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Risk factors for medication-related osteonecrosis of the jaws in menopausal women 更年期妇女与药物相关的颌骨坏死的风险因素
Pub Date : 2024-07-19 DOI: 10.20396/bjos.v23i00.8668457
Jocarla Campos Serafim, Gustavo Azevedo Pitol, Ester Victorino Coser, B. Albergaria, S. C. Kano, T. Velloso
Aim: This study aimed to identify risk factors for medicationrelated osteonecrosis of the jaw (MRONJ) by carrying out clinical and radiographic evaluations of patients with osteopenia and osteoporosis using bisphosphonates (BFs). Methods: After approval by the CCS/UFES Ethics Committee (registration number 2,738,749), consultations were undertaken, and data were collected from medical records in cooperation with sectors from UFES and the University hospital. A total of 50 patients, 29 with osteoporosis and 21 with osteopenia were selected. Patients underwent a clinical and a panoramic dental x-ray examination to assess risk factors associated with oral health and dental interventions. Results: All patients had at least one local risk factor, the most frequent being tooth extraction (100%) and periodontal disease (50%) which, if associated with the use of BFs, could lead to MRONJ. Among the systemic risk factors, the most common were diabetes and corticosteroid therapy. The most used BF was alendronate, administered orally. Conclusion: The dental surgeon should evaluate all patients with osteopenia and osteoporosis using BFs to determine whether there are other risks. Whether there may be other potential risks, acknowledging upon key risks factors surrounding MRONJ are critical for early diagnosis and successful dental treatment.
目的:本研究旨在通过对使用双膦酸盐(BFs)的骨质疏松症和骨质疏松症患者进行临床和影像学评估,确定药物相关性颌骨坏死(MRONJ)的风险因素。研究方法在获得 CCS/UFES 伦理委员会(注册号 2,738,749)批准后,与 UFES 和大学医院的相关部门合作进行会诊并从病历中收集数据。研究共选取了 50 名患者,其中 29 人患有骨质疏松症,21 人患有骨质疏松症。患者接受了临床和全景牙科 X 光检查,以评估与口腔健康和牙科干预相关的风险因素。结果显示所有患者都至少有一个局部风险因素,其中最常见的是拔牙(100%)和牙周病(50%),如果这些因素与使用碱性磷酸酯有关,则可能导致 MRONJ。在全身性风险因素中,最常见的是糖尿病和皮质类固醇治疗。使用最多的碱性磷酸酯是阿仑膦酸钠,口服给药。结论:牙科医生应评估所有使用碱性磷酸酯的骨质增生和骨质疏松症患者,以确定是否存在其他风险。无论是否存在其他潜在风险,认识到围绕 MRONJ 的关键风险因素对于早期诊断和成功的牙科治疗至关重要。
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引用次数: 0
Knowledge and conduct of dental students about mouthwash prior to dental procedures amid the COVID-19 pandemic 在 COVID-19 大流行期间,牙科专业学生在牙科手术前使用漱口水的知识和行为
Pub Date : 2024-07-19 DOI: 10.20396/bjos.v23i00.8670020
F. Al-Mashhadane, Leqaa H. Qibi, Faris Ghanim Ahmed Al-Taee
The coronavirus disease 2019 (COVID-19) generated an unusual condition around the world, affecting the essentials of clinical practice in dentistry. Aim: The purpose of this survey was to determine dental students’ conduct and knowledge regarding using pre-procedural mouthwashes. Methods: A cross-sectional study was undertaken for 148 undergraduate dental students at the Dental College/University of Mosul using an online questionnaire. participated in this survey, where 36.5% were female and 63.5% were male, and The survey format had 12 questions delivered to participants, and the replies were statistically analyzed. The data were imported and analyzed using SPSS software (version 22). Results: The current study found that 59.5% of participants thought pre-procedural mouthwash was helpful in preventing COVID-19 infections in dental settings, while 40.5% of participants believed that it is not, and for the most effective mouthrinse against COVID-19, 48.6% of participants said chlorhexidine for 30 seconds, while 51.4% said chlorhexidine for 60 seconds. Conclusions: Dental students are conscious of the value of pre-procedural mouthwash but need more clarity on the correct concentration, amount, and duration.
