Pub Date : 2024-05-17DOI: 10.12688/f1000research.145852.1
A. M. Ipekci, Maximilian Filsinger, Diana Buitrago-García, Cristopher I. Kobler Betancourt, Annika Frahsa, Nicola Low
Introduction The COVID-19 pandemic affected people’s health behaviours and health outcomes. Political or affective polarization could be associated with health behaviours such as mask-wearing or vaccine uptake and with health outcomes, e.g., infection or mortality rate. Political polarization relates to divergence or spread of ideological beliefs and affective polarization is about dislike between people of different political groups, such as ideologies or parties. The objectives of this study are to investigate and synthesize evidence about associations between both forms of polarization and COVID-19 health behaviours and outcomes. Methods In this systematic review, we will include quantitative studies that assess the relationship between political or affective polarization and COVID-19-related behaviours and outcomes, including adherence to mask mandates, vaccine uptake, infection and mortality rate. We will use a predetermined strategy to search EMBASE, Medline (Ovid), Cochrane Library, Cochrane COVID-19 Study Register, Global Health (Ovid), PsycInfo (Ovid), Web of Science, CINAHL, EconLit (EBSCOhost), WHO COVID-19 Database, iSearch COVID-19 Portfolio (NIH) and Google Scholar from 2019 to September 8 2023. One reviewer will screen unique records according to eligibility criteria. A second reviewer will verify the selection. Data extraction, using pre-piloted electronic forms, will follow a similar process. The risk of bias of the included studies will be assessed using the JBI checklist for analytical cross sectional studies. We will summarise the included studies descriptively and examine the heterogeneity between studies. Quantitative data pooling might not be feasible due to variations in measurement methods used to evaluate exposure, affective and political polarization. If there are enough relevant studies for statistical data synthesis, we will conduct a meta-analysis. Discussion This review will help to better understand the concept of polarization in the context of the COVID-19 pandemic and might inform decision making for future pandemics. Protocol registration PROSPERO ID: CRD42023475828.
{"title":"Polarization and health-related behaviours and outcomes during the COVID-19 pandemic: a systematic review protocol","authors":"A. M. Ipekci, Maximilian Filsinger, Diana Buitrago-García, Cristopher I. Kobler Betancourt, Annika Frahsa, Nicola Low","doi":"10.12688/f1000research.145852.1","DOIUrl":"https://doi.org/10.12688/f1000research.145852.1","url":null,"abstract":"Introduction The COVID-19 pandemic affected people’s health behaviours and health outcomes. Political or affective polarization could be associated with health behaviours such as mask-wearing or vaccine uptake and with health outcomes, e.g., infection or mortality rate. Political polarization relates to divergence or spread of ideological beliefs and affective polarization is about dislike between people of different political groups, such as ideologies or parties. The objectives of this study are to investigate and synthesize evidence about associations between both forms of polarization and COVID-19 health behaviours and outcomes. Methods In this systematic review, we will include quantitative studies that assess the relationship between political or affective polarization and COVID-19-related behaviours and outcomes, including adherence to mask mandates, vaccine uptake, infection and mortality rate. We will use a predetermined strategy to search EMBASE, Medline (Ovid), Cochrane Library, Cochrane COVID-19 Study Register, Global Health (Ovid), PsycInfo (Ovid), Web of Science, CINAHL, EconLit (EBSCOhost), WHO COVID-19 Database, iSearch COVID-19 Portfolio (NIH) and Google Scholar from 2019 to September 8 2023. One reviewer will screen unique records according to eligibility criteria. A second reviewer will verify the selection. Data extraction, using pre-piloted electronic forms, will follow a similar process. The risk of bias of the included studies will be assessed using the JBI checklist for analytical cross sectional studies. We will summarise the included studies descriptively and examine the heterogeneity between studies. Quantitative data pooling might not be feasible due to variations in measurement methods used to evaluate exposure, affective and political polarization. If there are enough relevant studies for statistical data synthesis, we will conduct a meta-analysis. Discussion This review will help to better understand the concept of polarization in the context of the COVID-19 pandemic and might inform decision making for future pandemics. Protocol registration PROSPERO ID: CRD42023475828.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140962615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-17DOI: 10.12688/f1000research.146897.1
Yindee Boontra, Chommakorn Thanetnit, M. Phanasathit
Objectives To investigate the impact of electroacupuncture on cognitive function, quality of life (QoL), and depression severity in patients with major depressive disorder (MDD). Methods This double-blinded randomized controlled trial included 60 participants aged 18-55 with cognitive symptoms related to MDD at Thammasat University Hospital. Participants were divided into two groups: the electroacupuncture group combined with standard antidepressant treatment (EG; n=30) and the control group receiving standard care with placebo acupuncture (CG; n=30). The study assessed 1) executive functions using the Trail making test- B and Stroop Color and Word Test, 2) delayed recall, and 3) subjective cognitive complaint and Quality of life (QoL) using WHODAS 2.0. Depressive symptoms were measured using the Thai version of the Patient Health Questionnaire (PHQ-9). Baseline and post-intervention assessments were conducted over 10 weeks. Mann-Whitney U test analyzed treatment effects by comparing median differences between groups. Results Both groups exhibited similar demographics and cognitive traits. Cognitive improvement was observed in both groups at the endpoint. Intention-to-treat analysis revealed significantly higher median scores for subjective cognitive complaints in the EG compared to the CG (EG: Median = 5.5, CG: Median = 0.0, p=0.049). No serious side effects were identified from either electroacupuncture or placebo acupuncture. Conclusions Electroacupuncture improved subjective complaints in MDD patients with cognitive symptoms, but did not show effects on specific cognitive functions, QoL, or depressive symptoms. This study provides initial evidence supporting the potential of electroacupuncture in MDD patients with cognitive symptoms, suggesting opportunities for further research. Trial registration NCT06239740, February 2, 2024, ClinicalTrials.gov.
