Pub Date : 2023-10-21DOI: 10.31557/apjcc.2023.8.4.841-843
Vrushab Rao, Bhooshan Zade
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{"title":"The Need to Consider Lymphoma as a Differential Diagnosis in Suspicious Bony Lesions","authors":"Vrushab Rao, Bhooshan Zade","doi":"10.31557/apjcc.2023.8.4.841-843","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.841-843","url":null,"abstract":"<jats:p>-</jats:p>","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-21DOI: 10.31557/apjcc.2023.8.4.815-818
Dharmaraj A, Sharad Singh, Rumita Singh, Sumanta Manna, Tazyeen Fatima
Risk factors for squamous cell carcinomas (SCCs) of the head and neck (HN) and oesophagus are similar. As such, synchronous primary tumors in these areas are not entirely uncommon. Definitive chemoradiation (CRT) is standard care for locally advanced HNSCC and is a preferred option for inoperable oesophageal SCC. Simultaneous treatment of both primaries with CRT can present technical challenges. We report a case of synchronous oropharyngeal and oesophageal SCC primary tumors treated simultaneously with definitive chemoradiotherapy.
{"title":"Management of Synchronous Locally Advanced Carcinoma Oropharynx and Early Stage Carcinoma Esophagus in a Tertiary Cancer Center: A Case Report","authors":"Dharmaraj A, Sharad Singh, Rumita Singh, Sumanta Manna, Tazyeen Fatima","doi":"10.31557/apjcc.2023.8.4.815-818","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.815-818","url":null,"abstract":"Risk factors for squamous cell carcinomas (SCCs) of the head and neck (HN) and oesophagus are similar. As such, synchronous primary tumors in these areas are not entirely uncommon. Definitive chemoradiation (CRT) is standard care for locally advanced HNSCC and is a preferred option for inoperable oesophageal SCC. Simultaneous treatment of both primaries with CRT can present technical challenges. We report a case of synchronous oropharyngeal and oesophageal SCC primary tumors treated simultaneously with definitive chemoradiotherapy.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-21DOI: 10.31557/apjcc.2023.8.4.697-702
Bhuvnesh Narayan Purohit, Satya Shankar Harsh, Priya Tawri, H. Kumar, N. Sharma, S. Jakhar
Background: Cancer is a leading health problem in India with approximately 1.1 million cases occurring each year. Cancer of the Larynx represents about 1% of the total cancer burden and accounts for 0.3% of all cancer deaths. Glottic tumors typically metastasize after they have directly invaded adjacent structures with better drainage. Glottic cancer has a high rate of cure and regardless of the modality used. Radiotherapy is generally the favoured treatment in most centers despite comparable cure rates for selected T1 and T2 glottis tumors. The present study was conducted to compare radiation induced acute and late treatment related toxicities of hypo-fractionated radiotherapy and conventional radiotherapy in early glottic cancer T1-2N0M0”.Material and Methods: The study was conducted in Acharya Tulsi Regional Cancer Treatment and Research Institute, Sardar Patel Medical College, Bikaner. It was done on 50 histologically proven new cases of early glottic cancer with age <70 years. Patients were treated by radiotherapy and randomized into either of the two arms Arm A (Study) and Arm B (Control). On ARM A Hypo-fractionated radiotherapy 55Gy/20# in 2.75Gy/# in 4 weeks and on ARM B Conventional radiotherapy 66Gy/33# in 2Gy/#6.5 weeks was given. Voice quality and toxicities were graded at the end of treatment, after 1, 2, 3 and 6 months. Data was analyzed using percentage, mean, chi square test and p-value. Results: Majority of the patients were in their 6th decade of life and all patients were male. Majority of the population had ECOG Performance Score of 1. 