Pub Date : 2020-05-08DOI: 10.1158/2159-8290.CD-RW2020-067
Myeloid-derived suppressor cells (MDSC) transmitted the metabolite methylglyoxal to CD8+ T cells.
髓源性抑制细胞（MDSC）将代谢产物甲基乙二醛传递给 CD8+ T 细胞。
{"title":"MDSCs Transfer Methylglyoxal to Suppress CD8+ T-cell Activity.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-067","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-067","url":null,"abstract":"Myeloid-derived suppressor cells (MDSC) transmitted the metabolite methylglyoxal to CD8+ T cells.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"21 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141205908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-08DOI: 10.1158/2159-8290.CD-RW2020-068
Most prostate luminal cells that survive androgen deprivation can contribute to organ regeneration.
大多数在雄激素剥夺后存活下来的前列腺管腔细胞都能促进器官再生。
{"title":"Remaining Prostate Luminal Cells Regenerate after Androgen Deprivation.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-068","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-068","url":null,"abstract":"Most prostate luminal cells that survive androgen deprivation can contribute to organ regeneration.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"6 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141206005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-24DOI: 10.1158/2159-8290.CD-RW2020-062
Tumors produce chemokines that attract neutrophils and cause them to undergo NETosis.
肿瘤会产生趋化因子，吸引中性粒细胞并使其发生 NETosis。
{"title":"Neutrophils Undergo NETosis to Block Cytotoxic Lymphocytes from Tumors.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-062","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-062","url":null,"abstract":"Tumors produce chemokines that attract neutrophils and cause them to undergo NETosis.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"127 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141210281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-24DOI: 10.1158/2159-8290.CD-RW2020-061
The breakage-fusion-bridge (BFB) cycle is linked to chromothripsis and yields chromosomal aberrations.
断裂-融合-桥（BFB）循环与染色体猝灭有关，并产生染色体畸变。
{"title":"Catastrophic Mutational Events Can Cause Cancer Genome Aberrations.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-061","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-061","url":null,"abstract":"The breakage-fusion-bridge (BFB) cycle is linked to chromothripsis and yields chromosomal aberrations.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"125 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141210102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-24DOI: 10.1158/2159-8290.CD-RW2020-060
Many oncogenes contain multiple individually weak mutations that collectively promote oncogenesis.
许多致癌基因包含多个单独的微弱突变，这些突变共同促进了肿瘤发生。
{"title":"Oncogenes Hit by Multiple Cooperating Mutations Are Common in Cancers.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-060","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-060","url":null,"abstract":"Many oncogenes contain multiple individually weak mutations that collectively promote oncogenesis.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"130 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141210204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-10DOI: 10.1158/2159-8290.CD-RW2020-055
Germline loss-of-function ELP1 variants were found in pediatric Sonic Hedgehog medulloblastomas.
在小儿Sonic Hedgehog髓母细胞瘤中发现了基因功能缺失的ELP1变体。
{"title":"ELP1 Loss Disrupts Protein Homeostasis to Promote SHH Medulloblastoma.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-055","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-055","url":null,"abstract":"Germline loss-of-function ELP1 variants were found in pediatric Sonic Hedgehog medulloblastomas.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"79 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141215404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-10DOI: 10.1158/2159-8290.CD-RW2020-053
Lurbinectedin produced responses in 35.2% of 105 patients with relapsed small-cell lung cancer.
在 105 名复发小细胞肺癌患者中，35.2% 的患者对鲁贝替尼产生了反应。
{"title":"Lurbinectedin Is Safe and Active in Relapsed Small-Cell Lung Cancer.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-053","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-053","url":null,"abstract":"Lurbinectedin produced responses in 35.2% of 105 patients with relapsed small-cell lung cancer.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"82 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141215606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-10DOI: 10.1158/2159-8290.CD-RW2020-054
Cysteine depletion caused ferroptosis in human pancreatic cancer cells and improved survival in mice.
半胱氨酸的缺失会导致人类胰腺癌细胞发生铁变态反应，并提高小鼠的存活率。
{"title":"Cysteine Is Required for Preventing Ferroptosis in Pancreatic Cancer.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-054","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-054","url":null,"abstract":"Cysteine depletion caused ferroptosis in human pancreatic cancer cells and improved survival in mice.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"79 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141215394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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