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SQUID-Based Magnetic Resonance Imaging at Ultra-Low Field Using the Backprojection Method 基于squid的超低场反投影成像技术
IF 0.9 4区 医学 Q3 Chemistry Pub Date : 2020-10-22 DOI: 10.1155/2020/8882329
Qingqian Guo, Chang-yu Ma, Xin Zhang, Yajie Xu, Meisheng Fan, P. Yu, Tao Hu, Yan Chang, Xiao-dong Yang
Ultra-low field magnetic resonance imaging (ULF MRI) is an effective imaging technique that applies the ultrasensitive detector of superconducting quantum interference device (SQUID) sensor to detect the MR signal at a microtesla field range. In this work, we designed and developed a SQUID-based ULF MRI system with a frequency-adjustable measurement field, the performance of which was characterized via water phantoms. In order to enhance the MR signals, a 500 mT Halbach magnet was used to prepolarize the magnetization of the sample prior to excitation. The signal-to-noise-ratio (SNR) of the spin-echo- (SE-) based pulse sequence can reach up to 70 in a single scan. The images were then reconstructed successfully by using the maximum likelihood expectation maximization (MLEM) algorithm based on the backprojection imaging method. It was demonstrated that an in-plane resolution of 1.8 × 1.8 mm2 can be achieved which indicated the feasibility of SQUID-based MRI at the ULF.
超低场磁共振成像(ULF MRI)是利用超导量子干涉器件(SQUID)传感器的超灵敏探测器在微特斯拉场范围内探测磁振信号的一种有效成像技术。在这项工作中,我们设计并开发了一个基于squid的ULF MRI系统,该系统具有频率可调的测量场,并通过水影来表征其性能。为了增强磁共振信号,在激发前使用500 mT哈尔巴赫磁体对样品进行预极化磁化。基于自旋回波(SE)的脉冲序列单次扫描的信噪比(SNR)可达70。利用基于反向投影成像方法的最大似然期望最大化(MLEM)算法成功地重建了图像。实验结果表明,基于squid的超光速核磁共振成像可达到1.8 × 1.8 mm2的面内分辨率。
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引用次数: 1
Capacitive versus Overlap Decoupling of Adjacent Radio Frequency Phased Array Coil Elements: An Imaging Robustness Comparison When Sample Load Varies for 3 Tesla MRI. 相邻射频相控阵线圈元件的电容去耦与重叠去耦:3 特斯拉核磁共振成像中样本负载变化时的成像稳健性比较。
IF 0.9 4区 医学 Q3 Chemistry Pub Date : 2020-01-01 Epub Date: 2020-12-15 DOI: 10.1155/2020/8828047
Michael J Beck, Dennis L Parker, J Rock Hadley

Phased array (PA) receive coils are built such that coil elements approximate independent antenna behavior. One method of achieving this goal is to use an available decoupling method to decouple adjacent coil elements. The purpose of this work was to compare the relative performance of two decoupling methods as a function of variation in sample load. Two PA receive coils with 5 channels (5-ch) each, equal outer dimensions, and formed on 12 cm diameter cylindrical phantoms of conductivities 0.3, 0.6, and 0.9 S/m were evaluated for relative signal-to-noise ratio (SNR) and parallel imaging performance. They were only tuned and matched to the 0.6 S/m phantom. Simulated and measured axial, sagittal, and coronal 5-ch PA coil SNR ratios were compared by dividing the overlap by the capacitive decoupled coil SNR results. Issues related to the selection of capacitor values for the two decoupling methods were evaluated by taking the ratio of the match and tune capacitors for large and small 2 channel (2-ch) PA coils. The SNR ratios showed that the SNR of the two decoupling methods were very similar. The inverse geometry-factor maps showed similar but better overall parallel imaging performance for the capacitive decoupled method. The quotients for the 2-ch PA coils' maximum and minimum capacitor value ratios are 3.28 and 1.38 for the large and 3.28 and 2.22 for the small PA. The results of this paper demonstrate that as the sample load varies, the capacitive and overlap decoupling methods are very similar in relative SNR and this similarity continues for parallel imaging performance. Although, for the 5-ch coils studied, the capacitive decoupling method has a slight SNR and parallel imaging advantage and it was noted that the capacitive decoupled coil is more likely to encounter unbuildable PA coil configurations.

