Aqueous rechargeable batteries using abundant multi-ion cations have received increasing attention in the energy storage field for their high safety and low cost. Layered double hydroxides (LDHs) possess a two-dimensional structure and exhibit great potential as cathodes for multi-ion intercalation. However, the insufficient active sites of LDHs result in low capacities in the discharging process. Interestingly, the LDHs after the deprotonation process exhibit favorable electrochemical performance of multi-cation intercalation. The deprotonation process of LDHs has been widely found in the oxygen evolution reaction and energy storage field, where LDHs lose H in laminates and converts to deprotonated γ-phase MOOHs (MOOs). Herein, we take a comprehensive overview of the dynamics structure transformation of the deprotonation process of LDHs. Furthermore, the development of advanced aqueous battery cathode and metal battery anode based on deprotonated LDHs for energy storage is explored and summarized. Finally, the perspective of deprotonated LDHs in the energy storage field is discussed.
{"title":"Deprotonated of layered double hydroxides during electrocatalytic water oxidation for multi-cations intercalation","authors":"Bowen Jin, Jianxiong Gao, Yunqi Zhang, Mingfei Shao","doi":"10.1002/smo.20230026","DOIUrl":"https://doi.org/10.1002/smo.20230026","url":null,"abstract":"Aqueous rechargeable batteries using abundant multi-ion cations have received increasing attention in the energy storage field for their high safety and low cost. Layered double hydroxides (LDHs) possess a two-dimensional structure and exhibit great potential as cathodes for multi-ion intercalation. However, the insufficient active sites of LDHs result in low capacities in the discharging process. Interestingly, the LDHs after the deprotonation process exhibit favorable electrochemical performance of multi-cation intercalation. The deprotonation process of LDHs has been widely found in the oxygen evolution reaction and energy storage field, where LDHs lose H in laminates and converts to deprotonated <i>γ</i>-phase MOOHs (MOOs). Herein, we take a comprehensive overview of the dynamics structure transformation of the deprotonation process of LDHs. Furthermore, the development of advanced aqueous battery cathode and metal battery anode based on deprotonated LDHs for energy storage is explored and summarized. Finally, the perspective of deprotonated LDHs in the energy storage field is discussed.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The smart emulsification and demulsification system with the light response is a useful tool in various industries, including green chemistry, catalytic reaction, pharmaceuticals, and environmental remediation. Herein, an ionic liquid crystal compound with a light triggered switch based on the azobenzene group [(4-{3-methyl-1-[3-(8-octyloxyoctyl)oxy-4-oxobutanoyl]imidazo-lium-1-yl}octyl)oxy] -N-(4-methylphenyl)benzene-1,2-diazene bromide (MOIAzo), was designed and synthesized, which could cause reversible transition between emulsification and demulsification through the light trigger. The ionic liquid has an efficient photoinduced liquefaction process, which dramatically lowers the melting point of ionic liquids from 79 to 9.2 oC. This significantly broadens the liquid state temperature of the ionic liquid crystal. The ionic liquid crystal MOIAzo exhibits both photoinduced and thermally induced nematic liquid crystal properties. The smart emulsion system was effectively employed in an eco-friendly water-saving dyeing process of cationic dyes for cationic dyeable polyester (CDP) fabrics, which used only half the amount of water compared with the conventional water bath dyeing method. After dyeing, the oil and water phases can be efficiently separated through the light irradiation, and the oil phase can be reused for the subsequent dyeing process. This novel smart emulsion dyeing method greatly reduces the water consumption and wastewater discharge. MOIAzo as a light-triggered ionic liquid molecule opens up new dimensions in green chemistry.
