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Associations between renal function, hippocampal volume, and cognitive impairment in 544 outpatients 544 名门诊患者的肾功能、海马体积与认知障碍之间的关系
Pub Date : 2024-06-04 DOI: 10.3389/fneur.2024.1347682
Lei-Yun Wu, Yuan-Yuan Lu, Shuang-Shuang Zheng, Ya-Dong Cui, Jie Lu, Ai-Hua Zhang
Cognitive impairment and brain atrophy are common in chronic kidney disease patients. It remains unclear whether differences in renal function, even within normal levels, influence hippocampal volume (HCV) and cognition. We aimed to investigate the association between estimated glomerular filtration rate (eGFR), HCV and cognition in outpatients.This single-center retrospective study enrolled 544 nonrenal outpatients from our hospital. All participants underwent renal function assessment and 3.0 T magnetic resonance imaging (MRI) in the same year. HCV was also measured, and cognitive assessments were obtained. The correlations between eGFR, HCV, and cognitive function were analyzed. Logistic regression analysis was performed to identify the risk factors for hippocampal atrophy and cognitive impairment. Receiver-operator curves (ROCs) were performed to find the cut-off value of HCV that predicts cognitive impairment.The mean age of all participants was 66.5 ± 10.9 years. The mean eGFR of all participants was 88.5 ± 15.1 mL/min/1.73 m2. eGFR was positively correlated with HCV and with Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores. Univariate and multivariate logistic regression analysis showed Age ≥ 65 years, eGFR < 75 mL/min/1.73 m2, Glucose ≥6.1 mmol/L and combined cerebral microvascular diseases were independent risk factors for hippocampal atrophy and Age ≥ 65 years, left hippocampal volume (LHCV) <2,654 mm3 were independent risk factors for cognitive impairment in outpatients. Although initial unadjusted logistic regression analysis indicated that a lower eGFR (eGFR < 75 mL/min/1.73 m2) was associated with poorer cognitive function, this association was lost after adjusting for confounding variables. ROC curve analysis demonstrated that LHCV <2,654 mm3 had the highest AUROC [(0.842, 95% CI: 0.808–0.871)], indicating that LHCV had a credible prognostic value with a high sensitivity and specificity for predicting cognitive impairment compared with age in outpatients.Higher eGFR was associated with higher HCV and better cognitive function. eGFR < 75 mL/min/1.73 m2 was an independent risk factor for hippocampal atrophy after adjusting for age. It is suggested that even eGFR < 75 mL/min/1.73 m2, lower eGFR may still be associated with hippocampal atrophy, which is further associated with cognitive impairment. LHCV was a favorable prognostic marker for predicting cognitive impairment rather than age.
认知障碍和脑萎缩在慢性肾病患者中很常见。即使在正常水平下,肾功能的差异是否会影响海马体体积(HCV)和认知能力,目前仍不清楚。我们旨在调查门诊患者的估计肾小球滤过率(eGFR)、HCV 和认知能力之间的关系。所有参与者都在同一年接受了肾功能评估和 3.0 T 磁共振成像(MRI)检查。同时还测量了丙肝病毒,并进行了认知评估。分析了 eGFR、HCV 和认知功能之间的相关性。为确定海马萎缩和认知障碍的风险因素,进行了逻辑回归分析。所有参与者的平均年龄为(66.5 ± 10.9)岁。所有参与者的平均 eGFR 为 88.5 ± 15.1 mL/min/1.73 m2。eGFR 与 HCV 以及迷你精神状态检查(MMSE)和蒙特利尔认知评估(MoCA)评分呈正相关。单变量和多变量逻辑回归分析显示,年龄≥65岁、eGFR < 75 mL/min/1.73 m2、血糖≥6.1 mmol/L和合并脑微血管疾病是海马萎缩的独立危险因素,而年龄≥65岁、左侧海马体积(LHCV)<2,654 mm3是门诊患者认知障碍的独立危险因素。尽管最初的未调整逻辑回归分析表明,较低的 eGFR(eGFR < 75 mL/min/1.73 m2)与较差的认知功能相关,但在调整了混杂变量后,这种关联性消失了。ROC曲线分析表明,LHCV<2,654 mm3的AUROC最高[(0.842, 95% CI: 0.808-0.871)],这表明与年龄相比,LHCV在预测门诊患者认知功能障碍方面具有可信的预后价值,并具有较高的敏感性和特异性。这表明,即使 eGFR < 75 mL/min/1.73 m2,较低的 eGFR 仍可能与海马体萎缩有关,而海马体萎缩又与认知功能障碍有关。LHCV 是预测认知功能损害的有利预后指标,而不是年龄。
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引用次数: 0
The importance of multimodal CT examination in stroke mimics diagnosis: design of prospective observational multicentre study 多模态 CT 检查在中风模拟诊断中的重要性:前瞻性多中心观察研究的设计
Pub Date : 2024-06-04 DOI: 10.3389/fneur.2024.1365986
Kateřina Dvorníková, Veronika Kunešová, Marcela Ely, S. Ostrý, Martin Čábal, Martin Reiser, Linda Machová, Markéta Pavlínová, Adéla Kondé, Pavel Eliáš, Tomáš Jonszta, Jaroslav Havelka, O. Volny, Michal Bar
