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Techniques for Theoretical Prediction of Immunogenic Peptides 免疫原肽的理论预测技术
Pub Date : 2024-03-19 DOI: 10.3390/encyclopedia4010038
Robert Friedman
Small peptides are an important component of the vertebrate immune system. They are important molecules for distinguishing proteins that originate in the host from proteins derived from a pathogenic organism, such as a virus or bacterium. Consequently, these peptides are central for the vertebrate host response to intracellular and extracellular pathogens. Computational models for prediction of these peptides have been based on a narrow sample of data with an emphasis on the position and chemical properties of the amino acids. In past literature, this approach has resulted in higher predictability than models that rely on the geometrical arrangement of atoms. However, protein structure data from experiment and theory are a source for building models at scale, and, therefore, knowledge on the role of small peptides and their immunogenicity in the vertebrate immune system. The following sections introduce procedures that contribute to theoretical prediction of peptides and their role in immunogenicity. Lastly, deep learning is discussed as it applies to immunogenetics and the acceleration of knowledge by a capability for modeling the complexity of natural phenomena.
小肽是脊椎动物免疫系统的重要组成部分。它们是区分宿主体内的蛋白质和来自病毒或细菌等病原体的蛋白质的重要分子。因此,这些肽是脊椎动物宿主应对细胞内和细胞外病原体的核心。预测这些肽的计算模型一直是基于狭窄的数据样本,重点是氨基酸的位置和化学性质。在过去的文献中,这种方法比依赖原子几何排列的模型具有更高的可预测性。然而,来自实验和理论的蛋白质结构数据是建立大规模模型的源泉,因此也是了解小肽在脊椎动物免疫系统中的作用及其免疫原性的源泉。下文将介绍有助于理论预测多肽及其免疫原性作用的程序。最后,将讨论深度学习在免疫遗传学中的应用,以及通过对复杂自然现象建模的能力来加速知识的发展。
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引用次数: 0
Climate Change Challenges in Temperate and Sub-Tropical Fruit Tree Cultivation 温带和亚热带果树栽培面临的气候变化挑战
Pub Date : 2024-03-15 DOI: 10.3390/encyclopedia4010036
P. Roussos
In the last few years, the world has experienced the impacts of climate change, such as elevated mean annual temperature, extreme weather events, drought, etc. Among living organisms, perennial plant species are the ones mostly exposed to climate change impacts, as they may experience different extreme events within the same year, such as flooding during some periods and drought in summer months, extremely low temperatures in winter but excessively high temperatures in summer, etc. Climate change affects a range of physiological functions of temperate fruit and nut tree species, such as their phenophases, bud dormancy release and vernalization, pollination and fruit set, fruit growth and quality, as well as bud sprouting and growth initiation. Besides these, the impact of climate change on pests, diseases, and weeds may generate significant negative interactions with tree physiology, threatening food production, food safety, and human welfare. In the present manuscript, a general aspect of climate change impacts on fruits’ and nut trees’ physiological functions is described and commented on.
在过去几年中,全球经历了气候变化的影响,如年平均气温升高、极端天气事件、干旱等。在生物中,多年生植物物种最容易受到气候变化的影响,因为它们可能在同一年内经历不同的极端事件,如某些时期洪水泛滥而夏季干旱、冬季气温极低而夏季气温过高等。气候变化会影响温带果树和坚果树种的一系列生理功能,如物候期、花芽休眠释放和春化、授粉和坐果、果实生长和质量,以及花芽萌发和生长启动。除此以外,气候变化对病虫害和杂草的影响可能会对树木生理产生重大负面影响,威胁粮食生产、食品安全和人类福祉。本手稿从总体上阐述了气候变化对果树和坚果树生理功能的影响,并对此进行了评论。
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引用次数: 0
The Effects of SARS-CoV-2 on the Angiopoietin/Tie Axis and the Vascular Endothelium SARS-CoV-2 对血管生成素/铁轴和血管内皮的影响
Pub Date : 2024-03-11 DOI: 10.3390/encyclopedia4010035
Dolgormaa Janchivlamdan, M. Shivkumar, Harprit Singh
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause potentially life-threatening coronavirus disease (COVID-19). COVID-19 is a multisystem disease and is associated with significant respiratory distress, systemic hyperinflammation, vasculitis, and multi-organ failure. SARS-CoV-2 causes the deterioration of numerous systems, with increasing evidence implying that COVID-19 affects the endothelium and vascular function. The endothelium is important for preserving vascular tone and homeostasis. The overactivation and dysfunction of endothelial cells are significant outcomes of severity in patients with COVID-19. The Angiopoietin 1/Tie 2 pathway plays an important role in endothelium quiescence and vessel stability. The disruption of Angiopoietin/Tie balance affects the vessel contact barrier and leads to vessel leakage, and this in turn causes endothelial dysfunction. Although vascular instability through SARS-CoV-2 is associated with endothelial dysfunction, it is still not understood if the virus affects the Angiopoietin/Tie axis directly or via other mechanisms such as cytokine storm and/or immune response associated with the infection. This review provides an overview of the impact SARS-CoV-2 has on endothelial function and more specifically on the Angiopoietin/Tie pathway.
