Pub Date : 2026-01-24DOI: 10.1016/j.ejim.2026.106726
Liangjun Mou, Liangchun Pan
{"title":"Fractional exhaled nitric oxide in acute exacerbations of chronic obstructive pulmonary disease: Beyond pooled means to individual precision.","authors":"Liangjun Mou, Liangchun Pan","doi":"10.1016/j.ejim.2026.106726","DOIUrl":"https://doi.org/10.1016/j.ejim.2026.106726","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106726"},"PeriodicalIF":6.1,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-24DOI: 10.1016/j.ejim.2025.106672
D Martínez-Urbistondo, J Carretero Gómez, P Martínez-Pérez
{"title":"A hierarchized proposal to integrate steatotic liver disease in cardiometabolic care: A new mindset to evaluate MASLD in Internal medicine.","authors":"D Martínez-Urbistondo, J Carretero Gómez, P Martínez-Pérez","doi":"10.1016/j.ejim.2025.106672","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.106672","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106672"},"PeriodicalIF":6.1,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.ejim.2026.106710
Luca Bonanni
{"title":"Cerebral small vessel disease: a potential risk modifier for future guidelines on management of dyslipidaemias.","authors":"Luca Bonanni","doi":"10.1016/j.ejim.2026.106710","DOIUrl":"https://doi.org/10.1016/j.ejim.2026.106710","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106710"},"PeriodicalIF":6.1,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-19DOI: 10.1016/j.ejim.2026.106712
Karol Momot, Michal Pruc, Bartosz Maj, Lukasz Szarpak
{"title":"Epicardial adipose tissue assessment for earlier cardiovascular risk prediction: from association to clinical utility.","authors":"Karol Momot, Michal Pruc, Bartosz Maj, Lukasz Szarpak","doi":"10.1016/j.ejim.2026.106712","DOIUrl":"https://doi.org/10.1016/j.ejim.2026.106712","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106712"},"PeriodicalIF":6.1,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1016/j.ejim.2026.106708
Matilde Ribeiro-Coimbra, Maria Carolina-Carvalho, Frederico Luís-Batista, Paulo Reis-Pina
{"title":"Use of continuous morphine infusions in end-of-life care in an internal medicine ward.","authors":"Matilde Ribeiro-Coimbra, Maria Carolina-Carvalho, Frederico Luís-Batista, Paulo Reis-Pina","doi":"10.1016/j.ejim.2026.106708","DOIUrl":"https://doi.org/10.1016/j.ejim.2026.106708","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106708"},"PeriodicalIF":6.1,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1016/j.ejim.2026.106704
Gianluca Rigatelli, Giuseppe Marchese, Ervis Hiso, Andrea Bertolini, Giuseppe Sammarco, Francesca Prevedello, Francesca Caneve, Santina Da Ros, Gabriele Braggion, Marco Zuin
Background: Although patent foramen ovale (PFO) transcatheter closure lowers recurrent cryptogenic stroke (CS), identifying patients who benefit most remains challenging. We developed, validated and assessed the diagnostic performance of a new scoring system to predict high-risk PFO patients who may benefit from PFO transcatheter closure in secondary prevention.
Methods: The CRISP-PFO score was derived from 936 PFO patients with a RoPE score ≥7, enrolled in a single-center prospective registry from March 2003 to March 2025. The score was derived from 624 patients and validated in 312 patients. Significant baseline variables (p < 0.1) from univariable logistic regression were entered into a multivariable model. Model performance was assessed via receiving operating curves and calibration slope. Patients were stratified into low-, intermediate-, and high-risk groups.
Results: In the derivation cohort, multivariate analysis identified four independent predictors of CS: permanent right-to-left shunt (2 points), ischemic brain lesions (2 points), an antero-posterior left atrial (LA) diameter ≥43 mm (1 point), and atrial septal aneurysm (1 point). Based on these factors, patients were stratified into low (0-2 points), intermediate (3-4 points), and high (5-6 points) risk categories, with event rates increasing across these groups (p<0.001). The CRISP-PFO score demonstrated strong diagnostic performance, with an AUC of 0.80-0.81, C-statistics of 0.78-0.79, and Hosmer-Lemeshow p-values of 0.44-0.47 in the derivation and validation cohorts, respectively.
Conclusions: The CRISP-PFO score is a novel and straightforward tool that accurately identifies PFO patients at high risk for CS who may benefit from transcatheter PFO closure.
{"title":"Optimizing patient selection for patent foramen ovale closure after stroke: The CRISP-PFO score.","authors":"Gianluca Rigatelli, Giuseppe Marchese, Ervis Hiso, Andrea Bertolini, Giuseppe Sammarco, Francesca Prevedello, Francesca Caneve, Santina Da Ros, Gabriele Braggion, Marco Zuin","doi":"10.1016/j.ejim.2026.106704","DOIUrl":"https://doi.org/10.1016/j.ejim.2026.106704","url":null,"abstract":"<p><strong>Background: </strong>Although patent foramen ovale (PFO) transcatheter closure lowers recurrent cryptogenic stroke (CS), identifying patients who benefit most remains challenging. We developed, validated and assessed the diagnostic performance of a new scoring system to predict high-risk PFO patients who may benefit from PFO transcatheter closure in secondary prevention.</p><p><strong>Methods: </strong>The CRISP-PFO score was derived from 936 PFO patients with a RoPE score ≥7, enrolled in a single-center prospective registry from March 2003 to March 2025. The score was derived from 624 patients and validated in 312 patients. Significant baseline variables (p < 0.1) from univariable logistic regression were entered into a multivariable model. Model performance was assessed via receiving operating curves and calibration slope. Patients were stratified into low-, intermediate-, and high-risk groups.</p><p><strong>Results: </strong>In the derivation cohort, multivariate analysis identified four independent predictors of CS: permanent right-to-left shunt (2 points), ischemic brain lesions (2 points), an antero-posterior left atrial (LA) diameter ≥43 mm (1 point), and atrial septal aneurysm (1 point). Based on these factors, patients were stratified into low (0-2 points), intermediate (3-4 points), and high (5-6 points) risk categories, with event rates increasing across these groups (p<0.001). The CRISP-PFO score demonstrated strong diagnostic performance, with an AUC of 0.80-0.81, C-statistics of 0.78-0.79, and Hosmer-Lemeshow p-values of 0.44-0.47 in the derivation and validation cohorts, respectively.</p><p><strong>Conclusions: </strong>The CRISP-PFO score is a novel and straightforward tool that accurately identifies PFO patients at high risk for CS who may benefit from transcatheter PFO closure.</p>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106704"},"PeriodicalIF":6.1,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-12DOI: 10.1016/j.ejim.2026.106699
Miao Yuan
{"title":"Optimizing cardiorenal protection in HFrEF: From pharmacological mechanisms to clinical implementation.","authors":"Miao Yuan","doi":"10.1016/j.ejim.2026.106699","DOIUrl":"https://doi.org/10.1016/j.ejim.2026.106699","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106699"},"PeriodicalIF":6.1,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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