Pub Date : 2026-01-05DOI: 10.1016/j.ejim.2026.106701
Ming Zhuang, JiaMin Qin, Lu Li
{"title":"Environmental PM10 exposure and MASLD: Challenges in translating gene-environment interactions into routine clinical care.","authors":"Ming Zhuang, JiaMin Qin, Lu Li","doi":"10.1016/j.ejim.2026.106701","DOIUrl":"https://doi.org/10.1016/j.ejim.2026.106701","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106701"},"PeriodicalIF":6.1,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.1016/j.ejim.2025.106692
G Sinigiani, L De Michieli, A Cipriani
{"title":"Advancing beyond multimodality: integrating quantitative imaging biomarkers into the clinical workflow of cardiac amyloidosis. Author's reply.","authors":"G Sinigiani, L De Michieli, A Cipriani","doi":"10.1016/j.ejim.2025.106692","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.106692","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106692"},"PeriodicalIF":6.1,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1016/j.ejim.2025.106690
Saurabh Sujanyal, Ivan Huespe, Aayushi Pareek, Devang Sanghavi, Nick Kelly
{"title":"Survival outcomes with LUCAS-AssiSTED VS MANUal CPR in in-hospital cardiac arrest obese patients.","authors":"Saurabh Sujanyal, Ivan Huespe, Aayushi Pareek, Devang Sanghavi, Nick Kelly","doi":"10.1016/j.ejim.2025.106690","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.106690","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106690"},"PeriodicalIF":6.1,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1016/j.ejim.2025.106694
Luca Crisanti, Jonas Glaeser, Pedro Lopez-Ayala, Luca Koechlin, Paolo Bima, Emel Kaplan, Jasper Boeddinghaus, Lena C Maeder, Katharina Rentsch, Oscar Miro, Michael Christ, Javier F Martin-Sanchez, Beata Morawiec, Felix Mahfoud, Ivo Strebel, Christian Mueller
Background: Growth differentiation factor 15 (GDF-15) is a stress-induced circulating cytokine known to predict mortality in patients with established myocardial infarction (MI) and has been implicated in the development of cachexia.
Methods: This international multicenter study aimed to investigate the diagnostic and prognostic performance of GDF-15 among unselected patients presenting with acute chest pain to the emergency department (ED). GDF-15, high-sensitivity cardiac troponin T (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations were measured at ED presentation. The primary diagnostic endpoint was Non-ST-elevation MI at presentation, and the primary prognostic endpoints were all-cause death at 90 days and 5-year follow-up.
Results: Among 4779 patients, median age 61 years, 33.2% female, 856 (17.9 %) were adjudicated to have MI, 994 (20.8%) to have other cardiac conditions, and 2929 (61.3%) to have non-cardiac disorders. GDF-15 exhibited only modest diagnostic accuracy for MI (AUC 0.69). During 5 years of follow-up, 557 (12.1%) deaths occurred. GDF-15 demonstrated a very high discriminative ability for all-cause death, both at 90 days (C-index 0.86, 95% CI 0.82-0.90) and at 5 years (C-index 0.84, 95% CI 0.82-0.85). This was comparable to hs-cTnT and NT-proBNP at 90 days, and higher at 5 years. When added to a rich-for-prior-information base model incorporating age, sex, cardiovascular risk factors, creatinine, hs-cTnT and NT-proBNP, GDF-15 provided meaningful incremental prognostic discrimination for 90 days and 5-year all-cause mortality.
Conclusions: In chest pain patients presenting to the ED, GDF-15 had very high prognostic accuracy for all-cause mortality over 5 years, outperforming both hs-cTnT and NT-proBNP.