46 (92%) of patients presented with hoarseness alone while 4 (8%) of them presented with hoarseness and dysphagia, which were comparable in both the groups. Histologically, patients had Squamous Cell carcinoma (SCC). In study vs control arm where 11 (44%) vs 5 (20%) patients were T1A, 9 (36%) vs 5 (20%) in T1B, 4 (20%) vs 10 (40%) in T2A and 1 (4%) vs 5 (20%) in T2B respectively. In the study arm 25 (100%) patients received 58.4 Gy (2GyEq) whereas in control population 15 (60%) received 66 Gy and the rest 10 (40%) received 64 Gy. All 25 (100%) patients in both arms completed treatment. At the end of treatment, only 3 (12%) patients in study arm and 5 (20%) in control arm had normal voice. At 1st month of follow up, 7 (28%) vs 9 (36%) patients, at 3rd month of follow up, 13 (52%) vs 15 (60%) patients and at 6th month follow up, 21 (84%) vs 22 (88%) patients in study and control arm respectively had normal voice. (X2 = 1.026, p value = 0.599). As compared, at the end of the treatment, at 1st, 3rd and 6th months follow up, grades of skin reactions, mucositis and dysphagia reduced from 2 to 1 and later 1 to 0. Conclusions: Hypo-fractionated radiotherapy is a safe modality of treatment with high local control rates, acceptable long term toxicities, favorable voice outcomes and symptomatic relief with added advantage of shorter treatment time which offers better patient compliance
{"title":"A Comparative Study of Hypofractionated Radiotherapy Versus Conventional Radiotherapy in Early Glottic Cancer T1-2n0m0","authors":"Bhuvnesh Narayan Purohit, Satya Shankar Harsh, Priya Tawri, H. Kumar, N. Sharma, S. Jakhar","doi":"10.31557/apjcc.2023.8.4.697-702","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.697-702","url":null,"abstract":"Background: Cancer is a leading health problem in India with approximately 1.1 million cases occurring each year. Cancer of the Larynx represents about 1% of the total cancer burden and accounts for 0.3% of all cancer deaths. Glottic tumors typically metastasize after they have directly invaded adjacent structures with better drainage. Glottic cancer has a high rate of cure and regardless of the modality used. Radiotherapy is generally the favoured treatment in most centers despite comparable cure rates for selected T1 and T2 glottis tumors. The present study was conducted to compare radiation induced acute and late treatment related toxicities of hypo-fractionated radiotherapy and conventional radiotherapy in early glottic cancer T1-2N0M0”.Material and Methods: The study was conducted in Acharya Tulsi Regional Cancer Treatment and Research Institute, Sardar Patel Medical College, Bikaner. It was done on 50 histologically proven new cases of early glottic cancer with age <70 years. Patients were treated by radiotherapy and randomized into either of the two arms Arm A (Study) and Arm B (Control). On ARM A Hypo-fractionated radiotherapy 55Gy/20# in 2.75Gy/# in 4 weeks and on ARM B Conventional radiotherapy 66Gy/33# in 2Gy/#6.5 weeks was given. Voice quality and toxicities were graded at the end of treatment, after 1, 2, 3 and 6 months. Data was analyzed using percentage, mean, chi square test and p-value. Results: Majority of the patients were in their 6th decade of life and all patients were male. Majority of the population had ECOG Performance Score of 1. 46 (92%) of patients presented with hoarseness alone while 4 (8%) of them presented with hoarseness and dysphagia, which were comparable in both the groups. Histologically, patients had Squamous Cell carcinoma (SCC). In study vs control arm where 11 (44%) vs 5 (20%) patients were T1A, 9 (36%) vs 5 (20%) in T1B, 4 (20%) vs 10 (40%) in T2A and 1 (4%) vs 5 (20%) in T2B respectively. In the study arm 25 (100%) patients received 58.4 Gy (2GyEq) whereas in control population 15 (60%) received 66 Gy and the rest 10 (40%) received 64 Gy. All 25 (100%) patients in both arms completed treatment. At the end of treatment, only 3 (12%) patients in study arm and 5 (20%) in control arm had normal voice. At 1st month of follow up, 7 (28%) vs 9 (36%) patients, at 3rd month of follow up, 13 (52%) vs 15 (60%) patients and at 6th month follow up, 21 (84%) vs 22 (88%) patients in study and control arm respectively had normal voice. (X2 = 1.026, p value = 0.599). As compared, at the end of the treatment, at 1st, 3rd and 6th months follow up, grades of skin reactions, mucositis and dysphagia reduced from 2 to 1 and later 1 to 0. Conclusions: Hypo-fractionated radiotherapy is a safe modality of treatment with high local control rates, acceptable