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Coronary Artery Bypass Grafting for Refractory Ventricular fibrillation after the Release of the Aortic Cross-Clamp in Patients Undergoing Aortic Valve Replacement: A Case Report 主动脉瓣置换术患者主动脉瓣横夹松开后难治性室颤的冠状动脉旁路移植术:病例报告
Pub Date : 2024-02-01 DOI: 10.59958/hsf.6713
Xiao-Jie Yu, Da-Shi Ma, Mu-Shui Qiu
Background: Ventricular fibrillation (VF) is a known complication after the release of the aortic cross-clamp (ACC) during cardiopulmonary bypass (CPB) surgery. Various factors contribute to persistent refractory VF, making its management challenging. This case report describes the successful treatment of postoperative refractory VF by coronary artery bypass grafting (CABG) in a patient undergoing aortic valve replacement (AVR) with ACC release. Case Presentation: A 52-year-old woman with a history of hypertension and ischemic cerebral infarction presented with symptoms of chest tightness, dyspnoea and palpitations. She underwent a modified maze procedure of radiofrequency ablation, mitral repair, left atrial appendage closure and mechanical AVR under a CPB procedure. Following the ACC release, the patient experienced recurrent VF that was unresponsive to standard interventions such as lidocaine, amiodarone and direct current shocks. The suspicion of right coronary artery (RCA) insufficiency led to the decision to perform CABG using the great saphenous vein. After the CABG procedure, the patient's heart rhythm gradually returned to sinus rhythm, and she had an uneventful recovery. Discussion and Conclusions: Refractory VF after the ACC release can pose diagnostic and treatment challenges. In this case, RCA insufficiency was suspected as the cause of refractory VF. The absence of blood flow in the proximal RCA and the presence of distal blood return during cardiac surface exploration supported this suspicion. Coronary artery bypass grafting using the great saphenous vein successfully restored normal sinus rhythm, confirming the diagnosis. This case emphasises the importance of considering coronary artery stenosis or occlusion as a potential cause of refractory VF after the ACC release during CPB, with CABG serving as a viable alternative treatment.
背景:心室颤动(VF)是心肺旁路(CPB)手术中主动脉交叉钳夹(ACC)松开后的一种已知并发症。导致持续难治性室颤的因素多种多样,使其治疗具有挑战性。本病例报告描述了通过冠状动脉旁路移植术(CABG)成功治疗了一名接受主动脉瓣置换术(AVR)并释放 ACC 的患者的术后难治性室颤。病例介绍:一名 52 岁的女性患者有高血压和缺血性脑梗塞病史,出现胸闷、呼吸困难和心悸症状。她在 CPB 手术下接受了改良迷宫术,包括射频消融、二尖瓣修复、左心房阑尾闭合和机械性 AVR。ACC 释放后,患者反复出现室颤,对利多卡因、胺碘酮和直流电冲击等标准干预措施无反应。由于怀疑右冠状动脉(RCA)功能不全,医生决定使用大隐静脉进行 CABG。CABG 手术后,患者的心律逐渐恢复为窦性心律,并顺利康复。讨论和结论:ACC 释放后的难治性室颤会给诊断和治疗带来挑战。在该病例中,RCA 功能不全被怀疑是导致难治性室颤的原因。在心脏表面探查时,RCA 近端没有血流,而远端有血液回流,这都支持了这一怀疑。使用大隐静脉进行冠状动脉旁路移植成功恢复了正常窦性心律,从而确诊了这一病例。该病例强调了将冠状动脉狭窄或闭塞视为 CPB 期间 ACC 释放后导致难治性室颤的潜在原因的重要性,而 CABG 是一种可行的替代治疗方法。
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引用次数: 0
Coronary Artery Bypass Grafting for Refractory Ventricular fibrillation after the Release of the Aortic Cross-Clamp in Patients Undergoing Aortic Valve Replacement: A Case Report 主动脉瓣置换术患者主动脉瓣横夹松开后难治性室颤的冠状动脉旁路移植术:病例报告
Pub Date : 2024-02-01 DOI: 10.59958/hsf.6713
Xiao-Jie Yu, Da-Shi Ma, Mu-Shui Qiu