{"title":"Smart emulsion system driven by light-triggered ionic liquid molecules and its application in eco-friendly water-saving dyeing","authors":"Aiqin Gao, Jiahui Liang, Mingxiao Jing, Xiyu Song, Aiqin Hou, Kongliang Xie","doi":"10.1002/smo.20230030","DOIUrl":"https://doi.org/10.1002/smo.20230030","url":null,"abstract":"The smart emulsification and demulsification system with the light response is a useful tool in various industries, including green chemistry, catalytic reaction, pharmaceuticals, and environmental remediation. Herein, an ionic liquid crystal compound with a light triggered switch based on the azobenzene group [(4-{3-methyl-1-[3-(8-octyloxyoctyl)oxy-4-oxobutanoyl]imidazo-lium-1-yl}octyl)oxy] -N-(4-methylphenyl)benzene-1,2-diazene bromide (MOIAzo), was designed and synthesized, which could cause reversible transition between emulsification and demulsification through the light trigger. The ionic liquid has an efficient photoinduced liquefaction process, which dramatically lowers the melting point of ionic liquids from 79 to 9.2 <sup>o</sup>C. This significantly broadens the liquid state temperature of the ionic liquid crystal. The ionic liquid crystal MOIAzo exhibits both photoinduced and thermally induced nematic liquid crystal properties. The smart emulsion system was effectively employed in an eco-friendly water-saving dyeing process of cationic dyes for cationic dyeable polyester (CDP) fabrics, which used only half the amount of water compared with the conventional water bath dyeing method. After dyeing, the oil and water phases can be efficiently separated through the light irradiation, and the oil phase can be reused for the subsequent dyeing process. This novel smart emulsion dyeing method greatly reduces the water consumption and wastewater discharge. MOIAzo as a light-triggered ionic liquid molecule opens up new dimensions in green chemistry.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140166791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Merve Kulbay, Kevin Yang Wu, Doanh Truong, Simon D. Tran
This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, and classification of hydrogels, the review explores their synthesis and responsive capabilities. Specific applications examined encompass topical drug delivery, contact lenses, intravitreal drug delivery, ocular adhesives, vitreous substitutes, and cell-based therapy. A methodical analysis, including an overview of relevant ocular structures and a comparative evaluation of hydrogel-based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, and research areas are identified. Our methodical approach, guided by an extensive literature review from 2017 to 2023, illuminates the unprecedented opportunities offered by hydrogels, along with pinpointing areas for further inquiry to facilitate their transition into clinical practice.
{"title":"Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications","authors":"Merve Kulbay, Kevin Yang Wu, Doanh Truong, Simon D. Tran","doi":"10.1002/smo.20230021","DOIUrl":"https://doi.org/10.1002/smo.20230021","url":null,"abstract":"This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, and classification of hydrogels, the review explores their synthesis and responsive capabilities. Specific applications examined encompass topical drug delivery, contact lenses, intravitreal drug delivery, ocular adhesives, vitreous substitutes, and cell-based therapy. A methodical analysis, including an overview of relevant ocular structures and a comparative evaluation of hydrogel-based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, and research areas are identified. Our methodical approach, guided by an extensive literature review from 2017 to 2023, illuminates the unprecedented opportunities offered by hydrogels, along with pinpointing areas for further inquiry to facilitate their transition into clinical practice.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140147245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Precise design and control of molecular self-assembly as living creatures are exciting ideas in the field of nanotechnology. Characterized with predesigned geometries and accurate spatial addressability, programmable DNA origami nanostructures have been recognized as optimized tools for assembling multiple functional components. A variety of biomolecules can be attached to the nanoscale drawing boards in a site-specific fashion, thus facilitating the precise construction of DNA origami-based materials for studies on biological interface. In this minireview, we highlight the recent advances in the precise construction of DNA origami-based materials with artificial bio-structures and/or biomimicking functions. The regulation of biological functions by these DNA origami-engineered assemblies at the bio-interface has been summarized and discussed.