背景：生长分化因子15 （GDF-15）是一种应激诱导的循环细胞因子，已知可预测心肌梗死（MI）患者的死亡率，并与恶病质的发展有关。方法：这项国际多中心研究旨在探讨GDF-15在未选择的急诊科（ED）急性胸痛患者中的诊断和预后表现。在ED出现时测量GDF-15、高敏心肌肌钙蛋白T （hs-cTnT）和n端前b型利钠肽（NT-proBNP）浓度。主要诊断终点为首发时的非st段抬高性心肌梗死，主要预后终点为90天全因死亡和5年随访。结果：4779例患者中位年龄61岁，33.2%为女性，856例（17.9%）确诊为心肌梗死，994例（20.8%）确诊为其他心脏疾病，2929例（61.3%）确诊为非心脏疾病。GDF-15对心肌梗死的诊断准确度不高（AUC 0.69）。在5年随访期间，发生557例（12.1%）死亡。GDF-15在90天（c -指数0.86,95% CI 0.82-0.90）和5年（c -指数0.84,95% CI 0.82-0.85）对全因死亡均表现出非常高的判别能力。这与90天时的hs-cTnT和NT-proBNP相当，5年时更高。当加入到包含年龄、性别、心血管危险因素、肌酐、hs-cTnT和NT-proBNP的丰富先验信息基础模型时，GDF-15对90天和5年全因死亡率提供了有意义的增量预后区分。结论：在就诊于急诊科的胸痛患者中，GDF-15对5年内全因死亡率的预后准确性非常高，优于hs-cTnT和NT-proBNP。
{"title":"Growth differentiation factor-15 in patients presenting with acute chest pain: Diagnostic and prognostic utility.","authors":"Luca Crisanti, Jonas Glaeser, Pedro Lopez-Ayala, Luca Koechlin, Paolo Bima, Emel Kaplan, Jasper Boeddinghaus, Lena C Maeder, Katharina Rentsch, Oscar Miro, Michael Christ, Javier F Martin-Sanchez, Beata Morawiec, Felix Mahfoud, Ivo Strebel, Christian Mueller","doi":"10.1016/j.ejim.2025.106694","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.106694","url":null,"abstract":"<p><strong>Background: </strong>Growth differentiation factor 15 (GDF-15) is a stress-induced circulating cytokine known to predict mortality in patients with established myocardial infarction (MI) and has been implicated in the development of cachexia.</p><p><strong>Methods: </strong>This international multicenter study aimed to investigate the diagnostic and prognostic performance of GDF-15 among unselected patients presenting with acute chest pain to the emergency department (ED). GDF-15, high-sensitivity cardiac troponin T (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations were measured at ED presentation. The primary diagnostic endpoint was Non-ST-elevation MI at presentation, and the primary prognostic endpoints were all-cause death at 90 days and 5-year follow-up.</p><p><strong>Results: </strong>Among 4779 patients, median age 61 years, 33.2% female, 856 (17.9 %) were adjudicated to have MI, 994 (20.8%) to have other cardiac conditions, and 2929 (61.3%) to have non-cardiac disorders. GDF-15 exhibited only modest diagnostic accuracy for MI (AUC 0.69). During 5 years of follow-up, 557 (12.1%) deaths occurred. GDF-15 demonstrated a very high discriminative ability for all-cause death, both at 90 days (C-index 0.86, 95% CI 0.82-0.90) and at 5 years (C-index 0.84, 95% CI 0.82-0.85). This was comparable to hs-cTnT and NT-proBNP at 90 days, and higher at 5 years. When added to a rich-for-prior-information base model incorporating age, sex, cardiovascular risk factors, creatinine, hs-cTnT and NT-proBNP, GDF-15 provided meaningful incremental prognostic discrimination for 90 days and 5-year all-cause mortality.</p><p><strong>Conclusions: </strong>In chest pain patients presenting to the ED, GDF-15 had very high prognostic accuracy for all-cause mortality over 5 years, outperforming both hs-cTnT and NT-proBNP.</p>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106694"},"PeriodicalIF":6.1,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1016/j.ejim.2025.106693
Mauro Gori, Luca Fazzini, Renata De Maria
{"title":"Reassessing the safety signal: Dihydropyridine calcium channel blockers in the era of quadruple therapy for heart failure. Author's reply.","authors":"Mauro Gori, Luca Fazzini, Renata De Maria","doi":"10.1016/j.ejim.2025.106693","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.106693","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106693"},"PeriodicalIF":6.1,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145897059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1016/j.ejim.2025.106689
Fuli Liu, Yuanming Ba
{"title":"Methodological and generalizability considerations in the study of bleeding risk with rivaroxaban vs apixaban in older VTE patients.","authors":"Fuli Liu, Yuanming Ba","doi":"10.1016/j.ejim.2025.106689","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.106689","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106689"},"PeriodicalIF":6.1,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145897128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.ejim.2025.07.017
Ahmed B. Shamsulddin
{"title":"DOACs vs. VKAs for renal protection: An established superiority gives rise to a new clinical paradox","authors":"Ahmed B. Shamsulddin","doi":"10.1016/j.ejim.2025.07.017","DOIUrl":"10.1016/j.ejim.2025.07.017","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"143 ","pages":"Article 106421"},"PeriodicalIF":6.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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