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Accuracy, concurrent validity, and test–retest reliability of pressure-based insoles for gait measurement in chronic stroke patients 用于慢性中风患者步态测量的压力鞋垫的准确性、并发有效性和测试-再测可靠性
Pub Date : 2024-04-03 DOI: 10.3389/fdgth.2024.1359771
Saskia Neumann, Christoph M. Bauer, Luca Nastasi, Julia Läderach, Eva Thürlimann, A. Schwarz, J.P.O. Held, C. A. Easthope
Introduction Wearables are potentially valuable tools for understanding mobility behavior in individuals with neurological disorders and how it changes depending on health status, such as after rehabilitation. However, the accurate detection of gait events, which are crucial for the evaluation of gait performance and quality, is challenging due to highly individual-specific patterns that also vary greatly in movement and speed, especially after stroke. Therefore, the purpose of this study was to assess the accuracy, concurrent validity, and test–retest reliability of a commercially available insole system in the detection of gait events and the calculation of stance duration in individuals with chronic stroke. Methods Pressure insole data were collected from 17 individuals with chronic stroke during two measurement blocks, each comprising three 10-min walking tests conducted in a clinical setting. The gait assessments were recorded with a video camera that served as a ground truth, and pressure insoles as an experimental system. We compared the number of gait events and stance durations between systems. Results and discussion Over all 3,820 gait events, 90.86% were correctly identified by the insole system. Recall values ranged from 0.994 to 1, with a precision of 1 for all measurements. The F1 score ranged from 0.997 to 1. Excellent absolute agreement (Intraclass correlation coefficient, ICC = 0.874) was observed for the calculation of the stance duration, with a slightly longer stance duration recorded by the insole system (difference of −0.01 s). Bland–Altmann analysis indicated limits of agreement of 0.33 s that were robust to changes in walking speed. This consistency makes the system well-suited for individuals post-stroke. The test–retest reliability between measurement timepoints T1 and T2 was excellent (ICC = 0.928). The mean difference in stance duration between T1 and T2 was 0.03 s. We conclude that the insole system is valid for use in a clinical setting to quantitatively assess continuous walking in individuals with stroke.
导言:可穿戴设备是了解神经系统疾病患者移动行为及其如何随健康状况变化(如康复后)的潜在重要工具。然而,准确检测步态事件是评估步态表现和质量的关键,但由于步态模式具有高度的个体特异性,而且在运动和速度方面差异很大,尤其是在中风后,因此检测步态事件具有挑战性。因此,本研究旨在评估一种市售鞋垫系统在检测慢性中风患者步态事件和计算站立持续时间方面的准确性、并发有效性和重复测试可靠性。方法 收集了 17 名慢性中风患者的压力鞋垫数据,在临床环境中进行了两次测量,每次测量包括三次 10 分钟的步行测试。步态评估是用摄像机记录的,摄像机作为地面实况,压力鞋垫作为实验系统。我们比较了不同系统的步态事件数量和站立持续时间。结果与讨论 在全部 3,820 个步态事件中,90.86% 被鞋垫系统正确识别。所有测量的召回值在 0.994 到 1 之间,精确度为 1。F1 得分为 0.997 至 1。在计算站立持续时间时,观察到了极好的绝对一致性(类内相关系数,ICC = 0.874),鞋垫系统记录的站立持续时间稍长(差异为-0.01 秒)。布兰德-阿尔特曼分析表明,一致性极限为 0.33 秒,且不受步行速度变化的影响。这种一致性使该系统非常适合中风后的患者。T1 和 T2 测量时间点之间的重复测试可靠性非常好(ICC = 0.928)。T1 和 T2 的站立时间平均相差 0.03 秒。我们的结论是,鞋垫系统可在临床环境中用于定量评估中风患者的连续行走能力。
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引用次数: 0
Pima County COVID-19 vaccine solutions dashboard project: lessons learned 皮马县 COVID-19 疫苗解决方案仪表板项目:经验教训
Pub Date : 2024-04-02 DOI: 10.3389/fdgth.2024.1345451
Tina Damalas, Eamon Penney, Theresa Cullen, Aaron Dibner-Dunlap, Cecelia English, Jacob Gomez, Amanda Sapp, Sara Selig, S. Sutermaster
Recent improvements in the accessibility of mapping tools and an increased recognition of the importance of leveraging data to inform public health operations has led to enthusiasm among public health departments to rapidly evolve their ability to analyze and apply data to programs. As the COVID-19 pandemic made evident, many health department data systems have been neglected for decades and data literacy among staff low. Significant federal dollars have been allocated to local health departments to modernize health systems. This case study recounts the effort to equip the Pima County Health Department with a highly sophisticated “COVID-19 Vaccines Solutions Dashboard” in 2021–2022, quantifying community vulnerability in the midst of the COVID-19 pandemic and shares key successes and challenges in process and outcomes that can guide other such dashboard initiatives. The experience informed the development of Pima' County Health Department's Data & Informatics Team as well as efforts to cultivate a more robust data culture throughout the department. Many health departments around the United States are in a similar position, and these lessons learned are widely applicable.
