inform future research.","PeriodicalId":501263,"journal":{"name":"medRxiv - Orthopedics","volume":"196 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141614401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives Osteoarthritis (OA) and has become a global public health problem. The purpose of this study was to elucidate the burden of OA across different geographic regions, ages, sexes, and types. Methods Publicly available data from the Global Burden of Disease 2021 were used in this study. The burden of OA was estimated at the global, SDI quintile, regional, and national levels from 1990 to 2021 through systematic analyses. Bayesian age-period-cohort models were utilized to predict the burden over the next 30 years. Results Globally, there were 607 million people suffering from OA with 46.6 million new cases and 21.3 million DALYs in 2021. The age-standardized incidence, prevalence and DALYs rates increased to 535.00, 6967.29, and 244.50 per 100,000 population, with knee OA accounting for more than 56%. The age-standardized rates of OA were higher in females than in males. East Asia, South Asia, and Western Europe were the top three regions and China, India, and the United States were the top three countries with the highest burdens. In addition, high body-mass index (BMI) resulted in 4.43 million DALYs with an increase of 205.10%. BAPC projections showed that the burden of OA will continue to rise over the next 30 years. Conclusions As populations ageing and global obesity rates rise, the burden of total OA and OA due to high BMI will continue to increase. Females and middle-aged and elderly patients are the current populations to focus on. The development and implementation of effective prevention and treatment strategies is critical.
目的 骨关节炎（OA）已成为全球性公共卫生问题。本研究旨在阐明不同地理区域、年龄、性别和类型的 OA 负担。通过系统分析估算了1990年至2021年全球、SDI五分位数、地区和国家层面的OA负担。结果 2021 年全球有 6.07 亿人患有 OA，新增病例 4660 万例，DALY 为 2130 万。年龄标准化发病率、患病率和残疾调整寿命年数比率分别增至每 10 万人 535.00 例、6967.29 例和 244.50 例，其中膝关节 OA 占 56% 以上。女性的年龄标准化 OA 患病率高于男性。东亚、南亚和西欧是发病率最高的三个地区，中国、印度和美国是发病率最高的三个国家。此外，高体重指数（BMI）导致 443 万 DALYs 的增加，增幅为 205.10%。结论 随着人口老龄化和全球肥胖率的上升，总OA负担和高体重指数导致的OA负担将继续增加。女性和中老年患者是当前需要重点关注的人群。制定和实施有效的预防和治疗策略至关重要。
{"title":"Epidemiological trends of osteoarthritis at the global, regional, and national levels from 1990 to 2021, with a projection from 2021 to 2050","authors":"Lichun Qiao, Miaoqian Li, Feidan Deng, Xinyue Wen, Jun Wang, Huan Deng, zhaowei Xue, Ping Wan, Rongqi Xiang, Yanjun Xie, Huifang He, Xiangyu Fan, Yufei Song, Jing Han","doi":"10.1101/2024.06.30.24309697","DOIUrl":"https://doi.org/10.1101/2024.06.30.24309697","url":null,"abstract":"Objectives Osteoarthritis (OA) and has become a global public health problem. The purpose of this study was to elucidate the burden of OA across different geographic regions, ages, sexes, and types.\u0000Methods Publicly available data from the Global Burden of Disease 2021 were used in this study. The burden of OA was estimated at the global, SDI quintile, regional, and national levels from 1990 to 2021 through systematic analyses. Bayesian age-period-cohort models were utilized to predict the burden over the next 30 years.\u0000Results Globally, there were 607 million people suffering from OA with 46.6 million new cases and 21.3 million DALYs in 2021. The age-standardized incidence, prevalence and DALYs rates increased to 535.00, 6967.29, and 244.50 per 100,000 population, with knee OA accounting for more than 56%. The age-standardized rates of OA were higher in females than in males. East Asia, South Asia, and Western Europe were the top three regions and China, India, and the United States were the top three countries with the highest burdens. In addition, high body-mass index (BMI) resulted in 4.43 million DALYs with an increase of 205.10%. BAPC projections showed that the burden of OA will continue to rise over the next 30 years.\u0000Conclusions As populations ageing and global obesity rates rise, the burden of total OA and OA due to high BMI will continue to increase. Females and middle-aged and elderly patients are the current populations to focus on. The development and implementation of effective prevention and treatment strategies is critical.","PeriodicalId":501263,"journal":{"name":"medRxiv - Orthopedics","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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