Non-contrast computed tomography (CT) and CT angiography are the gold standard in neuroimaging diagnostics in the case of suspected stroke. CT perfusion (CTP) may play an important role in the diagnosis of stroke mimics (SM), but currently, it is not a standard part of the stroke diagnostic procedure. The project is a multicentre prospective observational clinical research focused on refining the diagnostics of stroke and stroke mimics (SM) in hospital care.This study aimed to evaluate the degree of specificity and sensitivity of multimodal CT (NCCT, CTA, and CTP) in the diagnosis of SM versus stroke.In this study, we will include 3,000 patients consecutively admitted to the comprehensive stroke centres with a diagnosis of suspected stroke. On the basis of clinical parameters and the results of multimodal CT and magnetic resonance imaging (MRI), the diagnosis of stroke and SM will be established. To clarify the significance of the use of the multimodal CT scan, the analysis will include a comparison of the blinded results for each imaging scan performed by radiologists and AI technology and a comparison of the initial and final diagnosis of the enrolled patients. Based on our results, we will compare the economic indicators and costs that would be saved by not providing inadequate treatment to patients with SM.The expected outcome is to present an optimised diagnostic procedure that results in a faster and more accurate diagnosis, thereby eliminating the risk of inadequate treatment in patients with SM.clinicaltrials.gov, NCT06045455.
非对比计算机断层扫描(CT)和 CT 血管造影是疑似脑卒中神经影像诊断的金标准。CT 灌注(CTP)可在中风拟态(SM)的诊断中发挥重要作用,但目前还不是中风诊断程序的标准组成部分。该项目是一项多中心前瞻性观察临床研究,重点在于完善医院护理中的卒中和卒中模拟物(SM)诊断。本研究旨在评估多模态 CT(NCCT、CTA 和 CTP)在诊断 SM 与卒中时的特异性和敏感性程度。在本研究中,我们将纳入 3000 名连续入住综合卒中中心并诊断为疑似卒中的患者。根据临床参数、多模态 CT 和磁共振成像(MRI)结果,确定卒中和 SM 的诊断。为了明确使用多模态 CT 扫描的意义,分析将包括对放射科医生和人工智能技术进行的每次成像扫描的盲法结果进行比较,以及对入选患者的初始诊断和最终诊断进行比较。根据我们的结果,我们将比较不对 SM 患者进行不适当治疗所节省的经济指标和成本。预期结果是提出一种优化的诊断程序,使诊断更快、更准确,从而消除 SM 患者接受不适当治疗的风险。
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引用次数: 0
Evidence for reticulospinal plasticity underlying motor recovery in Brown-Séquard-plus Syndrome: a case report 布朗-塞卡尔-加综合征运动康复基础网状脊髓可塑性的证据:病例报告
Pub Date : 2024-06-04 DOI: 10.3389/fneur.2024.1335795
Antonia Maria Eilfort, Maria Rasenack, B. Zörner, Armin Curt, Linard Filli
Brown-Séquard Syndrome (BSS) is a rare neurological condition caused by a unilateral spinal cord injury (SCI). Upon initial ipsilesional hemiplegia, patients with BSS typically show substantial functional recovery over time. Preclinical studies on experimental BSS demonstrated that spontaneous neuroplasticity in descending motor systems is a key mechanism promoting functional recovery. The reticulospinal (RS) system is one of the main descending motor systems showing a remarkably high ability for neuroplastic adaptations after incomplete SCI. In humans, little is known about the contribution of RS plasticity to functional restoration after SCI. Here, we investigated RS motor drive to different muscles in a subject with Brown-Séquard-plus Syndrome (BSPS) five months post-injury using the StartReact paradigm. RS drive was compared between ipsi- and contralesional muscles, and associated with measures of functional recovery. Additionally, corticospinal (CS) drive was investigated using transcranial magnetic stimulation (TMS) in a subset of muscles. The biceps brachii showed a substantial enhancement of RS drive on the ipsi- vs. contralesional side, whereas no signs of CS plasticity were found ipsilesionally. This finding implies that motor recovery of ipsilesional elbow flexion is primarily driven by the RS system. Results were inversed for the ipsilesional tibialis anterior, where RS drive was not augmented, but motor-evoked potentials recovered over six months post-injury, suggesting that CS plasticity contributed to improvements in ankle dorsiflexion. Our findings indicate that the role of RS and CS plasticity in motor recovery differs between muscles, with CS plasticity being essential for the restoration of distal extremity motor function, and RS plasticity being important for the functional recovery of proximal flexor muscles after SCI in humans.