精确设计和控制分子自组装生物是纳米技术领域令人兴奋的想法。可编程 DNA 折纸纳米结构具有预先设计的几何形状和精确的空间寻址能力，被认为是组装多种功能组件的优化工具。各种生物分子都能以特定位点的方式附着在纳米级图板上，从而有助于精确构建基于 DNA 折纸的材料，用于生物界面研究。在这篇微型综述中，我们将重点介绍在精确构建具有人工生物结构和/或仿生功能的 DNA 折纸材料方面的最新进展。我们还总结并讨论了这些 DNA 折纸工程组装体在生物界面上对生物功能的调控。
{"title":"Precise construction of DNA origami-based materials for functional regulation on biological interface","authors":"Yushuai Wu, Xiaohui Wu, Run Tian, Yiming Wang, Baoquan Ding, Qiao Jiang","doi":"10.1002/smo.20230032","DOIUrl":"https://doi.org/10.1002/smo.20230032","url":null,"abstract":"Precise design and control of molecular self-assembly as living creatures are exciting ideas in the field of nanotechnology. Characterized with predesigned geometries and accurate spatial addressability, programmable DNA origami nanostructures have been recognized as optimized tools for assembling multiple functional components. A variety of biomolecules can be attached to the nanoscale drawing boards in a site-specific fashion, thus facilitating the precise construction of DNA origami-based materials for studies on biological interface. In this minireview, we highlight the recent advances in the precise construction of DNA origami-based materials with artificial bio-structures and/or biomimicking functions. The regulation of biological functions by these DNA origami-engineered assemblies at the bio-interface has been summarized and discussed.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140036459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Smart chiral liquid crystal elastomers are a class of soft photonic crystals with periodic nanostructures. There are two kinds of chiral liquid crystal elastomers with structural colors: cholesteric liquid crystal elastomers with a one-dimensional helical nanostructure and blue-phase liquid crystal elastomers with a three-dimensional photonic crystal nanostructure. The self-assembled nanostructure of chiral liquid crystal elastomers can be dynamically controlled under external stimulation, and the reflected color can be adjusted throughout the visible light range. Along with the development of innovative material systems and cutting-edge manufacturing technologies, researchers have proposed diverse strategies to design and synthesize chiral liquid crystal elastomers and have thoroughly investigated their properties and potential applications. Here, we provide a systematic review of the progress in the design and fabrication of smart chiral liquid crystal elastomers, focusing on the cholesteric liquid crystal elastomers via surface-enforced alignment, bar coating, 3D printing, anisotropic deswelling methods as well as the three-dimensional self-assembly of blue-phase liquid crystal elastomers without additional alignment. Smart chiral liquid crystal elastomers are able to respond quickly to external stimuli and have a wide range of applications in areas such as adaptive optics, color-changing camouflage, soft robotics, and information encryption. This review concludes with a perspective on the opportunities and challenges for the future development of smart chiral liquid crystal elastomers.
