Pub Date : 2024-05-16DOI: 10.1097/ICL.0000000000001102
Ashlie A Bernhisel, C. Nau, M. Schornack
ABSTRACT Patients who have undergone penetrating keratoplasty may have corneal edema because of endothelial cell dysfunction. Scleral lens wear may exacerbate edema, particularly if lens fit is suboptimal. Distinguishing between edema because of inherent endothelial cell dysfunction and swelling because of scleral lens-related hypoxia can be challenging. It is necessary, however, to identify the most likely cause of increased corneal thickness to determine whether the patient simply needs refitting for a different lens design or needs additional surgical intervention. This case report describes the utility of corneal tomographic imaging before and after scleral lens wear both to estimate endothelial cell function and to direct decisions when designing a scleral lens for a post-transplant eye.
{"title":"Post-Penetrating Keratoplasty Assessment of Endothelial Function With a Scleral Lens Challenge.","authors":"Ashlie A Bernhisel, C. Nau, M. Schornack","doi":"10.1097/ICL.0000000000001102","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001102","url":null,"abstract":"ABSTRACT\u0000Patients who have undergone penetrating keratoplasty may have corneal edema because of endothelial cell dysfunction. Scleral lens wear may exacerbate edema, particularly if lens fit is suboptimal. Distinguishing between edema because of inherent endothelial cell dysfunction and swelling because of scleral lens-related hypoxia can be challenging. It is necessary, however, to identify the most likely cause of increased corneal thickness to determine whether the patient simply needs refitting for a different lens design or needs additional surgical intervention. This case report describes the utility of corneal tomographic imaging before and after scleral lens wear both to estimate endothelial cell function and to direct decisions when designing a scleral lens for a post-transplant eye.","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":"108 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140968210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-16DOI: 10.1097/ICL.0000000000001099
Laurence Boily, L. Michaud, Marie-Lou Garon, Rémy Marcotte
OBJECTIVES To evaluate the retinal response to myopic defocus after the wear of soft multifocal contact lenses with high addition through electroretinography. METHODS Twenty-seven participants meeting inclusion criteria were enrolled. Tropicamide 1% drops (2) were instilled. Participants were then fitted with three different contact lenses: a single-vision spherical lens (SE +3.00 D), L1, serving as a control, and two soft multifocal lens designs (SE +3.00 D/add +10 D), one with a central distance zone of 4.0 mm (L2) and one with a central distance zone of 7.0 mm (L3). A global flash multifocal electroretinography was performed. Direct component (DC) amplitude, DC peak time, induced component (IC) amplitude, and IC peak time were recorded. Waveforms were grouped into five concentric areas, covering from 0° to 24° of retinal eccentricity. Differences of L2/L3 versus L1 were analyzed with t tests. Finally, correlations were calculated between the percentage of defocus in the pupil area versus the electroretinography results. RESULTS Results show that the DC amplitude, caused mainly by photoreceptors and bipolar cells, is not influenced by the design of the lenses. The IC amplitude, however, is significantly decreased when the lens with a smaller optical zone (L2) is worn. This significant difference only concerns the ring 5, which corresponds to a retinal eccentricity of 15.7° to 24.0°. CONCLUSION Soft multifocal lens designs influence the peripheral retinal reaction to defocus. A larger treatment zone seems to significantly impact the retinal response to defocus between 15.7° and 24.0° of eccentricity from the macula.
