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Analysis of COVID-19 epidemic with intervention impacts by a fractional operator 用分数算子分析 COVID-19 流行病的干预影响
S. Bhatter, Sangeeta Kumawat, Bhamini Bhatia, S. Purohit
This study introduces an innovative fractional methodology for analyzing the dynamics of COVID-19 outbreak, examining the impact of intervention strategies like lockdown, quarantine, and isolation on disease transmission. The analysis incorporates the Caputo fractional derivative to grasp long-term memory effects and non-local behavior in the advancement of the infection. Emphasis is placed on assessing the boundedness and non-negativity of the solutions. Additionally, the Lipschitz and Banach contraction theorem are utilized to validate the existence and uniqueness of the solution. We determine the basic reproduction number associated with the model utilizing the next generation matrix technique. Subsequently, by employing the normalized sensitivity index, we perform a sensitivity analysis of the basic reproduction number to effectively identify the controlling parameters of the model. To validate our theoretical findings, numerical simulations are conducted for various fractional order values, utilizing a two-step Lagrange interpolation technique. Furthermore, the numerical algorithms of the model are represented graphically to illustrate the effectiveness of the proposed methodology and to analyze the effect of arbitrary order derivatives on disease dynamics.
本研究引入了一种创新的分数方法来分析 COVID-19 的爆发动态,研究封锁、隔离和隔离等干预策略对疾病传播的影响。该分析结合了卡普托分式导数,以把握感染进展过程中的长期记忆效应和非局部行为。重点是评估解的有界性和非负性。此外,我们还利用 Lipschitz 和 Banach 收缩定理来验证解的存在性和唯一性。我们利用下一代矩阵技术确定了与模型相关的基本繁殖数。随后,通过使用归一化敏感性指数,我们对基本繁殖数进行了敏感性分析,从而有效地确定了模型的控制参数。为了验证我们的理论发现,我们利用两步拉格朗日插值技术对各种分数阶值进行了数值模拟。此外,该模型的数值算法以图形表示,以说明所提方法的有效性,并分析任意阶导数对疾病动力学的影响。
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引用次数: 0
The effect of a psychological scare on the dynamics of the tumor-immune interaction with optimal control strategy 心理恐慌对优化控制策略下肿瘤-免疫相互作用动态的影响
Rafel Ibrahim Salih, S. Jawad, K. Dehingia, Anusmita Das
Contracting cancer typically induces a state of terror among the individuals who are affected. Exploring how chemotherapy and anxiety work together to affect the speed at which cancer cells multiply and the immune system’s response model is necessary to come up with ways to stop the spread of cancer. This paper proposes a mathematical model to investigate the impact of psychological scare and chemotherapy on the interaction of cancer and immunity. The proposed model is accurately described. The focus of the model’s dynamic analysis is to identify the potential equilibrium locations. According to the analysis, it is possible to establish three equilibrium positions. The stability analysis reveals that all equilibrium points consistently exhibit stability under the defined conditions. The bifurcations occurring at the equilibrium sites are derived. Specifically, we obtained transcritical, pitchfork, and saddle-node bifurcation. Numerical simulations are employed to validate the theoretical study and ascertain the minimum therapy dosage necessary for eradicating cancer in the presence of psychological distress, thereby mitigating harm to patients. Fear could be a significant contributor to the spread of tumors and weakness of immune functionality.