{"title":"Effects of electroacupuncture on cognitive symptoms in major depressive disorder: a pilot study and randomized controlled trial","authors":"Yindee Boontra, Chommakorn Thanetnit, M. Phanasathit","doi":"10.12688/f1000research.146897.1","DOIUrl":"https://doi.org/10.12688/f1000research.146897.1","url":null,"abstract":"Objectives To investigate the impact of electroacupuncture on cognitive function, quality of life (QoL), and depression severity in patients with major depressive disorder (MDD). Methods This double-blinded randomized controlled trial included 60 participants aged 18-55 with cognitive symptoms related to MDD at Thammasat University Hospital. Participants were divided into two groups: the electroacupuncture group combined with standard antidepressant treatment (EG; n=30) and the control group receiving standard care with placebo acupuncture (CG; n=30). The study assessed 1) executive functions using the Trail making test- B and Stroop Color and Word Test, 2) delayed recall, and 3) subjective cognitive complaint and Quality of life (QoL) using WHODAS 2.0. Depressive symptoms were measured using the Thai version of the Patient Health Questionnaire (PHQ-9). Baseline and post-intervention assessments were conducted over 10 weeks. Mann-Whitney U test analyzed treatment effects by comparing median differences between groups. Results Both groups exhibited similar demographics and cognitive traits. Cognitive improvement was observed in both groups at the endpoint. Intention-to-treat analysis revealed significantly higher median scores for subjective cognitive complaints in the EG compared to the CG (EG: Median = 5.5, CG: Median = 0.0, p=0.049). No serious side effects were identified from either electroacupuncture or placebo acupuncture. Conclusions Electroacupuncture improved subjective complaints in MDD patients with cognitive symptoms, but did not show effects on specific cognitive functions, QoL, or depressive symptoms. This study provides initial evidence supporting the potential of electroacupuncture in MDD patients with cognitive symptoms, suggesting opportunities for further research. Trial registration NCT06239740, February 2, 2024, ClinicalTrials.gov.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140964666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Curculigo latifolia Dryand. ex W. T. Aiton, from the genus Curculigo, is a medicinal plant traditionally used to treat numerous illnesses such as fever, stomach aches, jaundice, wounds, and inflammation. C. latifolia is a perennial herb that is widely found in tropical and subtropical regions, such as Southeast Asia, Southern China, Bangladesh, Australia, and the Andaman Islands. This review collates the reported studies on the different aspects of C. latifolia from its plant description, nutritional value, phytochemistry, chemical composition, and pharmacological properties. This review aims to identify gaps in the literature and provide useful references for future work on this plant. Previous studies have shown that C. latifolia contains high mineral contents of calcium, iron, and magnesium, which are essential components of human health. Moreover, the plant is rich in phytochemicals, which play a prominent role in various pharmacological activities. The most common compounds identified included curculigoside, crassifoside I, nyasicoside, and curculigine. C. latifolia demonstrated high antioxidant activity through its ability to scavenge superoxide anions, 1,1–diphenyl–2–picrylhydrazyl (DPPH) and 2,2’-azino–bis(3–ethylbenzthiazoline–6–sulfonic acid) (ABTS) radicals, reducing ferric ions to ferrous complexes, iron chelation, and B-carotene bleaching. It was also shown that the roots, stems, and leaves of C. latifolia were effective in exerting antimicrobial activity against several microbial strains, including Bacillus cereus, Bacillus subtillis, Enterobacter aerogenes, Erwinia sp., Klebsiella sp., Pseudomonas sp., Candida albicans, Salmonella choleraesuis and Staphylococcus aureus. Moreover, the root, fruit, leaf, petiole, and rhizome extracts were found to improve glucose uptake and insulin secretion in diabetic rats, suggesting their antidiabetic potential. C. latifolia presents a wide range of medicinal properties that could make it a promising functional food or source of food supplements to prevent nutrition–related or chronic diseases.