{"title":"Effects of Optical Zone Variation of High-Addition Multifocal Contact Lenses on the Global Flash Multifocal Electroretinography.","authors":"Laurence Boily, L. Michaud, Marie-Lou Garon, Rémy Marcotte","doi":"10.1097/ICL.0000000000001099","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001099","url":null,"abstract":"OBJECTIVES\u0000To evaluate the retinal response to myopic defocus after the wear of soft multifocal contact lenses with high addition through electroretinography.\u0000\u0000\u0000METHODS\u0000Twenty-seven participants meeting inclusion criteria were enrolled. Tropicamide 1% drops (2) were instilled. Participants were then fitted with three different contact lenses: a single-vision spherical lens (SE +3.00 D), L1, serving as a control, and two soft multifocal lens designs (SE +3.00 D/add +10 D), one with a central distance zone of 4.0 mm (L2) and one with a central distance zone of 7.0 mm (L3). A global flash multifocal electroretinography was performed. Direct component (DC) amplitude, DC peak time, induced component (IC) amplitude, and IC peak time were recorded. Waveforms were grouped into five concentric areas, covering from 0° to 24° of retinal eccentricity. Differences of L2/L3 versus L1 were analyzed with t tests. Finally, correlations were calculated between the percentage of defocus in the pupil area versus the electroretinography results.\u0000\u0000\u0000RESULTS\u0000Results show that the DC amplitude, caused mainly by photoreceptors and bipolar cells, is not influenced by the design of the lenses. The IC amplitude, however, is significantly decreased when the lens with a smaller optical zone (L2) is worn. This significant difference only concerns the ring 5, which corresponds to a retinal eccentricity of 15.7° to 24.0°.\u0000\u0000\u0000CONCLUSION\u0000Soft multifocal lens designs influence the peripheral retinal reaction to defocus. A larger treatment zone seems to significantly impact the retinal response to defocus between 15.7° and 24.0° of eccentricity from the macula.","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":"13 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-25DOI: 10.1097/ICL.0000000000001093
Jenna Tauber, D. Ritterband, Joann J Kang
OBJECTIVES The aim of this report is to describe atypical corneal complications associated with dupilumab use. METHODS This is a series of four cases of adult patients with infiltrative or ulcerative keratitis secondary to dupilumab use. RESULTS All four patients in this series were prescribed dupilumab for the treatment of atopic dermatitis and developed infiltrative or ulcerative corneal lesions. In all cases, corneal disease was successfully managed with immediate discontinuation of dupilumab and topical steroid treatment. In two cases, the patient also received antibiotic eye drops for infection precautions. CONCLUSIONS Although dupilumab is most commonly associated with conjunctivitis, physicians should be aware of potential severe corneal complications for early identification and intervention.
{"title":"Corneal Complications Related to Dupilumab Use.","authors":"Jenna Tauber, D. Ritterband, Joann J Kang","doi":"10.1097/ICL.0000000000001093","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001093","url":null,"abstract":"OBJECTIVES\u0000The aim of this report is to describe atypical corneal complications associated with dupilumab use.\u0000\u0000\u0000METHODS\u0000This is a series of four cases of adult patients with infiltrative or ulcerative keratitis secondary to dupilumab use.\u0000\u0000\u0000RESULTS\u0000All four patients in this series were prescribed dupilumab for the treatment of atopic dermatitis and developed infiltrative or ulcerative corneal lesions. In all cases, corneal disease was successfully managed with immediate discontinuation of dupilumab and topical steroid treatment. In two cases, the patient also received antibiotic eye drops for infection precautions.\u0000\u0000\u0000CONCLUSIONS\u0000Although dupilumab is most commonly associated with conjunctivitis, physicians should be aware of potential severe corneal complications for early identification and intervention.","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":"58 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140656388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.1097/ICL.0000000000001094
Yu Yoshinaga, Takeshi Soma, Y. Oie, S. Koh, Kohji Nishida
PURPOSE To report a case of corneal endothelial damage caused by alcohol-containing chlorhexidine gluconate (CG-A) and its progression over time. METHODS This was a case report. RESULTS A 22-year-old man underwent neurosurgery under general anesthesia. CG-A (1%) was used for disinfection after the application of corneal protection tape. Postoperatively, the patient presented with hyperemia and swelling of the left conjunctiva and was referred to our department. Initial examination revealed left corneal epithelial erosion and corneal edema, which improved on postoperative day 14. The corneal endothelial cell density (ECD) was 3,345 cells/mm2 on day 14, decreased rapidly to 2,090 cells/mm2 on day 42, and slowly reduced to 1,122 cells/mm2 on day 168. Thereafter, no decrease in ECD was observed. CONCLUSIONS CG formulations can lead to a persistent decrease in ECD over several months, even after improvement of acute corneal edema.