2019 年冠状病毒病(COVID-19)在全球范围内引发了异常情况,影响了牙科临床实践的基本要素。目的:本调查旨在了解牙科学生使用术前漱口水的行为和知识。调查方法采用在线问卷的形式对摩苏尔大学牙科学院的 148 名牙科本科生进行了横断面研究。数据使用 SPSS 软件(22 版)进行导入和分析。结果本次研究发现,59.5% 的参与者认为术前漱口水有助于预防牙科环境中的 COVID-19 感染,40.5% 的参与者认为没有帮助;对于预防 COVID-19 最有效的漱口水,48.6% 的参与者表示洗必泰漱口 30 秒,51.4% 的参与者表示洗必泰漱口 60 秒。结论:牙科学生意识到了术前漱口水的价值,但需要进一步明确正确的浓度、用量和持续时间。
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引用次数: 0
Evaluation of change in knowledge, attitude, and practice of medical students towards early childhood oral health following educational intervention 评估教育干预后医科学生对幼儿口腔保健知识、态度和实践的变化
Pub Date : 2024-07-19 DOI: 10.20396/bjos.v23i00.8674088
KL Girish Babu, C. Jayalakshmi, Rosamma George
Medical health professionals have the opportunity to influence the oral health of children, as they are the first health professionals to come in contact with expectant mothers and parents of infants and toddlers. Aim: To evaluate and compare undergraduate medical students’ knowledge, attitude, and practice about early childhood oral health care before and after educational intervention. Methods: A cohort study was conducted among undergraduate medical students during their course. The baseline knowledge and attitude of 80 medical students were evaluated using a validated questionnaire (Phase I). Following, they completed 8 hours of educational intervention and their change in the knowledge and attitude was reassessed (Phase II). The intervention continued through web-based learning till they reached their residency. The students’ knowledge, attitude, and practice were again reassessed at the end of their residency (Phase III). Results: Knowledge: There was a significant increase in the knowledge about the term gum pads, from 70% in Phase I to 90% in Phase III. Only 30% of medical students knew that the oral cavity of a newborn was devoid of microorganisms during Phase I, but this knowledge improved to 86% in Phase III. Almost 58 to 90% of the medical students had a basic knowledge of the influence of high caries on mothers, the importance and benefit of antenatal counselling, and the effect of poor maternal health. In Phase I, although 92% were aware of the multifactorial pattern of dental caries, only 42% and 53% knew the causative organism and transmissibility of it from mother to child, respectively. Around 77% and 62% agreed that antenatal counselling and counselling on feeding and weaning, respectively, will prevent ECC. Attitude: The attitude towards treating primary teeth was less (66%) in Phase I, subsequently increasing to 100% at the end of Phase III. Practice: Following Phase III, most of them (88%) examined the child’s oral cavity during routine medical checkups in the Knee-to-Knee position (93%) and counted the number of teeth present (91%), and they were able to identify the dental carious teeth (88%). Conclusion: The medical curriculum should include a module on early childhood oral health.
