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Clinical toxicology in emergency medicine: 20 Years and beyond 急诊医学临床毒理学:20年及以后
IF 0.6 4区 医学 Q3 Medicine Pub Date : 2023-02-06 DOI: 10.1177/10249079231154241
Y. Chan, M. Tse
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引用次数: 1
Risk factors associated with bacteremia with drug-resistant organisms: Review of blood culture results in emergency department of a regional hospital 与耐药菌血症相关的危险因素:某地区医院急诊科血培养结果回顾
IF 0.6 4区 医学 Q3 Medicine Pub Date : 2023-01-31 DOI: 10.1177/10249079231151518
M. Lau, O. Wong
Early antibiotic administration in sepsis improves patient survival. Treatment with antibiotics should cover potential pathogens and should avoid overusing broad-spectrum antibiotics. We have to identify patients who have high risks of infection with drug-resistant organisms. A retrospective cohort study was conducted to identify potential risk factors associated with bloodstream infections with drug-resistant organisms to help the choice of empirical antibiotics in the emergency department. Adult patients with bloodstream infection diagnosed by blood culture in the emergency department in the period of 1 January 2020 to 31 December 2020 were included. Clinical features including chronic medical illnesses, clinical presentation and severity, and patients’ outcomes were identified in the electronic medical records. Bloodstream infection with drug-resistant organisms is defined as positive blood culture with bacteria resistant to either (1) amoxicillin/ clavulanic acid AND ceftriaxone or (2) amoxicillin/ clavulanic acid or ceftriaxone PLUS amikacin or levofloxacin. Univariate and multivariate analyses were conducted to identify risk factors associated with the study outcome. Among 105 patients with bloodstream infection, 17% were caused by drug-resistant organisms. Multivariate analysis showed that age is a risk factor associated with bloodstream infection with drug-resistant organisms (odds ratio: 1.04, 95% confidence interval: 1.0–1.08, p = 0.03). In conclusion, age is a significant risk factor for drug-resistant bloodstream infection in emergency department patients. Further research may be needed to find out the relationship between frailty and infection with drug-resistant organisms.
败血症早期应用抗生素可提高患者生存率。抗生素治疗应涵盖潜在的病原体,并应避免过度使用广谱抗生素。我们必须识别那些感染耐药生物风险较高的患者。进行了一项回顾性队列研究,以确定与耐药生物血液感染相关的潜在风险因素,从而帮助急诊科选择经验抗生素。纳入2020年1月1日至2020年12月31日期间在急诊科通过血液培养诊断为血液感染的成年患者。在电子医疗记录中确定了包括慢性疾病、临床表现和严重程度以及患者结局在内的临床特征。耐药生物的血流感染被定义为对(1)阿莫西林/克拉维酸和头孢曲松或(2)阿莫西林-克拉维酸或头孢曲松加阿米卡星或左氧氟沙星具有耐药性的细菌的阳性血液培养。进行单变量和多变量分析,以确定与研究结果相关的风险因素。在105名血液感染患者中,17%是由耐药生物引起的。多因素分析表明,年龄是与耐药生物血流感染相关的危险因素(比值比:1.04,95%置信区间:1.0-1.08,p = 0.03)。总之,年龄是急诊科患者耐药血流感染的重要危险因素。可能需要进一步的研究来找出虚弱和感染耐药生物之间的关系。
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引用次数: 0
Not as stiff as bamboo 不像竹子那么硬
IF 0.6 4区 医学 Q3 Medicine Pub Date : 2022-12-26 DOI: 10.1177/10249079221143303
Yat Hei Lo
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引用次数: 0
Global connection through the International Federation for Emergency Medicine (IFEM) 通过国际急诊医学联合会建立全球联系
IF 0.6 4区 医学 Q3 Medicine Pub Date : 2022-11-29 DOI: 10.1177/10249079221140626
H. Ho, K. Hung
Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). Hong Kong is a metropolitan vibrant city, connecting the world through our extensive networks, expertise, learning attitude and willingness to participate in matters outside Hong Kong. Within the field of medicine, healthcare professionals of Hong Kong are reputable internationally with health statistics ranking among the best in the world. Local emergency care workers have contributed to the credit for safeguarding health of citizens of Hong Kong. Emergency medicine (EM) is part of the emergency care (EC) spectrum. To ensure a healthy and safe community, EM should reach beyond the boundary of the hospital. International Federation for Emergency Medicine (IFEM) has recently enhanced its vision from ‘fostering the worldwide development of EM as a specialty’ to a wider scope of ‘advocating universal access to high quality emergency medical care around the world’. To achieve that vision, IFEM has three missions:
知识共享非商业CC BY-NC:本文根据知识共享归因非商业4.0许可条款分发(http://www.creativecommons.org/licenses/by-nc/4.0/)允许对作品进行非商业性使用、复制和分发,而无需进一步许可,前提是原始作品的归属符合SAGE和开放获取页面的规定(https://us.sagepub.com/en-us/nam/open-access-at-sage)。香港是一个充满活力的大都市,通过我们广泛的网络、专业知识、学习态度和参与香港以外事务的意愿,将世界连接起来。在医学方面,香港的医护人员在国际上享有良好声誉,其健康统计数字亦名列世界前列。当地急救人员为保障香港市民的健康做出了贡献。急诊医学(EM)是急诊医学(EC)的一部分。为了确保一个健康和安全的社区,EM应该超越医院的边界。国际急诊医学联合会(IFEM)最近将其愿景从“促进EM作为一门专业在全球范围内的发展”提升为“倡导在世界各地普及高质量的急诊医疗”。为了实现这一愿景,IFEM有三个任务:
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引用次数: 1
Effects of systemic antibiotics in early onset ventilator-associated pneumonia in trauma patients: A single-centre retrospective cohort study 系统性抗生素对创伤患者早期发作的呼吸机相关性肺炎的影响:一项单中心回顾性队列研究
IF 0.6 4区 医学 Q3 Medicine Pub Date : 2022-11-29 DOI: 10.1177/10249079221130828
C. Wong, Yau Tak Ng, K. Ching, Pui Kwan Ha, Chun Yu Leung, Wing Kiu Au, C. Lui, K. Tsui
Background: Ventilator-associated pneumonia is one of the commonest complications encountered in intubated patients: its incidence ranges from 20% to 60%, with higher incidences seen in patients with polytrauma. Ventilator-associated pneumonia can result in poor neurological outcomes upon discharge, longer duration of mechanical ventilation and prolonged intensive care unit stays. The use of systemic antibiotics has been proposed as one method to reduce this complication. However, its effectiveness remains to be determined, and concerns about bacterial resistance hinder its use. This study aims to evaluate the effects of systemic antibiotics on early ventilator-associated pneumonia prevention. Methods: This is a single-centred retrospective cohort study, using data in the local trauma registry from 2015 to 2020. Patients aged ⩾18 years who suffered from injury to the head or trunk and were intubated within 12 h of hospitalization were evaluated for early ventilator-associated pneumonia to determine the effectiveness of systemic antibiotics on the incidence of ventilator-associated pneumonia and to identify other risk factors for ventilator-associated pneumonia in patients suffering from trauma. Result: A total of 250 patients were recruited; 59 of them met the criteria for early onset ventilator-associated pneumonia. Early use of broad-spectrum antibiotics with potent anaerobic coverage was found to be protective for early onset ventilator-associated pneumonia (adjusted odds ratio = 0.228, p = 0.044). Increasing age and severe thoracic or abdominal injury were also found to be strong non-modifiable predictors for the development of early onset ventilator-associated pneumonia. Conclusion: Use of systemic antibiotics with potent anaerobic coverage within 3 h of injury was found to prevent early onset ventilator-associated pneumonia in those intubated within 12 h of injury. However, a large-scale randomized control trial may be needed to further evaluate its benefit and its potential side effects, most notably the risk of antibiotic resistance.