{"title":"Continuous Corneal Endothelial Damage by Chlorhexidine Alcohol Used for Disinfection in Nonophthalmic Surgery.","authors":"Yu Yoshinaga, Takeshi Soma, Y. Oie, S. Koh, Kohji Nishida","doi":"10.1097/ICL.0000000000001094","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001094","url":null,"abstract":"PURPOSE\u0000To report a case of corneal endothelial damage caused by alcohol-containing chlorhexidine gluconate (CG-A) and its progression over time.\u0000\u0000\u0000METHODS\u0000This was a case report.\u0000\u0000\u0000RESULTS\u0000A 22-year-old man underwent neurosurgery under general anesthesia. CG-A (1%) was used for disinfection after the application of corneal protection tape. Postoperatively, the patient presented with hyperemia and swelling of the left conjunctiva and was referred to our department. Initial examination revealed left corneal epithelial erosion and corneal edema, which improved on postoperative day 14. The corneal endothelial cell density (ECD) was 3,345 cells/mm2 on day 14, decreased rapidly to 2,090 cells/mm2 on day 42, and slowly reduced to 1,122 cells/mm2 on day 168. Thereafter, no decrease in ECD was observed.\u0000\u0000\u0000CONCLUSIONS\u0000CG formulations can lead to a persistent decrease in ECD over several months, even after improvement of acute corneal edema.","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":"29 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140659989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-23DOI: 10.1097/ICL.0000000000001088
Younga Kwon, Sang Beom Han, Song A Che, Kyungmin Koh, So Young Han, Chul Young Choi, Yongwoo Lee
OBJECTIVE To evaluate the effects of rigid corneal lenses (RCL) in patients with keratoconus, based on eccentricity. METHODS Eighty-four eyes from 84 patients were included in this retrospective comparative study. Based on the median value of eccentricity difference between the cornea and back surface of the RCL, the patients were divided into groups 1 (<0.08) and 2 (≥0.08). Visual acuity, refractive index, and corneal topography indices were compared before and three months after lens use. RESULTS Visual acuity, astigmatism, refractive error, corneal curvature, and corneal thickness improved significantly in both groups. Apical power and anterior elevation improved significantly in group 1, with small differences in eccentricity, but not in group 2. Changes in apical power before and after lens use were significantly different between the two groups. CONCLUSION The RCL was effective for the cornea of keratoconus, especially when the prescription was made with a small difference in eccentricity.
{"title":"Effect of Corneal and Lens Eccentricity Difference on Rigid Corneal Lens Treatment in Patients With Keratoconus.","authors":"Younga Kwon, Sang Beom Han, Song A Che, Kyungmin Koh, So Young Han, Chul Young Choi, Yongwoo Lee","doi":"10.1097/ICL.0000000000001088","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001088","url":null,"abstract":"OBJECTIVE\u0000To evaluate the effects of rigid corneal lenses (RCL) in patients with keratoconus, based on eccentricity.\u0000\u0000\u0000METHODS\u0000Eighty-four eyes from 84 patients were included in this retrospective comparative study. Based on the median value of eccentricity difference between the cornea and back surface of the RCL, the patients were divided into groups 1 (<0.08) and 2 (≥0.08). Visual acuity, refractive index, and corneal topography indices were compared before and three months after lens use.\u0000\u0000\u0000RESULTS\u0000Visual acuity, astigmatism, refractive error, corneal curvature, and corneal thickness improved significantly in both groups. Apical power and anterior elevation improved significantly in group 1, with small differences in eccentricity, but not in group 2. Changes in apical power before and after lens use were significantly different between the two groups.\u0000\u0000\u0000CONCLUSION\u0000The RCL was effective for the cornea of keratoconus, especially when the prescription was made with a small difference in eccentricity.","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":"38 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140667317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.1097/icl.0000000000001087
Leonie Vercauteren, Alejandra Consejo, Meindert Jan De Vries, Iva Krolo, Carina Koppen, Sorcha Ní Dhubhghaill
To report the clinical course and compare the utility of Scheimpflug tomography (ST) and anterior segment optical coherence tomography (AS-OCT) for central corneal thickness (CCT) and corneal densitometry (CD) assessment in patients with corneal crystals owing to nephropathic cystinosis.