long term toxicities, favorable voice outcomes and symptomatic relief with added advantage of shorter treatment time which offers better patient compliance","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: Cytoreductive surgery (CRS) is performed to treat macroscopic disease and Hyperthermic intraperitoneal chemotherapy (HIPEC) is used to treat the microscopic residual disease. Abdominal surgeries are sometimes associated with pulmonary complications and also prolonged hospital stays. The aim of this retrospective study was to determine the incidence of post-operative pulmonary complications occurring within 30 days following CRS and HIPEC. The risk factors responsible were also identified. Materials and methods: The retrospective study was done in patients who underwent CRS and HIPEC. Patient’s data was retrieved from 31st May 2018 to 30th June 2022. The data was obtained from the patient records and registers kept in the medical records library. Post operative pulmonary complications were noted and risk factors were identified. Results: There were 27 surgeries of CRS with HIPEC during the study period.The procedure was done in patients with the primary tumour of ovary, colon, appendix, ewings sarcoma pelvis and peritoneum. 6 patients developed post operative pulmonary complications. The complications included pleural effusion in 4 patients and acute respiratory distress syndrome (ARDS) in 2 patients. Conclusion: The incidence of postoperative pulmonary complications in our study was 22 % following CRS and HIPEC. Pleural effusion was the common complication noted, followed by (ARDS). The intrinsic disease in association with hypoalbuminemia (< 2gm/dl) was found to be an important factor for causing pleural effusion.
{"title":"Incidence of Post-operative Pulmonary Complications Following Cytoreductive Surgeries and HIPEC- A Retrospective Analytic Study","authors":"Roopesh Sureshan, Satheesan B, Sonali Opneja, Jashma C, Joona P, Namratha Divakaran, Mayan John","doi":"10.31557/apjcc.2023.8.4.681-684","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.681-684","url":null,"abstract":"Background and aims: Cytoreductive surgery (CRS) is performed to treat macroscopic disease and Hyperthermic intraperitoneal chemotherapy (HIPEC) is used to treat the microscopic residual disease. Abdominal surgeries are sometimes associated with pulmonary complications and also prolonged hospital stays. The aim of this retrospective study was to determine the incidence of post-operative pulmonary complications occurring within 30 days following CRS and HIPEC. The risk factors responsible were also identified. Materials and methods: The retrospective study was done in patients who underwent CRS and HIPEC. Patient’s data was retrieved from 31st May 2018 to 30th June 2022. The data was obtained from the patient records and registers kept in the medical records library. Post operative pulmonary complications were noted and risk factors were identified. Results: There were 27 surgeries of CRS with HIPEC during the study period.The procedure was done in patients with the primary tumour of ovary, colon, appendix, ewings sarcoma pelvis and peritoneum. 6 patients developed post operative pulmonary complications. The complications included pleural effusion in 4 patients and acute respiratory distress syndrome (ARDS) in 2 patients. Conclusion: The incidence of postoperative pulmonary complications in our study was 22 % following CRS and HIPEC. Pleural effusion was the common complication noted, followed by (ARDS). The intrinsic disease in association with hypoalbuminemia (< 2gm/dl) was found to be an important factor for causing pleural effusion.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-21DOI: 10.31557/apjcc.2023.8.4.685-689
Edakkadath R Sindhu, Aptha Y Das, Maya Padmanabhan, Chandran K Nair
