Pub Date : 2024-07-05DOI: 10.52727/2078-256x-2024-20-2-173-182
A. I. Zagorulko, M. V. Chernyaev, A. G. Koledinskiy
Today we can say with confidence that percutaneous coronary intervention is an effective, minimally invasive and safe method of treating coronary heart disease. As always complex problems require necessary solutions. One such challenge is the use of metallic covered stents because the stent frame remains permanently in the artery. The idea to create a bioresorbable scaffold appeared more than 20 years ago, and one of the pioneers was the Absorb scaffold, which was implanted in quantities of more than 150 000. During the existence of this stent, a large number of studies were carried out, strengths and weaknesses were identified and eventually came to the conclusion that it was discontinued, but creating Absorb gave a powerful drive to the invention of new types of scaffolds.
{"title":"Bioresorbable scaffolds: past and present. Clinical example of a 10-year follow-up of a patient with an implanted Absorb stent","authors":"A. I. Zagorulko, M. V. Chernyaev, A. G. Koledinskiy","doi":"10.52727/2078-256x-2024-20-2-173-182","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-2-173-182","url":null,"abstract":" Today we can say with confidence that percutaneous coronary intervention is an effective, minimally invasive and safe method of treating coronary heart disease. As always complex problems require necessary solutions. One such challenge is the use of metallic covered stents because the stent frame remains permanently in the artery. The idea to create a bioresorbable scaffold appeared more than 20 years ago, and one of the pioneers was the Absorb scaffold, which was implanted in quantities of more than 150 000. During the existence of this stent, a large number of studies were carried out, strengths and weaknesses were identified and eventually came to the conclusion that it was discontinued, but creating Absorb gave a powerful drive to the invention of new types of scaffolds.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141676515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-05DOI: 10.52727/2078-256x-2024-20-2-183-194
A. P. Kashirina, G. Simonova
At the present stage, non-high-density lipoprotein cholesterol (non-HDL-C) is intensively studied as a predictor of mortality from cardiovascular diseases. An increase in non-HDL-C content is associated with insulin resistance, which is a pathogenetic factor in the development of atherogenic (mixed) dyslipidemia, which is typical for people with metabolic syndrome (MS) and type 2 diabetes mellitus (TDM2). This review analyzes trends in non-HDL-C level since 1985 in foreign countries and in the Russian Federation. Based on the results of international epidemiological studies, conclusions are substantiated about the possibility of predicting the risk of developing MS and type 2 diabetes using the non-HDL-C. The necessity of conducting prospective cohort studies in the Russian population aimed at assessing the role of non-HDL-C in the early diagnosis of MS and TDM2 is shown. The search for literary sources in the electronic information databases eLIBRARY.RU and PubMed. The analysis included studies published from 1990 to 2023.
{"title":"Non-high-density lipoproteins cholesterol and cardiometabolic diseases","authors":"A. P. Kashirina, G. Simonova","doi":"10.52727/2078-256x-2024-20-2-183-194","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-2-183-194","url":null,"abstract":" At the present stage, non-high-density lipoprotein cholesterol (non-HDL-C) is intensively studied as a predictor of mortality from cardiovascular diseases. An increase in non-HDL-C content is associated with insulin resistance, which is a pathogenetic factor in the development of atherogenic (mixed) dyslipidemia, which is typical for people with metabolic syndrome (MS) and type 2 diabetes mellitus (TDM2). This review analyzes trends in non-HDL-C level since 1985 in foreign countries and in the Russian Federation. Based on the results of international epidemiological studies, conclusions are substantiated about the possibility of predicting the risk of developing MS and type 2 diabetes using the non-HDL-C. The necessity of conducting prospective cohort studies in the Russian population aimed at assessing the role of non-HDL-C in the early diagnosis of MS and TDM2 is shown. The search for literary sources in the electronic information databases eLIBRARY.RU and PubMed. The analysis included studies published from 1990 to 2023.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.52727/2078-256x-2024-20-2-162-172
I. N. Grigor’eva, D. Nepomnyashchikh