布朗-塞卡尔综合征(BSS)是一种罕见的神经系统疾病,由单侧脊髓损伤(SCI)引起。在最初出现同侧偏瘫时,布朗-塞卡尔综合征患者通常会随着时间的推移出现实质性的功能恢复。对实验性 BSS 的临床前研究表明,降序运动系统的自发性神经可塑性是促进功能恢复的关键机制。网状脊髓(RS)系统是主要的降序运动系统之一,在不完全损伤后表现出极高的神经可塑性适应能力。在人体中,人们对脊髓损伤后 RS 的可塑性对功能恢复的贡献知之甚少。在这里,我们使用 StartReact 范式研究了一名布朗-赛夸大综合征(BSPS)患者在伤后五个月对不同肌肉的 RS 运动驱动力。对同侧和对侧肌肉的 RS 驱动力进行了比较,并将其与功能恢复措施联系起来。此外,还使用经颅磁刺激(TMS)对部分肌肉的皮质脊髓(CS)驱动力进行了研究。肱二头肌显示同侧与对侧的 RS 驱动力大幅增强,而同侧没有发现 CS 可塑性的迹象。这一发现意味着同侧肘关节屈曲的运动恢复主要由 RS 系统驱动。同侧胫骨前肌的结果则相反,RS驱动力没有增强,但运动诱发电位在伤后六个月内得到恢复,这表明CS可塑性有助于踝关节外展的改善。我们的研究结果表明,RS和CS可塑性在不同肌肉的运动恢复中的作用是不同的,CS可塑性对四肢远端运动功能的恢复至关重要,而RS可塑性对脊髓损伤后近端屈肌的功能恢复非常重要。
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引用次数: 0
Efficacy and safety of combined stent retriever and contact aspiration vs. stent retriever alone on revascularization in patients with acute ischemic stroke: a systematic review and meta-analysis 急性缺血性脑卒中患者血管再通治疗中,联合使用支架回吸管和接触式抽吸器与单独使用支架回吸管的疗效和安全性对比:系统综述和荟萃分析
Pub Date : 2024-06-04 DOI: 10.3389/fneur.2024.1365876
Wei Li, Guo-hui Lin, Hong-hong Li, Peng-Bo Zhou, Yue-yang Chen, Hong-tao Sun, He-cheng Chen
Whether the efficacy of combined stent retriever and contact aspiration (S + A) is superior to stent retriever (S) alone for revascularisation in patients with large vessel occlusive stroke remains uncertain. The aim of this meta-analysis was to assess the safety and efficacy of combined stent retriever and contact aspiration for the treatment of acute ischaemic stroke with large vessel occlusion by comparing it with stent retriever alone.We systematically searched the PubMed, Embase, Web of Science, and The Cochrane Library databases for randomised controlled trials and observational studies (case-control and cohort studies) published before 1 October 2023 comparing the efficacy of combined stent retriever and contact aspiration versus tent retriever alone in patients with large vessel occlusive stroke. The end point of the primary efficacy observed in this meta-analysis study was the rate of first pass nearly complete or complete recanalisation (mTICI 2c-3). Secondary effectiveness nodes were: rate of first pass successful recanalisation (mTICI 2b-3), rate of near-complete or complete recanalisation of the postoperative vessel, rate of successful recanalisation of the postoperative vessel, and MRS 0–2 within 90 days. Safety endpoints were interoperative embolism, symptomatic intracranial haemorrhage, and mortality within 90 days.A total of 16 studies were included in the literature for this meta-analysis, with a total of 7,320 patients (S + C group: 3,406, S group: 3,914). A comprehensive analysis of the included literature showed that combined stent retriever and contact aspiration had a higher rate of near-complete or complete recanalisation of the postoperative vessel [OR = 1.53, 95% CI (1.24, 1.88), p < 0.0001] and rate of successful recanalisation of the postoperative vessel compared to stent retriever alone [OR = 1.83, 95% CI (1.55, 2.17), p < 0.00001]; there were no statistically significant differences between the two groups in terms of the rate of first pass nearly complete or complete recanalisation [OR = 1.00, 95% CI (0.83, 1.19), p = 0.96], rate of first pass successful recanalisation [OR = 1.02, 95% CI (0.85, 1.24), p = 0.81], interoperative embolism [OR = 0.93, 95% CI (0.72, 1.20), p = 0.56], symptomatic intracranial haemorrhage [OR = 1.14, 95% CI (0.87, 1.48), p = 0.33], MRS 0–2 within 90 days [OR = 0.89, 95% CI (0.76, 1.04), p = 0.14] and mortality within 90 days [OR = 1.11, 95% CI (0.94, 1.31), p = 0.22].Combined stent retriever and contact aspiration has a higher rate of postprocedural revascularisation (mTICI 2c-3/mTICI 2b-3) compared with stent retriever alone in patients with large vessel occlusion stroke. In addition, it was not superior to stenting alone in terms of the rate of first pass recanalisation (mTICI 2c-3/mTICI 2b-3), interoperative embolisation, symptomatic intracranial haemorrhage, good functional prognosis within 90 days and mortality within 90 days.
