Pub Date : 2023-12-15DOI: 10.52727/2078-256x-2023-19-4-444-456
E. V. Garbuzova, A. D. Khudiakova, S. E. Alekseev
The purpose of this review was to find an answer to the question: “Is there an association of adipokines (adiponectin, adipsin, interleukin-6, lipocalin-2, PAI-1, resistin, MCP-1, leptin, TNF-α, visfatin, omentin-1) with coronary artery disease and abdominal obesity in people under 65 years of age?”. Articles investigating patients aged 18 to 65 years with coronary heart disease were included. The analysis included only publications of the last 10 years (2013–2023). As a result of the analyzed literature, most of the publications of the last 10 years are devoted to studies conducted on persons over 65 years of age. At the same time, the available large studies and meta-analyses indicate a large contribution of adipocytokines to the development and course of coronary heart disease. Based on this, it is very relevant to study the adipocytokine profile in young and middle-aged people with coronary heart disease, especially against the background of AO.
{"title":"Associations of adipokines with coronary heart disease in young and middle-aged people","authors":"E. V. Garbuzova, A. D. Khudiakova, S. E. Alekseev","doi":"10.52727/2078-256x-2023-19-4-444-456","DOIUrl":"https://doi.org/10.52727/2078-256x-2023-19-4-444-456","url":null,"abstract":"The purpose of this review was to find an answer to the question: “Is there an association of adipokines (adiponectin, adipsin, interleukin-6, lipocalin-2, PAI-1, resistin, MCP-1, leptin, TNF-α, visfatin, omentin-1) with coronary artery disease and abdominal obesity in people under 65 years of age?”. Articles investigating patients aged 18 to 65 years with coronary heart disease were included. The analysis included only publications of the last 10 years (2013–2023). As a result of the analyzed literature, most of the publications of the last 10 years are devoted to studies conducted on persons over 65 years of age. At the same time, the available large studies and meta-analyses indicate a large contribution of adipocytokines to the development and course of coronary heart disease. Based on this, it is very relevant to study the adipocytokine profile in young and middle-aged people with coronary heart disease, especially against the background of AO.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.52727/2078-256x-2023-19-4-369-377
E. V. Korneeva, M. L. Voevoda, S. Semaev, V. Maksimov
The increase in cardiovascular diseases and their complications, diabetes mellitus and metabolic syndrome determines the relevance of early diagnosis and prevention of lipid metabolism disorders by identifying and studying genetic markers of predisposition to dyslipidemia in various populations depending on gender, age and ethnicity.Aim of the study was to investigate the associations of candidate genes CSK, MTHFR, ACE, ADRA2B and TCF7L2 with dyslipidemia in the young indigenous and non-indigenous population living in the Khanty-Mansy autonomous Okrug – Ugra.Material and methods. 863 young people aged 18–44 years were examined, clinical population included nonindigenous and indigenous men and women with metabolic syndrome (n = 344), the comparison group included non-indigenous and indigenous men and women without metabolic syndrome (n = 519). A study of the lipid profile and molecular genetic study was carried out using the polymerase chain reaction method for single nucleotide polymorphisms (SNPs): rs1378942 of the gene CSK, rs1801133 (C677T) of the gene MTHFR, gene ADRA2B, rs7903146 of the gene TCF7L2, rs1799752 of the gene ACE.Results. A high frequency of hypercholesterolemia (79.0 %) and hypertriglyceridemia (65.8 %) was found in the examined men and women. Statistically significant differences were established in the frequency of dyslipidemia in patients with metabolic syndrome by ethnicity and gender (p < 0.001). In the general cohort of men with metabolic syndrome hypercholesterolemia is associated with the TT genotype of SNP rs1801133 (C677T) of the gene MTHFR (p = 0.039), in the women – with the DD genotype of the gene ADRA2B (p = 0.010). In indigenous men of the clinical group an association of hypercholesterolemia with the minor T allele of the gene MTHFR (p = 0.005), of hypertriglyceridemia – with the minor T allele of the gene MTHFR (p = 0.031) and the T allele of the gene TCF7L2 (p = 0.031) was revealed. Among indigenous women of the clinical group hypercholesterolemia is associated with carriage of the minor T allele of the gene CSK (p < 0.001) and hypertriglyceridemia – with the D allele of the gene ADRA2B (p = 0.046).Conclusions. Carriage of minor alleles T of the MTHFR gene and D of the ADRA2B gene is associated with hypercholesterolemia among the examined young people and is statistically significantly higher in the group of patients with metabolic syndrome, as well as among indigenous residents of the KhantyMansiysk Autonomous Okrug – Ugra.