Background: Multiple myeloma is characterized by the uncontrolled proliferation of monoclonal plasma cells in the bone marrow, leading to the production of non-functional intact immunoglobulin chains. This retrospective study aimed to investigate the correlation between plasma cell percentage (below 60% and above 60%) in different types of monoclonal gammapathies (IgA, IgG) and various biochemical parameters.Methods: This analysis was conducted at the Division of Biochemistry in the Malabar Cancer Centre, a tertiary care cancer center in Kerala, India. A total of 89 patient case reports were reviewed, and complete treatment data were available for 60 patients. The study aimed to evaluate the relationship between plasma cell percentage (below 60% and above 60%) in different types of monoclonal gammapathies (IgA, IgG) and various biochemical parameters. Results: The majority of the patients enrolled in the study were above 60 years of age, and more men were included than women. Among the parameters studied, a significant increase in plasma protein level was observed in the group with a plasma cell percentage below 60% and IgG type monoclonal gammapathy (P value = 0.014, p < 0.05). Additionally, there was a significant elevation in WBC count in patients with plasma cell percentage below 60% and IgG type MM when compared to IgA type MM patients (p = 0.023, p < 0.05). However, no significant changes were observed in plasma protein level, liver enzyme activity, renal function, serum electrolytes, CBC, and calcium level between patients with plasma cell percentages above and below 60% in multiple myeloma. Conclusion: This study found that only a few biochemical and hematological parameters showed significant deviations between plasma cell percentages above and below 60% in different types of monoclonal gammapathies in multiple myeloma patients.
背景：多发性骨髓瘤的特点是骨髓中单克隆浆细胞不受控制地增殖，导致产生无功能的完整免疫球蛋白链。这项回顾性研究旨在探讨不同类型单克隆丙种球蛋白病（IgA、IgG）中浆细胞百分比（低于 60% 和高于 60%）与各种生化指标之间的相关性：分析在印度喀拉拉邦马拉巴尔癌症中心（Malabar Cancer Centre）的生物化学部进行。共审查了 89 份患者病例报告，并获得了 60 名患者的完整治疗数据。研究旨在评估不同类型单克隆丙种球蛋白病（IgA、IgG）中浆细胞百分比（低于 60% 和高于 60%）与各种生化指标之间的关系。研究结果参加研究的大多数患者年龄在 60 岁以上，男性多于女性。在研究的参数中，浆细胞百分比低于 60% 和 IgG 型单克隆丙种球蛋白病组的血浆蛋白水平明显升高（P 值 = 0.014，P < 0.05）。此外，与 IgA 型 MM 患者相比，浆细胞百分比低于 60% 和 IgG 型 MM 患者的白细胞计数明显升高（P = 0.023，P < 0.05）。然而，血浆蛋白水平、肝酶活性、肾功能、血清电解质、全血细胞计数和血钙水平在浆细胞百分比高于和低于60%的多发性骨髓瘤患者之间没有明显变化。结论本研究发现，在多发性骨髓瘤患者中，浆细胞百分比高于和低于 60% 的不同类型单克隆丙种球蛋白病患者之间，只有少数生化和血液学参数出现了显著偏差。
{"title":"Correlation of Plasma Cell Percentage and Monoclonal Gammapathies with Biochemical Parameters in Multiple Myeloma Patients: A Retrospective Study","authors":"Edakkadath R Sindhu, Aptha Y Das, Maya Padmanabhan, Chandran K Nair","doi":"10.31557/apjcc.2023.8.4.685-689","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.685-689","url":null,"abstract":"Background: Multiple myeloma is characterized by the uncontrolled proliferation of monoclonal plasma cells in the bone marrow, leading to the production of non-functional intact immunoglobulin chains. This retrospective study aimed to investigate the correlation between plasma cell percentage (below 60% and above 60%) in different types of monoclonal gammapathies (IgA, IgG) and various biochemical parameters.Methods: This analysis was conducted at the Division of Biochemistry in the Malabar Cancer Centre, a tertiary care cancer center in Kerala, India. A total of 89 patient case reports were reviewed, and complete treatment data were available for 60 patients. The study aimed to evaluate the relationship between plasma cell percentage (below 60% and above 60%) in different types of monoclonal gammapathies (IgA, IgG) and various biochemical parameters. Results: The majority of the patients enrolled in the study were above 60 years of age, and more men were included than women. Among the parameters studied, a significant increase in plasma protein level was observed in the group with a plasma cell percentage below 60% and IgG type monoclonal gammapathy (P value = 0.014, p < 0.05). Additionally, there was a significant elevation in WBC count in patients with plasma cell percentage below 60% and IgG type MM when compared to IgA type MM patients (p = 0.023, p < 0.05). However, no significant changes were observed in plasma protein level, liver enzyme activity, renal function, serum electrolytes, CBC, and calcium level between patients with plasma cell percentages above and below 60% in multiple myeloma. Conclusion: This study found that only a few biochemical and hematological parameters showed significant deviations between plasma cell percentages above and below 60% in different types of monoclonal gammapathies in multiple myeloma patients.