最近,制图工具的易用性得到了改善,人们也越来越认识到利用数据为公共卫生行动提供信息的重要性,这使得公共卫生部门热衷于快速发展其分析数据和将数据应用于计划的能力。正如 COVID-19 大流行所表明的,许多卫生部门的数据系统几十年来一直被忽视,工作人员的数据素养也很低。联邦已向地方卫生部门划拨了大量资金,用于卫生系统的现代化。本案例研究讲述了皮马县卫生局在 2021-2022 年期间为配备高度先进的 "COVID-19 疫苗解决方案仪表盘 "所做的努力,该仪表盘量化了 COVID-19 大流行期间社区的脆弱性,并分享了在过程和结果方面取得的主要成功和面临的主要挑战,这些成功和挑战可为其他此类仪表盘计划提供指导。这些经验为皮马县卫生局数据与信息小组的发展以及在整个部门培养更强大的数据文化提供了参考。美国的许多卫生部门都处于类似的境地,这些经验教训具有广泛的适用性。
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引用次数: 0
Upper limb movement quality measures: comparing IMUs and optical motion capture in stroke patients performing a drinking task 上肢运动质量测量:比较中风患者执行喝水任务时的 IMU 和光学运动捕捉
Pub Date : 2024-03-28 DOI: 10.3389/fdgth.2024.1359776
T. Unger, R. de Sousa Ribeiro, M. Mokni, T. Weikert, J. Pohl, A. Schwarz, J.P.O. Held, L. Sauerzopf, B. Kühnis, E. Gavagnin, A.R. Luft, R. Gassert, O. Lambercy, C. Awai Easthope, J.G. Schönhammer
Clinical assessment of upper limb sensorimotor function post-stroke is often constrained by low sensitivity and limited information on movement quality. To address this gap, recent studies proposed a standardized instrumented drinking task, as a representative daily activity combining different components of functional arm use. Although kinematic movement quality measures for this task are well-established, and optical motion capture (OMC) has proven effective in their measurement, its clinical application remains limited. Inertial Measurement Units (IMUs) emerge as a promising low-cost and user-friendly alternative, yet their validity and clinical relevance compared to the gold standard OMC need investigation.In this study, we conducted a measurement system comparison between IMUs and OMC, analyzing 15 established movement quality measures in 15 mild and moderate stroke patients performing the drinking task, using five IMUs placed on each wrist, upper arm, and trunk.Our findings revealed strong agreement between the systems, with 12 out of 15 measures demonstrating clinical applicability, evidenced by Limits of Agreement (LoA) below the Minimum Clinically Important Differences (MCID) for each measure.These results are promising, suggesting the clinical applicability of IMUs in quantifying movement quality for mildly and moderately impaired stroke patients performing the drinking task.