在大血管闭塞性卒中患者的血管再通治疗中,联合支架留置术和接触式抽吸术(S + A)的疗效是否优于单纯支架留置术(S)仍不确定。我们在 PubMed、Embase、Web of Science 和 Cochrane Library 数据库中系统检索了 2023 年 10 月 1 日之前发表的随机对照试验和观察性研究(病例对照和队列研究),比较了联合支架回流器和接触式抽吸与单独支架回流器在大血管闭塞性卒中患者中的疗效。这项荟萃分析研究观察的主要疗效终点是首次近完全或完全再通畅率(mTICI 2c-3)。次要疗效节点为:首次成功再通率(mTICI 2b-3)、术后血管近乎完全或完全再通率、术后血管成功再通率、90 天内 MRS 0-2。安全性终点为术中栓塞、无症状性颅内出血和90天内死亡率。本次荟萃分析共纳入了16项研究,共计7320名患者(S+C组:3406人,S组:3914人)。对所纳入文献的综合分析表明,联合使用支架回纳器和接触式抽吸术的术后血管近乎完全或完全再通率更高[OR = 1.53,95% CI (1.24, 1.88),P < 0.0001]和术后血管成功再通率与单纯支架回流术相比[OR = 1.83,95% CI (1.55,2.17),P < 0.00001];两组在首次近完全或完全再通率[OR = 1.00,95% CI (0.83,1.19),P = 0.96]、首次成功再通率[OR = 1.02,95% CI (0.85,1.24),P = 0.81]、术中栓塞[OR = 0.93,95% CI (0.72,1.20),P = 0.56]、无症状性颅内出血[OR = 1.14,95% CI (0.87,1.48),P = 0.33]、90 天内 MRS 0-2 [OR = 0.89,95% CI (0。在大血管闭塞性卒中患者中,联合使用支架回吸管和接触式抽吸与单独使用支架回吸管相比,术后血管再通率(mTICI 2c-3/mTICI 2b-3)更高。此外,就首通再通率(mTICI 2c-3/mTICI 2b-3)、术中栓塞、无症状颅内出血、90 天内功能预后良好率和 90 天内死亡率而言,该方法均不优于单纯支架植入术。
{"title":"Efficacy and safety of combined stent retriever and contact aspiration vs. stent retriever alone on revascularization in patients with acute ischemic stroke: a systematic review and meta-analysis","authors":"Wei Li, Guo-hui Lin, Hong-hong Li, Peng-Bo Zhou, Yue-yang Chen, Hong-tao Sun, He-cheng Chen","doi":"10.3389/fneur.2024.1365876","DOIUrl":"https://doi.org/10.3389/fneur.2024.1365876","url":null,"abstract":"Whether the efficacy of combined stent retriever and contact aspiration (S + A) is superior to stent retriever (S) alone for revascularisation in patients with large vessel occlusive stroke remains uncertain. The aim of this meta-analysis was to assess the safety and efficacy of combined stent retriever and contact aspiration for the treatment of acute ischaemic stroke with large vessel occlusion by comparing it with stent retriever alone.We systematically searched the PubMed, Embase, Web of Science, and The Cochrane Library databases for randomised controlled trials and observational studies (case-control and cohort studies) published before 1 October 2023 comparing the efficacy of combined stent retriever and contact aspiration versus tent retriever alone in patients with large vessel occlusive stroke. The end point of the primary efficacy observed in this meta-analysis study was the rate of first pass nearly complete or complete recanalisation (mTICI 2c-3). Secondary effectiveness nodes were: rate of first pass successful recanalisation (mTICI 2b-3), rate of near-complete or complete recanalisation of the postoperative vessel, rate of successful recanalisation of the postoperative vessel, and MRS 0–2 within 90 days. Safety endpoints were interoperative embolism, symptomatic intracranial haemorrhage, and mortality within 90 days.A total of 16 studies were included in the literature for this meta-analysis, with a total of 7,320 patients (S + C group: 3,406, S group: 3,914). A comprehensive analysis of the included literature showed that combined stent retriever and contact aspiration had a higher rate of near-complete or complete recanalisation of the postoperative vessel [OR = 1.53, 95% CI (1.24, 1.88), p < 0.0001] and rate of successful recanalisation of the postoperative vessel compared to stent retriever alone [OR = 1.83, 95% CI (1.55, 2.17), p < 0.00001]; there were no statistically significant differences between the two groups in terms of the rate of first pass nearly complete or complete recanalisation [OR = 1.00, 95% CI (0.83, 1.19), p = 0.96], rate of first pass successful recanalisation [OR = 1.02, 95% CI (0.85, 1.24), p = 0.81], interoperative embolism [OR = 0.93, 95% CI (0.72, 1.20), p = 0.56], symptomatic intracranial haemorrhage [OR = 1.14, 95% CI (0.87, 1.48), p = 0.33], MRS 0–2 within 90 days [OR = 0.89, 95% CI (0.76, 1.04), p = 0.14] and mortality within 90 days [OR = 1.11, 95% CI (0.94, 1.31), p = 0.22].Combined stent retriever and contact aspiration has a higher rate of postprocedural revascularisation (mTICI 2c-3/mTICI 2b-3) compared with stent retriever alone in patients with large vessel occlusion stroke. In addition, it was not superior to stenting alone in terms of the rate of first pass recanalisation (mTICI 2c-3/mTICI 2b-3), interoperative embolisation, symptomatic intracranial haemorrhage, good functional prognosis within 90 days and mortality within 90 days.","PeriodicalId":503840,"journal":{"name":"Frontiers in Neurology","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141267063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep and sleep-related breathing disorders in patients with spinal muscular atrophy: a changing perspective from novel treatments? 脊髓性肌肉萎缩症患者的睡眠和睡眠相关呼吸障碍:新疗法带来的视角变化?