{"title":"A review on the phytochemistry and biological activities of Curculigo latifolia Dryand ex. W.Aiton","authors":"Amanina Yusrina Taufik, Hartini Mohd Yasin, Norhayati Ahmad, Masayoshi Arai, Fairuzeta Ja'afar","doi":"10.12688/f1000research.148960.1","DOIUrl":"https://doi.org/10.12688/f1000research.148960.1","url":null,"abstract":"Curculigo latifolia Dryand. ex W. T. Aiton, from the genus Curculigo, is a medicinal plant traditionally used to treat numerous illnesses such as fever, stomach aches, jaundice, wounds, and inflammation. C. latifolia is a perennial herb that is widely found in tropical and subtropical regions, such as Southeast Asia, Southern China, Bangladesh, Australia, and the Andaman Islands. This review collates the reported studies on the different aspects of C. latifolia from its plant description, nutritional value, phytochemistry, chemical composition, and pharmacological properties. This review aims to identify gaps in the literature and provide useful references for future work on this plant. Previous studies have shown that C. latifolia contains high mineral contents of calcium, iron, and magnesium, which are essential components of human health. Moreover, the plant is rich in phytochemicals, which play a prominent role in various pharmacological activities. The most common compounds identified included curculigoside, crassifoside I, nyasicoside, and curculigine. C. latifolia demonstrated high antioxidant activity through its ability to scavenge superoxide anions, 1,1–diphenyl–2–picrylhydrazyl (DPPH) and 2,2’-azino–bis(3–ethylbenzthiazoline–6–sulfonic acid) (ABTS) radicals, reducing ferric ions to ferrous complexes, iron chelation, and B-carotene bleaching. It was also shown that the roots, stems, and leaves of C. latifolia were effective in exerting antimicrobial activity against several microbial strains, including Bacillus cereus, Bacillus subtillis, Enterobacter aerogenes, Erwinia sp., Klebsiella sp., Pseudomonas sp., Candida albicans, Salmonella choleraesuis and Staphylococcus aureus. Moreover, the root, fruit, leaf, petiole, and rhizome extracts were found to improve glucose uptake and insulin secretion in diabetic rats, suggesting their antidiabetic potential. C. latifolia presents a wide range of medicinal properties that could make it a promising functional food or source of food supplements to prevent nutrition–related or chronic diseases.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140965275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-17DOI: 10.12688/f1000research.140810.2
Laura Himanen, Erica Conte, Marianne Gauffriau, Tanja Strøm, Baron Wolf, Elizabeth Gadd
Background Research and researchers are heavily evaluated, and over the past decade it has become widely acknowledged that the consequences of evaluating the research enterprise and particularly individual researchers are considerable. This has resulted in the publishing of several guidelines and principles to support moving towards more responsible research assessment (RRA). To ensure that research evaluation is meaningful, responsible, and effective the International Network of Research Management Societies (INORMS) Research Evaluation Group created the SCOPE framework enabling evaluators to deliver on existing principles of RRA. SCOPE bridges the gap between principles and their implementation by providing a structured five-stage framework by which evaluations can be designed and implemented, as well as evaluated. Methods SCOPE is a step-by-step process designed to help plan, design, and conduct research evaluations as well as check effectiveness of existing evaluations. In this article, four case studies are presented to show how SCOPE has been used in practice to provide value-based research evaluation. Results This article situates SCOPE within the international work towards more meaningful and robust research evaluation practices and shows through the four case studies how it can be used by different organisations to develop evaluations at different levels of granularity and in different settings. Conclusions The article demonstrates that the SCOPE framework is rooted firmly in the existing literature. In addition, it is argued that it does not simply translate existing principles of RRA into practice, but provides additional considerations not always addressed in existing RRA principles and practices thus playing a specific role in the delivery of RRA. Furthermore, the use cases show the value of SCOPE across a range of settings, including different institutional types, sizes, and missions.