{"title":"Comparison of Scheimpflug Corneal Tomography and Anterior Segment Optical Coherence Tomography Measurements in Corneal Cystinosis: A Case Series.","authors":"Leonie Vercauteren, Alejandra Consejo, Meindert Jan De Vries, Iva Krolo, Carina Koppen, Sorcha Ní Dhubhghaill","doi":"10.1097/icl.0000000000001087","DOIUrl":"https://doi.org/10.1097/icl.0000000000001087","url":null,"abstract":"To report the clinical course and compare the utility of Scheimpflug tomography (ST) and anterior segment optical coherence tomography (AS-OCT) for central corneal thickness (CCT) and corneal densitometry (CD) assessment in patients with corneal crystals owing to nephropathic cystinosis.","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":"28 25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140630369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-16DOI: 10.1097/icl.0000000000001086
Cherie B Nau, Amy C Nau, Jennifer S Fogt, Jennifer S Harthan, Ellen S Shorter, Muriel M Schornack
Dry eye is a common condition that can decrease the quality of life. This survey-based study of persons with dry eye investigated self-reported treatments (initial, current), out-of-pocket expenses, time spent on self-management, sources of care, and sources of information about their condition.
{"title":"Patient-Reported Dry Eye Treatment and Burden of Care.","authors":"Cherie B Nau, Amy C Nau, Jennifer S Fogt, Jennifer S Harthan, Ellen S Shorter, Muriel M Schornack","doi":"10.1097/icl.0000000000001086","DOIUrl":"https://doi.org/10.1097/icl.0000000000001086","url":null,"abstract":"Dry eye is a common condition that can decrease the quality of life. This survey-based study of persons with dry eye investigated self-reported treatments (initial, current), out-of-pocket expenses, time spent on self-management, sources of care, and sources of information about their condition.","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140615271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1097/icl.0000000000001075
Michelle K Rhee, Meena Zakher, Michael Najac, Harold Arias, Jace Jo, Richard Gorham, Ken Moadel
The study received funding from Ocular Therapeutix, Inc., Bedford, MA.We undertook this study to compare the efficacy of intracanalicular dexamethasone 0.4 mg with topical prednisolone acetate (PA) 1% in controlling postoperative pain and inflammation in patients undergoing pterygium surgery.
{"title":"Comparing Intracanalicular and Topical Steroid Use in Patients Undergoing Pterygium Surgery.","authors":"Michelle K Rhee, Meena Zakher, Michael Najac, Harold Arias, Jace Jo, Richard Gorham, Ken Moadel","doi":"10.1097/icl.0000000000001075","DOIUrl":"https://doi.org/10.1097/icl.0000000000001075","url":null,"abstract":"The study received funding from Ocular Therapeutix, Inc., Bedford, MA.We undertook this study to compare the efficacy of intracanalicular dexamethasone 0.4 mg with topical prednisolone acetate (PA) 1% in controlling postoperative pain and inflammation in patients undergoing pterygium surgery.","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139668025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To examine and to understand the limbal stem-cell deficiency (LSCD) because of Steven-Johnson syndrome (SJS) in line with the new classification system for the first time in the literature.
{"title":"Severity Classification of Limbal Stem Cell Failure Due to Steven Johnson Syndrome in the Light of the Classification Consensus of Limbal Stem Cell Deficiency.","authors":"Zeynep Akgun, Melis Palamar, Sait Egrilmez, Ayse Yagci, Ozlem Barut Selver","doi":"10.1097/icl.0000000000001073","DOIUrl":"https://doi.org/10.1097/icl.0000000000001073","url":null,"abstract":"To examine and to understand the limbal stem-cell deficiency (LSCD) because of Steven-Johnson syndrome (SJS) in line with the new classification system for the first time in the literature.","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139667964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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