相控阵(PA)接收线圈的构造使线圈元件近似于独立的天线行为。实现这一目标的方法之一是使用现有的去耦方法对相邻线圈元件进行去耦。这项工作的目的是比较两种去耦方法的相对性能与样本负载变化的函数关系。两个功率放大器接收线圈各有 5 个通道(5-ch),外部尺寸相等,形成于直径为 12 厘米、电导率分别为 0.3、0.6 和 0.9 S/m 的圆柱形模型上,对它们的相对信噪比(SNR)和平行成像性能进行了评估。它们只与 0.6 S/m 的模型进行了调整和匹配。通过将重叠部分除以电容去耦线圈信噪比结果,比较了模拟和测量的轴向、矢状和冠状 5 通道 PA 线圈信噪比。通过计算大型和小型双通道(2-ch)PA 线圈的匹配电容和调整电容的比率,评估了与两种去耦方法的电容值选择有关的问题。信噪比显示,两种去耦方法的信噪比非常接近。反几何系数图显示,电容去耦方法的整体并行成像性能相似但更好。双通道功率放大器线圈的最大和最小电容值比商数分别为:大型功率放大器为 3.28 和 1.38,小型功率放大器为 3.28 和 2.22。本文的结果表明,随着样本负载的变化,电容式去耦方法和重叠式去耦方法的相对信噪比非常相似,这种相似性在并行成像性能方面继续保持。不过,对于所研究的 5 通道线圈,电容去耦方法在信噪比和并行成像方面略胜一筹,而且人们注意到,电容去耦线圈更有可能遇到无法构建的功率放大器线圈配置。
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引用次数: 0
The "Loopole" Antenna: A Hybrid Coil Combining Loop and Electric Dipole Properties for Ultra-High-Field MRI. Loopole" 天线:用于超高场磁共振成像的环形和电偶极子特性相结合的混合线圈
IF 0.9 4区 医学 Q3 Chemistry Pub Date : 2020-01-01 Epub Date: 2020-09-07 DOI: 10.1155/2020/8886543
Karthik Lakshmanan, Martijn Cloos, Ryan Brown, Riccardo Lattanzi, Daniel K Sodickson, Graham C Wiggins

Purpose: To revisit the "loopole," an unusual coil topology whose unbalanced current distribution captures both loop and electric dipole properties, which can be advantageous in ultra-high-field MRI.

Methods: Loopole coils were built by deliberately breaking the capacitor symmetry of traditional loop coils. The corresponding current distribution, transmit efficiency, and signal-to-noise ratio (SNR) were evaluated in simulation and experiments in comparison to those of loops and electric dipoles at 7 T (297 MHz).

Results: The loopole coil exhibited a hybrid current pattern, comprising features of both loops and electric dipole current patterns. Depending on the orientation relative to B0, the loopole demonstrated significant performance boost in either the transmit efficiency or SNR at the center of a dielectric sample when compared to a traditional loop. Modest improvements were observed when compared to an electric dipole.

Conclusion: The loopole can achieve high performance by supporting both divergence-free and curl-free current patterns, which are both significant contributors to the ultimate intrinsic performance at ultra-high field. While electric dipoles exhibit similar hybrid properties, loopoles maintain the engineering advantages of loops, such as geometric decoupling and reduced resonance frequency dependence on sample loading.