Pub Date : 2024-06-04 DOI: 10.3389/fneur.2024.1299205
E. Abati, E. Mauri, M. Rimoldi, Barbara Madini, Francesca Patria, G. Comi, Stefania Corti
Spinal Muscular Atrophy (SMA) is an inherited neuromuscular disorder characterized by progressive muscle weakness and atrophy, resulting from the degeneration of motor neurons in the spinal cord. A critical aspect of SMA is its impact on respiratory function. As the disease progresses, respiratory muscles, in particular intercostal muscles, become increasingly affected, leading to breathing difficulties and respiratory failure. Without intervention, many children with SMA type 1 die from respiratory failure before their second year of life. While assisted ventilation has improved survival, it often results in ventilator dependence. The development of new SMN-augmenting therapies has renewed optimism, but their long-term impact on respiratory function is uncertain, and non-invasive respiratory support remains an important part of SMA management. Despite the importance of respiratory support in SMA, knowledge regarding sleep disorders in this population is limited. This review aims to synthesize existing literature on sleep and sleep-related breathing disorders in patients with SMA, with a focus on SMA type 1. We summarize evidence of sleep-disordered breathing and respiratory failure in SMA, as well as outcomes and survival benefits associated with non-invasive or invasive ventilation with or without pharmacological therapies. We also discuss current knowledge regarding the effects of novel disease-modifying therapies for SMA on respiratory function and sleep. In conclusion, optimal care for children with SMA requires a multidisciplinary approach that includes neurology and respiratory specialists. This review highlights the importance of monitoring sleep and respiratory function in SMA, as well as the potential benefits and challenges associated with assisted ventilation combined with new therapies.
脊髓性肌肉萎缩症(SMA)是一种遗传性神经肌肉疾病,其特征是脊髓中的运动神经元发生变性,导致进行性肌肉无力和萎缩。SMA 的一个重要方面是对呼吸功能的影响。随着病情的发展,呼吸肌,尤其是肋间肌受到的影响越来越大,从而导致呼吸困难和呼吸衰竭。如果不进行干预,许多 1 型 SMA 患儿在出生后第二年就会死于呼吸衰竭。虽然辅助通气提高了存活率,但往往会导致对呼吸机的依赖。新的 SMN 增强疗法的开发使人们重拾乐观,但这些疗法对呼吸功能的长期影响尚不确定,无创呼吸支持仍是 SMA 治疗的重要组成部分。尽管呼吸支持在 SMA 中非常重要,但有关该人群睡眠障碍的知识却很有限。本综述旨在总结有关 SMA 患者睡眠和睡眠相关呼吸紊乱的现有文献,重点关注 SMA 1 型。我们总结了 SMA 患者睡眠呼吸障碍和呼吸衰竭的证据,以及采用或不采用药物疗法的无创或有创通气治疗的效果和生存益处。我们还讨论了目前有关 SMA 新型疾病调节疗法对呼吸功能和睡眠影响的知识。总之,SMA 患儿的最佳治疗需要包括神经科和呼吸科专家在内的多学科方法。本综述强调了监测 SMA 睡眠和呼吸功能的重要性,以及辅助通气与新疗法相结合的潜在益处和挑战。
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引用次数: 0
Case report: Spontaneous regression of extruded lumbar disc herniation with acupuncture therapy 病例报告:针灸疗法使腰椎间盘突出症自然消退
Pub Date : 2024-06-03 DOI: 10.3389/fneur.2024.1381292
Haiwen Liang, Jianhao Huang
Most patients with lumbar disc herniation (LDH) derive benefit from conservative treatment, prompting growing global interest in non-surgical approaches. Despite being recognized as one of the effective conservative therapies, there is currently limited evidence to support the sole efficacy of acupuncture in treating patients with acute extruded LDH. Here we report the case of a 52-year-old male who presented with low back pain and persistent radiating lower limb pain and numbness. Physical examination and magnetic resonance imaging (MRI) revealed an extruded LDH at the L5/S1 level, compressing the nerve root and causing severe radiculopathy symptoms. After 23 days of continuous inpatient acupuncture treatment, followed by 5 intermittent outpatient acupuncture treatment over 2 months, patient’s pain and numbness was significantly alleviated and a followed-up MRI showed a remarkable regression of the extruded disc fragment. In this case, acupuncture as a monotherapy is safe and effective, but more conclusive evidence is needed.