{"title":"Smart chiral liquid crystal elastomers: Design, properties and application","authors":"Yuan Liu, Jiazhe Ma, Yanzhao Yang, Cristian Valenzuela, Xuan Zhang, Ling Wang, Wei Feng","doi":"10.1002/smo.20230025","DOIUrl":"https://doi.org/10.1002/smo.20230025","url":null,"abstract":"Smart chiral liquid crystal elastomers are a class of soft photonic crystals with periodic nanostructures. There are two kinds of chiral liquid crystal elastomers with structural colors: cholesteric liquid crystal elastomers with a one-dimensional helical nanostructure and blue-phase liquid crystal elastomers with a three-dimensional photonic crystal nanostructure. The self-assembled nanostructure of chiral liquid crystal elastomers can be dynamically controlled under external stimulation, and the reflected color can be adjusted throughout the visible light range. Along with the development of innovative material systems and cutting-edge manufacturing technologies, researchers have proposed diverse strategies to design and synthesize chiral liquid crystal elastomers and have thoroughly investigated their properties and potential applications. Here, we provide a systematic review of the progress in the design and fabrication of smart chiral liquid crystal elastomers, focusing on the cholesteric liquid crystal elastomers via surface-enforced alignment, bar coating, 3D printing, anisotropic deswelling methods as well as the three-dimensional self-assembly of blue-phase liquid crystal elastomers without additional alignment. Smart chiral liquid crystal elastomers are able to respond quickly to external stimuli and have a wide range of applications in areas such as adaptive optics, color-changing camouflage, soft robotics, and information encryption. This review concludes with a perspective on the opportunities and challenges for the future development of smart chiral liquid crystal elastomers.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140003015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Si-Yu Wang, Ying-Hao Pan, Yu-Chen Qu, Xiao-Xiao Chen, Na Shao, Li-Ya Niu, Qing-Zheng Yang
Glutathione (GSH)-activated prodrugs are promising for overcoming the limitations of conventional anti-tumor drugs. However, current GSH-responsive disulfide groups exhibit unregulated reactivity, making it impossible to precisely control the drug release rate. We herein report a series of GSH-responsive prodrugs with a “three-in-one” molecular design by integrating a fluorescence report unit, stimuli-responsive unit and chemodrug into one scaffold with tunable aromatic nucleophilic substitution (SNAr) reactivity. The drug release rate of these prodrugs is tailored by modification of substituent groups with different electron-withdrawing or -donating abilities on the BODIPY core. Furthermore, the prodrugs self-assemble in water to form nanoparticles that serve as photosensitizers to produce reactive oxygen species upon irradiation for photodynamic therapy (PDT). The PDT process also increases the concentration of GSH in cells, further promoting the release of drugs for chemotherapy. This strategy provides a powerful platform for sequential photodynamic and chemotherapy with tunable drug release rates and synergistic therapeutic effects.
{"title":"Activatable theranostic prodrug scaffold with tunable drug release rate for sequential photodynamic and chemotherapy","authors":"Si-Yu Wang, Ying-Hao Pan, Yu-Chen Qu, Xiao-Xiao Chen, Na Shao, Li-Ya Niu, Qing-Zheng Yang","doi":"10.1002/smo.20230024","DOIUrl":"https://doi.org/10.1002/smo.20230024","url":null,"abstract":"Glutathione (GSH)-activated prodrugs are promising for overcoming the limitations of conventional anti-tumor drugs. However, current GSH-responsive disulfide groups exhibit unregulated reactivity, making it impossible to precisely control the drug release rate. We herein report a series of GSH-responsive prodrugs with a “three-in-one” molecular design by integrating a fluorescence report unit, stimuli-responsive unit and chemodrug into one scaffold with tunable aromatic nucleophilic substitution (S<sub>N</sub>Ar) reactivity. The drug release rate of these prodrugs is tailored by modification of substituent groups with different electron-withdrawing or -donating abilities on the BODIPY core. Furthermore, the prodrugs self-assemble in water to form nanoparticles that serve as photosensitizers to produce reactive oxygen species upon irradiation for photodynamic therapy (PDT). The PDT process also increases the concentration of GSH in cells, further promoting the release of drugs for chemotherapy. This strategy provides a powerful platform for sequential photodynamic and chemotherapy with tunable drug release rates and synergistic therapeutic effects.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139918132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ian Cheng-Yi Hou, Liang Li, Hongyu Zhang, Panče Naumov
The multifaceted switches are part of our everyday life from the macroscopic to the molecular world. A molecular switch operating in the solution and in the crystalline state is very different. In this review, we summarize the state-of-the-art of smart molecular crystal switches based on molecular martensites. These crystal switches respond to external stimuli and reversibly change between states, retaining their macroscopic integrity. The operation of the switches predominantly relies on temperature alterations or mechanical stress, with emerging methods based on photothermal effects, photoisomerization, and host-guest chemistry. The capability of changing the molecular orientation and interaction in smart molecular crystal switches offers opportunities in several applications, including actuators, reversibly shaping structural materials, optoelectronic and magnetic materials, as well as switchable porous materials. Smart molecular crystal switches have vast potential in modern scientific and technological progress. The ongoing research shapes a rich landscape for innovation and future scientific exploration across diverse disciplines.