目的:重新审视 "环极 "这种不寻常的线圈拓扑结构,它的不平衡电流分布同时具有环极和电偶极子特性,在超高场磁共振成像中具有优势:方法:故意打破传统环形线圈的电容对称性,从而制造出环形线圈。结果:环极线圈在 7 T (297 MHz) 下表现出混合电流分布、传输效率和信噪比(SNR):环极线圈表现出一种混合电流模式,同时具有环极和电偶极子电流模式的特征。与传统环形线圈相比,环形线圈在介质样本中心的发射效率或信噪比都有显著提高,具体取决于相对于 B0 的方向。与电偶极子相比,其性能略有提高:环极可通过支持无发散和无卷曲电流模式实现高性能,这两种模式对超高场的最终内在性能都有重要贡献。虽然电偶极表现出类似的混合特性,但环极保持了环极的工程优势,如几何解耦和降低共振频率对样品负载的依赖性。
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引用次数: 0
Thermal Effects Associated with RF Exposures in Diagnostic MRI: Overview of Existing and Emerging Concepts of Protection 诊断性MRI中与射频暴露相关的热效应:现有和新出现的保护概念概述
IF 0.9 4区 医学 Q3 Chemistry Pub Date : 2019-06-17 DOI: 10.1155/2019/9618680
J. S. van den Brink
Apart from magnetic attraction risks, the primary biophysical concern associated with MRI is radiofrequency heating of the human body and associated discomfort, health deterioration, or potential burns. This paper reviews experimental data and numerical modeling of systemic (core and brain) temperature and local thermal effects associated with diagnostic MRI exposures at 1.5T (64 MHz) and 3.0T (128 MHz). Allowable temperatures and duration of systemic exposure are established based on knowledge of (short-term) human thermobiology. Longer term effects related to DNA damage or altered cellular pathways are not covered in this review. Updated limits are proposed for core temperature increase (≤1.3°C) and for Specific Absorption (<4 kJ/kg). The potential use of thermal dose (CEM43) for local thermal protection is described, and previously proposed exposure limit values are evaluated against available data from current MRI practice. Gaps in knowledge are identified, and recommendations for additional research are provided.
除了磁吸引风险外,与MRI相关的主要生物物理问题是人体的射频加热以及相关的不适、健康恶化或潜在烧伤。本文回顾了1.5T (64 MHz)和3.0T (128 MHz) MRI诊断暴露相关的系统(核心和大脑)温度和局部热效应的实验数据和数值模拟。系统暴露的允许温度和持续时间是根据(短期)人体热生物学知识建立的。与DNA损伤或细胞通路改变有关的长期影响未在本综述中涉及。提出了核心温度升高(≤1.3°C)和比吸收(<4 kJ/kg)的更新限值。描述了热剂量(CEM43)用于局部热防护的潜在用途,并根据当前MRI实践的可用数据评估了先前提出的暴露极限值。指出了知识上的差距,并提出了进一步研究的建议。
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引用次数: 18
Inherent Geometry Correction for Diffusion EPI Using the Reference Echoes as Navigators 利用参考回波作导航的扩散EPI的固有几何校正
IF 0.9 4区 医学 Q3 Chemistry Pub Date : 2019-05-26 DOI: 10.1155/2019/4139726
J. S. van den Brink, J. Koonen
Diffusion-weighted EPI has become an indispensable tool in body MRI. Geometric distortions due to field inhomogeneities are more prominent at large field–of–view and require correction for comparison with T2W TSE. Several known correction methods require acquisition of additional lengthy scans, which are difficult to apply in body imaging. We implement and evaluate a geometry correction method based on the already available non phase-encoded EPI reference data used for Nyquist ghost removal. The method is shown to provide accurate and robust global geometry correction in the absence of strong, local phase offsets. It does not require additional time for calibrations and is directly compatible with parallel imaging methods. The resulting images can serve as improved starting point for additional geometry correction methods relying on feature extraction and registration.
扩散加权EPI已成为人体MRI中不可缺少的工具。由于视场不均匀性造成的几何畸变在大视场中更为突出,需要与T2W TSE进行校正。一些已知的校正方法需要额外的长时间扫描,这很难应用于身体成像。我们实现并评估了一种几何校正方法,该方法基于已经可用的用于Nyquist鬼影去除的非相位编码EPI参考数据。在没有强的局部相位偏移的情况下,该方法可以提供精确和鲁棒的全局几何校正。它不需要额外的校准时间,并与平行成像方法直接兼容。所得到的图像可以作为依赖于特征提取和配准的其他几何校正方法的改进起点。
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引用次数: 0
Multi-channel helical-antenna inner-volume RF coils for ultra-high field MR scanners 用于超高场磁共振扫描仪的多通道螺旋天线内容积射频线圈
IF 0.9 4区 医学 Q3 Chemistry Pub Date : 2019-02-07 DOI: 10.1002/cmr.b.21405
Pranav S. Athalye, Milan M. Ilić, Pierre-Francois van de Moortele, Andrew J. M. Kiruluta, Branislav M. Notaroš