罹患癌症通常会让患者感到恐惧。要想找到阻止癌症扩散的方法,就必须探索化疗和焦虑如何共同影响癌细胞的繁殖速度和免疫系统的反应模型。本文提出了一个数学模型来研究心理恐慌和化疗对癌症与免疫相互作用的影响。所提出的模型描述准确。模型动态分析的重点是确定潜在的平衡位置。根据分析,可以确定三个平衡位置。稳定性分析表明,在规定的条件下,所有平衡点都始终表现出稳定性。平衡点上出现的分岔也被推导出来。具体来说,我们得到了跨临界分岔、杈形分岔和鞍形节点分岔。通过数值模拟验证了理论研究,并确定了在存在心理困扰的情况下根除癌症所需的最小治疗剂量,从而减轻了对患者的伤害。恐惧可能是导致肿瘤扩散和免疫功能减弱的重要因素。
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引用次数: 0
Design optimal neural network based on new LM training algorithm for solving 3D - PDEs 基于新 LM 训练算法设计最优神经网络,用于求解 3D - PDEs
Farah F. Ghazi, L. Tawfiq
In this article, we design an optimal neural network based on new LM training algorithm. The traditional algorithm of LM required high memory, storage and computational overhead because of it required the updated of Hessian approximations in each iteration. The suggested design implemented to converts the original problem into a minimization problem using feed forward type to solve non-linear 3D - PDEs. Also, optimal design is obtained by computing the parameters of learning with highly precise. Examples are provided to portray the efficiency and applicability of this technique. Comparisons with other designs are also conducted to demonstrate the accuracy of the proposed design.
本文基于新的 LM 训练算法设计了一种最优神经网络。传统的 LM 算法每次迭代都需要更新 Hessian 近似值,因此需要大量内存、存储和计算开销。所建议的设计利用前馈类型将原始问题转换为最小化问题,以解决非线性三维多项式问题。同时,通过高精度计算学习参数,可以获得最佳设计。我们提供了一些例子来说明这项技术的效率和适用性。还与其他设计进行了比较,以证明所提设计的准确性。
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引用次数: 0
Exploring constraint qualification-free optimality conditions for linear second-order cone programming 探索线性二阶锥编程的无约束条件最优化条件
O. Kostyukova, T. Tchemisova
Linear second-order cone programming (SOCP) deals with optimization problems characterized by a linear objective function and a feasible region defined by linear equalities and second-order cone constraints. These constraints involve the norm of a linear combination of variables, enabling the representation of a wide range of convex sets. The SOCP serves as a potent tool for addressing optimization challenges across engineering, finance, machine learning, and various other domains. In this paper, we introduce new optimality conditions tailored for {SOCP} problems. These conditions have the form of two optimality criteria that are obtained without the requirement of any constraint qualifications and are defined explicitly. The first criterion utilizes the concept of immobile indices of constraints. The second criterion, without relying explicitly on immobile indices, introduces a special finite vector set for assessing optimality. To demonstrate the effectiveness of these criteria, we present two illustrative examples highlighting their applicability. We compare the obtained criteria with other known optimality conditions and show the advantage of the former ones.
线性二阶锥体程序设计(SOCP)处理的是以线性目标函数和由线性等式和二阶锥体约束条件定义的可行区域为特征的优化问题。这些约束条件涉及变量线性组合的规范,可以表示各种凸集。SOCP 是解决工程、金融、机器学习和其他各种领域优化难题的有力工具。在本文中,我们介绍了为{SOCP}问题量身定制的新优化条件。这些条件由两个最优性标准组成,无需任何约束条件即可获得,并且定义明确。第一个标准利用了约束条件不动指数的概念。第二个标准没有明确依赖不动指数,而是引入了一个特殊的有限向量集来评估最优性。为了证明这些标准的有效性,我们列举了两个示例来突出它们的适用性。我们将获得的标准与其他已知的最优性条件进行了比较,并显示了前者的优势。
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引用次数: 0
Existence and uniqueness study for partial neutral functional fractional differential equation under Caputo derivative 卡普托导数下偏中性函数分微分方程的存在性和唯一性研究
N. Sene, A. Ndiaye
The partial neutral functional fractional differential equation described by the fractional operator is considered in the present investigation. The used fractional operator is the Caputo derivative. In the present paper, the fractional resolvent operators have been defined and used to prove the existence of the unique solution of the fractional neutral differential equations. The fixed point theorem has been used in existence investigations. For an illustration of our results in this paper, an example has been provided as well.