Aim of the review – to present an analysis of the literature data on the association of serum lipids with the presence of gallstone disease (GSD), as well as with the main risk factors for GSD – age, female sex, obesity, type 2 diabetes mellitus (DM2), arterial hypertension (AH) over a 50-year period. In numerous studies, hypertriglyceridemia (HTH), hypocholesterolemia of high-density lipoproteins (hypo-HDL) have been recognized as risk factors for GSD. In 1994–1995 in Novosibirsk (WHO MONICA project), in a population sample of women aged 25-64 (n = 870) and men aged 35–54 (n = 399) with sonographic diagnoses of GSD, GSD is much more common among men and women with lipid metabolism disorders: the highest frequency of GSD was noted in the 4th quartile of the distribution of total cholesterol (TC) levels (4.5 % for men and 12.4 % for women). For LDL cholesterol, the highest incidence of GSD was noted in the 5th quintile of the distribution (3.8 % in men and 10.9 % in women). When calculating by the largest χ2 method in women, the levels of TC (178 mg/dl), TG (177 mg/dl) in the blood were determined, exceeding which significantly increases the chance of GSD, for HDL cholesterol (68.5 mg/dl) the model is insignificant. There was a correlation between blood lipids and age, BMI, and DM2 in women with GSD, but not in men with GSD. The lipid profile in patients with GSD is not associated with AH. Most authors recognize GSD as a lipid-associated disease. However, the literature data are contradictory: there are opinions about a direct, inverse or absent association of blood lipids with GSD, perhaps due to differences in the design, size, and ethnicity of the subjects, as well as since the level of serum lipids is closely correlated with other risk factors for GSD, which significantly complicates the differentiated assessment of their contribution to the process of gallstone formation. Further studies of the contribution of lipid factors to the development of GSD are needed.
{"title":"Blood lipids in gallstone disease: associations with risk factors","authors":"I. N. Grigor’eva, D. Nepomnyashchikh","doi":"10.52727/2078-256x-2024-20-2-162-172","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-2-162-172","url":null,"abstract":" Aim of the review – to present an analysis of the literature data on the association of serum lipids with the presence of gallstone disease (GSD), as well as with the main risk factors for GSD – age, female sex, obesity, type 2 diabetes mellitus (DM2), arterial hypertension (AH) over a 50-year period. In numerous studies, hypertriglyceridemia (HTH), hypocholesterolemia of high-density lipoproteins (hypo-HDL) have been recognized as risk factors for GSD. In 1994–1995 in Novosibirsk (WHO MONICA project), in a population sample of women aged 25-64 (n = 870) and men aged 35–54 (n = 399) with sonographic diagnoses of GSD, GSD is much more common among men and women with lipid metabolism disorders: the highest frequency of GSD was noted in the 4th quartile of the distribution of total cholesterol (TC) levels (4.5 % for men and 12.4 % for women). For LDL cholesterol, the highest incidence of GSD was noted in the 5th quintile of the distribution (3.8 % in men and 10.9 % in women). When calculating by the largest χ2 method in women, the levels of TC (178 mg/dl), TG (177 mg/dl) in the blood were determined, exceeding which significantly increases the chance of GSD, for HDL cholesterol (68.5 mg/dl) the model is insignificant. There was a correlation between blood lipids and age, BMI, and DM2 in women with GSD, but not in men with GSD. The lipid profile in patients with GSD is not associated with AH. Most authors recognize GSD as a lipid-associated disease. However, the literature data are contradictory: there are opinions about a direct, inverse or absent association of blood lipids with GSD, perhaps due to differences in the design, size, and ethnicity of the subjects, as well as since the level of serum lipids is closely correlated with other risk factors for GSD, which significantly complicates the differentiated assessment of their contribution to the process of gallstone formation. Further studies of the contribution of lipid factors to the development of GSD are needed.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.52727/2078-256x-2024-20-2-136-144
O. I. Gushchina, N. G. Lozhkina, N. V. Basov, E. V. Gaisler, A. Rogachev, Y. S. Sotnikova, Yu. V. Patrushev, A. Pokrovsky
An acute coronary event in the presence of SARS-CoV-2 infection has its own characteristics that affect the course of the disease and the choice of treatment methods. Due to the lack of data on this category of patients, it is necessary to look for ways to determine the risk of adverse outcomes of this condition, including the difficulties of risk stratification. Aim: assessment of clinical and laboratory parameters and features of the clinical course in patients with ACS in combination with SARS-CoV-2 infection at the hospital stage. Construction of a prognostic model for the risk of death. Materials and methods. The study included 225 patients admitted to the regional vascular center with a diagnosis of ACS and a verified diagnosis of SARS-CoV-2 infection. Initially, 120 general clinical, biochemical and instrumental parameters were assessed. The second stage involved analysis of plasma metabolites in 73 patients. Results. A predictive model was constructed highlighting the eight most significant variables that correlate with in-hospital mortality in patients with ACS in combination with SARS-CoV-2: age, the presence of atrial fibrillation (except for that first detected in ACS), acute kidney injury, CKD above stage 2, severe and extremely severe course of SARS-CoV-2 infection, levels of ferritin, albumin and glycemia in the blood serum upon admission to the hospital. The present study identified new markers of mortality risk, such as C18 ceramide (d18:1/22:0) and ceramide (d18:1/24:0) levels. Conclusions. The proposed approach to assessing the risk of nosocomial death in acute coronary syndrome in combination with SARS-CoV-2 infection has good prognostic accuracy and is easy to use.
