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Israel Medical Association Journal最新文献

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Nitrous Oxide-induced Myeloneuropathy Due to Recreational Abuse. 娱乐性滥用一氧化二氮导致的脊髓神经病。
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Israel Medical Association Journal
Pub Date : 2024-05-01
Ron Dabby, Diana Paleacu Kertesz, Ilia Demurchev, Oded Hershkovich, Mira Ginsberg, Menachem Sadeh

Background: The recreational use of nitrous oxide (N2O) has increased in recent years with a noticeable surge in the incidence of nitrous oxide-related myeloneuropathy.

Objectives: To raise awareness of increasing myeloneuropathy due to recreational nitrous oxide misuse in Israel.

Methods: We conducted a case series documenting the clinical and investigative features of eight patients presenting with nitrous oxide-induced myeloneuropathy who were admitted to our departments.

Results: Paresthesia was the chief complaint in all patients, with sensory gait ataxia being a common feature, which was often accompanied by Romberg's sign and mild lower limb weakness. Vitamin B12 levels were below the normal range in seven patients, accompanied by elevated homocysteine and methylmalonic acid levels. Magnetic resonance imaging scans revealed hyperintense signals in the dorsal columns of the cervical spine. All patients improved following vitamin B12 injections.

Conclusions: Enhancing awareness, prompting the use of appropriate investigations, and advocating for timely treatment are needed to overcome the risks associated with nitrous oxide misuse.

背景：近年来，一氧化二氮（N2O）的娱乐性使用有所增加，与一氧化二氮相关的骨髓神经病的发病率也明显激增：目的：提高人们对以色列因娱乐性滥用一氧化二氮而导致骨髓神经病日益增多的认识：我们进行了一项病例系列研究，记录了本部门收治的八名一氧化二氮诱发骨髓神经病患者的临床和检查特征：结果：所有患者的主诉均为麻痹，感觉性步态共济失调是其共同特征，通常伴有罗姆伯格征和轻度下肢无力。7 名患者的维生素 B12 水平低于正常范围，同时伴有同型半胱氨酸和甲基丙二酸水平升高。磁共振成像扫描显示颈椎背柱有高强度信号。所有患者在注射维生素 B12 后均有所好转：要克服滥用一氧化二氮带来的风险，就必须提高人们的认识，促使他们进行适当的检查，并提倡及时治疗。
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引用次数: 0
Under the Surface: Malignancy Unveiled in a Young Woman with Dermatomyositis. 表面之下揭开皮肌炎年轻女性恶性肿瘤的神秘面纱
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Israel Medical Association Journal
Pub Date : 2024-05-01
Oren Biham, Shira Sophie Hudes, Aviya Kedmi, Uriel Wachsman, Mohamed Abo Sbet, Eduard Ling, Lior Zeller
{"title":"Under the Surface: Malignancy Unveiled in a Young Woman with Dermatomyositis.","authors":"Oren Biham, Shira Sophie Hudes, Aviya Kedmi, Uriel Wachsman, Mohamed Abo Sbet, Eduard Ling, Lior Zeller","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 5","pages":"315-317"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Geriatrism: A Novel Concept in the Medical Field. 老年医学：医疗领域的新概念。
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Israel Medical Association Journal
Pub Date : 2024-05-01
Eliyahu Hayim Mizrahi
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引用次数: 0
Gout, Hyperuricemia, and Ear Function: A Systematic Review. 痛风、高尿酸血症与耳功能：系统回顾
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Israel Medical Association Journal
Pub Date : 2024-05-01
Thelma L Skare, Jozélio Freire de Carvalho
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引用次数: 0
Intranasal Corticosteroids: A Personalized Medicine Approach. 鼻内皮质类固醇：个性化医疗方法。
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Israel Medical Association Journal
Pub Date : 2024-05-01
Tomer Boldes, Benny Nageris, Firas Kassem, Ameen Biadsee
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引用次数: 0
The Healthcare System in Theresienstadt: Heroism and Challenges. 特莱西恩施塔特的医疗保健系统：英雄主义与挑战。
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Israel Medical Association Journal
Pub Date : 2024-04-01
Philip J Hashkes
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引用次数: 0
Electrocautery-induced Inappropriate Implantable Cardiac Defibrillator Shock. 电灼引起的植入式心脏除颤器不适当电击。
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Israel Medical Association Journal
Pub Date : 2024-04-01
Dante Antonelli, Vladimir Poletaev, Vidal Essebag, Alexander Feldman
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引用次数: 0
Exploring the Link Between Ankylosing Spondylitis and Inflammatory Bowel Disease: A Retrospective Cohort Study. 探索强直性脊柱炎与炎症性肠病之间的联系：回顾性队列研究
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Israel Medical Association Journal
Pub Date : 2024-04-01
Kassem Sharif, Adi Lahat, Yonatan Shneor Patt, Niv Ben-Shabat, Mahmud Omar, Abdulla Watad, Howard Amital, Omer Gendelman

Background: Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) are chronic conditions with overlapping pathogenic mechanisms. The genetic predisposition and inflammatory pathways common to both diseases suggest a syndemic relationship. While some evidence points to a connection between the two conditions, other reports do not support this link.