严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)感染可导致潜在的危及生命的冠状病毒病(COVID-19)。COVID-19 是一种多系统疾病,与严重的呼吸困难、全身炎症、血管炎和多器官衰竭有关。SARS-CoV-2 导致多个系统恶化,越来越多的证据表明 COVID-19 影响内皮和血管功能。内皮对维持血管张力和平衡非常重要。内皮细胞的过度激活和功能障碍是 COVID-19 患者病情严重的重要后果。血管生成素 1/Tie 2 通路在内皮细胞静止和血管稳定性方面发挥着重要作用。血管生成素/铁平衡的破坏会影响血管接触屏障,导致血管渗漏,进而引起内皮功能障碍。虽然 SARS-CoV-2 导致的血管不稳定与内皮功能障碍有关,但目前还不清楚病毒是直接影响血管生成素/铁轴,还是通过其他机制(如细胞因子风暴和/或与感染有关的免疫反应)影响血管生成素/铁轴。本综述概述了 SARS-CoV-2 对内皮功能的影响,特别是对血管生成素/Tie 通路的影响。
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引用次数: 0
Human Resources’ Burnout 人力资源的职业倦怠
Pub Date : 2024-03-06 DOI: 10.3390/encyclopedia4010032
Olga Alexandra Chinita Pirrolas, P. Correia
The reality of the occurrence of burnout in human resources has been increasingly recognised as a result of today’s transforming and competitive society, which exerts a very high level of stress and anxiety on workers, generating a notorious problem in the field of human resource management. Problems related to symptoms of exhaustion, mental weakness, personal devaluation, inability to solve professional problems, restlessness, and eating disorders. These problems manifest themselves in terms of personality, triggering feelings of threat, panic, nervousness, or suicide. Such disorders pose a threat not only to the person but also to the quality of their professional activities. In this way, burnout syndrome can cause a mental and physical breakdown requiring complex medical assistance. In view of the above, it is imperative that organisations take preventative and corrective measures to tackle this phenomenon. This entry covers topics such as the history of the concept of burnout, the concept, its causes and consequences, and predictive methods. By approaching the aforementioned topics using the existing literature on burnout syndrome, this entry aims to demystify the subject of burnout in human resources.
由于当今社会不断变革,竞争激烈,工人们承受着巨大的压力和焦虑,人力资源管理领域出现了一个臭名昭著的问题。这些问题与精疲力竭、精神虚弱、个人贬值、无法解决职业问题、烦躁不安和饮食失调等症状有关。这些问题表现在人格方面,会引发威胁感、恐慌、紧张或自杀。这些病症不仅对个人,而且对其职业活动的质量构成威胁。因此,职业倦怠综合症会导致精神和身体崩溃,需要复杂的医疗救助。有鉴于此,各组织必须采取预防和纠正措施来应对这一现象。本条目涵盖的主题包括职业倦怠概念的历史、概念、其原因和后果以及预测方法。通过利用现有关于职业倦怠综合症的文献来探讨上述主题,本条目旨在揭开人力资源职业倦怠这一主题的神秘面纱。
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引用次数: 0
Antitumor Strategies Targeting Peptidergic Systems 针对肽能系统的抗肿瘤策略
Pub Date : 2024-03-06 DOI: 10.3390/encyclopedia4010031
Francisco D Rodríguez, Rafael Coveñas
Peptidergic systems show promise as targets for fighting tumors. While some peptides encourage the growth and spread of tumor cells and angiogenic mechanisms, others display antitumor properties. As such, peptide ligands and receptor antagonists could be used as antitumor agents alone or in conjunction with chemotherapy or radiotherapy. Peptide receptor antagonists can counteract the oncogenic effects of specific peptides by inducing apoptosis in various types of tumor cells, hindering cancer cell migration and inhibiting angiogenesis. Peptides and peptide receptor antagonists are not currently used in clinical practice as antitumor agents. Still, aprepitant, a neurokinin 1 receptor antagonist, is a promising candidate due to its ability to promote apoptosis in many cancer cells. However, to utilize aprepitant as an anticancer agent, the dosage must be increased and administered for a more extended period. Moving beyond current protocols for aprepitant’s use as an antiemetic is essential. Additionally, a common anticancer strategy with aprepitant is possible regardless of cancer cell type. Finally, combining aprepitant with chemotherapy or radiotherapy is encouraged.