本研究考虑的是由分数算子描述的偏中性函数分数微分方程。所使用的分数算子是 Caputo 导数。本文定义了分数解析算子,并用它来证明分数中性微分方程唯一解的存在性。存在性研究中使用了定点定理。为了说明本文的结果,还提供了一个例子。
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引用次数: 0
An accurate finite difference formula for the numerical solution of delay-dependent fractional optimal control problems 用于数值求解延迟相关分数最优控制问题的精确有限差分公式
D. Băleanu, M. Hajipour, A. Jajarmi
Time-delay fractional optimal control problems (OCPs) are an important research area for developing effective control and optimization strategies to address complex phenomena occurring in various natural sciences, such as physics, chemistry, biology, and engineering. By considering fractional OCPs with time delays, we can design control strategies that take into account the system's history and optimize its behavior over a given time horizon. However, applying the Pontryagin principle of maximization to solve these problems leads to a boundary value problem (BVP) that includes delay and advance terms, making analytical solutions difficult and demanding. To address this issue, this paper presents a precise finite difference formula to solve the aforementioned advance-delay BVP numerically. The suggested approximate method's error analysis and convergence properties are provided, and several illustrative examples demonstrate the applicability, validity, and accuracy of the proposed approach. Simulation results confirm the proposed technique's advantages for the optimal control of delay fractional dynamical equations.
时延分数最优控制问题(OCPs)是一个重要的研究领域,用于开发有效的控制和优化策略,以解决物理学、化学、生物学和工程学等各种自然科学中出现的复杂现象。通过考虑带有时间延迟的分数 OCP,我们可以设计出考虑到系统历史的控制策略,并优化其在给定时间范围内的行为。然而,应用庞特里亚金(Pontryagin)最大化原理来解决这些问题会导致边界值问题(BVP),其中包括延迟和提前项,从而使分析求解变得困难和苛刻。为解决这一问题,本文提出了一种精确的有限差分公式,用于数值求解上述提前-延迟 BVP。本文提供了所建议近似方法的误差分析和收敛特性,并通过几个示例证明了所建议方法的适用性、有效性和准确性。仿真结果证实了所提技术在延迟分式动力方程优化控制方面的优势。
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引用次数: 0
Further refinements and inequalities of Fejer's type via GA-convexity 通过 GA-convexity 进一步完善费耶类型的不等式
Muhammad Amer Latif, H. Budak, A. Kashuri
In this study, we introduce some new mappings in connection with Hermite-Hadamard and Fejer type integral inequalities which have been proved using the GA-convex functions. As a consequence, we obtain certain new inequalities of the Fejer type that provide refinements of the Hermite-Hadamard and Fejer type integral inequalities that have already been obtained.
在本研究中,我们引入了一些与赫尔米特-哈达马德和费耶型积分不等式相关的新映射,这些不等式已利用 GA 凸函数证明。因此,我们得到了某些新的 Fejer 型不等式,这些不等式是对已得到的 Hermite-Hadamard 和 Fejer 型积分不等式的完善。
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引用次数: 0
Intuitionistic fuzzy eigenvalue problem 直觉模糊特征值问题
Tahir Ceylan
The purpose of this paper is the study of the eigenvalues of the second order fuzzy boundary value problem (FBVP). By using the (alpha-beta)-level set of intuitionistic fuzzy numbers and Zadeh's extension principle, the FBVP is solved with the proposed method. Furthermore, a numerical example is illustrated and the advantages of the proposed approach are compared with other well-known methods such as the solutions based on the generalized Hukuhara derivative.