{"title":"Assessment of the risk of in-hospital fatality in patients with acute coronary syndrome and SARS-CoV-2 infection: challenges and prospects","authors":"O. I. Gushchina, N. G. Lozhkina, N. V. Basov, E. V. Gaisler, A. Rogachev, Y. S. Sotnikova, Yu. V. Patrushev, A. Pokrovsky","doi":"10.52727/2078-256x-2024-20-2-136-144","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-2-136-144","url":null,"abstract":" An acute coronary event in the presence of SARS-CoV-2 infection has its own characteristics that affect the course of the disease and the choice of treatment methods. Due to the lack of data on this category of patients, it is necessary to look for ways to determine the risk of adverse outcomes of this condition, including the difficulties of risk stratification. Aim: assessment of clinical and laboratory parameters and features of the clinical course in patients with ACS in combination with SARS-CoV-2 infection at the hospital stage. Construction of a prognostic model for the risk of death. Materials and methods. The study included 225 patients admitted to the regional vascular center with a diagnosis of ACS and a verified diagnosis of SARS-CoV-2 infection. Initially, 120 general clinical, biochemical and instrumental parameters were assessed. The second stage involved analysis of plasma metabolites in 73 patients. Results. A predictive model was constructed highlighting the eight most significant variables that correlate with in-hospital mortality in patients with ACS in combination with SARS-CoV-2: age, the presence of atrial fibrillation (except for that first detected in ACS), acute kidney injury, CKD above stage 2, severe and extremely severe course of SARS-CoV-2 infection, levels of ferritin, albumin and glycemia in the blood serum upon admission to the hospital. The present study identified new markers of mortality risk, such as C18 ceramide (d18:1/22:0) and ceramide (d18:1/24:0) levels. Conclusions. The proposed approach to assessing the risk of nosocomial death in acute coronary syndrome in combination with SARS-CoV-2 infection has good prognostic accuracy and is easy to use.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.52727/2078-256x-2024-20-2-154-161
V. N. Maksimov, S. V. Minnikh, A. Ivanova
Cardiovascular diseases are the leading cause of non-violent deaths in the world. Criteria for the formation of high-risk groups are necessary for primary prevention of disease development. This was the reason for research on the development of riskmeters. A brief description of the history of the creation of CHD riskmeters. The review provides a description of the current challenges in assessing individual risk for CHD. The main approaches to the creation of riskmeters have not changed significantly for several decades. The increase in the size of study groups and the number of molecular genetic markers undoubtedly give certain results. However, in order to move from the population level to the individual level, it is necessary to take into account many more factors in the assessment. That is, it is necessary to learn how to analyze the most complex set of data of one person (genome, transcriptome, proteome, and maybe even microbiome) not only with a deep understanding of the mechanisms of its functioning (from conception to death), but also possible disorders, based on the available features. And for this purpose it is necessary to rely not only and not so much on statistical data, but on maximally similar sets of individual data (first of all, relatives). It seems that similarity should be evaluated by an artificial intelligence system trained on a colossal array of individual data.
