Pub Date : 2024-07-15DOI: 10.3389/fpsyt.2024.1403718
Ronja Rutschmann, Nina Romanczuk-Seiferth, Andrew Gloster, Christoph Richter
Increasing psychological flexibility is considered an important mechanism of change in psychotherapy across diagnoses. In particular, Acceptance and Commitment Therapy (ACT) primarily aims at increasing psychological flexibility in order to live a more fulfilling and meaningful life. The purpose of this study is to examine 1) how psychological flexibility changes during an ACT-based treatment in a transdiagnostic day hospital and 2) how this change is related to changes in symptomatology, quality of life, and general level of functioning.90 patients of a psychiatric day hospital participated in the study. Psychological flexibility, symptomatology, and quality of life were assessed at three measurement time points (admission, discharge, and 3-month follow-up). The level of functioning was assessed at admission and discharge. Differences in psychological flexibility were tested via two-sided paired samples t-tests. Correlations of residualized change scores were calculated to detect associations between changes in psychological flexibility and other outcomes.Psychological flexibility increased significantly from pre-treatment to post-treatment (d = .43, p <.001) and from pre-treatment to follow-up (d = .54, p <.001). This change was significantly correlated to a decrease in symptomatology (r = .60 –.83, p <.001) and an increase in most dimensions of quality of life (r = -.43 – -.75, p <.001) and general level of functioning (r =-.34, p = .003).This study adds further evidence for psychological flexibility as a transdiagnostic process variable of successful psychotherapy. Limitations are discussed.
在各种诊断中，提高心理灵活性被认为是心理治疗的一个重要改变机制。尤其是接受与承诺疗法（ACT），其主要目的是提高心理灵活性，从而过上更充实、更有意义的生活。本研究的目的是探讨：1）在跨诊断日间医院进行以 ACT 为基础的治疗期间，心理灵活性如何发生变化；2）这种变化与症状学、生活质量和一般功能水平的变化有何关系。在三个测量时间点（入院、出院和 3 个月随访）对心理灵活性、症状和生活质量进行了评估。功能水平在入院和出院时进行评估。心理灵活性的差异通过双侧配对样本 t 检验进行检验。心理灵活性从治疗前到治疗后显著增加（d = .43，p <.001），从治疗前到随访显著增加（d = .54，p <.001）。这种变化与症状的减少（r = .60 -.83, p <.001）以及生活质量（r = -.43 - -.75, p <.001）和一般功能水平（r =-.34, p = .003）的提高有明显的相关性。这项研究进一步证明了心理灵活性是心理治疗成功的一个跨诊断过程变量。本文讨论了研究的局限性。
{"title":"Increasing psychological flexibility is associated with positive therapy outcomes following a transdiagnostic ACT treatment","authors":"Ronja Rutschmann, Nina Romanczuk-Seiferth, Andrew Gloster, Christoph Richter","doi":"10.3389/fpsyt.2024.1403718","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1403718","url":null,"abstract":"Increasing psychological flexibility is considered an important mechanism of change in psychotherapy across diagnoses. In particular, Acceptance and Commitment Therapy (ACT) primarily aims at increasing psychological flexibility in order to live a more fulfilling and meaningful life. The purpose of this study is to examine 1) how psychological flexibility changes during an ACT-based treatment in a transdiagnostic day hospital and 2) how this change is related to changes in symptomatology, quality of life, and general level of functioning.90 patients of a psychiatric day hospital participated in the study. Psychological flexibility, symptomatology, and quality of life were assessed at three measurement time points (admission, discharge, and 3-month follow-up). The level of functioning was assessed at admission and discharge. Differences in psychological flexibility were tested via two-sided paired samples t-tests. Correlations of residualized change scores were calculated to detect associations between changes in psychological flexibility and other outcomes.Psychological flexibility increased significantly from pre-treatment to post-treatment (d = .43, p <.001) and from pre-treatment to follow-up (d = .54, p <.001). This change was significantly correlated to a decrease in symptomatology (r = .60 –.83, p <.001) and an increase in most dimensions of quality of life (r = -.43 – -.75, p <.001) and general level of functioning (r =-.34, p = .003).This study adds further evidence for psychological flexibility as a transdiagnostic process variable of successful psychotherapy. Limitations are discussed.","PeriodicalId":506619,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141644301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.3389/fpsyt.2024.1386842
Anna Havelková, David Havelka, Kateřina Koros Bartošová
In the Western world, more than one-third of the patients of productive age hospitalized for severe mental illness (SMI) are parents. Each of their offspring is exposed to several stressors related to their parent’s illness and hospitalization, which puts them at an increased risk of developing mental health problems. In the Czech Republic, no statistics are currently available about the families of patients with SMI, inpatients who are parents, or data about their children (ages ≤18 years). Therefore, our research aim was to describe the prevalence of parenthood among hospitalized patients with SMI, assess the number of children and determine the extent to which offspring information was present in medical records.Quantitative data from medical records (2,768 patients, aged 18–63 years, hospitalized for SMI between 2017 and 2020) from two large inpatient psychiatric facilities were examined. Parental information, demographic characteristics, number of children, and other available data were collected.The prevalence of parenthood among inpatients with SMI was 34.6%. Parenthood was most prevalent among female patients and patients with recurrent depressive and bipolar disorders. The total number of offspring in 957 patient-parents was 1781 (41.7% minors under the age of 18). Information on parenthood was available in 99.7% of cases; information on the age of offspring, custody, and sociodemographic situation varies, being included in 73% to 89.7% of the medical records (some details were more frequently recorded than others).The data obtained may help to better understand and address the specifics of these families and thus serve as a basis for the development of prevention programs.