大多数腰椎间盘突出症(LDH)患者都能从保守治疗中获益,这促使全球对非手术疗法的兴趣与日俱增。尽管针灸是公认的有效保守疗法之一,但目前仅有有限的证据支持针灸治疗急性腰椎间盘突出症患者的疗效。在此,我们报告了一例 52 岁男性患者的病例,该患者出现腰背痛、持续性下肢放射痛和麻木。体格检查和磁共振成像(MRI)显示,L5/S1 水平有一挤压性 LDH,压迫神经根,导致严重的根性病变症状。经过 23 天的连续住院针灸治疗,以及 2 个月内 5 次间歇性门诊针灸治疗后,患者的疼痛和麻木症状明显缓解,随访的核磁共振成像显示挤压的椎间盘碎片明显消退。在这个病例中,针灸作为单一疗法是安全有效的,但还需要更多确凿证据。
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引用次数: 0
Safety and efficacy of peripheral metaraminol infusion in patients with neurological conditions: a single-center retrospective observational study 神经系统疾病患者输注外周美他胺醇的安全性和有效性:一项单中心回顾性观察研究
Pub Date : 2024-06-03 DOI: 10.3389/fneur.2024.1398827
Pan Han, Yu Zhou
Metaraminol is a sympathomimetic amine vasopressor that can be administrated through a peripheral venous access. However, limited evidence restricts its application in critically ill patients. This study aimed to investigate the safety and efficacy of peripheral metaraminol infusion in patients with neurological conditions.Patients who received peripheral metaraminol infusion between May 2019 and April 2022 were recruited. Data on baseline characteristics, clinical parameters, and infusion-related complications were retrospectively collected and analyzed.273 patients who received metaraminol were enrolled. Of these, 35 (12.8%) patients required central venous catheter insertion due to inability in achieving hemodynamic stability following peripheral metaraminol monotherapy. In 29,574.2 hours of vasopressor infusion, metaraminol infusion resulted achievement of the target blood pressure 73.4% of the time. Meanwhile, adverse events occurred in 5 patients and resolved after local tissue treatment.Metaraminol could provide hemodynamic support and avoid complications associated with a central venous catheter and delay in vasopressor administration. Through careful and close monitoring, peripheral metaraminol infusion is safe and feasible for patients with neurological conditions. Future large-scale, prospective, multicenter studies are needed to evaluate the safety and efficacy of metaraminol infusion through a peripheral intravenous catheter.
美他胺醇是一种拟交感胺类血管抑制剂,可通过外周静脉通路给药。然而,有限的证据限制了其在重症患者中的应用。本研究旨在调查外周美他胺醇输注在神经系统疾病患者中的安全性和有效性,招募了2019年5月至2022年4月期间接受外周美他胺醇输注的患者。对基线特征、临床参数和输注相关并发症的数据进行了回顾性收集和分析。其中,35 例(12.8%)患者因外周美他明醇单药治疗后无法实现血流动力学稳定而需要插入中心静脉导管。在 29574.2 小时的血管舒张剂输注过程中,73.4% 的患者在输注美他胺醇后达到了目标血压。美他胺醇可提供血流动力学支持,并避免中心静脉导管和血管加压剂输注延迟带来的并发症。通过仔细严密的监测,外周输注美他胺醇对神经系统疾病患者是安全可行的。未来需要进行大规模、前瞻性、多中心研究,以评估通过外周静脉导管输注甲氨醇的安全性和有效性。
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引用次数: 0
Effectiveness of galcanezumab on sleep quality, migraine outcome, and multidimensional patient-reported outcome measures: a real-world experience in Turkish patients with episodic and chronic migraine 加卡尼珠单抗对睡眠质量、偏头痛疗效和患者报告的多维疗效指标的影响:土耳其偶发性和慢性偏头痛患者的实际体验
Pub Date : 2024-06-03 DOI: 10.3389/fneur.2024.1411238
Elif Ilgaz Aydınlar, Tuba Erdogan Soyukibar, Pınar Yalınay Dikmen
This real-world study aimed to investigate the impact of galcanezumab on sleep quality, migraine outcome and multidimensional patient-reported outcomes measures (PROMs) in patients with episodic migraine (EM) and chronic migraine (CM).Fifty-four patients with episodic migraine (n = 24) or chronic migraine (n = 30) received a 3-month series of galcanezumab injections and were evaluated for sleep quality, measured using the Pittsburgh Sleep Quality Index (PSQI), as well as migraine outcomes such as monthly headache days (MHDs), monthly migraine days (MMDs), and headache severity. Patient-reported outcome measures (PROMs) such as the Migraine Disability Assessment Scale (MIDAS), Headache