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The incidence of UTI after TURBT in the early stages can result in morbidity, increase the length of stay, and patient costs, even if not treated can be a risk factor for bladder tumor recurrence. The global incidence of post-TURBT UTI varies between 2-39%. This study aims to determine the incidence of UTI in post-TURBT patients. Materials and Methods: This study was a cross-sectional retrospective study. The research data was taken from the medical records of patients who underwent TURBT between 2017 - 2021 at a tertiary hospital. UTI after the TURBT was defined by symptoms of fever (≥ 38oC) and the results of urinalysis examination with positive bacteriuria. While asymptomatic bacteriuria (ABU) is defined by the results of a positive bacteriuria examination without symptoms of fever. The results of the study were processed with descriptive statistics and then presented in the form of tables and explanatory narratives. Statistical analysis was performed using SPSS version 26 with a p-value < 0.05 considered statistically significant. Results: 140 patients underwent the TURBT. The data collected were 92 patients. In the pre TURBT, 56 (60,9%) patients were positive for bacteriuria, but 55 (59,8%) patients did not have fever symptoms. There were 1(1.1%) patient who had UTI before the TURBT. This patient was treated first with an antibiotic before the TURBT procedure. After the TURBT, 9 (9,7%) patients underwent urinalysis. A total of 4 (4.3%) patients experienced UTI after the TURBT and 3 (3.3%) experienced ABU after the TURBT. The incidence of UTI after the TURBT increased the length of stay of the patient (p = 0,003). Conclusion: The incidence of post-TURBT UTI is 4.3%. Only 9,8% of patients underwent urinalysis after the TURBT.
{"title":"Urinary Tract Infection in Patients after Transurethral Resection of Bladder Tumor Procedure in Tertiary Hospital","authors":"Andi Kusnawan, Sawkar Vijay Pramod, Ferry Safriadi","doi":"10.31557/apjcc.2023.8.4.669-673","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.669-673","url":null,"abstract":"Introduction: The incidence of UTI after TURBT in the early stages can result in morbidity, increase the length of stay, and patient costs, even if not treated can be a risk factor for bladder tumor recurrence. The global incidence of post-TURBT UTI varies between 2-39%. This study aims to determine the incidence of UTI in post-TURBT patients. Materials and Methods: This study was a cross-sectional retrospective study. The research data was taken from the medical records of patients who underwent TURBT between 2017 - 2021 at a tertiary hospital. UTI after the TURBT was defined by symptoms of fever (≥ 38oC) and the results of urinalysis examination with positive bacteriuria. While asymptomatic bacteriuria (ABU) is defined by the results of a positive bacteriuria examination without symptoms of fever. The results of the study were processed with descriptive statistics and then presented in the form of tables and explanatory narratives. Statistical analysis was performed using SPSS version 26 with a p-value < 0.05 considered statistically significant. Results: 140 patients underwent the TURBT. The data collected were 92 patients. In the pre TURBT, 56 (60,9%) patients were positive for bacteriuria, but 55 (59,8%) patients did not have fever symptoms. There were 1(1.1%) patient who had UTI before the TURBT. This patient was treated first with an antibiotic before the TURBT procedure. After the TURBT, 9 (9,7%) patients underwent urinalysis. A total of 4 (4.3%) patients experienced UTI after the TURBT and 3 (3.3%) experienced ABU after the TURBT. The incidence of UTI after the TURBT increased the length of stay of the patient (p = 0,003). Conclusion: The incidence of post-TURBT UTI is 4.3%. Only 9,8% of patients underwent urinalysis after the TURBT.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-21DOI: 10.31557/apjcc.2023.8.4.691-695