{"title":"Prevalence of parenthood among hospitalized adult patients with severe mental illness: a quantitative data analysis","authors":"Anna Havelková, David Havelka, Kateřina Koros Bartošová","doi":"10.3389/fpsyt.2024.1386842","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1386842","url":null,"abstract":"In the Western world, more than one-third of the patients of productive age hospitalized for severe mental illness (SMI) are parents. Each of their offspring is exposed to several stressors related to their parent’s illness and hospitalization, which puts them at an increased risk of developing mental health problems. In the Czech Republic, no statistics are currently available about the families of patients with SMI, inpatients who are parents, or data about their children (ages ≤18 years). Therefore, our research aim was to describe the prevalence of parenthood among hospitalized patients with SMI, assess the number of children and determine the extent to which offspring information was present in medical records.Quantitative data from medical records (2,768 patients, aged 18–63 years, hospitalized for SMI between 2017 and 2020) from two large inpatient psychiatric facilities were examined. Parental information, demographic characteristics, number of children, and other available data were collected.The prevalence of parenthood among inpatients with SMI was 34.6%. Parenthood was most prevalent among female patients and patients with recurrent depressive and bipolar disorders. The total number of offspring in 957 patient-parents was 1781 (41.7% minors under the age of 18). Information on parenthood was available in 99.7% of cases; information on the age of offspring, custody, and sociodemographic situation varies, being included in 73% to 89.7% of the medical records (some details were more frequently recorded than others).The data obtained may help to better understand and address the specifics of these families and thus serve as a basis for the development of prevention programs.","PeriodicalId":506619,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.3389/fpsyt.2024.1408878
J. Herrera-Pérez, O. T. Hernández-Hernández, Mónica Flores-Ramos, J. Cueto-Escobedo, J. Rodríguez-Landa, Lucía Martínez-Mota
Menopausal women may experience symptoms of depression, sometimes even progressing clinical depression requiring treatment to improve quality of life. While varying levels of estrogen in perimenopause may contribute to an increased biological vulnerability to mood disturbances, the effectiveness of estrogen replacement therapy (ERT) in the relief of depressive symptoms remains controversial. Menopausal depression has a complex, multifactorial etiology, that has limited the identification of optimal treatment strategies for the management of this psychiatric complaint. Nevertheless, clinical evidence increasingly supports the notion that estrogen exerts neuroprotective effects on brain structures related to mood regulation. Indeed, research using preclinical animal models continues to improve our understanding of menopause and the effectiveness of ERT and other substances at treating depression-like behaviors. However, questions regarding the efficacy of ERT in perimenopause have been raised. These questions may be answered by further investigation using specific animal models of reduced ovarian function. This review compares and discusses the advantages and pitfalls of different models emulating the menopausal stages and their relationship with the onset of depressive-like signs, as well as the efficacy and mechanisms of conventional and novel ERTs in treating depressive-like behavior. Ovariectomized young rats, middle-to-old aged intact rats, and females treated with reprotoxics have all been used as models of menopause, with stages ranging from surgical menopause to perimenopause. Additionally, this manuscript discusses the impact of organistic and therapeutic variables that may improve or reduce the antidepressant response of females to ERT. Findings from these models have revealed the complexity of the dynamic changes occurring in brain function during menopausal transition, reinforcing the idea that the best approach is timely intervention considering the opportunity window, in addition to the careful selection of treatment according to the presence or absence of reproductive tissue. Additionally, data from animal models has yielded evidence to support new promising estrogens that could be considered as ERTs with antidepressant properties and actions in endocrine situations in which traditional ERTs are not effective.