Background: Ventricular fibrillation (VF) is a known complication after the release of the aortic cross-clamp (ACC) during cardiopulmonary bypass (CPB) surgery. Various factors contribute to persistent refractory VF, making its management challenging. This case report describes the successful treatment of postoperative refractory VF by coronary artery bypass grafting (CABG) in a patient undergoing aortic valve replacement (AVR) with ACC release. Case Presentation: A 52-year-old woman with a history of hypertension and ischemic cerebral infarction presented with symptoms of chest tightness, dyspnoea and palpitations. She underwent a modified maze procedure of radiofrequency ablation, mitral repair, left atrial appendage closure and mechanical AVR under a CPB procedure. Following the ACC release, the patient experienced recurrent VF that was unresponsive to standard interventions such as lidocaine, amiodarone and direct current shocks. The suspicion of right coronary artery (RCA) insufficiency led to the decision to perform CABG using the great saphenous vein. After the CABG procedure, the patient's heart rhythm gradually returned to sinus rhythm, and she had an uneventful recovery. Discussion and Conclusions: Refractory VF after the ACC release can pose diagnostic and treatment challenges. In this case, RCA insufficiency was suspected as the cause of refractory VF. The absence of blood flow in the proximal RCA and the presence of distal blood return during cardiac surface exploration supported this suspicion. Coronary artery bypass grafting using the great saphenous vein successfully restored normal sinus rhythm, confirming the diagnosis. This case emphasises the importance of considering coronary artery stenosis or occlusion as a potential cause of refractory VF after the ACC release during CPB, with CABG serving as a viable alternative treatment.
背景:心室颤动(VF)是心肺旁路(CPB)手术中主动脉交叉钳夹(ACC)松开后的一种已知并发症。导致持续难治性室颤的因素多种多样,使其治疗具有挑战性。本病例报告描述了通过冠状动脉旁路移植术(CABG)成功治疗了一名接受主动脉瓣置换术(AVR)并释放 ACC 的患者的术后难治性室颤。病例介绍:一名 52 岁的女性患者有高血压和缺血性脑梗塞病史,出现胸闷、呼吸困难和心悸症状。她在 CPB 手术下接受了改良迷宫术,包括射频消融、二尖瓣修复、左心房阑尾闭合和机械性 AVR。ACC 释放后,患者反复出现室颤,对利多卡因、胺碘酮和直流电冲击等标准干预措施无反应。由于怀疑右冠状动脉(RCA)功能不全,医生决定使用大隐静脉进行 CABG。CABG 手术后,患者的心律逐渐恢复为窦性心律,并顺利康复。讨论和结论:ACC 释放后的难治性室颤会给诊断和治疗带来挑战。在该病例中,RCA 功能不全被怀疑是导致难治性室颤的原因。在心脏表面探查时,RCA 近端没有血流,而远端有血液回流,这都支持了这一怀疑。使用大隐静脉进行冠状动脉旁路移植成功恢复了正常窦性心律,从而确诊了这一病例。该病例强调了将冠状动脉狭窄或闭塞视为 CPB 期间 ACC 释放后导致难治性室颤的潜在原因的重要性,而 CABG 是一种可行的替代治疗方法。
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引用次数: 0
Analysis of the Influencing Factors of Postoperative Constipation in Patients Undergoing Cardiovascular Surgery: A Cross-Sectional and Prospective Study 心血管手术患者术后便秘的影响因素分析:一项横断面前瞻性研究
Pub Date : 2024-01-18 DOI: 10.59958/hsf.7031
Ping Zhang, Chun Liu, Wen Qi, Xiaoli Xie, Yunyan Su
Background: The aim of this study was to estimate the potential influencing factors of postoperative constipation in patients undergoing cardiovascular surgery. Methods: This study included a cohort of 379 patients who underwent cardiovascular surgery at Nanjing Drum Tower Hospital. The patient cohort was stratified into two groups based on the presence or absence of postoperative constipation. Utilizing logistic regression analysis, both univariate and multivariate analyses were conducted to elucidate the factors influencing defecation problems. The predictive accuracy of the findings was subsequently evaluated through the receiver operating characteristic (ROC) curve. Results: Among the cohort of 379 patients subjected to cardiovascular surgery, a noteworthy 20.8% (n = 79) reported incidences of postoperative defecation issues. A multivariate logistic regression analysis showed that age (odds ratio (OR) = 1.063, 95% confidence interval (CI) 1.034–1.097, p < 0.001), operation time (OR = 1.004, 95% CI: 1.000–1.008, p = 0.028), ventilator usage time (OR = 1.032, 95% CI: 1.010–1.055, p = 0.004), polypharmacy (OR = 2.134, 95% CI: 1.069–4.321, p = 0.032), use of cough medicine (OR = 2.981, 95% CI: 1.271–6.942, p = 0.011) and psychological or behavioral barriers to defecation in the hospital environment (OR = 31.039, 95% CI: 14.313–73.179, p < 0.001) were independent risk factors for postoperative constipation in patients undergoing cardiovascular surgery. The area under the curve (AUC) for predicting postoperative constipation was 0.885. Conclusion: In the pursuit of optimizing postoperative recovery and mitigating postoperative constipation incidence, a targeted approach is imperative. Specifically, a focused intervention directed towards elderly patients, extended operation and prolonged ventilator durations, polypharmacy regimens, use of cough medicine, and those with psychological or behavioral barriers to defecation within the hospital milieu emerges as pivotal.
背景:本研究旨在评估心血管手术患者术后便秘的潜在影响因素。研究方法本研究纳入了在南京鼓楼医院接受心血管手术的 379 例患者。根据是否存在术后便秘将患者分为两组。利用逻辑回归分析进行单变量和多变量分析,以阐明影响排便问题的因素。随后,通过接收器操作特征曲线(ROC)对研究结果的预测准确性进行了评估。结果在 379 名心血管手术患者中,有 20.8%(n = 79)的患者报告了术后排便问题。多变量逻辑回归分析显示,年龄(比值比 (OR) = 1.063,95% 置信区间 (CI) 1.034-1.097,p < 0.001)、手术时间(OR = 1.004,95% CI:1.000-1.008,p = 0.028)、呼吸机使用时间(OR = 1.032,95% CI:1.010-1.055,p = 0.004)、多种药物(OR = 2.134,95% CI:1.069-4.321,p = 0.032)、使用止咳药(OR = 2.981,95% CI:1.271-6.942,p = 0.011)和医院环境中排便的心理或行为障碍(OR = 31.039,95% CI:14.313-73.179,p < 0.001)是心血管手术患者术后便秘的独立危险因素。预测术后便秘的曲线下面积(AUC)为 0.885。结论为了优化术后恢复并降低术后便秘发生率,必须采取有针对性的方法。具体来说,针对老年患者、手术时间过长和呼吸机使用时间过长的患者、使用多种药物治疗的患者、使用止咳药的患者以及在医院环境中排便存在心理或行为障碍的患者采取重点干预措施至关重要。
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引用次数: 0
AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte AKAP1 在 AHF 肾病患者中减少心肌细胞的铁突变
Pub Date : 2024-01-14 DOI: 10.59958/hsf.5717
Yifeng Fang, Junpeng Xu, Ruofei Huang
Background: This study mainly investigated the mechanism and effects of AKAP1 in renal patients with acute heart failure (AHF). Methods: Patients with renal patients with AHF and normal volunteers were collected. The left anterior descending arteries (LAD) of mice were ligated to induce myocardial infarction. Results: AKAP1 messenger RNA (mRNA) expression was found to be down-regulated in renal patients with AHF. The serum levels of AKAP1 mRNA expression were negatively correlated with collagen I/III in patients. AKAP1 mRNA and protein expression in the heart tissue of mice with AHF were also found to be down-regulated in a time-dependent manner. Short hairpin (Sh)-AKAP1 promotes AHF in a mouse model. AKAP1 up-regulation reduces reactive oxygen species (ROS)-induced oxidative stress in an In Vitro model. AKAP1 up-regulation also reduces ROS-induced lipid peroxidation ferroptosis in an In Vitro model. AKAP1 induces NDUFS1 expression to increase GPX4 activity levels. AKAP1 protein interlinked with the NDUFS1 protein. Up-regulation of the AKAP1 gene reduced NDUFS1 ubiquitination, while down-regulation of the AKAP1 gene increased NDUFS1 ubiquitination in a model. In vivo imaging showed that the sh-AKAP1 virus reduced NDUFS1 expression in the heart of a mouse model. Conclusions: AKAP1 reduced ROS-induced lipid peroxidation ferroptosis through the inhibition of ubiquitination of NDUFS by mitochondrial damage in model of renal patients with AHF, suggest a novel target for AHF treatment.