RF coil design for human ultra-high field (7 T and higher) magnetic resonance (MR) imaging is an area of intense development, to overcome difficult challenges such as RF excitation spatial heterogeneity and low RF transfer efficiency into the spin system. This article proposes a novel category of multi-channel RF volume coil structures at both 7 T and 10.5 T based on a subject-loaded multifilar helical-antenna RF coil that aims at addressing these problems. In some prior applications of helix antennas as MR RF coils at 7 T, the imaged sample was positioned outside the helix. Here, we introduce a radically different approach, with the inner volume of a helix antenna being utilized to image a sample. The new coil uniquely combines traveling-wave behavior through the overall antenna wire structure and near-field RF interaction between the conducting elements and the imaged tissues. It thus benefits from the congruence of far- and near-field regimes. Design and analysis of the novel inner-volume coils are performed by numerical simulations using multiple computational electromagnetics techniques. The fabricated coil prototypes are tested, validated, and evaluated experimentally in 7-T and 10.5-T MR human wide bore (90-cm) MR scanners. Phantom data at 7 T show good consistency between numerical simulations and experimental results. Simulated B1+ transmit efficiencies, in T/√W, are comparable to those of some of the conventional and state-of-the-art RF coil designs at 7 T. Experimental results at 10.5 T show the scalability of the helix coil design.

用于人体超高场(7 T及以上)磁共振(MR)成像的射频线圈设计是一个激烈发展的领域,以克服诸如射频激发空间异质性和低射频传输效率到自旋系统等难题。本文提出了一种新型的7 T和10.5 T的多通道射频体积线圈结构,基于主体负载的多丝状螺旋天线射频线圈,旨在解决这些问题。在先前的一些应用中,螺旋天线作为7 T的MR RF线圈,成像样品位于螺旋外。在这里,我们介绍了一种完全不同的方法,利用螺旋天线的内部体积对样本进行成像。新型线圈独特地结合了通过整体天线导线结构的行波行为和导电元件与成像组织之间的近场射频相互作用。因此,它受益于远场和近场状态的一致性。采用多种计算电磁学技术对新型内容积线圈进行了数值模拟设计和分析。制造的线圈原型在7-T和10.5-T MR人体宽孔(90厘米)MR扫描仪上进行了实验测试、验证和评估。7t时的模拟数据与实验结果吻合较好。模拟的B1+传输效率,在T/√W下,与一些传统的和最先进的射频线圈设计在7 T下的效率相当,在10.5 T下的实验结果显示了螺旋线圈设计的可扩展性。
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引用次数: 3
OpenForce MR: A low-cost open-source MR-compatible force sensor OpenForce MR:一种低成本的开源MR兼容力传感器
IF 0.9 4区 医学 Q3 Chemistry Pub Date : 2019-02-03 DOI: 10.1002/cmr.b.21404
Francesco Santini, Oliver Bieri, Xeni Deligianni

