Iraqi Journal of Veterinary Sciences最新文献_第2页

Age related neoplasm in experimental animals 实验动物中的老年性肿瘤

Iraqi Journal of Veterinary Sciences

Pub Date : 2024-04-01 DOI: 10.33899/ijvs.2023.141723.3136

H. B. Al-sabaawy

The albino rats are commonly recognized as tumor-resistant and appreciable research interest because of the scarcity of reports and article papers on neoplasm tumors. In this regard, we have encountered ten male and female spontaneous cases of tumor investigated in the veterinary medicine college, experimental animal house. Liver and kidney neoplasms were observed in the animals, ages 2-2.5 years. Tumor masses were measured grossly, giving different shapes and sizes. Histopathological analyses of these tumors revealed degenerative changes represented by cystic alteration, basophilic cell infiltration, reduced cytoplasm, permanent hyperchromatic nuclei, necrosis mass, papillary projection, metaplasia of epithelial lining, nest of cancerous cell, and tubules of tumors cell, in addition to clumpy chromatin with irregular nuclear membranes as well. The neoplastic cell had a positive immunoreactive. The correlation coefficient between BCL2&PAX8 showed significant differences; IHC scoring was done based on the observations of cell reactivity in each field as follows: negative and positive represented by weak reaction as five cytoplasmic positive cells per field, moderate IHC reactivity was 10-15cells positive, furthermore, intense positive staining where more than 15 cytoplasmic positively cell per field. Our results suggest that spontaneous aged-related neoplasms represented by renal and hepatocellular carcinoma were at stages 3 and 4 in the liver and kidney. Our study's conclusion revealed numerous markers of primary hepatic and renal cell carcinoma, yet a specific marker cannot be used to identify all types of cancer. The study and investigation of these markers will significantly impact the early detection, prognosis, and treatment of cancer.

白化大鼠是公认的抗肿瘤动物，由于有关肿瘤的报道和论文较少，因此研究兴趣很高。在这方面，我们在兽医学院的实验动物房中遇到了 10 例雌雄自发性肿瘤病例。这些动物的年龄为 2-2.5 岁，观察到肝脏和肾脏肿瘤。对肿瘤肿块进行了大体测量，结果显示其形状和大小各不相同。这些肿瘤的组织病理学分析表明，其退行性变化表现为囊性改变、嗜碱性细胞浸润、细胞质减少、核永久性高色素、坏死块、乳头状突起、上皮内膜变性、癌细胞巢和肿瘤细胞小管，此外还有不规则核膜的团块状染色质。肿瘤细胞具有阳性免疫反应。BCL2和PAX8之间的相关系数显示出显著差异；根据每个视野中细胞反应性的观察结果进行IHC评分：阴性和阳性代表弱反应，即每个视野中有5个细胞质阳性细胞；中度IHC反应性为10-15个阳性细胞；此外，强阳性染色为每个视野中有15个以上细胞质阳性细胞。我们的研究结果表明，以肾癌和肝癌为代表的自发性老年相关肿瘤处于肝脏和肾脏的 3 期和 4 期。我们的研究结论揭示了原发性肝癌和肾细胞癌的许多标记物，但一种特定的标记物并不能用于识别所有类型的癌症。对这些标志物的研究和调查将对癌症的早期检测、预后和治疗产生重大影响。

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