Amrita Talukdar, R. Barman, M. Hazarika, Gaurav Das
Background: The aim of the present study was to study the pattern of microbial flora, their susceptibility patterns, and clinical variables among bloodstream infections in febrile neutropenic patients with solid tumors and hematological malignancies in the paediatric age group in North-East India. Methods: It was a retrospective and observational study done in a single tertiary care cancer centre in North-East India. The study period was from 1st January 2020 to 31st December 2021. The study population included all the patients below the age of 18 years who developed febrile neutropenia during treatment for a diagnosed cancer. Results: A total of 378 blood culture samples were studied. Febrile neutropenia was found in 252 patients (66.7%). There were 45 positive blood cultures (17.8%) among them. Gram-negative and gram-positive organisms accounted for 62% and 38% of all positive cultures respectively. Escherichia coli (39%) was the most common gram-negative isolate, followed by Klebsiella pneumoniae (32%), Pseudomonas aeruginosa (18%) and Acinetobacter baumannii (7%). Coagulase-negative Staphylococci (CoNS) was the most common gram-positive isolate (47%). Sensitivity to beta-lactam/beta-lactamase inhibitor (BL/BLI) antibiotics like cefaperazone/sulbactam was seen in 60% of Pseudomonas isolates. Sensitivity to colistin was noted in 89% of Klebsiella and 82% of E. coli isolates. The incidence of methicillin resistant staphylococcus aureus (MRSA) was 50%. Conclusion: The knowledge of the microbiological profile and resistance patterns among patients treated for paediatric cancer with febrile neutropenia is a key factor in deciding the antimicrobial policy.
{"title":"Bloodstream Infections in Paediatric Cancer Patients with Febrile Neutropenia in a Tertiary Cancer Centre in North-East India","authors":"Amrita Talukdar, R. Barman, M. Hazarika, Gaurav Das","doi":"10.31557/apjcc.2023.8.4.691-695","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.691-695","url":null,"abstract":"Background: The aim of the present study was to study the pattern of microbial flora, their susceptibility patterns, and clinical variables among bloodstream infections in febrile neutropenic patients with solid tumors and hematological malignancies in the paediatric age group in North-East India. Methods: It was a retrospective and observational study done in a single tertiary care cancer centre in North-East India. The study period was from 1st January 2020 to 31st December 2021. The study population included all the patients below the age of 18 years who developed febrile neutropenia during treatment for a diagnosed cancer. Results: A total of 378 blood culture samples were studied. Febrile neutropenia was found in 252 patients (66.7%). There were 45 positive blood cultures (17.8%) among them. Gram-negative and gram-positive organisms accounted for 62% and 38% of all positive cultures respectively. Escherichia coli (39%) was the most common gram-negative isolate, followed by Klebsiella pneumoniae (32%), Pseudomonas aeruginosa (18%) and Acinetobacter baumannii (7%). Coagulase-negative Staphylococci (CoNS) was the most common gram-positive isolate (47%). Sensitivity to beta-lactam/beta-lactamase inhibitor (BL/BLI) antibiotics like cefaperazone/sulbactam was seen in 60% of Pseudomonas isolates. Sensitivity to colistin was noted in 89% of Klebsiella and 82% of E. coli isolates. The incidence of methicillin resistant staphylococcus aureus (MRSA) was 50%. Conclusion: The knowledge of the microbiological profile and resistance patterns among patients treated for paediatric cancer with febrile neutropenia is a key factor in deciding the antimicrobial policy.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-12DOI: 10.31557/apjcc.2023.8.3.655-657
Sevda Dalar
Paragangliomas are neuroendocrine neoplasms. They can be functional or non-functional. Although they can be seen in different localizations, they are rarely seen in the bladder. They may accompany hereditary syndromes. In this case report, a case of paraganglioma located in the bladder in a patient followed up with VHL syndrome is presented.