Measuring the force exerted by muscles during dynamic MR acquisition (either imaging or spectroscopy) provides important information for the standardization of the exercise performed in the scanner and is therefore important for reproducible results in musculoskeletal imaging. However, existing commercial solutions for such measurements are often very expensive and impractical. In this work, a novel, open-source, versatile force sensor made of non-magnetic, off-the-shelf components is presented. The sensor is based on four aluminum Wheatstone bridge load cells enclosed in a custom-built aluminum frame. These cells are connected to an Arduino microcontroller for data acquisition and serial communication with a host computer, on which a dedicated program visualizes and logs the recorded force in real time. All components were chosen to be compatible with the MR environment, commercially available, and low cost. The sensor was calibrated with a commercial dynamometer and subsequently tested in multiple MR acquisition scenarios (static morphological imaging, cine imaging during contraction, velocity-encoded imaging). The sensor correctly recorded data during all tested sequences, without cross-interference between the MR and the force acquisitions. Minor susceptibility artifacts are visible in the immediate vicinity of the sensor, but they did not impair the evaluation of the muscle of interest. In conclusion, the development of a low-cost, MR-compatible force sensor is feasible, and its usage does not interfere with MR acquisition. The full specifications of the sensor, including hardware design, firmware and host software are publicly released as open-source for the potential benefit of the whole community.

在动态MR采集(成像或光谱)过程中测量肌肉施加的力为扫描仪中执行的运动的标准化提供了重要信息,因此对于肌肉骨骼成像的可重复性结果非常重要。然而,这种测量的现有商业解决方案通常非常昂贵且不切实际。在这项工作中,提出了一种新的、开源的、通用的力传感器,由非磁性、现成的组件制成。该传感器是基于四个铝制惠斯通桥式称重传感器封闭在一个定制的铝制框架。这些单元连接到Arduino微控制器进行数据采集,并与主机进行串行通信,在主机上专用程序实时可视化并记录记录的力。所有组件都选择了与MR环境兼容、可商用且成本低的组件。该传感器使用商用测力计进行校准,随后在多种磁共振采集场景(静态形态学成像、收缩期间的电影成像、速度编码成像)中进行测试。传感器在所有测试序列中正确记录数据,在MR和力获取之间没有交叉干扰。在传感器附近可以看到轻微的敏感性伪影,但它们不会损害感兴趣肌肉的评估。总之,开发一种低成本、与磁共振兼容的力传感器是可行的,而且它的使用不会干扰磁共振采集。为了整个社区的潜在利益,传感器的完整规格,包括硬件设计、固件和主机软件都作为开源公开发布。
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引用次数: 4
Traveling-wave meets standing-wave: A simulation study using pair-of-transverse-dipole-ring coils for adjustable longitudinal coverage in ultra-high field MRI 行波与驻波相遇:利用横向偶极环线圈在超高场MRI中可调纵向覆盖的模拟研究
IF 0.9 4区 医学 Q3 Chemistry Pub Date : 2019-01-08 DOI: 10.1002/cmr.b.21402
Xinqiang Yan, John C. Gore, William A. Grissom

At ultrahigh fields (B0 ≥ 7T), it is challenging to cover a large field of view using single-row conventional RF coils (standing wave resonators) due to the limited physical dimensions. In contrast, traveling wave approaches can excite large fields of view even using a relatively simple hardware setup, but suffer from poor efficiency and high local specific absorption rate in non-imaged regions. In this study, we propose and numerically analyze a new coil which combines the concept of traveling wave and standing wave. The new coil consists of a pair of transverse dipole rings (PTDR) whose separation is adjusted according to the desired imaging coverage. The PTDR coil was validated using electromagnetic simulations in phantoms and human leg models, which showed that coverage can be as long as 60 cm. When the coverage of the PTDR coil was shortened to 20 cm to cover the knees only, it's transmit and specific absorption rate efficiencies were 84% and 37% higher than those of the 50 cm coverage, respectively.