背景:呼吸机相关性肺炎是插管患者最常见的并发症之一:其发病率在20%至60%之间,多发性创伤患者的发病率更高。呼吸机相关性肺炎可能导致出院后神经系统不良、机械通气持续时间延长和重症监护室住院时间延长。已经提出使用系统性抗生素作为减少这种并发症的一种方法。然而,它的有效性仍有待确定,对细菌耐药性的担忧阻碍了它的使用。本研究旨在评估系统性抗生素对早期呼吸机相关性肺炎预防的作用。方法:这是一项单中心回顾性队列研究,使用2015年至2020年当地创伤登记处的数据。18岁患者 头部或躯干受伤并在12年内插管的患者 评估早期呼吸机相关肺炎的住院时间,以确定全身抗生素对呼吸机相关肺炎发病率的有效性,并确定创伤患者发生呼吸机相关肺炎其他危险因素。结果:共招募250名患者;其中59例符合早期发病的呼吸机相关性肺炎的标准。发现早期使用具有强效厌氧覆盖的广谱抗生素对早发呼吸机相关肺炎具有保护作用(调整比值比 = 0.228,p = 0.044)。年龄的增加和严重的胸部或腹部损伤也被发现是早期发病的呼吸机相关肺炎发展的强有力的不可改变的预测因素。结论:使用具有强大厌氧覆盖率的系统性抗生素在3 在12岁以内插管的患者中,发现损伤小时可以预防早期发作的呼吸机相关肺炎 h受伤。然而,可能需要进行大规模的随机对照试验,以进一步评估其益处及其潜在副作用,尤其是抗生素耐药性的风险。
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引用次数: 1
Reciprocal Abstracts January 2023 互惠摘要2023年1月
IF 0.6 4区 医学 Q3 Medicine Pub Date : 2022-11-29 DOI: 10.1177/10249079221141756
B Editor's note: b The I Hong Kong Journal of Emergency Medicine i has partnered with a small group of selected journals of international emergency medicine societies to share from each a highlighted research study, as selected monthly by their editors. B Conclusions: b There was an increased odds of delayed intracranial hemorrhage within 90 days in older ED head injured patients prescribed warfarin compared to patients not on anticoagulation. Among patients not anticoagulated, 586 (1.0%) had a delayed intracranial hemorrhage, 54 (1.8%) patients on warfarin, and 78 (1.0%) patients on a direct oral anticoagulant had a delayed intracranial hemorrhage. [Extracted from the article]
B编者按:B《香港急诊医学杂志》与国际急诊医学学会的一小部分精选期刊合作,分享其编辑每月精选的每一项重点研究。B结论:B与未服用抗凝剂的患者相比,服用华法林的老年ED头部损伤患者在90天内发生延迟性颅内出血的几率增加。在未进行抗凝剂治疗的患者中,586名(1.0%)患者出现延迟性颅内出血,54名(1.8%)患者服用华法林,78名(1.0%。[摘自文章]
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引用次数: 0
Prediction rule of supratherapeutic peak serum salicylate level in poisoning patients attending emergency departments 急诊科中毒患者血清水杨酸超治疗峰值水平的预测规律
IF 0.6 4区 医学 Q3 Medicine Pub Date : 2022-11-19 DOI: 10.1177/10249079221138205
Chan Suen Wah, Chan Chi Keung, Ng Yau Tak, Lui Chun Tat, Fung Hin Tat
Analgesic poisoning is common in Hong Kong. Analgesics containing salicylate are easily available. Salicylate poisoning may be encountered in the daily practice of the accident and emergency department. The issue of routine salicylate screening was discussed in a number of articles, and the viewpoints of most authors were that routine salicylate screening was unnecessary. The primary outcome is to explore the predictive factors of supratherapeutic peak serum salicylate level (>2.17 mmol/L) and delineate the role of routine screening serum salicylate level in poisoned patients attending the accident and emergency department. This is a retrospective cohort study. Poisoning cases presented to Hong Kong Poison Information Centre between 1 July 2008 and 31 October 2020 with serum salicylate level checked were included. The demographics, laboratory parameters and clinical outcomes were reviewed. There were 8673 cases included with serum salicylate level checked, accounting for 17% of all poisoning cases. Sixty-six (0.76%) cases had supratherapeutic peak serum salicylate level and 11 (0.13%) of them were undeclared salicylate ingestion. Worse clinical outcomes were observed in cases with supratherapeutic peak serum salicylate level. Univariate analysis showed that tinnitus, hyperthermia, alkalaemia, metabolic acidosis, respiratory alkalosis and therapeutic use of aspirin were significantly associated with supratherapeutic peak serum salicylate level. Variables with p < 0.3 were entered into the backward stepwise logistic regression by likelihood ratio. A clinical prediction rule with three attributes (tinnitus, therapeutic use of aspirin and partial pressure of CO2 <5 kPa) was derived. It showed 100% sensitivity in internal validation. Serum salicylate level should be checked in poisoned patients with (1) tinnitus, (2) the therapeutic use of aspirin or (3) partial pressure of CO2 <5 kPa in arterial or venous blood gas. Routine salicylate screening remained a tool for clinicians not experienced in toxicology.