{"title":"Modern approaches to the assessment of individual risk of CHD development: status, problems, prospects","authors":"V. N. Maksimov, S. V. Minnikh, A. Ivanova","doi":"10.52727/2078-256x-2024-20-2-154-161","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-2-154-161","url":null,"abstract":" Cardiovascular diseases are the leading cause of non-violent deaths in the world. Criteria for the formation of high-risk groups are necessary for primary prevention of disease development. This was the reason for research on the development of riskmeters. A brief description of the history of the creation of CHD riskmeters. The review provides a description of the current challenges in assessing individual risk for CHD. The main approaches to the creation of riskmeters have not changed significantly for several decades. The increase in the size of study groups and the number of molecular genetic markers undoubtedly give certain results. However, in order to move from the population level to the individual level, it is necessary to take into account many more factors in the assessment. That is, it is necessary to learn how to analyze the most complex set of data of one person (genome, transcriptome, proteome, and maybe even microbiome) not only with a deep understanding of the mechanisms of its functioning (from conception to death), but also possible disorders, based on the available features. And for this purpose it is necessary to rely not only and not so much on statistical data, but on maximally similar sets of individual data (first of all, relatives). It seems that similarity should be evaluated by an artificial intelligence system trained on a colossal array of individual data.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141677861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.52727/2078-256x-2024-20-2-145-153
V. Gafarov, E. Gromova, I. Gagulin, D. Denisova, A. N. Tripelgorn, A. Gafarova
Aim of the study was to analyze the associations of vital exhaustion (VE) with smoking and physical activity among people 25–44 years old in the city of Novosibirsk. Material and methods. A study was carried out on a random representative sample of people aged 25–44 years from the database of the Territorial Compulsory Health Insurance Fund in one of the districts of Novosibirsk in 2013–2016. 975 individuals were examined, including 427 men (age 34.0 ± 0.4 years) and 548 women (age 35.0 ± 0.4 years). The response rate was 50 %. To assess the level of vital exhaustion (VE), the MOPSY scale for VE was proposed; attitudes towards smoking and physical activity were studied using the “Knowledge and attitude towards one’s health” scale, previously tested and validated for the study population in the WHO program “MONICA-psychosocial (MOPSY)”. The materials were processed in accordance with the algorithms presented by the WHO program “MONICA” and the results were obtained on the scales. Results. VE was observed in 48.6 % of participants. 58.9 % of respondents smoked (p < 0.001). Among individuals with a high level of VE (HVE), 10.5 % attempted to change smoking, but were unsuccessful (p < 0.05). Respondents were asked the question: “Do you do physical exercises at home?”, among persons with HVE of both sexes, the answer “I should have done exercises, but I don’t” prevailed in 53.2 % cases (p < 0.01). To the question: “How do you spend your leisure time?” among people with HVE, the answer “physically passive” was more common – 38 % (p < 0.001). Conclusions. Individuals with HVE have a greater dependence on smoking and a lower level of physical activity.
{"title":"Associations of vital exhaustion and behavioral risk factors for cardiovascular diseases in young people","authors":"V. Gafarov, E. Gromova, I. Gagulin, D. Denisova, A. N. Tripelgorn, A. Gafarova","doi":"10.52727/2078-256x-2024-20-2-145-153","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-2-145-153","url":null,"abstract":" Aim of the study was to analyze the associations of vital exhaustion (VE) with smoking and physical activity among people 25–44 years old in the city of Novosibirsk. Material and methods. A study was carried out on a random representative sample of people aged 25–44 years from the database of the Territorial Compulsory Health Insurance Fund in one of the districts of Novosibirsk in 2013–2016. 975 individuals were examined, including 427 men (age 34.0 ± 0.4 years) and 548 women (age 35.0 ± 0.4 years). The response rate was 50 %. To assess the level of vital exhaustion (VE), the MOPSY scale for VE was proposed; attitudes towards smoking and physical activity were studied using the “Knowledge and attitude towards one’s health” scale, previously tested and validated for the study population in the WHO program “MONICA-psychosocial (MOPSY)”. The materials were processed in accordance with the algorithms presented by the WHO program “MONICA” and the results were obtained on the scales. Results. VE was observed in 48.6 % of participants. 58.9 % of respondents smoked (p < 0.001). Among individuals with a high level of VE (HVE), 10.5 % attempted to change smoking, but were unsuccessful (p < 0.05). Respondents were asked the question: “Do you do physical exercises at home?”, among persons with HVE of both sexes, the answer “I should have done exercises, but I don’t” prevailed in 53.2 % cases (p < 0.01). To the question: “How do you spend your leisure time?” among people with HVE, the answer “physically passive” was more common – 38 % (p < 0.001). Conclusions. Individuals with HVE have a greater dependence on smoking and a lower level of physical activity.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-03DOI: 10.52727/2078-256x-2024-20-2-92-99
A. S. Vorobyov, G. I. Lifshits, E. Zelenskaya, K. Y. Nikolaev