Objectives: To investigate the association between AS and the subsequent incidence of IBD. To identify potential risk factors and effect modifiers that contribute to this relationship.

Methods: Utilizing the Chronic Disease Registry of Clalit Health Services, we conducted a retrospective cohort study of individuals diagnosed with AS between January 2002 and December 2018. We compared these patients with age- and sex-matched controls, excluding those with a prior diagnosis of IBD. Statistical analyses included chi-square and t-tests for demographic comparisons, and Cox proportional hazards models for evaluating the risk of IBD development, with adjustments for various co-morbidities and demographic factors.

Results: The study included 5825 AS patients and 28,356 controls. AS patients demonstrated a significantly higher incidence of IBD with hazard ratios of 6.09 for Crohn's disease and 2.31 for ulcerative colitis, after multivariate adjustment. The overall incidence of IBD in the AS cohort was significantly higher compared to controls.

Conclusions: AS patients exhibit a markedly increased risk of developing IBD. These findings advocate for heightened clinical vigilance for IBD symptoms in AS patients and suggest the need for a multidisciplinary approach to patient care. Further research into the shared pathogenic pathways is needed to develop personalized treatment strategies and improve patient management.

背景：强直性脊柱炎（AS）和炎症性肠病（IBD）是致病机制相互重叠的慢性疾病。这两种疾病共同的遗传倾向和炎症途径表明它们之间存在一种综合征关系。虽然一些证据表明这两种疾病之间存在联系，但其他报告并不支持这种联系：研究强直性脊柱炎与随后的 IBD 发病率之间的关系。方法：利用慢性疾病数据库（Chronic Disease Data Center）对强直性脊柱炎与 IBD 发病率之间的关系进行研究：利用 Clalit 健康服务机构的慢性病登记处，我们对 2002 年 1 月至 2018 年 12 月期间确诊为强直性脊柱炎的患者进行了一项回顾性队列研究。我们将这些患者与年龄和性别相匹配的对照组进行了比较，但不包括之前诊断为 IBD 的患者。统计分析包括用于人口统计学比较的卡方检验（chi-square）和t检验，以及用于评估IBD发病风险的Cox比例危险模型，并对各种并发症和人口统计学因素进行了调整：研究包括5825名强直性脊柱炎患者和28356名对照者。经多变量调整后，强直性脊柱炎患者的IBD发病率明显较高，克罗恩病的危险比为6.09，溃疡性结肠炎的危险比为2.31。与对照组相比，强直性脊柱炎队列中IBD的总发病率明显更高：结论：强直性脊柱炎患者罹患 IBD 的风险明显增加。这些发现表明，临床上应提高对强直性脊柱炎患者 IBD 症状的警惕，并建议对患者的护理需要采用多学科方法。需要进一步研究共同的致病途径，以制定个性化的治疗策略并改善患者管理。
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引用次数: 0
Klatskin Signet Ring Cell Neuroendocrine Tumor of the Biliary Tree. 胆管克氏环细胞神经内分泌瘤
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Israel Medical Association Journal
Pub Date : 2024-04-01
Eden Gerszman, Esther Kazlow, Victoria Vlasov, Dvir Froylich, Jacob Dickstein, Riad Haddad, Ahmad Mahamid
{"title":"Klatskin Signet Ring Cell Neuroendocrine Tumor of the Biliary Tree.","authors":"Eden Gerszman, Esther Kazlow, Victoria Vlasov, Dvir Froylich, Jacob Dickstein, Riad Haddad, Ahmad Mahamid","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50268,"journal":{"name":"Israel Medical Association Journal","volume":"26 4","pages":"247-250"},"PeriodicalIF":1.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Starvation Osteoporosis in Shoah Survivors: Emphasis on Descendant Generations. 纳粹浩劫幸存者的饥饿性骨质疏松症：重视后代。
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Israel Medical Association Journal
Pub Date : 2024-04-01
George M Weisz
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引用次数: 0
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