研究背景本研究主要探讨AKAP1在急性心力衰竭(AHF)肾病患者中的作用机制。研究方法收集急性心力衰竭肾病患者和正常志愿者。结扎小鼠左前降支动脉(LAD)诱发心肌梗死。结果发现AHF肾病患者的AKAP1信使RNA(mRNA)表达下调。患者血清中 AKAP1 mRNA 的表达水平与胶原 I/III 呈负相关。研究还发现,AHF 小鼠心脏组织中的 AKAP1 mRNA 和蛋白表达也呈时间依赖性下调。短发夹(Sh)-AKAP1 可促进小鼠模型中的 AHF。在体外模型中,AKAP1上调可降低活性氧(ROS)诱导的氧化应激。在体外模型中,上调 AKAP1 还能减少 ROS 诱导的脂质过氧化铁中毒。AKAP1 可诱导 NDUFS1 的表达,从而提高 GPX4 的活性水平。AKAP1 蛋白与 NDUFS1 蛋白相互连接。在一个模型中,上调 AKAP1 基因可减少 NDUFS1 泛素化,而下调 AKAP1 基因可增加 NDUFS1 泛素化。体内成像显示,sh-AKAP1 病毒减少了小鼠模型心脏中 NDUFS1 的表达。结论在 AHF 肾病模型中,AKAP1 通过抑制线粒体损伤对 NDUFS 的泛素化,减少了 ROS 诱导的脂质过氧化铁中毒,为 AHF 治疗提供了一个新靶点。
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引用次数: 0
Working Around: The Use of AngioVac and Micra Transcatheter Leadless Pacemaker Implantation in a Critically Ill Patient Receiving Extracorporeal Membrane Oxygenation 四处奔波:在接受体外膜氧合的重症患者中使用 AngioVac 和 Micra 经导管无引线起搏器植入术
Pub Date : 2024-01-09 DOI: 10.59958/hsf.6223
Ryan Morse, Mark Joseph
The use of extracorporeal membrane oxygenation (ECMO) in critically ill patients has been on the rise in recent years. While ECMO has provided substantial benefit to patients who need cardiopulmonary support, its required use of large-bore catheters in major blood vessels often precludes the use of other transcatheter therapies. In this article, we demonstrate that two transcatheter procedures, AngioVac right-sided cardiac thrombus removal and Micra leadless pacemaker placement, both requiring large bore access, can both be safely and effectively implemented in patients who are dependent on ECMO to maintain cardiopulmonary function.
近年来,体外膜肺氧合(ECMO)在重症患者中的使用呈上升趋势。虽然 ECMO 为需要心肺支持的患者带来了巨大的益处,但由于需要在大血管中使用大口径导管,因此往往无法使用其他经导管疗法。在本文中,我们展示了两种经导管手术,即 AngioVac 右侧心肌血栓清除术和 Micra 无导线起搏器置入术,这两种手术都需要大口径入路,但对于依赖 ECMO 维持心肺功能的患者来说,它们都可以安全有效地实施。
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The Heart Surgery Forum
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