{"title":"The SCOPE framework – implementing ideals of responsible research assessment","authors":"Laura Himanen, Erica Conte, Marianne Gauffriau, Tanja Strøm, Baron Wolf, Elizabeth Gadd","doi":"10.12688/f1000research.140810.2","DOIUrl":"https://doi.org/10.12688/f1000research.140810.2","url":null,"abstract":"Background Research and researchers are heavily evaluated, and over the past decade it has become widely acknowledged that the consequences of evaluating the research enterprise and particularly individual researchers are considerable. This has resulted in the publishing of several guidelines and principles to support moving towards more responsible research assessment (RRA). To ensure that research evaluation is meaningful, responsible, and effective the International Network of Research Management Societies (INORMS) Research Evaluation Group created the SCOPE framework enabling evaluators to deliver on existing principles of RRA. SCOPE bridges the gap between principles and their implementation by providing a structured five-stage framework by which evaluations can be designed and implemented, as well as evaluated. Methods SCOPE is a step-by-step process designed to help plan, design, and conduct research evaluations as well as check effectiveness of existing evaluations. In this article, four case studies are presented to show how SCOPE has been used in practice to provide value-based research evaluation. Results This article situates SCOPE within the international work towards more meaningful and robust research evaluation practices and shows through the four case studies how it can be used by different organisations to develop evaluations at different levels of granularity and in different settings. Conclusions The article demonstrates that the SCOPE framework is rooted firmly in the existing literature. In addition, it is argued that it does not simply translate existing principles of RRA into practice, but provides additional considerations not always addressed in existing RRA principles and practices thus playing a specific role in the delivery of RRA. Furthermore, the use cases show the value of SCOPE across a range of settings, including different institutional types, sizes, and missions.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140962256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-17DOI: 10.12688/f1000research.146149.1
V. Mingkwansook, Urusaya Wangprasertkul, Warit Tarathipmon, Arvemas Watcharakorn
Objective To compare iodine density (ID) and contrast-enhanced attenuation value (CEAV) from dual-layer spectral computed tomography (DLSCT) scans of lymphomatous, metastatic squamous cell carcinoma (SCCA), and normal cervical lymph nodes. Methods Data including ID and CEAV were retrospectively collected from patients who underwent DLSCT of the neck between January 2020 and August 2023. Results from each group (lymphomatous, metastatic SCCA, and normal) were compared and analyzed using one-way ANOVA and receiver operating characteristic curve. Results 129 cervical lymph nodes were collected from patients who met the inclusion criteria (50, 41, and 38 nodes from the lymphomatous, metastatic SCCA, and normal group, respectively). The mean ID of lymphomatous, metastatic SCCA, and normal nodes was 1.01±0.27, 1.36±0.28, and 1.45±0.29 mg/mL, respectively. Comparing lymphomatous nodes with metastatic SCCA nodes, the lymphomatous nodes had significantly lower values of ID (p<0.002) and CEAV (p<0.001). Similarly, when comparing lymphomatous nodes with normal nodes, the lymphomatous nodes had significantly lower values of ID (p<0.001) and CEAV (p<0.001). The optimal ID cut-off value for distinguishing between lymphomatous and metastatic SCCA nodes was 1.175 mg/ml (specificity of 84.2%, sensitivity 77.8%, AUC 0.788, P = 0.003). The optimal CEAV cut-off value was 77.5 HU (specificity 88.9%, sensitivity 78.9%, AUC 0.851, P<0.001). Conclusions The ID and CEAV measurements from DLSCT were significantly different between lymphomatous, metastatic SCCA, and normal lymph nodes. These findings indicate that DLSCT can be used to distinguish between these conditions in the diagnosis of cervical lymph nodes.
{"title":"Iodine density of lymphoma, metastatic SCCA, and normal cervical lymph nodes: Based on DLSCT","authors":"V. Mingkwansook, Urusaya Wangprasertkul, Warit Tarathipmon, Arvemas Watcharakorn","doi":"10.12688/f1000research.146149.1","DOIUrl":"https://doi.org/10.12688/f1000research.146149.1","url":null,"abstract":"Objective To compare iodine density (ID) and contrast-enhanced attenuation value (CEAV) from dual-layer spectral computed tomography (DLSCT) scans of lymphomatous, metastatic squamous cell carcinoma (SCCA), and normal cervical lymph nodes. Methods Data including ID and CEAV were retrospectively collected from patients who underwent DLSCT of the neck between January 2020 and August 2023. Results from each group (lymphomatous, metastatic SCCA, and normal) were compared and analyzed using one-way ANOVA and receiver operating characteristic curve. Results 129 cervical lymph nodes were collected from patients who met the inclusion criteria (50, 41, and 38 nodes from the lymphomatous, metastatic SCCA, and normal group, respectively). The mean ID of lymphomatous, metastatic SCCA, and normal nodes was 1.01±0.27, 1.36±0.28, and 1.45±0.29 mg/mL, respectively. Comparing lymphomatous nodes with metastatic SCCA nodes, the lymphomatous nodes had significantly lower values of ID (p<0.002) and CEAV (p<0.001). Similarly, when comparing lymphomatous nodes with normal nodes, the lymphomatous nodes had significantly lower values of ID (p<0.001) and CEAV (p<0.001). The optimal ID cut-off value for distinguishing between lymphomatous and metastatic SCCA nodes was 1.175 mg/ml (specificity of 84.2%, sensitivity 77.8%, AUC 0.788, P = 0.003). The optimal CEAV cut-off value was 77.5 HU (specificity 88.9%, sensitivity 78.9%, AUC 0.851, P<0.001). Conclusions The ID and CEAV measurements from DLSCT were significantly different between lymphomatous, metastatic SCCA, and normal lymph nodes. These findings indicate that DLSCT can be used to distinguish between these conditions in the diagnosis of cervical lymph nodes.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140965135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-17DOI: 10.12688/f1000research.150799.1