Impact Test-6 (HIT-6), SF-36 Health-related Quality of Life (HRQoL), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI) were additionally included in the assessment.The percentage of patients with poor sleep quality (total PSQI scores ≥ 5) was 72.7% at baseline, decreasing to 57.5% and 56.2% at the 1st and 2nd months, respectively. By the 3rd month of galcanezumab injections, significant improvement was observed in the sleep disturbances domain in the overall study population (p = 0.016), and in subgroups of patients with low anxiety levels (p = 0.016) and none/minimal depression (p = 0.035) at baseline. Patients with sleep disorder at baseline exhibited marked improvements in total PSQI scores (p = 0.027) and in the subjective sleep quality (p = 0.034) and daytime dysfunction (p = 0.013) domains, by the 3rd month. Over the 1st, 2nd, and 3rd months, there were significant improvements in MHDs (p < 0.001), MMDs (p < 0.001), HIT-6 scores (p < 0.001 for each), BAI scores (p < 0.001 for each), BDI scores (p ranged from 0.048 to <0.001), and HRQoL scores (p ranged from 0.012 to <0.001).Galcanezumab demonstrates notable benefits in improving sleep quality, along with a comorbidity-based and domain-specific effect on sleep parameters, which involved sleep disturbances domain in patients without depression or anxiety at baseline but the total PSQI scores, subjective sleep quality and daytime dysfunction in those with sleep disorder at baseline. The treatment also facilitates rapid-onset enhancements in migraine outcomes as well as various PROMs.
这项真实世界研究旨在调查加仑珠单抗对发作性偏头痛(EM)和慢性偏头痛(CM)患者的睡眠质量、偏头痛疗效和多维患者报告疗效指标(PROMs)的影响。54名发作性偏头痛患者(24人)或慢性偏头痛患者(30人)接受了为期3个月的加康单抗注射,并接受了睡眠质量评估(采用匹兹堡睡眠质量指数(PSQI)测量)以及偏头痛结果评估(如每月头痛天数(MHD)、每月偏头痛天数(MMD)和头痛严重程度)。评估还包括偏头痛残疾评估量表(MIDAS)、头痛影响测试-6(HIT-6)、SF-36健康相关生活质量(HRQoL)、贝克焦虑量表(BAI)和贝克抑郁量表(BDI)等患者报告结果指标(PROMs)。睡眠质量差(PSQI总分≥5)的患者比例在基线时为72.7%,在第1个月和第2个月分别降至57.5%和56.2%。在注射加卡尼珠单抗的第3个月,整个研究人群的睡眠障碍领域有明显改善(p = 0.016),基线焦虑水平低(p = 0.016)和无/轻度抑郁(p = 0.035)的亚群患者的睡眠障碍领域也有明显改善。基线睡眠障碍患者的 PSQI 总分(p = 0.027)以及主观睡眠质量(p = 0.034)和日间功能障碍(p = 0.013)领域在第 3 个月时均有明显改善。在第1、第2和第3个月,MHD(p<0.001)、MMD(p<0.001)、HIT-6评分(各p<0.001)、BAI评分(各p<0.001)、BDI评分(p从0.048到<0.001不等)和HRQoL评分(p从0.012到<0.001不等)均有显著改善。伽卡尼单抗在改善睡眠质量方面疗效显著,同时对睡眠参数具有基于合并症和领域特异性的影响,其中基线时无抑郁或焦虑的患者涉及睡眠障碍领域,而基线时有睡眠障碍的患者则涉及PSQI总分、主观睡眠质量和日间功能障碍。该疗法还有助于快速改善偏头痛的治疗效果以及各种PROMs。
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引用次数: 0
The randomized study of enteral nutrition with rapid versus conventional administration in acute stroke patients; the protocol of rapid EN trial 急性脑卒中患者肠内营养快速给药与常规给药的随机研究;快速 EN 试验方案
Pub Date : 2024-06-03 DOI: 10.3389/fneur.2024.1393345
Kentaro Suzuki, Hidetaka Onodera, Rie Sugiyama, S. Okubo, Naoto Kimura, S. Kaku, Rieko Seki, Satoshi Fujita, Koichi Nomura, Taiki Takagiwa, Izumi Katafuchi, Homare Nakamura, T. Kanamaru, Momoyo Oda, Shohei Kimura, Shota Sonoda, H. Kakita, Toshiaki Otsuka, Kazumi Kimura
Enteral nutrition is beneficial for stroke patients with oral intake difficulties. However, it is time consuming and may interfere with routine medical care. Therefore, there is a clinical benefit if enteral nutrition can be safely administered in a short time. Although our retrospective study showed the safety of rapid administration, it remains unclear whether rapid administration of enteral nutrition is as safe as conventional administration.The randomized study of Enteral Nutrition with Rapid versus conventional administration in acute stroke patients (Rapid EN trial) aims to clarify the safety of rapid feeding of enteral nutrition compared with conventional