Aim. To evaluate the associations of VEGFR2 rs2305948 polymorphism with the occurrence of cardiovascular events during long-term follow-up in patients with myocardial infarction. Material and methods. The study included 218 patients with acute infarction (MI), mean age 57.7 ± 9.9 years (M ± SD). After clinical examination and preparation, patients urgently underwent coronary angiography followed by percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). All patients underwent determination of the rs2305948 VEGFR2 allelic variant by polymerase chain reaction. The duration of long-term follow-up of these patients was 9 years (from 2015 to 2024). Results. It was determined that during long-term follow-up, patients with rs2305948 VEGFR (C/T and T/T), in contrast to patients with rs2305948 VEGFR (C/C), were more likely to experience cardiovascular death, recurrent acute coronary syndrome (ACS), recurrent revascularization and a combined end point (cardiovascular death, recurrent ACS, coronary stent/bypass thrombosis, acute ischemic cerebrovascular accident, repeated myocardial revascularization). Using multivariate analysis, it was determined that the occurrence of cardiovascular death during long-term follow-up is directly influenced by the Charlton comorbidity index (p < 0.001) and rs2305948 VEGFR2 (C/T and T/T) (p = 0.030). The onset of a combined endpoint is directly determined by the Charlton comorbidity index (p = 0.014) and rs2305948 VEGFR2 (C/T and T/T) (p = 0.034) and vice versa by subsequent outpatient treatment with high doses of statins (p < 0.001). Conclusions. The presence of rs2305948 VEGFR (C/T and T/T) in patients with MI increases the likelihood of cardiovascular death by 2.82 times and the combined endpoint by 2.10 times during long-term follow-up (9 years).
{"title":"Associations of VEGFR2 rs2305948 polymorphism with long-term prognosis of myocardial infarction","authors":"A. S. Vorobyov, G. I. Lifshits, E. Zelenskaya, K. Y. Nikolaev","doi":"10.52727/2078-256x-2024-20-2-92-99","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-2-92-99","url":null,"abstract":" Aim. To evaluate the associations of VEGFR2 rs2305948 polymorphism with the occurrence of cardiovascular events during long-term follow-up in patients with myocardial infarction. Material and methods. The study included 218 patients with acute infarction (MI), mean age 57.7 ± 9.9 years (M ± SD). After clinical examination and preparation, patients urgently underwent coronary angiography followed by percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). All patients underwent determination of the rs2305948 VEGFR2 allelic variant by polymerase chain reaction. The duration of long-term follow-up of these patients was 9 years (from 2015 to 2024). Results. It was determined that during long-term follow-up, patients with rs2305948 VEGFR (C/T and T/T), in contrast to patients with rs2305948 VEGFR (C/C), were more likely to experience cardiovascular death, recurrent acute coronary syndrome (ACS), recurrent revascularization and a combined end point (cardiovascular death, recurrent ACS, coronary stent/bypass thrombosis, acute ischemic cerebrovascular accident, repeated myocardial revascularization). Using multivariate analysis, it was determined that the occurrence of cardiovascular death during long-term follow-up is directly influenced by the Charlton comorbidity index (p < 0.001) and rs2305948 VEGFR2 (C/T and T/T) (p = 0.030). The onset of a combined endpoint is directly determined by the Charlton comorbidity index (p = 0.014) and rs2305948 VEGFR2 (C/T and T/T) (p = 0.034) and vice versa by subsequent outpatient treatment with high doses of statins (p < 0.001). Conclusions. The presence of rs2305948 VEGFR (C/T and T/T) in patients with MI increases the likelihood of cardiovascular death by 2.82 times and the combined endpoint by 2.10 times during long-term follow-up (9 years).","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141681635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-03DOI: 10.52727/2078-256x-2024-20-2-100-107
Y. Polonskaya, E. Kashtanova, E. Stakhneva, S. R. Ledovskikh, V. S. Shramko, E. V. Sadovski, D. Denisova, Yulia I. Ragino
Objective: to investigate pro- and anti-inflammatory markers and blood adipokines in young people with arterial hypertension (AH) on the background of abdominal obesity (AO). Materials and methods. 510 people were included in the study, of which 257 people with hypertension, of which 164 were with AO. In the control group (without AH) there were 253 people of comparable gender and age, with AO – 101 people. The content of adipsin, lipocalin-2, resistin, TNF-α, IL-6, IL-8, IL-10, IL-17a, IL-17e, IL-17f was determined in all blood by multiplex analysis. Statistical processing was carried out in the SPSS 13.0 program. Results. When comparing the studied parameters in the studied groups, statistically significant differences were obtained for lipocalin-2, resistin, adipsin, IL-6 and IL-17a, all these indicators were higher in the group with hypertension. There was no difference between the control and the group with hypertension in other biomarkers. There was no effect of AO on the level of the studied markers in the control group. For the main group, the difference between the subgroups with and without AO was obtained for lipocalin. Also, the systolic pressure level was significantly higher in the group with AO. Correlation analysis revealed a weak association of systolic and diastolic blood pressure with TNF-α, IL-6, adipsin, lipocalin-2, resistin and waist circumference. the association of body mass index with lipocalin-2, IL-6 and TNF-α (p < 0.01), a strong association of adipsin, lipocalin-2, resistin with TNF-α and IL-17a (p < 0.01). Conclusion. Of the markers we studied, elevated levels of adipsin, lipocalin-2, resistin, IL-6 and IL-17a can serve as potential biomarkers indicating a high probability of developing early hypertension in people under 45 years of age. Systolic and diastolic blood pressure levels also increase with an increase in waist circumference.