Hanen Boukhris, H. Hajjami, Souha Ben youssef
Background The “all-on-four” concept represents a significant advancement in dental implantology. particularly beneficial in cases of extensive jaw bone loss where invasive bone regeneration procedures are typically required. However, the successful implementation of this technique necessitates meticulous planning concerning implant selection, materials, and prosthesis design. The recent introduction of PEEK (Polyetheretherketone) in dentistry, especially in all-on-four prosthetics, prompts questions regarding its clinical efficacy and comparative biomechanical and biological advantages over conventional materials such as titanium and zirconia. While some studies have compared PEEK with other materials, systematic reviews evaluating its efficacy are scarce. This systematic review protocol intends to assess the evidence regarding the viability of PEEK as a potential alternative within the all-on-four approach in dental implantology. Methods This systematic review protocol will adhere to the Cochrane Handbook for Systematic Review of Interventions and align with the Methodological Expectations of the Cochrane Intervention Reviews (MECIR) guidelines. Utilizing a comprehensive search strategy, multiple databases, including PubMed, EMBASE, Scopus, EBSCO, Web of Science, Cochrane Central, and registries of clinical trials, will be explored. The search aims to identify randomized controlled trials and non-randomized studies investigating the application of PEEK in the all-on-four approach for dental procedures. Emphasizing clinically relevant outcomes such as implant survival, prosthesis success, peri-implant complications, and patient satisfaction, this review aims to provide insights into the effectiveness and potential benefits of using PEEK in all-on-four prosthetics. Non-randomized studies will be assessed for bias using ROBINS-I, while randomized controlled trials will undergo evaluation with the Cochrane Risk of Bias assessment tool, ROB II. Discussion The outcomes derived from this systematic review hold great significance for dental practitioners exploring the all-on-four concept. Understanding PEEK’s advantages and limitations compared to titanium and zirconia facilitates tailored treatment plans, enhancing success and satisfaction, ultimately improving dental care quality. Systematic review registration PROSPERO: CRD42024531175 (Registered on 13/04/2024).
背景 "四对一 "概念是牙科种植学的一大进步，尤其适用于颌骨大面积缺失的病例，因为这种病例通常需要进行侵入性骨再生手术。然而，要成功实施这一技术，必须对种植体的选择、材料和修复体的设计进行周密的规划。最近，PEEK（聚醚醚酮）被引入牙科领域，尤其是用于全牙列修复，这引发了有关其临床疗效以及与钛和氧化锆等传统材料相比在生物力学和生物学方面的优势的问题。虽然有些研究将 PEEK 与其他材料进行了比较，但评估其功效的系统综述却很少。本系统综述方案旨在评估 PEEK 作为牙科种植中 "四对一 "方法的潜在替代材料的可行性。方法 本系统综述方案将遵循《科克伦干预措施系统综述手册》，并符合《科克伦干预措施综述方法学期望》（MECIR）指南。我们将采用综合检索策略，探索多个数据库，包括 PubMed、EMBASE、Scopus、EBSCO、Web of Science、Cochrane Central 和临床试验登记处。搜索的目的是确定调查在牙科手术的 "全对四 "方法中应用 PEEK 的随机对照试验和非随机研究。本综述强调与临床相关的结果，如种植体存活率、修复成功率、种植体周围并发症和患者满意度，旨在深入探讨在全对四修复中使用 PEEK 的有效性和潜在益处。非随机研究将使用 ROBINS-I 进行偏倚评估，而随机对照试验将使用 Cochrane 偏倚风险评估工具 ROB II 进行评估。讨论 本系统综述得出的结果对牙科医生探索 "四位一体 "概念具有重要意义。了解 PEEK 与钛和氧化锆相比的优势和局限性有助于制定量身定制的治疗方案，提高成功率和满意度，最终提高牙科护理质量。系统综述注册 PROSPERO：CRD42024531175（注册日期：2024 年 4 月 13 日）。
{"title":"Clinical Outcomes of Polyetheretherketone (PEEK) Hybrid Prosthesis in All-on-Four Rehabilitation: A Systematic Review Protocol","authors":"Hanen Boukhris, H. Hajjami, Souha Ben youssef","doi":"10.12688/f1000research.150799.1","DOIUrl":"https://doi.org/10.12688/f1000research.150799.1","url":null,"abstract":"Background The “all-on-four” concept represents a significant advancement in dental implantology. particularly beneficial in cases of extensive jaw bone loss where invasive bone regeneration procedures are typically required. However, the successful implementation of this technique necessitates meticulous planning concerning implant selection, materials, and prosthesis design. The recent introduction of PEEK (Polyetheretherketone) in dentistry, especially in all-on-four prosthetics, prompts questions regarding its clinical efficacy and comparative biomechanical and biological advantages over conventional materials such as titanium and zirconia. While some studies have compared PEEK with other materials, systematic reviews evaluating its efficacy are scarce. This systematic review protocol intends to assess the evidence regarding the viability of PEEK as a potential alternative within the all-on-four approach in dental implantology. Methods This systematic review protocol will adhere to the Cochrane Handbook for Systematic Review of Interventions and align with the Methodological Expectations of the Cochrane Intervention Reviews (MECIR) guidelines. Utilizing a comprehensive search strategy, multiple databases, including PubMed, EMBASE, Scopus, EBSCO, Web of Science, Cochrane Central, and registries of clinical trials, will be explored. The search aims to identify randomized controlled trials and non-randomized studies investigating the application of PEEK in the all-on-four approach for dental procedures. Emphasizing clinically relevant outcomes such as implant survival, prosthesis success, peri-implant complications, and patient satisfaction, this review aims to provide insights into the effectiveness and potential benefits of using PEEK in all-on-four prosthetics. Non-randomized studies will be assessed for bias using ROBINS-I, while randomized controlled trials will undergo evaluation with the Cochrane Risk of Bias assessment tool, ROB II. Discussion The outcomes derived from this systematic review hold great significance for dental practitioners exploring the all-on-four concept. Understanding PEEK’s advantages and limitations compared to titanium and zirconia facilitates tailored treatment plans, enhancing success and satisfaction, ultimately improving dental care quality. Systematic review registration PROSPERO: CRD42024531175 (Registered on 13/04/2024).","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140962579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-17DOI: 10.12688/f1000research.144117.1