医疗卫生专业人员有机会影响儿童的口腔健康,因为他们是最早接触准妈妈和婴幼儿父母的医疗卫生专业人员。目的:评估和比较医学本科生在教育干预前后对幼儿口腔保健知识、态度和实践的掌握情况。方法:在医学院本科生中开展一项队列研究:在医学本科生中开展了一项队列研究。使用经过验证的问卷对 80 名医学生的基础知识和态度进行了评估(第一阶段)。随后,他们完成了 8 小时的教育干预,并重新评估了他们在知识和态度上的变化(第二阶段)。干预措施通过网络学习持续进行,直到他们到达住院医师岗位。在实习期结束时,再次对学生的知识、态度和实践进行重新评估(第三阶段)。结果如下知识:对牙龈垫一词的了解有了明显增加,从第一阶段的 70% 增加到第三阶段的 90%。在第一阶段,只有 30% 的医学生知道新生儿口腔中没有微生物,但在第三阶段,这一知识知晓率提高到 86%。近 58%至 90%的医科学生对龋齿高发对母亲的影响、产前咨询的重要性和好处以及母亲健康状况不佳的影响有基本的了解。在第一阶段,虽然有 92% 的人知道龋齿的多因素模式,但分别只有 42% 和 53% 的人知道致病菌和龋齿在母婴之间的传播性。约 77%和 62%的人同意产前咨询和喂养及断奶咨询可预防龋齿。态度:在第一阶段,对治疗乳牙的态度较差(66%),随后在第三阶段结束时上升到 100%。实践:在第三阶段结束后,大多数人(88%)在例行体检时以膝对膝的姿势检查儿童口腔(93%),并清点牙齿数量(91%),他们能够识别龋齿(88%)。结论医学课程应包括幼儿口腔健康模块。
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引用次数: 0
Histomorphometric comparison of two different preclinical models to evaluate the bone repair in grafted areas 对两种不同临床前模型进行组织形态计量学比较,以评估移植区域的骨修复情况
Pub Date : 2024-06-03 DOI: 10.20396/bjos.v23i00.8673937
Julia Raulino Lima, P. Soares, Lucas De Sousa Goulart Pereira, Leidys Rodríguez Perdomo, S. C. Pigossi, Guilherme José Pimentel Lopes de Oliveira
Aim: This study was performed to compare two different rat defect models (critical calvaria defects versus guided bone regeneration in the mandibular ramus) used to evaluate bone repair in grafted areas. Methods: A total of 12 rats were allocated in two groups according the experimental model used to evaluate the bone repair in grafted areas: a critical sized-calvaria defect of 5 mm filled with bone graft (n=6) and a mandibular ramus filled with the bone graft associated with a Teflon dome-shaped membrane (n=6). Both groups were grafted with deproteinized bovine bone graft. After 60 days, the animals were euthanized and the samples obtained were submitted to histomorphometry analysis to evaluate the relative amount of bone, remaining bone substitute, and soft tissue within the grafted areas. Results: No differences were observed between the preclinical models evaluated in relation to the amount of bone tissue formation (19.93 ± 4.55% in calvaria vs. 21.00 ± 8.20% in mandible). However, there was a smaller amount of soft tissue (43.20 ± 10.97% vs. 57.79 ± 7.61 %; p<0.01) and a greater amount of bone substitute remaining (35.80 ± 5.52% vs. 22.28 ± 4.36 %; p<0.05) in the grafted areas in the mandible compared to calvaria defect. Conclusion: Preclinical models for the analysis of bone repair in grafted areas in the mandible and critical sized-calvaria defects showed different responses in relation to the amount of soft tissue and bone substitute remnants.