止痛剂中毒在香港很常见。含有水杨酸的镇痛药很容易获得。在急诊科的日常工作中可能会遇到水杨酸中毒。许多文章讨论了常规水杨酸筛查的问题,大多数作者认为常规水杨酸筛查是不必要的。主要目的是探讨血清水杨酸水平治疗超峰值(>2.17 mmol/L)的预测因素,并描述常规筛查血清水杨酸水平在急诊科中毒患者中的作用。这是一项回顾性队列研究。包括在2008年7月1日至2020年10月31日期间向香港毒物信息中心提交的中毒病例,并检查了血清水杨酸水平。回顾了人口统计学、实验室参数和临床结果。检查水杨酸水平8673例,占全部中毒病例的17%。66例(0.76%)患者血清水杨酸水平高于治疗峰值,11例(0.13%)患者未申报水杨酸摄入。在血清水杨酸水平达到治疗峰值的病例中观察到较差的临床结果。单因素分析显示,耳鸣、高热、碱血症、代谢性酸中毒、呼吸性碱中毒和治疗性使用阿司匹林与治疗性峰值血清水杨酸水平显著相关。采用似然比法将p < 0.3的变量输入后向逐步logistic回归。导出了具有耳鸣、阿司匹林治疗性使用和CO2分压<5 kPa三个属性的临床预测规则。内部验证灵敏度为100%。中毒患者应检查血清水杨酸水平(1)耳鸣,(2)治疗使用阿司匹林或(3)动脉血或静脉血气体CO2分压<5 kPa。常规水杨酸筛查仍然是临床医生没有毒理学经验的工具。
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引用次数: 0
Patients with heat-related illness admitted to an intensive care unit in Hong Kong: A single-centre retrospective study (2009–2020) 香港重症监护室收治的热相关疾病患者:一项单中心回顾性研究(2009-2020)
IF 0.6 4区 医学 Q3 Medicine Pub Date : 2022-10-13 DOI: 10.1177/10249079221129030
C. Chan, H. Shum, P. Wu, Nyw Leung, LL Chang, W. Yan
Introduction: In Hong Kong, heat-related illness (HRI) represents an important cause of morbidity and mortality among healthy adults engaging in outdoor activities during summer. It can result in intensive care unit (ICU) admission. This retrospective study aimed to profile critically ill patients with HRI and identify potential risk factors for mortality. Methods: This retrospective case series included adults with HRI from 1 January 2009 to 30 June 2020 admitted to the ICU of Pamela Youde Nethersole Eastern Hospital (PYNEH). Demographics, admission severity, co-morbidities, and laboratory investigations were analysed. Outcome data studied included mortality, ICU length of stay (LOS), ventilator days, and hospital LOS. Results: Among the 38 individuals included, 97% were hikers. About 92.1% of patients survived, while 7.9% expired. The median age of the patients was 48 years, and 78.9% were men. Hypertension was the most frequent concurrent disorder. Most cases were presented during the hot summer months of May (29%), July (24%) and August (18%). The localities’ median peak temperature and humidity were 33.2°C and 88%, respectively. Ninety-two percent of patients were airlifted to the hospital by helicopters. The median peak body temperature was 40.3°C. Central nervous system derangement (Glasgow Coma Scale (GCS) score ⩽ 8) was the top presenting feature (65.7%). About 57.9% of patients required vasopressor support, followed by mechanical ventilation (50%) and renal replacement therapy (31.6%). Conclusions: Most critically ill patients suffering from HRI were hikers and middle-aged adults. Mortality was 7.9% despite advanced life support in ICU. Raising public awareness of the associated risk with hiking in hot summer is essential for the prevention of HRI.