脑卒中后上肢感觉运动功能的临床评估往往受到灵敏度低和运动质量信息有限的限制。为了弥补这一不足,最近的研究提出了一项标准化的仪器饮水任务,作为一项具有代表性的日常活动,结合了手臂功能使用的不同组成部分。尽管针对这项任务的运动学运动质量测量方法已经成熟,而且光学运动捕捉(OMC)已被证明能有效测量运动质量,但其临床应用仍然有限。在本研究中,我们对惯性测量单元(IMU)和光学运动捕捉(OMC)的测量系统进行了比较,分析了 15 名轻度和中度中风患者在执行喝水任务时的 15 项已确立的运动质量测量指标,并在手腕、上臂和躯干上各安装了 5 个惯性测量单元。我们的研究结果表明,这两种测量系统之间具有很强的一致性,15 项测量中有 12 项具有临床适用性,每项测量的一致性限值(LoA)均低于最小临床重要性差异(MCID)。
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引用次数: 0
A comparative study in class imbalance mitigation when working with physiological signals 利用生理信号缓解类失衡的比较研究
Pub Date : 2024-03-26 DOI: 10.3389/fdgth.2024.1377165
Rawan S. Abdulsadig, Esther Rodriguez-Villegas
Class imbalance is a common challenge that is often faced when dealing with classification tasks aiming to detect medical events that are particularly infrequent. Apnoea is an example of such events. This challenge can however be mitigated using class rebalancing algorithms. This work investigated 10 widely used data-level class imbalance mitigation methods aiming towards building a random forest (RF) model that attempts to detect apnoea events from photoplethysmography (PPG) signals acquired from the neck. Those methods are random undersampling (RandUS), random oversampling (RandOS), condensed nearest-neighbors (CNNUS), edited nearest-neighbors (ENNUS), Tomek’s links (TomekUS), synthetic minority oversampling technique (SMOTE), Borderline-SMOTE (BLSMOTE), adaptive synthetic oversampling (ADASYN), SMOTE with TomekUS (SMOTETomek) and SMOTE with ENNUS (SMOTEENN). Feature-space transformation using PCA and KernelPCA was also examined as a potential way of providing better representations of the data for the class rebalancing methods to operate. This work showed that RandUS is the best option for improving the sensitivity score (up to 11%). However, it could hinder the overall accuracy due to the reduced amount of training data. On the other hand, augmenting the data with new artificial data points was shown to be a non-trivial task that needs further development, especially in the presence of subject dependencies, as was the case in this work.
在处理旨在检测特别不常见的医疗事件的分类任务时,类别不平衡是一个经常面临的挑战。呼吸暂停就是此类事件的一个例子。不过,这种挑战可以通过类再平衡算法来缓解。这项工作研究了 10 种广泛使用的数据级类不平衡缓解方法,旨在建立一个随机森林(RF)模型,尝试从颈部采集的光电血压计(PPG)信号中检测呼吸暂停事件。这些方法包括随机欠采样 (RandUS)、随机超采样 (RandOS)、压缩近邻 (CNNUS)、编辑近邻 (ENNUS)、Tomek 链接 (TomekUS)、合成少数超采样技术 (SMOTE)、边界线-SMOTE (BLSMOTE)、自适应合成超采样 (ADASYN)、SMOTE with TomekUS (SMOTETomek) 和 SMOTE with ENNUS (SMOTEENN)。此外,还研究了使用 PCA 和 KernelPCA 进行特征空间转换的潜在方法,以便为类再平衡方法的运行提供更好的数据表示。这项工作表明,RandUS 是提高灵敏度得分的最佳选择(最高可达 11%)。然而,由于训练数据量的减少,它可能会影响整体准确性。另一方面,用新的人工数据点扩充数据被证明是一项非同小可的任务,需要进一步开发,尤其是在存在主体依赖性的情况下,这项工作就是如此。
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引用次数: 0
Multidimensional digital biomarker phenotypes for mild cognitive impairment: considerations for early identification, diagnosis and monitoring 轻度认知障碍的多维数字生物标记表型:早期识别、诊断和监测的考虑因素
Pub Date : 2024-03-06 DOI: 10.3389/fdgth.2024.1265846
Tracy Milner, Matthew R. G. Brown, Chelsea Jones, Ada W. S. Leung, S. Brémault-Phillips