{"title":"Association of CSK, MTHFR, ACE, ADRA2B, TCF7L2 gene polymorphisms with dyslipidemia among indigenous and non-indigenous people of Khanty-Mansy Autonomous Okrug – Yugra","authors":"E. V. Korneeva, M. L. Voevoda, S. Semaev, V. Maksimov","doi":"10.52727/2078-256x-2023-19-4-369-377","DOIUrl":"https://doi.org/10.52727/2078-256x-2023-19-4-369-377","url":null,"abstract":"The increase in cardiovascular diseases and their complications, diabetes mellitus and metabolic syndrome determines the relevance of early diagnosis and prevention of lipid metabolism disorders by identifying and studying genetic markers of predisposition to dyslipidemia in various populations depending on gender, age and ethnicity.Aim of the study was to investigate the associations of candidate genes CSK, MTHFR, ACE, ADRA2B and TCF7L2 with dyslipidemia in the young indigenous and non-indigenous population living in the Khanty-Mansy autonomous Okrug – Ugra.Material and methods. 863 young people aged 18–44 years were examined, clinical population included nonindigenous and indigenous men and women with metabolic syndrome (n = 344), the comparison group included non-indigenous and indigenous men and women without metabolic syndrome (n = 519). A study of the lipid profile and molecular genetic study was carried out using the polymerase chain reaction method for single nucleotide polymorphisms (SNPs): rs1378942 of the gene CSK, rs1801133 (C677T) of the gene MTHFR, gene ADRA2B, rs7903146 of the gene TCF7L2, rs1799752 of the gene ACE.Results. A high frequency of hypercholesterolemia (79.0 %) and hypertriglyceridemia (65.8 %) was found in the examined men and women. Statistically significant differences were established in the frequency of dyslipidemia in patients with metabolic syndrome by ethnicity and gender (p < 0.001). In the general cohort of men with metabolic syndrome hypercholesterolemia is associated with the TT genotype of SNP rs1801133 (C677T) of the gene MTHFR (p = 0.039), in the women – with the DD genotype of the gene ADRA2B (p = 0.010). In indigenous men of the clinical group an association of hypercholesterolemia with the minor T allele of the gene MTHFR (p = 0.005), of hypertriglyceridemia – with the minor T allele of the gene MTHFR (p = 0.031) and the T allele of the gene TCF7L2 (p = 0.031) was revealed. Among indigenous women of the clinical group hypercholesterolemia is associated with carriage of the minor T allele of the gene CSK (p < 0.001) and hypertriglyceridemia – with the D allele of the gene ADRA2B (p = 0.046).Conclusions. Carriage of minor alleles T of the MTHFR gene and D of the ADRA2B gene is associated with hypercholesterolemia among the examined young people and is statistically significantly higher in the group of patients with metabolic syndrome, as well as among indigenous residents of the KhantyMansiysk Autonomous Okrug – Ugra.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.52727/2078-256x-2023-19-4-378-384
K. Y. Nikolaev, Ya. K. Lapitskaya, I. A. Kosarev, N. F. Dadashova
Aim of the study was to evaluate the effect of elevated level of low-density lipoprotein cholesterol (LDL-C) on surfactant protein SP-A and SP-D content in blood, as a new factor of atherogenesis, in men and women in Novosibirsk.Materials and methods. The study included 174 people (87 men and 87 women), residents of Novosibirsk, aged 45 to 69 years. An anthropometric examination, measurement of blood pressure, determination of the lipid spectrum, blood glucose and surfactant proteins SP-A and SP-D content (enzyme immunoassay).Results. According to the results of the examination, 82 examined persons (47.1 %) were included in the group with LDL-C content > 3.0 mmol/l(main group), 92 – in the group with LDL-C content ≤ 3.0 mmol/l (comparison group) (52.9 %). The value of high SP-A and SP-D content (upper quartile) was determined, which amounted to ≥ 1413 pg/ml SP-A in men and ≥ 1649 pg/ml in women, and ≥ 1772 ng/ml SP-D in men and ≥ 1626 ng/ml in women. It was found that in the main group, the body weight of the examined persons was lower than in the comparison group, and high SP-A level was more common (p = 0.033). In the total sample a direct association of upper quartile SP-A level with LDL-C content > 3.0 mmol/l was revealed (p = 0.021). Using multivariate analysis, it was found that LDL-C concentration > 3.0 mmol/l is an independent factor that directly affects the dependent variable the presence of high SP-A level in general totality of examined individuals (odds ratio 2.20, 95 % confidence interval 1.05–4.62, p = 0.036).Conclusions. In men and women of Novosibirsk, aged 45–69 years, high blood SP-A level (≥ 1413 pg/ml in men and ≥ 1649 pg/ml in women) occurs more often at LDL-C content > 3.0 mmol/l than at LDL-C level ≤ 3.0 mmol/l. In the total sample of the examined persons, a direct association of high SP-A with LDL-C content > 3.0 mmol/l was revealed, and using multivariate analysis it was found that LDL-C concentration > 3.0 mmol/l directly affects the presence of high blood SP-A level and increases the probability of this event by 2.2 times.
{"title":"The effect of elevated low-density lipoprotein cholesterol on surfactant proteins SP-A and SP-D content as a new mechanism of atherogenesis","authors":"K. Y. Nikolaev, Ya. K. Lapitskaya, I. A. Kosarev, N. F. Dadashova","doi":"10.52727/2078-256x-2023-19-4-378-384","DOIUrl":"https://doi.org/10.52727/2078-256x-2023-19-4-378-384","url":null,"abstract":"Aim of the study was to evaluate the effect of elevated level of low-density lipoprotein cholesterol (LDL-C) on surfactant protein SP-A and SP-D content in blood, as a new factor of atherogenesis, in men and women in Novosibirsk.Materials and methods. The study included 174 people (87 men and 87 women), residents of Novosibirsk, aged 45 to 69 years. An anthropometric examination, measurement of blood pressure, determination of the lipid spectrum, blood glucose and surfactant proteins SP-A and SP-D content (enzyme immunoassay).Results. According to the results of the examination, 82 examined persons (47.1 %) were included in the group with LDL-C content > 3.0 mmol/l(main group), 92 – in the group with LDL-C content ≤ 3.0 mmol/l (comparison group) (52.9 %). The value of high SP-A and SP-D content (upper quartile) was determined, which amounted to ≥ 1413 pg/ml SP-A in men and ≥ 1649 pg/ml in women, and ≥ 1772 ng/ml SP-D in men and ≥ 1626 ng/ml in women. It was found that in the main group, the body weight of the examined persons was lower than in the comparison group, and high SP-A level was more common (p = 0.033). In the total sample a direct association of upper quartile SP-A level with LDL-C content > 3.0 mmol/l was revealed (p = 0.021). Using multivariate analysis, it was found that LDL-C concentration > 3.0 mmol/l is an independent factor that directly affects the dependent variable the presence of high SP-A level in general totality of examined individuals (odds ratio 2.20, 95 % confidence interval 1.05–4.62, p = 0.036).Conclusions. In men and women of Novosibirsk, aged 45–69 years, high blood SP-A level (≥ 1413 pg/ml in men and ≥ 1649 pg/ml in women) occurs more often at LDL-C content > 3.0 mmol/l than at LDL-C level ≤ 3.0 mmol/l. In the total sample of the examined persons, a direct association of high SP-A with LDL-C content > 3.0 mmol/l was revealed, and using multivariate analysis it was found that LDL-C concentration > 3.0 mmol/l directly affects the presence of high blood SP-A level and increases the probability of this event by 2.2 times.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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