Rishabh Dhabalia, S. Kashikar
Background T2-weighted hyperintensities in the spinal cord are a complex and diagnostically challenging entity that can present with diverse clinical features. This study protocol outlines a comprehensive investigation to understand the causes, clinical and imaging characteristics, and correlation with pathological findings of T2-weighted hyperintensities in the spinal cord. By establishing a systematic assessment approach, this study seeks to provide valuable insights into these abnormalities’ diagnostic and prognostic implications. Methods The study will be conducted as a prospective observational design. Patients with clinically diagnosed or suspected spinal cord injury presenting with intramedullary T2-weighted hyperintensity and referred for MRI evaluation will be included. Data collection will encompass patient demographics, clinical features, and extensive imaging parameters. Pathological data, when available, will be correlated with imaging findings. Various statistical methods will be employed to analyse the data, including frequency analysis, comparative tests, logistic regression, and survival analysis. Expected Results The study anticipates elucidating the spectrum of etiologies underlying T2-weighted hyperintensities in the spinal cord and their clinical and imaging profiles. The systematic approach will offer a structured diagnostic method, while correlations with pathological data will provide an enhanced understanding of these conditions. The results are expected to provide clinicians with valuable insights into diagnosing, treating, and prognosticating patients with spinal cord hyperintensities.
{"title":"An observational cross-sectional study of the role of magnetic resonance imaging in the evaluation of T2-weighted hyperintensities in the spinal cord in tertiary care hospital in central India","authors":"Rishabh Dhabalia, S. Kashikar","doi":"10.12688/f1000research.144117.1","DOIUrl":"https://doi.org/10.12688/f1000research.144117.1","url":null,"abstract":"Background T2-weighted hyperintensities in the spinal cord are a complex and diagnostically challenging entity that can present with diverse clinical features. This study protocol outlines a comprehensive investigation to understand the causes, clinical and imaging characteristics, and correlation with pathological findings of T2-weighted hyperintensities in the spinal cord. By establishing a systematic assessment approach, this study seeks to provide valuable insights into these abnormalities’ diagnostic and prognostic implications. Methods The study will be conducted as a prospective observational design. Patients with clinically diagnosed or suspected spinal cord injury presenting with intramedullary T2-weighted hyperintensity and referred for MRI evaluation will be included. Data collection will encompass patient demographics, clinical features, and extensive imaging parameters. Pathological data, when available, will be correlated with imaging findings. Various statistical methods will be employed to analyse the data, including frequency analysis, comparative tests, logistic regression, and survival analysis. Expected Results The study anticipates elucidating the spectrum of etiologies underlying T2-weighted hyperintensities in the spinal cord and their clinical and imaging profiles. The systematic approach will offer a structured diagnostic method, while correlations with pathological data will provide an enhanced understanding of these conditions. The results are expected to provide clinicians with valuable insights into diagnosing, treating, and prognosticating patients with spinal cord hyperintensities.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140964115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-17DOI: 10.12688/f1000research.149350.1
Huda Abu-Qtaish
Background Learning apps can be helpful to non-native language learners in learning Arabic, which includes speaking, writing, and speaking exercises. When learners become better in the language, they become more confident in interacting with the community, thus affecting their Cultural Intelligence (CQ) and Acculturation (AC). This study aimed to explore the relationship between the CQ and AC among non-native learners of Arabic. Additionally, the study aimed to investigate the potential impacts of learning apps and gender. Methods This study used a correlational approach, involving a sample of 102 non-native Arabic language learners in Jordan. To assess these factors, this study used the Cultural Intelligence Scale and the Acculturation Survey. Results The findings of this study revealed a positive correlation between the CQ and AC. Furthermore, the use of apps can provide CQ and AC levels. In addition, the study determined that gender did not play a significant role in influencing learners. Conclusion the utilization of educational apps has been shown to enhance both CQ and AC. Thus, it is imperative to encourage learners to engage with these apps, as they foster cultural awareness, thereby facilitating the process of learning Arabic.