Mild Cognitive Impairment (MCI) poses a challenge for a growing population worldwide. Early identification of risk for and diagnosis of MCI is critical to providing the right interventions at the right time. The paucity of reliable, valid, and scalable methods for predicting, diagnosing, and monitoring MCI with traditional biomarkers is noteworthy. Digital biomarkers hold new promise in understanding MCI. Identifying digital biomarkers specifically for MCI, however, is complex. The biomarker profile for MCI is expected to be multidimensional with multiple phenotypes based on different etiologies. Advanced methodological approaches, such as high-dimensional statistics and deep machine learning, will be needed to build these multidimensional digital biomarker profiles for MCI. Comparing patients to these MCI phenotypes in clinical practice can assist clinicians in better determining etiologies, some of which may be reversible, and developing more precise care plans. Key considerations in developing reliable multidimensional digital biomarker profiles specific to an MCI population are also explored.
轻度认知功能障碍(MCI)给全球日益增长的人口带来了挑战。早期识别和诊断 MCI 风险对于在正确的时间提供正确的干预措施至关重要。值得注意的是,利用传统生物标记预测、诊断和监测 MCI 的可靠、有效和可扩展的方法非常缺乏。数字生物标志物为了解 MCI 带来了新希望。然而,识别专门用于 MCI 的数字生物标志物非常复杂。MCI 的生物标志物特征预计是多维的,具有基于不同病因的多种表型。要建立 MCI 的多维数字生物标志物图谱,需要采用高维统计和深度机器学习等先进方法。在临床实践中将患者与这些 MCI 表型进行比较,可以帮助临床医生更好地确定病因(其中有些病因可能是可逆的),并制定更精确的护理计划。此外,还探讨了开发针对 MCI 群体的可靠的多维数字生物标志物特征的关键注意事项。
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引用次数: 0
Editorial: Insights in digital health communication: 2023 社论:数字健康传播的启示:2023 年
Pub Date : 2024-03-01 DOI: 10.3389/fdgth.2024.1368666
Carol Maher, Ben Singh
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引用次数: 0
Experiences, barriers and expectations regarding current patient monitoring systems among ICU nurses in a University Hospital in Lebanon: a qualitative study 黎巴嫩一所大学医院重症监护室护士对当前病人监护系统的体验、障碍和期望:一项定性研究
Pub Date : 2024-02-19 DOI: 10.3389/fdgth.2024.1259409
Ahmad Rayan, S. Al-Ghabeesh, Mirna Fawaz, Amal Behar, Amina Toumi
The aim of the study is to assess the experiences, barriers, and expectations regarding current patient monitoring systems among intensive care unit nurses at one university hospital.A qualitative exploratory study approach was adopted to test the research questions.Intensive care unit personnel placed a high value on practical criteria such as user friendliness and visualization while assessing the present monitoring system. Poor alarm handling was recognized as possible patient safety hazards. The necessity of high accessibility was highlighted once again for a prospective system; wireless, noninvasive, and interoperability of monitoring devices were requested; and smart phones for distant patient monitoring and alert management improvement were required.Core comments from ICU personnel are included in this qualitative research on patient monitoring. All national healthcare involved parties must focus more on user-derived insights to ensure a speedy and effective introduction of digital health technologies in the ICU. The findings from the alarm control or mobile device studies might be utilized to train ICU personnel to use new technology, minimize alarm fatigue, increase medical device accessibility, and develop interoperability standards in critical care practice.
