Pub Date : 2024-04-04DOI: 10.1158/2159-8290.CD-24-0154
Luis A. Diaz, Lewis C. Cantley
{"title":"Continuing the Conversation.","authors":"Luis A. Diaz, Lewis C. Cantley","doi":"10.1158/2159-8290.CD-24-0154","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-24-0154","url":null,"abstract":"","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"28 4","pages":"550-551"},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140746166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.1158/2159-8290.CD-24-0097
M. Alcolea, Direna Alonso-Curbelo, Chiara Ambrogio, S. Bullman, Ana Luísa Correia, Aurélie Ernst, Christopher J. Halbrook, G. Kelly, Amanda W Lund, D. Quail, M. Ruscetti, E. Shema, Ingunn M. Stromnes, Wai Leong Tam
{"title":"Cancer Hallmarks: Piecing the Puzzle Together.","authors":"M. Alcolea, Direna Alonso-Curbelo, Chiara Ambrogio, S. Bullman, Ana Luísa Correia, Aurélie Ernst, Christopher J. Halbrook, G. Kelly, Amanda W Lund, D. Quail, M. Ruscetti, E. Shema, Ingunn M. Stromnes, Wai Leong Tam","doi":"10.1158/2159-8290.CD-24-0097","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-24-0097","url":null,"abstract":"","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"11 18","pages":"674-682"},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-01DOI: 10.1158/2159-8290.CD-RW2020-079
Anti-PD-1 was safe to add to anti-HER2 plus chemotherapy in HER2-positive esophagogastric cancers.
对于HER2阳性食管胃癌患者，在抗HER2加化疗的基础上加用抗PD-1是安全的。
{"title":"Pembrolizumab May Enhance Current Treatments for Esophagogastric Cancers.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-079","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-079","url":null,"abstract":"Anti-PD-1 was safe to add to anti-HER2 plus chemotherapy in HER2-positive esophagogastric cancers.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"3 2","pages":"901"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141202318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-01DOI: 10.1158/2159-8290.CD-RW2020-071
Loss of the gluconeogenic enzyme FBP1 promoted hepatocellular carcinoma development in mice.
葡萄糖生成酶 FBP1 的缺失会促进小鼠肝细胞癌的发展。
{"title":"FBP1 Is a Tumor Suppressor Linking Hepatic Metabolism to Tumorigenesis.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-071","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-071","url":null,"abstract":"Loss of the gluconeogenic enzyme FBP1 promoted hepatocellular carcinoma development in mice.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"19 1","pages":"OF13"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141204899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-01DOI: 10.1158/2159-8290.CD-RW2020-082
Whether metastases were seeded mono- or polyclonally depended on cancer site and treatment.
转移瘤是单克隆还是多克隆播种取决于癌症部位和治疗方法。
{"title":"Metastasis Has Multiple Origins and Occurs Early in Tumorigenesis.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-082","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-082","url":null,"abstract":"Whether metastases were seeded mono- or polyclonally depended on cancer site and treatment.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"5 7","pages":"903"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141202163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-29DOI: 10.1158/2159-8290.CD-RW2020-080
Tissue-resident memory T cells and tumor-infiltrating lymphocytes (TIL) partitioned into two types.
组织驻留记忆 T 细胞和肿瘤浸润淋巴细胞（TIL）分为两种类型。
{"title":"Tumor-Infiltrating T Cells Mimic Tissue-Resident T-cell Heterogeneity.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-080","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-080","url":null,"abstract":"Tissue-resident memory T cells and tumor-infiltrating lymphocytes (TIL) partitioned into two types.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141202315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-22DOI: 10.1158/2159-8290.CD-RW2020-077
T-cell exhaustion was a four-stage process; the transition to terminal exhaustion was irreversible.
T 细胞衰竭分为四个阶段；过渡到最终衰竭是不可逆的。
{"title":"T-cell Exhaustion Is an Epigenetically Driven Multistage Process.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-077","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-077","url":null,"abstract":"T-cell exhaustion was a four-stage process; the transition to terminal exhaustion was irreversible.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"81 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141203605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-22DOI: 10.1158/2159-8290.CD-RW2020-074
Ezh2-mutant germinal center B cells depended on follicular dendritic cells rather than Tfh cells.
Ezh2突变的生殖中心B细胞依赖于滤泡树突状细胞，而不是Tfh细胞。
{"title":"Mutant EZH2 Drives Follicular Lymphoma by Altering B-cell Dependencies.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-074","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-074","url":null,"abstract":"Ezh2-mutant germinal center B cells depended on follicular dendritic cells rather than Tfh cells.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"79 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141203628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-22DOI: 10.1158/2159-8290.CD-RW2020-075
Colorectal cancer cells lost biosynthetic capabilities in an irreversible differentiation process.
大肠癌细胞在不可逆的分化过程中丧失了生物合成能力。
{"title":"Differentiation of Cancer Stem Cells Halts Protein and rRNA Synthesis.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-075","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-075","url":null,"abstract":"Colorectal cancer cells lost biosynthetic capabilities in an irreversible differentiation process.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"81 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141203608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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