目的:本研究旨在比较两种不同的大鼠缺损模型(临界小腿缺损与下颌骨横梁引导骨再生),以评估移植区域的骨修复情况。方法:根据用于评估移植区域骨修复的实验模型,将总共 12 只大鼠分为两组:用植骨填充 5 毫米大小的临界腓肠肌缺损(6 只)和用与特氟龙圆顶膜相关的植骨填充下颌骨横梁(6 只)。两组均采用去蛋白牛骨移植。60 天后,动物被安乐死,获得的样本被送去进行组织形态学分析,以评估移植区域内骨、剩余骨替代物和软组织的相对数量。结果所评估的临床前模型在骨组织形成量方面没有差异(小腿骨为 19.93 ± 4.55%,下颌骨为 21.00 ± 8.20%)。不过,与腓骨缺损相比,下颌骨移植区域的软组织数量较少(43.20 ± 10.97% vs. 57.79 ± 7.61%;p<0.01),而剩余的骨替代物数量较多(35.80 ± 5.52% vs. 22.28 ± 4.36%;p<0.05)。结论用于分析下颌骨移植区和临界大小颅骨缺损区骨修复情况的临床前模型在软组织和骨替代物残留量方面表现出不同的反应。
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引用次数: 0
Accuracy of the integrated electronic apex locator in locating simulated perforation under various irrigating solutions in an in vitro study 在一项体外研究中,综合电子牙尖定位仪在各种灌洗溶液下定位模拟穿孔的准确性
Pub Date : 2024-06-03 DOI: 10.20396/bjos.v23i00.8671118
Chintan Joshi, Surabhi Joshi, Urooj Desai, Sweety Thumar, Aashray Patel, Ankita Khunt
Aim: This study’s objective was to assess the accuracy of the integrated apex locator in identifying artificial root canal perforations in the presence of saline, chlorhexidine, sodium hypochlorite, QMix, and MTAD. Methods: The root canals of 60 single-rooted extracted human teeth were perforated artificially at a point 10 mm away from the root apex. After measuring the actual lengths up to the perforation point, the teeth were then put within an alginate mould for measurements using an integrated apex locator. Using a #20 K-file in the presence of NaCl, CHX, MTAD, NaOCl, and QMix, an electronic apex locator was used to measure the perforations electronically in accordance with the manufacturer’s instructions. Between the measurements, each canal was dried with paper points after being irrigated with distilled water. The accuracy of all the readings was calculated at ± 0.5 mm. Statistical analyses were performed using the Z-test. Results: In comparison to the MTAD, NaOCl, and Qmix, saline and chlorhexidine scored more readings in the ± 0.5 mm range of the perforation site, and the difference was statistically significant. Conclusion: The most precise electronic measurements of artificial perforation were obtained in the presence of chlorhexidine or saline.
目的:本研究旨在评估综合根尖定位仪在生理盐水、洗必泰、次氯酸钠、QMix 和 MTAD 存在的情况下识别人工根管穿孔的准确性。方法:在距根尖 10 毫米处对 60 颗单根拔牙的根管进行人工穿孔。测量穿孔点的实际长度后,将牙齿放入藻酸盐模型中,使用综合根尖定位仪进行测量。在 NaCl、CHX、MTAD、NaOCl 和 QMix 的作用下,使用 20 号 K 锉,按照制造商的说明,使用电子根尖定位仪对穿孔进行电子测量。在两次测量之间,用蒸馏水冲洗每个牙管后,用纸点擦干。所有读数的精确度计算为 ± 0.5 毫米。统计分析采用 Z 检验。结果:与 MTAD、NaOCl 和 Qmix 相比,生理盐水和洗必泰在穿孔部位 ± 0.5 毫米范围内的读数更多,差异具有统计学意义。结论在使用洗必泰或生理盐水的情况下,人工穿孔的电子测量结果最为精确。
{"title":"Accuracy of the integrated electronic apex locator in locating simulated perforation under various irrigating solutions in an in vitro study","authors":"Chintan Joshi, Surabhi Joshi, Urooj Desai, Sweety Thumar, Aashray Patel, Ankita Khunt","doi":"10.20396/bjos.v23i00.8671118","DOIUrl":"https://doi.org/10.20396/bjos.v23i00.8671118","url":null,"abstract":"Aim: This study’s objective was to assess the accuracy of the integrated apex locator in identifying artificial root canal perforations in the presence of saline, chlorhexidine, sodium hypochlorite, QMix, and MTAD. Methods: The root canals of 60 single-rooted extracted human teeth were perforated artificially at a point 10 mm away from the root apex. After measuring the actual lengths up to the perforation point, the teeth were then put within an alginate mould for measurements using an integrated apex locator. Using a #20 K-file in the presence of NaCl, CHX, MTAD, NaOCl, and QMix, an electronic apex locator was used to measure the perforations electronically in accordance with the manufacturer’s instructions. Between the measurements, each