本研究旨在评估一家大学医院重症监护室护士对当前病人监护系统的体验、障碍和期望。重症监护室人员在评估当前监护系统时,非常重视用户友好性和可视化等实用标准。警报处理不当可能对患者安全造成危害。他们再次强调了未来系统的高可用性;要求监控设备具有无线、非侵入性和互操作性;并要求使用智能手机对患者进行远程监控和改进警报管理。所有国家医疗机构的相关人员都必须更加关注用户的意见,以确保在重症监护室快速有效地引入数字医疗技术。警报控制或移动设备研究的结果可用于培训重症监护室人员使用新技术、减少警报疲劳、提高医疗设备的可及性以及制定重症监护实践中的互操作性标准。
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引用次数: 0
When all computers shut down: the clinical impact of a major cyber-attack on a general hospital 当所有计算机关闭时:重大网络攻击对一家综合医院的临床影响
Pub Date : 2024-02-16 DOI: 10.3389/fdgth.2024.1321485
Benyamine Abbou, Boris Kessel, M. Ben Natan, R. Gabbay-Benziv, Dikla Dahan Shriki, Anna Ophir, Nimrod Goldschmid, Adi Klein, Ariel Roguin, M. Dudkiewicz
Healthcare organizations operate in a data-rich environment and depend on digital computerized systems; thus, they may be exposed to cyber threats. Indeed, one of the most vulnerable sectors to hacks and malware is healthcare. However, the impact of cyberattacks on healthcare organizations remains under-investigated.This study aims to describe a major attack on an entire medical center that resulted in a complete shutdown of all computer systems and to identify the critical actions required to resume regular operations.This study was conducted on a public, general, and acute care referral university teaching hospital.We report the different recovery measures on various hospital clinical activities and their impact on clinical work.The system malfunction of hospital computers did not reduce the number of heart catheterizations, births, or outpatient clinic visits. However, a sharp drop in surgical activities, emergency room visits, and total hospital occupancy was observed immediately and during the first postattack week. A gradual increase in all clinical activities was detected starting in the second week after the attack, with a significant increase of 30% associated with the restoration of the electronic medical records (EMR) and laboratory module and a 50% increase associated with the return of the imaging module archiving. One limitation of the present study is that, due to its retrospective design, there were no data regarding the number of elective internal care hospitalizations that were considered crucial.The risk of ransomware cyberattacks is growing. Healthcare systems at all levels of the hospital should be aware of this threat and implement protocols should this catastrophic event occur. Careful evaluation of steady computer system recovery weekly enables vital hospital function, even under a major cyberattack. The restoration of EMR, laboratory systems, and imaging archiving modules was found to be the most significant factor that allowed the return to normal clinical hospital work.
医疗机构在数据丰富的环境中运行,依赖于数字化的计算机系统;因此,它们可能面临网络威胁。事实上,医疗保健行业是最容易受到黑客和恶意软件攻击的行业之一。本研究旨在描述一起针对整个医疗中心、导致所有计算机系统完全关闭的重大攻击事件,并确定恢复正常运营所需的关键行动。本研究针对一家公立、综合、急症转诊大学教学医院进行,我们报告了医院各种临床活动的不同恢复措施及其对临床工作的影响。然而,在攻击发生后的第一周内,手术活动、急诊室就诊人数和医院总占用率急剧下降。从袭击发生后的第二周开始,所有临床活动逐渐增加,其中与电子病历(EMR)和实验室模块恢复相关的活动显著增加了 30%,与影像模块归档恢复相关的活动增加了 50%。本研究的一个局限性是,由于采用的是回顾性设计,因此没有关于被认为至关重要的选择性内科住院次数的数据。各级医院的医疗保健系统都应意识到这一威胁,并在发生灾难性事件时执行相关协议。每周对稳定的计算机系统恢复进行仔细评估,即使在重大网络攻击的情况下,也能保证医院的重要功能。我们发现,恢复医疗记录系统、实验室系统和影像存档模块是使医院临床工作恢复正常的最重要因素。
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Frontiers in Digital Health
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