{"title":"The Paraganglioma of the Bladder in a Patient with Von Hippel-Lindau Syndrome","authors":"Sevda Dalar","doi":"10.31557/apjcc.2023.8.3.655-657","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.3.655-657","url":null,"abstract":"Paragangliomas are neuroendocrine neoplasms. They can be functional or non-functional. Although they can be seen in different localizations, they are rarely seen in the bladder. They may accompany hereditary syndromes. In this case report, a case of paraganglioma located in the bladder in a patient followed up with VHL syndrome is presented.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139340906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-12DOI: 10.31557/apjcc.2023.8.3.533-537
S. Jakhar, Shankar Singh Dhaka, S. Dhaka, Rajesh Kumar, Guman Singh, N. Sharma, Dr H. S. Kumar
Background: Majority of Head and Neck Squamous Cell Cancer patients in India present in advanced stages. They are not candidates for multimodality treatment due to loco-regionally advanced disease and poor performance status. Hypo-fractionated regimens have been used for palliation of advanced head and neck cancers. Purpose: The purpose of this study to compare the acute and late toxicity and overall response of octa shot and quad shot radiation therapy as palliative regime in locally advanced head and neck cancers.Materials and methods: A hospital based prospective, randomized study was conducted with 50 patients of advanced Squamous cell carcinoma of head and neck, 25 patients taken in each arm. Two fractions(3.5Gy/#) per day six hours apart was given in four consecutive days (Octa shot). Two fractions (3.5Gy/#) per day six hours apart was given in two consecutive days repeated for one more cycle with a interval of two weeks (Quad shot). Acute toxicities monitored at day 15 &30 and late at 3 & 6 months after the treatment started. Results: Octa shot had slightly better loco-regional control but the difference was statistically insignificant. Octa shot had more grade 2 skin and mucosal reaction than Quad shot. Symptomatic relief, subjective regression and improved QOL were better in Octa shot than Quad shot. Conclusion: The study concludes that “octa shot” is an effective palliative radiotherapy regime with greater yet manageable toxicity in comparison to Quad shot regimen. This regime not only strikes a balance between the economic burden, treatment time, machine load but also helps in selecting patients for further dose escalation based on treatment response and symptomatic relief. However more such trials with longer follow up and larger sample size are required for stronger evidences.
{"title":"Comparative Evaluation of Octa Shot Versus Quad Shot Palliative Radiotherapy for Advanced Head and Neck Cancer Patients","authors":"S. Jakhar, Shankar Singh Dhaka, S. Dhaka, Rajesh Kumar, Guman Singh, N. Sharma, Dr H. S. Kumar","doi":"10.31557/apjcc.2023.8.3.533-537","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.3.533-537","url":null,"abstract":"Background: Majority of Head and Neck Squamous Cell Cancer patients in India present in advanced stages. They are not candidates for multimodality treatment due to loco-regionally advanced disease and poor performance status. Hypo-fractionated regimens have been used for palliation of advanced head and neck cancers. Purpose: The purpose of this study to compare the acute and late toxicity and overall response of octa shot and quad shot radiation therapy as palliative regime in locally advanced head and neck cancers.Materials and methods: A hospital based prospective, randomized study was conducted with 50 patients of advanced Squamous cell carcinoma of head and neck, 25 patients taken in each arm. Two fractions(3.5Gy/#) per day six hours apart was given in four consecutive days (Octa shot). Two fractions (3.5Gy/#) per day six hours apart was given in two consecutive days repeated for one more cycle with a interval of two weeks (Quad shot). Acute toxicities monitored at day 15 &30 and late at 3 & 6 months after the treatment started. Results: Octa shot had slightly better loco-regional control but the difference was statistically insignificant. Octa shot had more grade 2 skin and mucosal reaction than Quad shot. Symptomatic relief, subjective regression and improved QOL were better in Octa shot than Quad shot. Conclusion: The study concludes that “octa shot” is an effective palliative radiotherapy regime with greater yet manageable toxicity in comparison to Quad shot regimen. This regime not only strikes a balance between the economic burden, treatment time, machine load but also helps in selecting patients for further dose escalation based on treatment response and symptomatic relief. However more such trials with longer follow up and larger sample size are required for stronger evidences.