{"title":"Abdominal obesity and levels of inflammatory markers and adipokines in young people with hypertension","authors":"Y. Polonskaya, E. Kashtanova, E. Stakhneva, S. R. Ledovskikh, V. S. Shramko, E. V. Sadovski, D. Denisova, Yulia I. Ragino","doi":"10.52727/2078-256x-2024-20-2-100-107","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-2-100-107","url":null,"abstract":" Objective: to investigate pro- and anti-inflammatory markers and blood adipokines in young people with arterial hypertension (AH) on the background of abdominal obesity (AO). Materials and methods. 510 people were included in the study, of which 257 people with hypertension, of which 164 were with AO. In the control group (without AH) there were 253 people of comparable gender and age, with AO – 101 people. The content of adipsin, lipocalin-2, resistin, TNF-α, IL-6, IL-8, IL-10, IL-17a, IL-17e, IL-17f was determined in all blood by multiplex analysis. Statistical processing was carried out in the SPSS 13.0 program. Results. When comparing the studied parameters in the studied groups, statistically significant differences were obtained for lipocalin-2, resistin, adipsin, IL-6 and IL-17a, all these indicators were higher in the group with hypertension. There was no difference between the control and the group with hypertension in other biomarkers. There was no effect of AO on the level of the studied markers in the control group. For the main group, the difference between the subgroups with and without AO was obtained for lipocalin. Also, the systolic pressure level was significantly higher in the group with AO. Correlation analysis revealed a weak association of systolic and diastolic blood pressure with TNF-α, IL-6, adipsin, lipocalin-2, resistin and waist circumference. the association of body mass index with lipocalin-2, IL-6 and TNF-α (p < 0.01), a strong association of adipsin, lipocalin-2, resistin with TNF-α and IL-17a (p < 0.01). Conclusion. Of the markers we studied, elevated levels of adipsin, lipocalin-2, resistin, IL-6 and IL-17a can serve as potential biomarkers indicating a high probability of developing early hypertension in people under 45 years of age. Systolic and diastolic blood pressure levels also increase with an increase in waist circumference.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141681036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-03DOI: 10.52727/2078-256x-2024-20-2-108-120
T. S. Alkhimova, D. Y. Sedykh, O. Khryachkova, V. Kashtalap, O. Barbarash
Aim of the study was to investigate the effects of standard observation and its evaluation with active physician monitoring (APM) in patients with myocardial infarction (MI) under different dietary patterns. Material and methods. The prospective interventional study initially included 170 patients living in the city of Kemerovo and the Kemerovo Municipal District who were urgently hospitalized at the Kemerovo Clinical Cardiology Clinic with a diagnosis of MI. On days 3–5 of hospital stay, nutrition for the month preceding the MI was assessed using a questionnaire using the questionnaire “Semi-quantitative assessment of the frequency of food consumption by the adult population.” Using factor analysis using the method of principal components, the main nutritional stereotypes of patientswith MI were identified: protein-fat (n = 40, 23.5 %), fruit and cereal (n = 52, 30.6 %), milk-carbohydrate (n = 51, 30.0 %), mixed (n = 27, 15.9 %). Before discharge, 150 patients were randomized into groups: standard outpatient observation (n = 75) and its combination with APM (n = 75), and 20 patients were excluded due to lack of access to Telegram app or refusal to further participate in the study. APM meant telephone calls to patients (at least once a month) and the sending of medical recommendations on secondary prevention issues through the Telegram channel (2–3 times a week). After 1 year, in each of the groups of patients with MI, having different dietary patterns, the end points were compared: for all – the frequency of deaths, for the living – emergency hospitalizations for ischemic events, as well as adherence to treatment and regular outpatient monitoring, achievement of target cardiovascular parameters – vascular health (blood pressure (BP), resting heart rate (HR), low-density lipoprotein (LDL)). Results. When comparing the results of standard outpatient observation and the combination with APM within a year after MI, it was revealed that patients with a combination of standard outpatient observation and APM had 4.75 times fewer emergency hospitalizations for cardiovascular reasons (p < 0.001), a trend towards fewer the number of deaths due to