canal was dried with paper points after being irrigated with distilled water. The accuracy of all the readings was calculated at ± 0.5 mm. Statistical analyses were performed using the Z-test. Results: In comparison to the MTAD, NaOCl, and Qmix, saline and chlorhexidine scored more readings in the ± 0.5 mm range of the perforation site, and the difference was statistically significant. Conclusion: The most precise electronic measurements of artificial perforation were obtained in the presence of chlorhexidine or saline.","PeriodicalId":504767,"journal":{"name":"Brazilian Journal of Oral Sciences","volume":"11 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141269377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stability of dentin matrix treated with caffeic acid phenethyl ester at different concentrations 用不同浓度的咖啡酸苯乙酯处理牙本质基质的稳定性
Pub Date : 2024-05-06 DOI: 10.20396/bjos.v23i00.8674006
Aline Honorato Damázio, R. Basting, Enrico Coser Bridi, F. França, Flávia Lucisano Botelho do Amaral, C. Turssi, W. F. Vieira Junior, R. Basting
Aim: The aim of this study was to investigate the impact of pretreatment with ethanolic solutions of caffeic acid phenethyl ester (CAPE) at varying concentrations on the dentin collagen matrix, specifically focusing on its biomodification potential. This was assessed through evaluations of the modulus of elasticity and changes in mass. Methods: Seventy dentin collagen matrices (demineralized sticks) were prepared to receive treatments with ethanolic solutions of CAPE at concentrations of 0.05%, 0.1%, 0.5%, or 2.5%, or with control treatment solutions (distilled water or ethanol) for one hour. The dentin matrices were evaluated for modulus of elasticity and mass before (baseline), immediately after treatment (immediately), and after storage in Simulated Body Fluid (SBF) for time intervals of 1 and 3 months. Results: Generalized linear models for repeated measures over time indicated no significant differences between groups (p=0.7530) or between different time points (p=0.4780) in terms of the modulus of elasticity. Regarding mass variation, no differences were observed in the time interval between 1 month and the immediate time (p=0.0935). However, at the 3-month mark compared to the immediate time, the 0.1% CAPE group exhibited less mass loss compared to the water group (p=0.0134). Conclusion: This study concludes that various concentrations of CAPE in an ethanolic solution did not affect the modulus of elasticity of dentin, suggesting that CAPE lacks biomodifying potential in this context. However, it was observed that 0.1% CAPE positively influenced the variation in mass over different evaluation time intervals.
目的:本研究旨在探讨不同浓度的咖啡酸苯乙酯(CAPE)乙醇溶液预处理对牙本质胶原基质的影响,特别是对其生物改性潜力的影响。通过评估弹性模量和质量变化来评估其生物改性潜力。方法制备 70 个牙本质胶原基质(脱矿棒),分别用浓度为 0.05%、0.1%、0.5% 或 2.5% 的 CAPE 乙醇溶液或对照处理溶液(蒸馏水或乙醇)处理一小时。对牙本质基质进行弹性模量和质量评估,评估时间分别为治疗前(基线)、治疗后立即(立即)以及在模拟体液(SBF)中存放 1 个月和 3 个月。结果:根据时间重复测量的广义线性模型显示,在弹性模量方面,组间(P=0.7530)或不同时间点间(P=0.4780)无明显差异。在质量变化方面,在 1 个月和当前时间之间没有观察到差异(p=0.0935)。然而,在 3 个月时,0.1% CAPE 组与水组相比较,质量损失较少(p=0.0134)。结论本研究得出结论,乙醇溶液中不同浓度的 CAPE 不会影响牙本质的弹性模量,这表明 CAPE 在这方面缺乏生物改性潜力。不过,研究发现 0.1% CAPE 对不同评估时间间隔内的质量变化有积极影响。
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引用次数: 0
Risk factors associated with occlusal caries in first permanent molars in a school program 与学校课程中第一恒磨牙咬合龋相关的风险因素
Pub Date : 2024-05-06 DOI: 10.20396/bjos.v23i00.8673595
Bianca Mattos dos Santos Guerra, Patrícia Papoula Gorni Reis, R. C. Jorge, V. Soviero