简介:在香港,热相关疾病(HRI)是夏季从事户外活动的健康成年人发病和死亡的重要原因。它可能导致重症监护病房(ICU)的入院。本回顾性研究旨在分析重症HRI患者,并确定潜在的死亡危险因素。方法:本回顾性病例系列包括2009年1月1日至2020年6月30日在东部尤德夫人那打素医院(PYNEH) ICU住院的成人HRI患者。分析了人口统计学、入院严重程度、合并症和实验室调查。研究的结局数据包括死亡率、ICU住院时间(LOS)、呼吸机天数和医院LOS。结果:在纳入的38个人中,97%是徒步旅行者。92.1%的患者存活,7.9%的患者死亡。患者的中位年龄为48岁,78.9%为男性。高血压是最常见的并发疾病。大多数病例出现在炎热的夏季5月(29%)、7月(24%)和8月(18%)。各地区的平均峰值温度和湿度分别为33.2°C和88%。92%的病人被直升机空运到医院。体温峰值中位数为40.3°C。中枢神经系统紊乱(格拉斯哥昏迷量表(GCS)评分≥8)是最高的表现特征(65.7%)。约57.9%的患者需要血管加压药物支持,其次是机械通气(50%)和肾脏替代治疗(31.6%)。结论:重症HRI患者以徒步旅行者和中年人居多。尽管在ICU进行了高级生命支持,但死亡率为7.9%。提高公众对炎热夏季徒步旅行相关风险的认识对于预防HRI至关重要。
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引用次数: 0
Reciprocal Abstracts November 22 互惠摘要11月22日
IF 0.6 4区 医学 Q3 Medicine Pub Date : 2022-10-03 DOI: 10.1177/10249079221130602
C. S. Dam, Majon Muller
Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). Annals of Emergency Medicine
知识共享非商业CC BY-NC:本文根据知识共享归因非商业4.0许可条款分发(http://www.creativecommons.org/licenses/by-nc/4.0/)允许对作品进行非商业性使用、复制和分发,而无需进一步许可,前提是原始作品的归属符合SAGE和开放获取页面的规定(https://us.sagepub.com/en-us/nam/open-access-at-sage)。急救医学年报
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引用次数: 1
A manikin study comparing the performance of traditional Macintosh laryngoscope, GlideScope®, Airtraq®, and video-optical intubation stylet in endotracheal intubation used by emergency doctors in simulated difficult airway intubation: A pilot study 一项人体模型研究,比较了传统Macintosh喉镜、GlideScope®、Airtraq®和视频光学插管探针在模拟困难气道插管中的气管插管中的性能:一项试点研究
IF 0.6 4区 医学 Q3 Medicine Pub Date : 2022-09-23 DOI: 10.1177/10249079221125023
Yu On Li, O. Wong, S. Ko, Hing Man Ma, C. Lit, Yau Ngai Shih
Background: The video-optical intubation stylet (VS) is a slim, rigid but flexible intubating device that aids physicians to intubate patients, particularly with difficult airways. Objectives: The objective of this study was to compare the performance of emergency department doctors in using different intubating devices for intubation in an airway manikin simulating different difficult airway scenarios. Methods: Thirty emergency department doctors were recruited in a pilot study. Their performance of using traditional Macintosh laryngoscope, GlideScope®, Airtraq® and C-MAC® Video Stylet were compared in three situations: normal, restricted cervical motion and limited oral aperture. The time for intubation, first attempt success rate, failure rate, dental injury and the subjective ease of different devices by the participants were compared. Result: The mean intubation time by VS in each scenario was significantly shorter compared with other devices (Normal: 19.77s vs 24.67–28.19s, p = 0.014; Cervical restriction: 20.85 vs 26.17–31.26s, p = 0.008; Limited oral aperture:19.03 vs 29.35, p = 0.001). However, there was no significant difference in failure rate or first attempt success rate. The incidence of dental injury was significantly lower with VS than other laryngoscopes (p = 0.001, p < 0.05 and p < 0.05 in normal, cervical restriction and limited oral aperture scenarios, respectively). Moreover, participants appreciated that VS was the easiest device to intubate in each scenario. (p < 0.05 in all scenarios) Conclusion: The performance of VS was comparable to or even better than the commonly used laryngoscopes in the emergency department in airway management. When adequate training is provided, VS can be a potentially good alternative for tracheal intubation in different situations.
背景:视频光学插管管心针(VS)是一种细长、坚硬但灵活的插管设备,可帮助医生为患者插管,尤其是气道困难的患者。目的:本研究的目的是比较急诊科医生在模拟不同气道困难场景的气道模型中使用不同插管装置进行插管的表现。方法:在一项试点研究中招募了30名急诊科医生。比较了他们在三种情况下使用传统Macintosh喉镜、GlideScope®、Airtraq®和C-MAC®视频笔的性能:正常、受限的颈部运动和受限的口腔孔径。比较了参与者的插管时间、首次尝试成功率、失败率、牙齿损伤和不同器械的主观简易性。结果:与其他装置相比,VS在每种情况下的平均插管时间显著缩短(正常:19.77s VS 24.67-28.19s,p = 0.014;宫颈限制:20.85 vs 26.17–31.26秒,p = 0.008;有限口腔孔径:19.03 vs 29.35,p = 0.001)。然而,失败率或首次尝试成功率没有显著差异。VS的牙伤发生率明显低于其他喉镜(p = 0.001,p < 0.05和p < 在正常、宫颈受限和口腔受限情况下分别为0.05)。此外,参与者意识到VS在每种情况下都是最容易插管的设备。(p < 0.05)结论:VS在气道管理方面的表现与急诊科常用喉镜相当,甚至更好。当提供足够的训练时,VS可能是在不同情况下气管插管的一个潜在的好选择。
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引用次数: 0
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Hong Kong Journal of Emergency Medicine
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