cardiovascular causes (p = 0.053), and the combined end point (death + emergency cardiovascular hospitalizations) was recorded 4.8 times less frequently. In patients from the groups of standard outpatient follow-up and its combination of APM and standard outpatient follow-up for a year after MI, regardless of dietary pattern, there were no significant differences in the frequency of deaths and emergency hospitalizations for ischemic events, adherence to prognosis-improving therapy, the proportion of those achieving target blood pressure, and heart rate. However, during this observation, patients who had a fruit-cereal diet before MI were more likely to report regular outpatient visits during the year post-MI (p = 0.009), and patients with a protein-fat diet were more likely to subsequently achieve target L
{"title":"Effects of standard observation and its combination with active medical monitoring in patients with myocardial infarction with various dietary patterns","authors":"T. S. Alkhimova, D. Y. Sedykh, O. Khryachkova, V. Kashtalap, O. Barbarash","doi":"10.52727/2078-256x-2024-20-2-108-120","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-2-108-120","url":null,"abstract":" Aim of the study was to investigate the effects of standard observation and its evaluation with active physician monitoring (APM) in patients with myocardial infarction (MI) under different dietary patterns. Material and methods. The prospective interventional study initially included 170 patients living in the city of Kemerovo and the Kemerovo Municipal District who were urgently hospitalized at the Kemerovo Clinical Cardiology Clinic with a diagnosis of MI. On days 3–5 of hospital stay, nutrition for the month preceding the MI was assessed using a questionnaire using the questionnaire “Semi-quantitative assessment of the frequency of food consumption by the adult population.” Using factor analysis using the method of principal components, the main nutritional stereotypes of patientswith MI were identified: protein-fat (n = 40, 23.5 %), fruit and cereal (n = 52, 30.6 %), milk-carbohydrate (n = 51, 30.0 %), mixed (n = 27, 15.9 %). Before discharge, 150 patients were randomized into groups: standard outpatient observation (n = 75) and its combination with APM (n = 75), and 20 patients were excluded due to lack of access to Telegram app or refusal to further participate in the study. APM meant telephone calls to patients (at least once a month) and the sending of medical recommendations on secondary prevention issues through the Telegram channel (2–3 times a week). After 1 year, in each of the groups of patients with MI, having different dietary patterns, the end points were compared: for all – the frequency of deaths, for the living – emergency hospitalizations for ischemic events, as well as adherence to treatment and regular outpatient monitoring, achievement of target cardiovascular parameters – vascular health (blood pressure (BP), resting heart rate (HR), low-density lipoprotein (LDL)). Results. When comparing the results of standard outpatient observation and the combination with APM within a year after MI, it was revealed that patients with a combination of standard outpatient observation and APM had 4.75 times fewer emergency hospitalizations for cardiovascular reasons (p < 0.001), a trend towards fewer the number of deaths due to cardiovascular causes (p = 0.053), and the combined end point (death + emergency cardiovascular hospitalizations) was recorded 4.8 times less frequently. In patients from the groups of standard outpatient follow-up and its combination of APM and standard outpatient follow-up for a year after MI, regardless of dietary pattern, there were no significant differences in the frequency of deaths and emergency hospitalizations for ischemic events, adherence to prognosis-improving therapy, the proportion of those achieving target blood pressure, and heart rate. However, during this observation, patients who had a fruit-cereal diet before MI were more likely to report regular outpatient visits during the year post-MI (p = 0.009), and patients with a protein-fat diet were more likely to subsequently achieve target L","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141681545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-03DOI: 10.52727/2078-256x-2024-20-2-121-135
S. E. Semaev, L. V. Shcherbakova, P. S. Orlov, D. Ivanoshchuk, S. Malyutina, V. Gafarov, M. Voevoda, Yulia I. Ragino, E. Shakhtshneider