Aim: Evaluate the longitudinal status of dental caries in the occlusal surface of first permanent molars (FPM) and to identify risk factors for the progression to cavitated caries lesions in a school oral health program. Methods: Children who were enrolled in the program between September 2017 and October 2019, 5 to 10 years-old, presenting the four FPM were included. Four calibrated examiners assessed dental caries according to Nyvad criteria. Descriptive analysis included frequency, mean, and standard deviation calculations. Chi-square test was used in the bivariate analysis and, logistic regression adjusted for cluster effect was used to identify significant risk factors for cavity among the following independent variables: gender, age in the baseline, deft, upper/lower molar, initial caries score, Molar Incisor Hypomineralization (MIH), fluorosis, occlusal sealing. Odds ratio (OR) and respective confidence intervals (CI) are presented. Results: From 174 children enrolled in the program between 2017/2019, 120 were reevaluated in 2022. Eleven (2.6%) FPM in 11 children (9.2%) presented cavitated caries in the follow up examination. Significant risk factors for cavity were caries experience in the primary teeth (OR = 5.59; CI: 1.4 – 22.3) and the presence of MIH (OR = 5.33; CI: 1.6 – 18.1). Most of the active lesions in the follow up were considered active in the baseline examination. Conclusions: The progression to cavity was relatively low, significantly influenced by past caries experience and MIH.
目的:评估第一恒磨牙(FPM)咬合面龋齿的纵向状况,并确定学校口腔健康计划中发展为龋洞的风险因素。研究方法纳入2017年9月至2019年10月期间参加该项目、5至10岁、出现四颗FPM的儿童。四名经过校准的检查员根据 Nyvad 标准对龋齿进行评估。描述性分析包括频率、平均值和标准差计算。双变量分析中使用了卡方检验(Chi-square test),并使用调整了聚类效应的逻辑回归(Logistic regression)在以下自变量中识别出龋齿的重要风险因素:性别、基线年龄、脱发、上/下臼齿、初始龋齿评分、臼齿切牙低矿化(MIH)、氟中毒、咬合封闭。结果显示了比值比(OR)和各自的置信区间(CI)。结果:在 2017/2019 年间参加该计划的 174 名儿童中,有 120 名儿童在 2022 年接受了重新评估。11名儿童(9.2%)中的11名(2.6%)FPM在后续检查中出现龋齿。造成龋齿的重要风险因素是基牙龋坏(OR = 5.59;CI:1.4 - 22.3)和存在MIH(OR = 5.33;CI:1.6 - 18.1)。大多数随访中的活动性病变在基线检查中被认为是活动性的。结论龋齿的发展程度相对较低,但受既往龋病经历和MIH的影响较大。
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引用次数: 0
ENAM gene polymorphisms associated with dental anomalies in individuals with cleft lip and palate 与唇腭裂患者牙齿畸形相关的ENAM基因多态性
Pub Date : 2024-05-03 DOI: 10.20396/bjos.v23i00.8671330
F. Oliveira, C. F. Santos, T. Dionísio, L. T. Neves, G. Dalben, Eloá Cristina Passucci Ambrosio, P. K. Jorge, M. A. A. M. Machado, T. M. Oliveira
Aim: This study aimed to investigate the occurrence of enamelin gene (ENAM) single nucleotide polymorphisms (SNP) and ENAM polymorphism association with dental anomalies (DA) in individuals with unilateral or bilateral cleft lip and palate (CLP). Methods: Saliva samples were collected from 147 individuals aged between 6 and 15 years-old, both genders, and divided into 4 groups: Group 1 (G1) - CLP and DA; Group 2 (G2) - CLP without DA; Group 3 (G3) - without CLP with DA; Group 4 (G4) - without CLP and DA. The genomic DNA was extracted from saliva samples and the following ENAM SNPs markers were genotyped: rs3796703, rs3796704, rs3796705, rs7671281, rs2609428, and rs35951442. Fisher exact and Pearson’s Chi-square tests statistically analyzed the results (α=5%). Results: Individuals without CLP with DA (Group 3 - 19.2%) showed statistically higher prevalence of SNP rs2609428 heterozygotes (p=0.006) than individuals with CLP and DA (Group 1 - 0%). Individuals without CLP (10%) exhibited statistically higher prevalence of mutated heterozygotes/homozygous (p=0.028) than in individuals with CLP (1.3%). Conclusion: SNP rs2609428 marker of ENAM gene may be associated with dental anomalies in individuals without cleft lip and palate.