feeding.This is an investigator-initiated, multicenter, prospective, randomized, open-label, blinded end-point clinical trial. Eligible criteria include acute stroke patients who have difficulty with oral intake defined as severe altered consciousness (Japan Coma Scale 10–300) or modified water swallowing test <4. The target enrollment is 700 patients, with 350 patients receiving rapid enteral nutrition at a rate of 100 mL in 5 min (Rapid EN group) and 350 patients receiving conventional enteral nutrition at a rate of 100 mL in 30 min (Conventional EN group).The primary outcome is the incidence of one or more complications of vomiting or diarrhea or pneumonia within 7 days would be non-inferior in the rapid EN group compared to the conventional EN group. Secondary outcomes were total time spent on enteral nutrition within 7 days from enteral nutrition, the incidence of vomiting, diarrhea and pneumonia within 3 or 7 days, and the rate of favorable clinical outcome.Since no previous reports have focused on the speed of administration, we felt it was necessary to prove the safety of rapid administration. If this study shows positive results, it will not only benefit patients, but also reduce the burden of medical care. We believe this study is novel and will be useful in clinical practice.https://rctportal.niph.go.jp/s/detail/um?trial_id=UMIN000046610 Identifier UMIN000046610.
肠内营养对有口腔摄入困难的中风患者有益。但是,肠内营养耗时较长,可能会影响常规医疗护理。因此,如果能在短时间内安全地给予肠内营养,则会带来临床益处。尽管我们的回顾性研究显示快速给药是安全的,但快速给肠内营养是否与常规给药一样安全仍不清楚。"急性脑卒中患者肠内营养快速给药与常规给药的随机研究(Rapid EN 试验)"旨在明确肠内营养快速喂养与常规喂养相比的安全性。这是一项由研究者发起的多中心、前瞻性、随机、开放标签、终点盲法临床试验。符合条件的患者包括急性脑卒中患者,其口腔摄入困难定义为严重的意识改变(日本昏迷量表 10-300)或改良水吞咽测试 <4。目标注册人数为 700 名患者,其中 350 名患者接受 5 分钟内 100 毫升的快速肠内营养(快速肠内营养组),350 名患者接受 30 分钟内 100 毫升的常规肠内营养(常规肠内营养组)。主要结果是快速肠内营养组与常规肠内营养组相比,7 天内一种或多种呕吐、腹泻或肺炎并发症的发生率不劣于常规肠内营养组。次要结果是:从肠内营养开始 7 天内使用肠内营养的总时间,3 天或 7 天内呕吐、腹泻和肺炎的发生率,以及临床结果良好率。由于之前没有任何报告关注给药速度,我们认为有必要证明快速给药的安全性。如果这项研究显示出积极的结果,它不仅会造福患者,还会减轻医疗负担。我们相信这项研究具有新颖性,并将在临床实践中发挥作用。https://rctportal.niph.go.jp/s/detail/um?trial_id=UMIN000046610 Identifier UMIN000046610。
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引用次数: 0
Where the cerebral infarction meets child, be vigilant about patent foramen ovale: a case report 脑梗塞与儿童相遇,警惕卵圆孔未闭:病例报告
Pub Date : 2024-05-17 DOI: 10.3389/fneur.2024.1363867
Zai-qiang Zhang, Jia-wang Ding
While cerebral infarction in children is rare, its prognosis is poor, and this condition can seriously burden society and families. A correlation between patent foramen ovale (PFO) and ischemic stroke has not been found in pediatric patients.We report a 7-year-old boy who suffered from multiple cerebral infarctions. Subsequently, the patient was diagnosed with an abnormal shunt of PFO. He underwent PFO closure and was followed up for 1 year. The patient did not experience any further cerebral infarction.With this case report, we want to illustrate that although the incidence rate of ischemic cerebral infarction in adolescents is very low, we should not neglect the role of PFO. Therefore, after exclusion other causes of cerebral infarction, PFO should be considered in adolescent and adult stroke patients with adult closure criteria in the same way.
儿童脑梗死虽然罕见,但预后不良,会给社会和家庭带来严重负担。我们报告了一名患有多发性脑梗塞的 7 岁男孩。随后,患者被诊断为 PFO 分流异常。他接受了 PFO 关闭术,并接受了 1 年的随访。通过本病例报告,我们想说明,虽然青少年缺血性脑梗死的发病率很低,但我们不应忽视 PFO 的作用。因此,在排除其他脑梗死原因后,对于青少年和成人卒中患者,应按照成人闭合标准考虑 PFO。
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引用次数: 0
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Frontiers in Neurology
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