肽能系统有望成为抗肿瘤的目标。一些肽能促进肿瘤细胞的生长和扩散以及血管生成机制,而另一些肽则具有抗肿瘤特性。因此,肽配体和受体拮抗剂可单独或与化疗或放疗一起用作抗肿瘤药物。肽受体拮抗剂可通过诱导各类肿瘤细胞凋亡、阻碍癌细胞迁移和抑制血管生成来抵消特定肽的致癌作用。肽和肽受体拮抗剂目前尚未作为抗肿瘤药物用于临床实践。不过,神经激肽 1 受体拮抗剂阿普瑞坦(aprepitant)由于能够促进许多癌细胞凋亡,因此是一种很有前途的候选药物。然而,要将阿普瑞坦用作抗癌药物,必须增加剂量并延长给药时间。因此,必须超越目前将阿培坦用作止吐药的方案。此外,无论癌细胞类型如何,使用阿瑞匹坦的共同抗癌策略都是可行的。最后,鼓励将阿瑞匹坦与化疗或放疗结合使用。
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引用次数: 0
The Lost Shantytowns of Barcelona 巴塞罗那失落的棚户区
Pub Date : 2024-03-03 DOI: 10.3390/encyclopedia4010030
M. Wynn
Shantytowns still existed in many of Southern Europe’s major cities in the second half of the 20th century, although many have now been demolished. The purpose of this article is to highlight the history and evolution of some of the main shantytowns that remained in Barcelona in the mid-1970s, track their subsequent demolition, and reflect on the fate of the shanty dwellers. This form of self-build housing, usually lacking in basic services, played a vital role in providing shelter for immigrant families and the urban poor. A strong neighbourhood identity existed in many of these shantytowns, and national and local policies that aimed at their demolition and the re-housing of residents, often in low-quality housing blocks, proved problematic. The shantytowns studied here are La Perona, the Tres Turons, Campo de la Bota, and Ramon Casellas, which together comprised over 2000 shanty dwellings in the 1970s. Drawing on photographs taken at the time and existing literature, and using recent images from Google Earth, the demise of these shantytowns is examined, and the policies and plans that determined their fate are discussed. This article finds that the shanty dwellers experienced mixed fortunes, some being forcibly removed and re-housed in tower blocks with associated social-economic problems, whilst others played an active part in the design of replacement housing, implemented in situ where the shanty dwellings once existed. This article contributes to existing studies on shantytowns in Barcelona, which received scant attention from academics at the time, and which only now are being recognised as an important aspect of Barcelona’s urban history.