目的:本研究旨在探讨单侧或双侧唇腭裂(CLP)患者釉质素基因(ENAM)单核苷酸多态性(SNP)的发生以及ENAM多态性与牙齿畸形(DA)的相关性。研究方法收集 147 名 6 至 15 岁男女儿童的唾液样本,并将其分为 4 组:第 1 组 (G1) - 有唇腭裂和畸形;第 2 组 (G2) - 有唇腭裂但无畸形;第 3 组 (G3) - 无唇腭裂但有畸形;第 4 组 (G4) - 无唇腭裂但有畸形。从唾液样本中提取基因组 DNA 并对以下ENAM SNPs 标记进行基因分型:rs3796703、rs3796704、rs3796705、rs7671281、rs2609428 和 rs35951442。费舍尔精确检验和皮尔逊卡方检验对结果进行了统计分析(α=5%)。结果无CLP伴DA者(第3组-19.2%)的SNP rs2609428杂合子发生率(p=0.006)高于CLP伴DA者(第1组-0%)。在统计学上,未患 CLP 的个体(10%)比患 CLP 的个体(1.3%)显示出更高的突变杂合子/杂合子发生率(p=0.028)。结论ENAM基因的SNP rs2609428标记可能与无唇腭裂患者的牙齿畸形有关。
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引用次数: 0
Can oral health have an impact on academic performance and school absenteeism? 口腔健康对学习成绩和旷课有影响吗?
Pub Date : 2024-05-02 DOI: 10.20396/bjos.v23i00.8670322
Sarah Arangurem Karam, F. Costa, L. A. Chisini, R. Darley, F. F. Demarco, M. Corrêa
Aim: The study aimed to evaluate the association between oral health and academic performance and/or school absenteeism. Methods: Electronic searches were performed of the PubMed, Web of Science, SCOPUS and LILACS/BVS databases. We included observational studies that evaluated the association between dental caries, tooth loss, dental pain or oral health status with school absenteeism or academic performance. The studies had to contain a representative sample of the population: schoolchildren, children or adolescents. After the removal of duplicates, the electronic searches produced 3,789 articles. Of these, 25 studies were included in the systematic review and 13 in the meta-analysis. Results: Considering all the studies evaluated in the meta-analysis, seven articles satisfied 100% of the Joanna Briggs Institute Critical Appraisal checklist, and six contained between 90% and 75% positive answers. The pooled effects showed that the chances of school absenteeism were 31% higher in subjects with dental caries (OR 1.31; 95%CI 1.12-1.54). Students with fair/poor dental health had a 50% higher chance of suffering poor academic performance (OR 1.50; 95%CI 1.22-1.84) and 34% higher chance of having problems at school (OR 1.34; 95%CI 1.06-1.70). Students with a history of toothache had a 3.7 higher chance of being absent from school (OR 6.65; 95%CI 1.60-8.32) and 71% higher chance of missing class due to toothache (OR 1.71; 95%CI 1.15-2.56). Subjects with a history of toothache had a 2.5 times higher chance of suffering poor academic performance (OR 2.58; 95% CI 2.04-3.27). Conclusion: Therefore, students with oral problems were more likely to take time off school and present inferior academic performance.