本文旨在研究二阶模糊边界值问题(FBVP)的特征值。通过使用直觉模糊数的(alpha-beta)级集和 Zadeh 的扩展原理,本文提出了解决二阶模糊边界值问题的方法。此外,还举例说明了一个数值实例,并将所提方法的优势与其他著名方法(如基于广义赫原导数的求解方法)进行了比较。
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引用次数: 0
Artificial bee colony algorithm for operating room scheduling problem with dedicated/flexible resources and cooperative operations 具有专用/灵活资源和合作操作的手术室调度问题的人工蜂群算法
G. Bektur, Hatice Kübra Aslan
In this study operating room scheduling (ORS) problem is addressed in multi-resource manner. In the addressed problem, besides operating rooms (ORs) and surgeons, the anesthesia team is also considered as an additional resource. The surgeon(s) who will perform the operation have already been assigned to the patients and is a dedicated resource. The assignment of the anesthesia team has been considered as a decision problem and a flexible resource. In this study, cooperative operations are also considered. A mixed integer linear programming (MILP) model is proposed for the problem. Since the problem is NP-hard, an artificial bee colony (ABC) algorithm is proposed for the problem. The solutions of the ABC are compared with the MILP model and random search.
本研究以多资源方式解决手术室调度(ORS)问题。在该问题中,除了手术室和外科医生,麻醉团队也被视为额外资源。将实施手术的外科医生已经分配给病人,是一种专用资源。麻醉团队的分配被视为一个决策问题和一种灵活的资源。本研究还考虑了合作操作。针对该问题提出了一个混合整数线性规划(MILP)模型。由于该问题具有 NP 难度,因此提出了一种人工蜂群(ABC)算法。将 ABC 算法的解与 MILP 模型和随机搜索进行了比较。
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引用次数: 0
Fractional model for blood flow under MHD influence in porous and non-porous media 多孔和无孔介质中受 MHD 影响的血流分数模型
Fatma Ayaz, Kubra Heredag
In this research, the Magnetohydrodynamic flow model within a porous vessel containing blood was examined. What makes this study intriguing is the inclusion of a fractional-order derivative term in the Magnetohydrodynamic flow system equations. Fractional derivatives were chosen for their ability to encompass both integer and fractional-order derivatives, leading to more realistic modeling results. The numerical solution for the partial differential equation system was obtained using the finite differences method. Solutions were derived using both central difference and backward difference approaches to enhance the reliability of the results. The Grünwald-Letnikov derivative approach was employed for the fractional derivative term, while the Crank-Nicolson method was applied for other terms. Solutions were obtained for velocity, temperature, and concentration profiles. Subsequently, a thorough analysis was conducted to investigate variations in these solutions for changing values of significant flow parameters such as Hartmann number, Grashof number, solute Grashof number, a small positive constant, radiation parameter, Prandtl number, and Schmidt number. Additionally, the study analyzed changes in the fractional derivative order. Finally, the impact of flow parameters on flow in a non-porous medium was investigated, and the results were presented graphically. The study highlighted the significant effects of various parameters on blood flow.
本研究对含有血液的多孔容器内的磁流体流动模型进行了研究。这项研究之所以引人入胜,是因为在磁流体动力学流动系统方程中加入了分数阶导数项。之所以选择分数导数,是因为分数导数能够同时包含整数阶导数和分数阶导数,从而获得更真实的建模结果。偏微分方程系统的数值解是通过有限差分法获得的。为了提高结果的可靠性,采用了中心差分法和后向差分法求解。对分数导数项采用了 Grünwald-Letnikov 导数法,而对其他项则采用了 Crank-Nicolson 法。获得了速度、温度和浓度曲线的解决方案。随后,研究人员进行了深入分析,以研究在哈特曼数、格拉肖夫数、溶质格拉肖夫数、小正常数、辐射参数、普朗特数和施密特数等重要流动参数值发生变化时,这些解的变化情况。此外,研究还分析了分数导数阶次的变化。最后,研究了流动参数对无孔介质中流动的影响,并以图表形式展示了结果。研究强调了各种参数对血流的重要影响。
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引用次数: 0
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An International Journal of Optimization and Control: Theories & Applications (IJOCTA)
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