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139340807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Tobacco is consumed in both smoked and smokeless forms. STEP Survey Sri Lanka 2015 showed that 29.4% males and 0.1% females were current smokers, Smokeless Tobacco (SLT) use was found in 26% of males and 5% of females. Dental setting could be considered as a suitable venue to provide brief health education message to persuade quit from tobacco. The aim of this study was to assess the effectiveness of brief intervention among tobacco users attending the Institute of Oral Health, Maharagama, Sri Lanka. Methods: Dental Surgeons provide routine care for the patients at the OPD and assess the use of tobacco at the beginning and help patients to quit tobacco which takes only 3-5 minutes. Method of intervention of this study is to provide brief messages to quit tobacco based on oral health effects due to tobacco use: staining teeth, status of periodontal health, halitosis, smoker’s keratosis, whiteness (burning) of the mucosa and palate and chewer’s mucosa. Tobacco quit rate and attempts were assessed through the telephone conversation in 3 months, 6 months intervals. Results: One hundred and twenty eighty subjects were recruited for the study, 45 (35%) failed to contact after 6 months interval which yielded the total sample of 83. Among 73 betel chewers, 46 (63%) subjects were completely quit the habit after 6 months. Eight out of 10 subjects who chew betel quid more than 5 quid per day quit. Among 22 smokers, 7 (32%) completely quit smoking with brief intervention at dental setting. Conclusion: Brief intervention at dental setting immensely helps to quit habit of daily betel chewers. This is an ongoing study relatively larger sample is needed for confirmation of the findings.
{"title":"An Assessment of the Effectiveness of an Intervention to Quit Tobacco Use in Patients Seek Treatment from the Institute of Oral Health, Maharagama, Sri Lanka","authors":"Hemantha Amarasinghe, Wfd Ananda, Skd Hariachandra, Radg Subashani, KS Wipularathna, Asf Nadira, Ruwan D. Jayasinghe","doi":"10.31557/apjcc.2023.8.3.529-532","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.3.529-532","url":null,"abstract":"Background: Tobacco is consumed in both smoked and smokeless forms. STEP Survey Sri Lanka 2015 showed that 29.4% males and 0.1% females were current smokers, Smokeless Tobacco (SLT) use was found in 26% of males and 5% of females. Dental setting could be considered as a suitable venue to provide brief health education message to persuade quit from tobacco. The aim of this study was to assess the effectiveness of brief intervention among tobacco users attending the Institute of Oral Health, Maharagama, Sri Lanka. Methods: Dental Surgeons provide routine care for the patients at the OPD and assess the use of tobacco at the beginning and help patients to quit tobacco which takes only 3-5 minutes. Method of intervention of this study is to provide brief messages to quit tobacco based on oral health effects due to tobacco use: staining teeth, status of periodontal health, halitosis, smoker’s keratosis, whiteness (burning) of the mucosa and palate and chewer’s mucosa. Tobacco quit rate and attempts were assessed through the telephone conversation in 3 months, 6 months intervals. Results: One hundred and twenty eighty subjects were recruited for the study, 45 (35%) failed to contact after 6 months interval which yielded the total sample of 83. Among 73 betel chewers, 46 (63%) subjects were completely quit the habit after 6 months. Eight out of 10 subjects who chew betel quid more than 5 quid per day quit. Among 22 smokers, 7 (32%) completely quit smoking with brief intervention at dental setting. Conclusion: Brief intervention at dental setting immensely helps to quit habit of daily betel chewers. This is an ongoing study relatively larger sample is needed for confirmation of the findings.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139340799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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