{"title":"Smart molecular crystal switches","authors":"Ian Cheng-Yi Hou, Liang Li, Hongyu Zhang, Panče Naumov","doi":"10.1002/smo.20230031","DOIUrl":"https://doi.org/10.1002/smo.20230031","url":null,"abstract":"The multifaceted switches are part of our everyday life from the macroscopic to the molecular world. A molecular switch operating in the solution and in the crystalline state is very different. In this review, we summarize the state-of-the-art of smart molecular crystal switches based on molecular martensites. These crystal switches respond to external stimuli and reversibly change between states, retaining their macroscopic integrity. The operation of the switches predominantly relies on temperature alterations or mechanical stress, with emerging methods based on photothermal effects, photoisomerization, and host-guest chemistry. The capability of changing the molecular orientation and interaction in smart molecular crystal switches offers opportunities in several applications, including actuators, reversibly shaping structural materials, optoelectronic and magnetic materials, as well as switchable porous materials. Smart molecular crystal switches have vast potential in modern scientific and technological progress. The ongoing research shapes a rich landscape for innovation and future scientific exploration across diverse disciplines.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139758424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is a great challenge to discover novel chemical reactions suitable for biological analysis in a living system. The development of novel protein thiol blocking agents is a crucial need for exploring protein thiol functions in protein refolding, signal transduction, and redox regulation. We are always keen on seeking novel chemical reactions applied to endogenous biological macromolecules or protein thiol sensing, blocking, and labeling. In the present work, we have successfully developed a novel agent to block protein thiol by enhanced electron-withdrawing inductive effects. This sensing and blocking process was detailedly monitored by UV-vis, fluorescent spectra, and SDS-Page gel separation. The spectral studies demonstrated that the agent could react ultrafastly with thiol within seconds at μM level. Furthermore, fluorescent imaging in cells and in vivo was further used for the validation of its ability to sensing and blocking thiol, providing evidence of downregulated protein thiols in Parkinson's disease. The enhanced electron-withdrawing inductive effect strategy in this work may provide a general guideline for designing protein thiol agent.
{"title":"Electron-withdrawing inductive effects enhanced strategy for protein thiol sensing and blocking agent design","authors":"Liangwei Zhang, Shudi Liu, Xia Zhang, Jinyu Sun, Lingxin Chen","doi":"10.1002/smo.20230022","DOIUrl":"https://doi.org/10.1002/smo.20230022","url":null,"abstract":"It is a great challenge to discover novel chemical reactions suitable for biological analysis in a living system. The development of novel protein thiol blocking agents is a crucial need for exploring protein thiol functions in protein refolding, signal transduction, and redox regulation. We are always keen on seeking novel chemical reactions applied to endogenous biological macromolecules or protein thiol sensing, blocking, and labeling. In the present work, we have successfully developed a novel agent to block protein thiol by enhanced electron-withdrawing inductive effects. This sensing and blocking process was detailedly monitored by UV-<i>vis</i>, fluorescent spectra, and SDS-Page gel separation. The spectral studies demonstrated that the agent could react ultrafastly with thiol within seconds at μM level. Furthermore, fluorescent imaging in cells and in vivo was further used for the validation of its ability to sensing and blocking thiol, providing evidence of downregulated protein thiols in Parkinson's disease. The enhanced electron-withdrawing inductive effect strategy in this work may provide a general guideline for designing protein thiol agent.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139758438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ling Sum Liu, Hoi Man Leung, Yuzhen Cai, Pik Kwan Lo
Stimuli-responsive DNA-based logic gates have emerged as a promising field at the intersection of synthetic biology and nanotechnology. These gates exploit the unique properties of DNA molecules to perform programmable computational operations in response to specific stimuli. This review provides a comprehensive overview of recent advancements in the design, working principles, and applications of stimuli-responsive DNA-based logic gates. The progress made in developing various types of logic gates triggered by metal ions, pH, oligonucleotides, small molecules, proteins, and light is highlighted. The applications of these logic gates in imaging and biosensing, drug delivery, synthetic biology and molecular computing are discussed. This review underscores the significant contributions and future prospects of stimuli-responsive DNA-based logic gates in advancing the field of nanotechnology.