{"title":"The intersection between menopause and depression: overview of research using animal models","authors":"J. Herrera-Pérez, O. T. Hernández-Hernández, Mónica Flores-Ramos, J. Cueto-Escobedo, J. Rodríguez-Landa, Lucía Martínez-Mota","doi":"10.3389/fpsyt.2024.1408878","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1408878","url":null,"abstract":"Menopausal women may experience symptoms of depression, sometimes even progressing clinical depression requiring treatment to improve quality of life. While varying levels of estrogen in perimenopause may contribute to an increased biological vulnerability to mood disturbances, the effectiveness of estrogen replacement therapy (ERT) in the relief of depressive symptoms remains controversial. Menopausal depression has a complex, multifactorial etiology, that has limited the identification of optimal treatment strategies for the management of this psychiatric complaint. Nevertheless, clinical evidence increasingly supports the notion that estrogen exerts neuroprotective effects on brain structures related to mood regulation. Indeed, research using preclinical animal models continues to improve our understanding of menopause and the effectiveness of ERT and other substances at treating depression-like behaviors. However, questions regarding the efficacy of ERT in perimenopause have been raised. These questions may be answered by further investigation using specific animal models of reduced ovarian function. This review compares and discusses the advantages and pitfalls of different models emulating the menopausal stages and their relationship with the onset of depressive-like signs, as well as the efficacy and mechanisms of conventional and novel ERTs in treating depressive-like behavior. Ovariectomized young rats, middle-to-old aged intact rats, and females treated with reprotoxics have all been used as models of menopause, with stages ranging from surgical menopause to perimenopause. Additionally, this manuscript discusses the impact of organistic and therapeutic variables that may improve or reduce the antidepressant response of females to ERT. Findings from these models have revealed the complexity of the dynamic changes occurring in brain function during menopausal transition, reinforcing the idea that the best approach is timely intervention considering the opportunity window, in addition to the careful selection of treatment according to the presence or absence of reproductive tissue. Additionally, data from animal models has yielded evidence to support new promising estrogens that could be considered as ERTs with antidepressant properties and actions in endocrine situations in which traditional ERTs are not effective.","PeriodicalId":506619,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-11DOI: 10.3389/fpsyt.2024.1456763
Anna-Rita Atti
{"title":"Editorial: Exploring the association between metabolism and psychiatric disorders","authors":"Anna-Rita Atti","doi":"10.3389/fpsyt.2024.1456763","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1456763","url":null,"abstract":"","PeriodicalId":506619,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141655357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-11DOI: 10.3389/fpsyt.2024.1443304
C. Heidbreder, Mark K. Greenwald, Bernard Le Foll, Phil Skolnick
{"title":"Editorial: Discovery, development and implementation of improved options for treating opioid overdose in the synthetic opioid era","authors":"C. Heidbreder, Mark K. Greenwald, Bernard Le Foll, Phil Skolnick","doi":"10.3389/fpsyt.2024.1443304","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1443304","url":null,"abstract":"","PeriodicalId":506619,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141656412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.3389/fpsyt.2024.1412901
Jagadeesh S Rao, Maria Alejandra Tangarife, Ram Mukunda
{"title":"Neurobiological alteration in agitation in Alzheimer’s disease and possible interventions","authors":"Jagadeesh S Rao, Maria Alejandra Tangarife, Ram Mukunda","doi":"10.3389/fpsyt.2024.1412901","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1412901","url":null,"abstract":"","PeriodicalId":506619,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141666374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-08DOI: 10.3389/fpsyt.2024.1450368
Carlo Custodero
{"title":"Editorial: Challenges in dementia care: a global perspective","authors":"Carlo Custodero","doi":"10.3389/fpsyt.2024.1450368","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1450368","url":null,"abstract":"","PeriodicalId":506619,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141668111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-05DOI: 10.3389/fpsyt.2024.1453218
Paolo Meneguzzo
{"title":"Editorial: COVID-19 and eating disorders 2023: lessons learnt and future directions for research","authors":"Paolo Meneguzzo","doi":"10.3389/fpsyt.2024.1453218","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1453218","url":null,"abstract":"","PeriodicalId":506619,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.3389/fpsyt.2024.1444818
Massimo Tusconi, Dennis Kätzel, Teresa Sánchez-Gutiérrez
{"title":"Editorial: Reviews in psychiatry 2023: schizophrenia","authors":"Massimo Tusconi, Dennis Kätzel, Teresa Sánchez-Gutiérrez","doi":"10.3389/fpsyt.2024.1444818","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1444818","url":null,"abstract":"","PeriodicalId":506619,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.3389/fpsyt.2024.1432822
Sandra Montagud-Romero, V. Gómez-Murcia, F. Fernández-Gómez, Cristina Núñez
{"title":"Editorial: Exploring prevention strategies and treatment in addictive disorders","authors":"Sandra Montagud-Romero, V. Gómez-Murcia, F. Fernández-Gómez, Cristina Núñez","doi":"10.3389/fpsyt.2024.1432822","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1432822","url":null,"abstract":"","PeriodicalId":506619,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141677332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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