20 世纪下半叶,南欧许多大城市仍然存在棚户区,尽管许多棚户区现已被拆除。本文旨在重点介绍 20 世纪 70 年代中期巴塞罗那仍存在的一些主要棚户区的历史和演变情况,追踪这些棚户区随后被拆除的情况,并思考棚户区居民的命运。这种形式的自建房通常缺乏基本服务,但在为移民家庭和城市贫民提供住所方面发挥了重要作用。许多棚户区存在着强烈的邻里认同感,国家和地方政策旨在拆除这些棚户区并重新安置居民(通常是安置在低质量的住宅区),但事实证明这些政策存在问题。本文研究的棚户区包括 La Perona、Tres Turons、Campo de la Bota 和 Ramon Casellas,在 20 世纪 70 年代,这些棚户区共有 2000 多座棚屋。文章根据当时拍摄的照片和现有文献,并利用谷歌地球的最新图像,对这些棚户区的消亡进行了研究,并讨论了决定其命运的政策和计划。本文发现,棚户区居民的命运好坏参半,一些人被强制搬迁,重新安置在塔楼里,并面临相关的社会经济问题,而另一些人则积极参与了替代住房的设计,并在棚户区曾经存在的地方就地实施。这篇文章对现有的关于巴塞罗那棚户区的研究有所贡献,这些棚户区在当时很少受到学术界的关注,直到现在才被认为是巴塞罗那城市历史的一个重要方面。
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引用次数: 0
Unpacking Transdisciplinary Research Scenarios in Architecture and Urbanism 解读建筑与城市规划中的跨学科研究方案
Pub Date : 2024-02-11 DOI: 10.3390/encyclopedia4010025
Ashraf M. Salama, Madhavi P. Patil
Research in architecture and urbanism is a complex undertaking. It involves a multitude of challenges, approaches, variables, diverse scales, and types of environments to examine. This entry dives into the complexities of architectural and urban research and explores the integration of diverse approaches into various research topics or domains. Recognizing the dynamic interplay of human, cultural, technological, and environmental factors in architecture and urbanism, it proposes a transdisciplinary approach to bridge existing disciplinary and methodological boundaries. This entry adopts and operationalizes a comprehensive approach that encompasses hybrid scenario development, integrated socio-spatial analysis, a revised experiential approach, and the integration of environmental psychology into architectural and urban studies. These components are envisioned to harmonize various methodologies and to depict a picture of what research in architecture and urbanism could be within an identified set of domains. This approach is grounded in a rigorous literature review, empirical evidence, and relevant validation through case studies. The application of this approach instigates a series of research scenarios which act as frameworks that provide new insights into design and practice-based research, building anatomy research, city dynamics research, housing dynamics research, and user perception studies. Each scenario demonstrates the applicability of combining theoretical insights with empirical investigations. The implications of these scenarios for architectural and urban research emphasize the significance of transdisciplinarity and highlights the importance of integrating diverse theoretical tenets and methodological insights to address the complex challenges of research in architecture and urbanism.
建筑和城市规划研究是一项复杂的工作。它涉及众多挑战、方法、变量、不同尺度以及需要研究的环境类型。本条目深入探讨了建筑和城市研究的复杂性,并探讨了将各种方法整合到不同研究课题或领域的问题。本条目认识到建筑和城市化中人类、文化、技术和环境因素的动态相互作用,提出了一种跨学科方法,以弥合现有的学科和方法论界限。该条目采用了一种综合方法并将其付诸实施,其中包括混合情景开发、综合社会空间分析、经修订的体验方法以及将环境心理学纳入建筑和城市研究。这些组成部分旨在协调各种方法论,并描绘出建筑和城市化研究在已确定的一系列领域中的前景。这种方法以严格的文献综述、经验证据和通过案例研究进行的相关验证为基础。这种方法的应用产生了一系列研究方案,这些方案作为框架,为设计和基于实践的研究、建筑解剖学研究、城市动力学研究、住房动力学研究和用户感知研究提供了新的见解。每个情景都展示了将理论见解与实证调查相结合的适用性。这些情景对建筑和城市研究的影响强调了跨学科的意义,并突出了整合不同理论信条和方法论见解的重要性,以应对建筑和城市研究的复杂挑战。
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引用次数: 0
Unpacking Transdisciplinary Research Scenarios in Architecture and Urbanism 解读建筑与城市规划中的跨学科研究方案
Pub Date : 2024-02-11 DOI: 10.3390/encyclopedia4010025
Ashraf M. Salama, Madhavi P. Patil
Research in architecture and urbanism is a complex undertaking. It involves a multitude of challenges, approaches, variables, diverse scales, and types of environments to examine. This entry dives into the complexities of architectural and urban research and explores the integration of diverse approaches into various research topics or domains. Recognizing the dynamic interplay of human, cultural, technological, and environmental factors in architecture and urbanism, it proposes a transdisciplinary approach to bridge existing disciplinary and methodological boundaries. This entry adopts and operationalizes a comprehensive approach that encompasses hybrid scenario development, integrated socio-spatial analysis, a revised experiential approach, and the integration of environmental psychology into architectural and urban studies. These components are envisioned to harmonize various methodologies and to depict a picture of what research in architecture and urbanism could be within an identified set of domains. This approach is grounded in a rigorous literature review, empirical evidence, and relevant validation through case studies. The application of this approach instigates a series of research scenarios which act as frameworks that provide new insights into design and practice-based research, building anatomy research, city dynamics research, housing dynamics research, and user perception studies. Each scenario demonstrates the applicability of combining theoretical insights with empirical investigations. The implications of these scenarios for architectural and urban research emphasize the significance of transdisciplinarity and highlights the importance of integrating diverse theoretical tenets and methodological insights to address the complex challenges of research in architecture and urbanism.