背景学习应用程序可以帮助非母语语言学习者学习阿拉伯语，其中包括口语、写作和演讲练习。当学习者的语言能力提高后，他们在与社会互动时会更加自信，从而影响他们的文化智能（CQ）和文化适应（AC）。本研究旨在探讨阿拉伯语非母语学习者的文化智商（CQ）和文化适应（AC）之间的关系。此外，本研究还旨在调查学习应用程序和性别的潜在影响。方法 本研究采用了相关方法，涉及约旦 102 名非母语阿拉伯语学习者。为了评估这些因素，本研究使用了文化智能量表和文化适应调查。结果 研究结果显示，CQ 与 AC 之间存在正相关。此外，应用程序的使用可以提高 CQ 和 AC 水平。此外，研究还发现，性别对学习者的影响并不明显。结论 教育应用程序的使用已被证明可以提高 CQ 和 AC。因此，必须鼓励学习者使用这些应用程序，因为它们可以培养文化意识，从而促进阿拉伯语的学习过程。
{"title":"Cultural intelligence and acculturation among non-native Arabic learners: the impact of learning apps","authors":"Huda Abu-Qtaish","doi":"10.12688/f1000research.149350.1","DOIUrl":"https://doi.org/10.12688/f1000research.149350.1","url":null,"abstract":"Background Learning apps can be helpful to non-native language learners in learning Arabic, which includes speaking, writing, and speaking exercises. When learners become better in the language, they become more confident in interacting with the community, thus affecting their Cultural Intelligence (CQ) and Acculturation (AC). This study aimed to explore the relationship between the CQ and AC among non-native learners of Arabic. Additionally, the study aimed to investigate the potential impacts of learning apps and gender. Methods This study used a correlational approach, involving a sample of 102 non-native Arabic language learners in Jordan. To assess these factors, this study used the Cultural Intelligence Scale and the Acculturation Survey. Results The findings of this study revealed a positive correlation between the CQ and AC. Furthermore, the use of apps can provide CQ and AC levels. In addition, the study determined that gender did not play a significant role in influencing learners. Conclusion the utilization of educational apps has been shown to enhance both CQ and AC. Thus, it is imperative to encourage learners to engage with these apps, as they foster cultural awareness, thereby facilitating the process of learning Arabic.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140966142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-16DOI: 10.12688/f1000research.144101.1
A. Ahuja, Sachin Agrawal, Sunil Kumar
Vitamin D functions as a prohormone that promotes bone mineralization by regulating calcium and phosphate levels in the skeletal system. It is a fat-soluble vitamin that is required for immunomodulation, cytokine regulation, and cell proliferation. As a result, Vitamin D is a powerful hormone with pleiotropic effects that improve overall health. Sepsis is the leading cause of death in critically unwell people. According to a recent study, numerous trace minerals and nutrients have the ability to alter the human body, and supplementing these nutrients can improve the prognosis of sepsis patients. A considerable number of patients in the intensive care unit (ICU) have low vitamin D levels, a frequent condition that can increase the risk of infectious diseases. According to various studies, severely ill patients admitted to the ICU who have a vitamin D deficiency are at a higher risk of requiring mechanical ventilation and facing a higher likelihood of mortality. Nonetheless, the connection between insufficient vitamin D levels and mortality in sepsis patients remains a topic of debate.
维生素 D 是一种促激素，通过调节骨骼系统中的钙和磷酸盐水平来促进骨骼矿化。它是一种脂溶性维生素，免疫调节、细胞因子调节和细胞增殖都需要它。因此，维生素 D 是一种强大的激素，具有改善整体健康的多重效应。败血症是危重病人死亡的主要原因。根据最近的一项研究，许多微量矿物质和营养素具有改变人体的能力，补充这些营养素可以改善败血症患者的预后。重症监护室（ICU）中有相当多的病人维生素 D 含量较低，这种情况经常发生，会增加感染疾病的风险。多项研究表明，重症监护室的重症患者如果缺乏维生素 D，则需要机械通气的风险更高，死亡的可能性也更大。然而，脓毒症患者维生素 D 水平不足与死亡率之间的关系仍是一个争论不休的话题。
{"title":"A study protocol for vitamin-D level in sepsis and its outcome in patients admitted to the medical intensive care unit","authors":"A. Ahuja, Sachin Agrawal, Sunil Kumar","doi":"10.12688/f1000research.144101.1","DOIUrl":"https://doi.org/10.12688/f1000research.144101.1","url":null,"abstract":"Vitamin D functions as a prohormone that promotes bone mineralization by regulating calcium and phosphate levels in the skeletal system. It is a fat-soluble vitamin that is required for immunomodulation, cytokine regulation, and cell proliferation. As a result, Vitamin D is a powerful hormone with pleiotropic effects that improve overall health. Sepsis is the leading cause of death in critically unwell people. According to a recent study, numerous trace minerals and nutrients have the ability to alter the human body, and supplementing these nutrients can improve the prognosis of sepsis patients. A considerable number of patients in the intensive care unit (ICU) have low vitamin D levels, a frequent condition that can increase the risk of infectious diseases. According to various studies, severely ill patients admitted to the ICU who have a vitamin D deficiency are at a higher risk of requiring mechanical ventilation and facing a higher likelihood of mortality. Nonetheless, the connection between insufficient vitamin D levels and mortality in sepsis patients remains a topic of debate.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140969422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.12688/f1000research.143492.1