在超高场(B0≥7T)下,由于物理尺寸有限,使用单排传统RF线圈(驻波谐振器)覆盖大视场是具有挑战性的。相比之下,行波方法即使使用相对简单的硬件设置也可以激发大视场,但在非成像区域效率低,局部比吸收率高。本文提出了一种结合行波和驻波概念的新型线圈,并对其进行了数值分析。新线圈由一对横向偶极环(PTDR)组成,其分离可根据所需的成像覆盖范围进行调整。PTDR线圈在人体模型和人体腿部模型上进行了电磁模拟,结果表明其覆盖范围可达60厘米。当PTDR线圈的覆盖面积缩短至20 cm仅覆盖膝盖时,其透射率和比吸收率效率分别比覆盖面积为50 cm时高84%和37%。
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引用次数: 5
Coupled actuators with a mechanically synchronized phase during MR elastography: A phantom feasibility study 磁流变弹性成像过程中具有机械同步相位的耦合致动器:一项幻影可行性研究
IF 0.9 4区 医学 Q3 Chemistry Pub Date : 2019-01-02 DOI: 10.1002/cmr.b.21403
Wiebke Neumann, Vanessa R. Lehnart, Yannik Vetter, Andreas Bichert, Lothar R. Schad, Frank G. Zöllner

Introduction

Magnetic resonance elastography (MRE) is an MR imaging method for the quantification of spatial stiffness of soft tissues using mechanically induced dynamic shear waves. In some applications, the penetration of shear waves can be limited through attenuation and shadowing of the waves. In order to increase the actuator performance, we present a dual driver approach to compensate for shear wave attenuation and to achieve better coverage over the entire region of interest.

Materials and Methods

(a) We designed pneumatic turbines that created a sinusoidal centrifugal force due to an eccentric weight. Two turbines were connected in-phase with each eccentric weight having the same angular position relative to its pivot point. (b) We developed a tissue elasticity mimicking abdominal phantom. (c) The phantom served as a test object to investigate the feasibility to generate shear waves at two surface origins with the dual actuator system and to compare it against a single actuation setup.

Results and Discussion

A stable phase relationship of the shear waves generated by the turbines was achieved as the positions of the eccentric weights were mechanically fixed. The abdominal phantom yielded sufficient MR signal. Liver and rib cage were clearly visible in MR imaging. The shear waves generated by the dual turbine propagated through the region of interest. Our turbine design is reproducible through 3D printing and can be integrated into existing clinical equipment for 1.5 T and 3 T scanners.

磁共振弹性成像(MRE)是一种利用机械诱导的动态剪切波来量化软组织空间刚度的磁共振成像方法。在某些应用中,横波的穿透可以通过波的衰减和阴影来限制。为了提高致动器的性能,我们提出了一种双驱动器方法来补偿横波衰减,并在整个感兴趣的区域实现更好的覆盖。材料和方法(a)我们设计了气动涡轮机,由于偏心重量而产生正弦离心力。两台涡轮机相连接,每个偏心重量相对于其枢轴点具有相同的角位置。(b)我们开发了一种模拟腹部幻像的组织弹性。(c)幻影作为测试对象,研究双驱动系统在两个表面原点产生剪切波的可行性,并将其与单驱动装置进行比较。结果与讨论通过机械固定偏心砝码的位置,得到了水轮机产生的剪切波的稳定相位关系。腹部幻像产生足够的MR信号。肝脏和胸腔在磁共振成像中清晰可见。双涡轮产生的剪切波通过感兴趣的区域传播。我们的涡轮设计可通过3D打印重现,并可集成到现有的1.5 T和3t扫描仪的临床设备中。
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引用次数: 3
NMR Concepts 核磁共振的概念
IF 0.9 4区 医学 Q3 Chemistry Pub Date : 2018-10-03 DOI: 10.1002/cmr.b.21390
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引用次数: 0
期刊
Concepts in Magnetic Resonance Part B-Magnetic Resonance Engineering
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