基于刺激响应 DNA 的逻辑门已成为合成生物学和纳米技术交叉领域的一个前景广阔的领域。这些逻辑门利用 DNA 分子的独特性质，在特定刺激下执行可编程的计算操作。本综述全面概述了基于刺激响应 DNA 逻辑门的设计、工作原理和应用方面的最新进展。重点介绍了在开发由金属离子、pH 值、寡核苷酸、小分子、蛋白质和光触发的各类逻辑门方面取得的进展。讨论了这些逻辑门在成像和生物传感、药物输送、合成生物学和分子计算方面的应用。这篇综述强调了基于刺激响应 DNA 的逻辑门在推动纳米技术领域发展方面的重大贡献和未来前景。
{"title":"Recent progress in stimuli-responsive DNA-based logic gates: Design, working principles and biological applications","authors":"Ling Sum Liu, Hoi Man Leung, Yuzhen Cai, Pik Kwan Lo","doi":"10.1002/smo.20230023","DOIUrl":"https://doi.org/10.1002/smo.20230023","url":null,"abstract":"Stimuli-responsive DNA-based logic gates have emerged as a promising field at the intersection of synthetic biology and nanotechnology. These gates exploit the unique properties of DNA molecules to perform programmable computational operations in response to specific stimuli. This review provides a comprehensive overview of recent advancements in the design, working principles, and applications of stimuli-responsive DNA-based logic gates. The progress made in developing various types of logic gates triggered by metal ions, pH, oligonucleotides, small molecules, proteins, and light is highlighted. The applications of these logic gates in imaging and biosensing, drug delivery, synthetic biology and molecular computing are discussed. This review underscores the significant contributions and future prospects of stimuli-responsive DNA-based logic gates in advancing the field of nanotechnology.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139758448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hao Wu, Lei Wang, Xiao Qian, Wanwan Wang, Yu Si, Rensong Sun, Engin U. Akkaya
Metastable endoperoxides with beta-amyloid fibrils targeting benzothiazole moieties were designed and synthesized. Singlet oxygen released from these endoperoxides by thermal cycloreversion reaction was shown to cause significant structural changes on the amyloid assemblies. Most importantly, the cytotoxicity of the beta-amyloid fibrils on the PC12 cells were significantly reduced in the presence of endoperoxides. This observation, coupled with the fact that neither external oxygen, nor light is needed for this transformation, is very promising.
{"title":"Benzothiazole-endoperoxide conjugates protect PC12 cells against β-amyloid-induced cell death via singlet oxygen mediated oxidative detoxification of fibrils","authors":"Hao Wu, Lei Wang, Xiao Qian, Wanwan Wang, Yu Si, Rensong Sun, Engin U. Akkaya","doi":"10.1002/smo.20230019","DOIUrl":"https://doi.org/10.1002/smo.20230019","url":null,"abstract":"Metastable endoperoxides with beta-amyloid fibrils targeting benzothiazole moieties were designed and synthesized. Singlet oxygen released from these endoperoxides by thermal cycloreversion reaction was shown to cause significant structural changes on the amyloid assemblies. Most importantly, the cytotoxicity of the beta-amyloid fibrils on the PC12 cells were significantly reduced in the presence of endoperoxides. This observation, coupled with the fact that neither external oxygen, nor light is needed for this transformation, is very promising.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139093476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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