A relevant task for the healthcare system is to identify the groups most predisposed to cardiovascular diseases (CVD) of atherosclerotic genesis. Risk stratification is an important component of choosing a management strategy for both CVD patients and those with risk factors. The individual risk of an unfavorable cardiovascular outcome is determined by genetic factors in addition to lifestyle factors. The aim of the work was to examine the association of variants of the APOE, CETP and chromosomal region 9p21.3 with coronary heart disease (CHD), myocardial infarction (MI) and acute heart failure (ACF) in a sample of residents of Novosibirsk. Material and methods. Sample: 2516 participants of the HAPIEE project (57.5 ± 0.2 years old, male to female ratio 45:55). The choice of the variants of the APOE, CETP and the chromosomal region 9p21.3 was due to their significant association with CVD according to several studies and meta-analyses. Genotyping of rs708272, rs429358 and rs7412 was performed by Real-Time PCR using TaqMan reagents; genotyping of rs1333049 was performed using a commercial KASP kit. Results. Allele C of rs1333049 was associated with an increased risk of CHD, MI and AHF in the subgroup of men (p = 0,008) and in the general group (p = 0,002). In the general group, the incidence of CHD, MI and AHF was significantly lower in carriers of the G allele (odds ratio 0.748, 95 % confidence interval 0.606–0.924, p = 0.007). We confirmed the association of the ɛ2/ɛ4 genotype of the APOE gene with CHD, MI and AHF among males (p = 0.007) and in the whole study sample (p = 0.009). In the women subgroup the genotype ɛ2/ɛ2 (p < 0.0001) was associated with CHD, MI and AHF, while in carriers of the genotype ɛ3/ɛ3, the incidence of CHD, MI and AHF was significantly lower (odds ratio 0.675, 95 % confidence interval 0.509–0.894, p = 0,006). Conclusions. This work shows the association of rs1333049 of chromosomal region 9p21.3 and rs429358&rs7412 of the APOE gene with the risk of CHD, MI and AHF in a sample of residents of Novosibirsk. These variants may be recommended for inclusion into a genetic risk score.
{"title":"Association of variants of the APOE, CETP genes and the 9P21.3 chromosomal region with coronary heart disease, myocardial infarction and acute heart failure","authors":"S. E. Semaev, L. V. Shcherbakova, P. S. Orlov, D. Ivanoshchuk, S. Malyutina, V. Gafarov, M. Voevoda, Yulia I. Ragino, E. Shakhtshneider","doi":"10.52727/2078-256x-2024-20-2-121-135","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-2-121-135","url":null,"abstract":" A relevant task for the healthcare system is to identify the groups most predisposed to cardiovascular diseases (CVD) of atherosclerotic genesis. Risk stratification is an important component of choosing a management strategy for both CVD patients and those with risk factors. The individual risk of an unfavorable cardiovascular outcome is determined by genetic factors in addition to lifestyle factors. The aim of the work was to examine the association of variants of the APOE, CETP and chromosomal region 9p21.3 with coronary heart disease (CHD), myocardial infarction (MI) and acute heart failure (ACF) in a sample of residents of Novosibirsk. Material and methods. Sample: 2516 participants of the HAPIEE project (57.5 ± 0.2 years old, male to female ratio 45:55). The choice of the variants of the APOE, CETP and the chromosomal region 9p21.3 was due to their significant association with CVD according to several studies and meta-analyses. Genotyping of rs708272, rs429358 and rs7412 was performed by Real-Time PCR using TaqMan reagents; genotyping of rs1333049 was performed using a commercial KASP kit. Results. Allele C of rs1333049 was associated with an increased risk of CHD, MI and AHF in the subgroup of men (p = 0,008) and in the general group (p = 0,002). In the general group, the incidence of CHD, MI and AHF was significantly lower in carriers of the G allele (odds ratio 0.748, 95 % confidence interval 0.606–0.924, p = 0.007). We confirmed the association of the ɛ2/ɛ4 genotype of the APOE gene with CHD, MI and AHF among males (p = 0.007) and in the whole study sample (p = 0.009). In the women subgroup the genotype ɛ2/ɛ2 (p < 0.0001) was associated with CHD, MI and AHF, while in carriers of the genotype ɛ3/ɛ3, the incidence of CHD, MI and AHF was significantly lower (odds ratio 0.675, 95 % confidence interval 0.509–0.894, p = 0,006). Conclusions. This work shows the association of rs1333049 of chromosomal region 9p21.3 and rs429358&rs7412 of the APOE gene with the risk of CHD, MI and AHF in a sample of residents of Novosibirsk. These variants may be recommended for inclusion into a genetic risk score.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141682524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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