目的:本研究旨在评估口腔健康与学习成绩和/或旷课之间的关系。研究方法在 PubMed、Web of Science、SCOPUS 和 LILACS/BVS 数据库中进行电子检索。我们纳入了评估龋齿、牙齿脱落、牙痛或口腔健康状况与旷课或学习成绩之间关系的观察性研究。研究必须包含具有代表性的人群样本:学童、儿童或青少年。在去除重复内容后,电子检索共产生了 3,789 篇文章。其中,25 项研究被纳入系统综述,13 项研究被纳入荟萃分析。分析结果考虑到荟萃分析中评估的所有研究,有 7 篇文章 100%符合乔安娜-布里格斯研究所的批判性评估清单,有 6 篇文章的正面回答在 90% 到 75% 之间。汇总效应显示,有龋齿的学生旷课的几率要高出 31%(OR 1.31;95%CI 1.12-1.54)。牙齿健康状况一般/较差的学生学习成绩较差的几率高出 50%(OR 1.50;95%CI 1.22-1.84),在学校出现问题的几率高出 34%(OR 1.34;95%CI 1.06-1.70)。有牙痛病史的学生缺课的几率要高出 3.7(OR 6.65;95%CI 1.60-8.32),因牙痛缺课的几率要高出 71%(OR 1.71;95%CI 1.15-2.56)。有牙痛病史的受试者学习成绩差的几率要高出 2.5 倍(OR 2.58;95%CI 2.04-3.27)。结论是因此,有口腔问题的学生更有可能休学,学习成绩也更差。
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引用次数: 0
Combination of phototherapy for treatment of labial necrotizing lesion 联合光疗治疗唇部坏死性病变
Pub Date : 2024-05-02 DOI: 10.20396/bjos.v23i00.8672214
Elaine Aparecida Rocha Domingues, Lana Luiza da Cruz Silva, Marcelly Silva Dourado, Cintia Teles de Argôlo
Lip necrotizing lesions are painful, complex to heal, and negatively impact the patient’s orofacial condition. The present study reports a clinical case of a necrotizing lesion on the lower lip in a 38-year-old male patient, previously healthy, f ive days after receiving the first dose of the SARS-COV-2 vaccine, with an initial diagnosis of labial herpes zoster, with secondary infection and unsatisfactory response to clinical treatment. After debridement of the necrotic tissue, followed by a combination of antimicrobial photodynamic therapy (aPDT), photobiomodulation therapy (PBMT) and hydrofiber dressing with silver, the patient evolved with complete healing of the lip lesion and satisfactory restoration of orofacial functions after 7 days. According to the present case report, this combination of phototherapy modalities suggests to be a promising tool for the treatment of necrotizing labial lesions.
唇部坏死性病变疼痛难忍,愈合复杂,对患者的口腔状况有负面影响。本研究报告了一例下唇坏死性病变的临床病例,患者男性,38 岁,既往身体健康,在接种第一剂 SARS-COV-2 疫苗 5 天后,初步诊断为唇部带状疱疹,继发感染,临床治疗效果不佳。在对坏死组织进行清创后,联合使用了抗菌光动力疗法(aPDT)、光生物调节疗法(PBMT)和含银水纤维敷料,7 天后,患者的唇部病变完全愈合,口面部功能也得到了满意的恢复。根据本病例报告,这种联合光疗方法是治疗唇部坏死性病变的一种很有前途的手段。
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引用次数: 0
期刊
Brazilian Journal of Oral Sciences
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