建筑和城市规划研究是一项复杂的工作。它涉及众多挑战、方法、变量、不同尺度以及需要研究的环境类型。本条目深入探讨了建筑和城市研究的复杂性,并探讨了将各种方法整合到不同研究课题或领域的问题。本条目认识到建筑和城市化中人类、文化、技术和环境因素的动态相互作用,提出了一种跨学科方法,以弥合现有的学科和方法论界限。该条目采用了一种综合方法并将其付诸实施,其中包括混合情景开发、综合社会空间分析、经修订的体验方法以及将环境心理学纳入建筑和城市研究。这些组成部分旨在协调各种方法论,并描绘出建筑和城市化研究在已确定的一系列领域中的前景。这种方法以严格的文献综述、经验证据和通过案例研究进行的相关验证为基础。这种方法的应用产生了一系列研究方案,这些方案作为框架,为设计和基于实践的研究、建筑解剖学研究、城市动力学研究、住房动力学研究和用户感知研究提供了新的见解。每个情景都展示了将理论见解与实证调查相结合的适用性。这些情景对建筑和城市研究的影响强调了跨学科的意义,并突出了整合不同理论信条和方法论见解的重要性,以应对建筑和城市研究的复杂挑战。
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引用次数: 0
Supporting the Professional and Career Development of Doctoral Students 支持博士生的专业和职业发展
Pub Date : 2024-02-09 DOI: 10.3390/encyclopedia4010024
Carol Rivas
A doctoral student is someone studying for a doctoral degree, which is generally considered to be the highest academic qualification a university can award. The student develops research experience, while making an in-depth and original contribution to knowledge. They are supervised by university staff members (usually there are two, or a small panel) who train, mentor, and support the doctoral student. Professional and career development refers to support that helps students to not only grow as individuals and independent researchers, but to also have the option to successfully pursue either academic or non-academic roles after graduation. While this entry considers some international contexts, it is particularly oriented to the United Kingdom (UK) model, and to the most common doctoral degree, the Doctor of Philosophy (PhD).
博士生是指攻读博士学位的人,博士学位通常被认为是大学所能授予的最高学术资格。学生在对知识做出深入和原创性贡献的同时,还能积累研究经验。他们接受大学教职员工(通常有两名或一个小组)的指导,这些教职员工负责培训、指导和支持博士生。专业和职业发展指的是帮助学生不仅成长为个人和独立研究人员,而且在毕业后还能选择成功地从事学术或非学术工作的支持。虽然本条目考虑了一些国际背景,但它尤其以英国(UK)模式和最常见的博士学位--哲学博士(PhD)--为导向。
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引用次数: 0
Supporting the Professional and Career Development of Doctoral Students 支持博士生的专业和职业发展
Pub Date : 2024-02-09 DOI: 10.3390/encyclopedia4010024
Carol Rivas
A doctoral student is someone studying for a doctoral degree, which is generally considered to be the highest academic qualification a university can award. The student develops research experience, while making an in-depth and original contribution to knowledge. They are supervised by university staff members (usually there are two, or a small panel) who train, mentor, and support the doctoral student. Professional and career development refers to support that helps students to not only grow as individuals and independent researchers, but to also have the option to successfully pursue either academic or non-academic roles after graduation. While this entry considers some international contexts, it is particularly oriented to the United Kingdom (UK) model, and to the most common doctoral degree, the Doctor of Philosophy (PhD).
博士生是指攻读博士学位的人,博士学位通常被认为是大学所能授予的最高学术资格。学生在对知识做出深入和原创性贡献的同时,还能积累研究经验。他们接受大学教职员工(通常有两名或一个小组)的指导,这些教职员工负责培训、指导和支持博士生。专业和职业发展指的是帮助学生不仅成长为个人和独立研究人员,而且在毕业后还能选择成功地从事学术或非学术工作的支持。虽然本条目考虑了一些国际背景,但它尤其以英国(UK)模式和最常见的博士学位--哲学博士(PhD)--为导向。
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引用次数: 0
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