Ridwana Maher Manna, S. Hasan, Rifat Hannan, Tahamina Akter, Md. Masum Mrida, Mohammad Delwer Hossain Hawlader
Background Coronavirus disease 2019 (COVID-19) shows a wide range of clinical manifestations, including asymptomatic presentation to severe pneumonia, acute respiratory distress syndrome, and respiratory failure. Although COVID-19 disease progression was studied elsewhere, it is largely unknown in Bangladesh. Methods We conducted this cross-sectional study in November 2020 to January 2021 on patients diagnosed with COVID-19 confirmed by Reverse Transcription-Polymerase Chain Reaction (RT-PCR). Pearson chi-square tests were used to assess the disease progressions across selected variables. A logistic regression model was used to assess the associated factors of COVID-19 infection for explanatory variables. All statistics were performed using the Stata software version 14.0 (Stata corporation, college station, Texas, USA). Results A total of 384 of respondents were involved in the survey. Of participants, most males (73%), unmarried (69%), aged 18 to 35 years during survey, and lived in urban community (73%). Overall, 41% of patients were in asymptotic condition, 44% were in mild condition, while 17% were moderate to severe conditions. Male patients and patients over 50 years had severe symptoms, accounting for 52% and 50%, respectively. Nearly half of business persons and office employees had severe symptoms. Almost all married patients (98%) had severe symptoms. The severity of symptoms was also higher for patients living in urban areas (79%), smoking (95%), and not physically active (52%). Patients with diabetes, asthma/COPD, and cancer were significantly associated with severe stage of COVID-19 (p≤0.05). Patient’s age, gender, smoking status, diabetics, working conditions significantly affect Covid-19 disease progression. Conclusion The study found that 7.03% of patients had severe, 9.11% had moderate and 40.36% had asymptomatic conditions. The heterogenic association between the disease progressions with age, sex, residence, marital status, smoking habits, diabetes, physical exercise, working conditions, sedentary lifestyles. Findings highlight the idea of using vulnerability ratings for each risk factor related to disease progression.
{"title":"Determinants of Disease Progression in Bangladeshi COVID-19 Patients: A Cross-sectional Survey","authors":"Ridwana Maher Manna, S. Hasan, Rifat Hannan, Tahamina Akter, Md. Masum Mrida, Mohammad Delwer Hossain Hawlader","doi":"10.12688/f1000research.143492.1","DOIUrl":"https://doi.org/10.12688/f1000research.143492.1","url":null,"abstract":"Background Coronavirus disease 2019 (COVID-19) shows a wide range of clinical manifestations, including asymptomatic presentation to severe pneumonia, acute respiratory distress syndrome, and respiratory failure. Although COVID-19 disease progression was studied elsewhere, it is largely unknown in Bangladesh. Methods We conducted this cross-sectional study in November 2020 to January 2021 on patients diagnosed with COVID-19 confirmed by Reverse Transcription-Polymerase Chain Reaction (RT-PCR). Pearson chi-square tests were used to assess the disease progressions across selected variables. A logistic regression model was used to assess the associated factors of COVID-19 infection for explanatory variables. All statistics were performed using the Stata software version 14.0 (Stata corporation, college station, Texas, USA). Results A total of 384 of respondents were involved in the survey. Of participants, most males (73%), unmarried (69%), aged 18 to 35 years during survey, and lived in urban community (73%). Overall, 41% of patients were in asymptotic condition, 44% were in mild condition, while 17% were moderate to severe conditions. Male patients and patients over 50 years had severe symptoms, accounting for 52% and 50%, respectively. Nearly half of business persons and office employees had severe symptoms. Almost all married patients (98%) had severe symptoms. The severity of symptoms was also higher for patients living in urban areas (79%), smoking (95%), and not physically active (52%). Patients with diabetes, asthma/COPD, and cancer were significantly associated with severe stage of COVID-19 (p≤0.05). Patient’s age, gender, smoking status, diabetics, working conditions significantly affect Covid-19 disease progression. Conclusion The study found that 7.03% of patients had severe, 9.11% had moderate and 40.36% had asymptomatic conditions. The heterogenic association between the disease progressions with age, sex, residence, marital status, smoking habits, diabetes, physical exercise, working conditions, sedentary lifestyles. Findings highlight the idea of using vulnerability ratings for each risk factor related to disease progression.","PeriodicalId":504605,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140985112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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