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Are Hospital Admissions (Costs) and Mortality Rate Impacted by Guideline-driven Treatment of Heart Failure?: A Comparison between Participants in the “CorBene” CMP and Standard-care Patients on the Basis of Propensity Score Matching 指导原则驱动的心力衰竭治疗会影响入院率(成本)和死亡率吗?基于倾向得分匹配的 "CorBene "CMP参与者与标准护理患者之间的比较
Pub Date : 2024-02-09 DOI: 10.1055/s-0044-1779660
Josef Ehling, Hans Jürgen Noblé, Detlef Gysan, Mareike Möller, Franz Goss, Winfried Haerer, Simon Glück, Paul Martin Bansmann
Heart failure (HF) is one of the most common diagnoses on admission to hospital in Germany, and one which incurs high costs. Integrated care in case management programs (CMPs) aims to improve treatment quality in the sense of guideline-driven treatment, while reducing hospital admissions, hospital costs, and mortality. A total of 1,844 patient data records from 11 German statutory health insurance companies enrolled in the CMP (intervention group [IG]) were compared with 1,844 standard-care patients (control group) using propensity score matching. The two groups were assessed over three follow-up observation periods regarding the endpoints' treatment costs, hospitalization rate, indicators for treatment quality (diagnostics, physician contact), and mortality. The evaluation revealed no significant differences regarding overall costs. The IG incurred significantly higher outpatient costs, but the medication costs and inpatient costs were not significantly different. There were also no significant differences in the number of hospital admissions. Patients within the CMP had significantly more frequent contact with a cardiologist, and underwent echocardiographic examination significantly more frequently. Mortality during the first follow-up observation year was considerably more favorable for the IG. There are indications that treatment quality is improved in HF patients.
在德国,心力衰竭(HF)是最常见的入院诊断之一,也是费用较高的一种疾病。病例管理项目(CMPs)中的综合护理旨在提高指南驱动治疗的治疗质量,同时降低入院率、住院费用和死亡率。我们采用倾向得分匹配法,将来自德国 11 家法定医疗保险公司的 1844 份参加病例管理计划的患者数据记录(干预组 [IG])与 1844 份标准护理患者数据记录(对照组)进行了比较。在三个随访观察期内,对两组患者的治疗费用、住院率、治疗质量指标(诊断、医生联系)和死亡率等终点进行了评估。评估结果显示,两组在总费用方面没有明显差异。IG 的门诊费用明显较高,但药物费用和住院费用没有显著差异。入院次数也无明显差异。CMP患者与心脏病专家接触的频率明显更高,接受超声心动图检查的频率也明显更高。在第一个随访观察年中,IG 的死亡率要高得多。有迹象表明,高血压患者的治疗质量有所提高。
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引用次数: 0
Are Hospital Admissions (Costs) and Mortality Rate Impacted by Guideline-driven Treatment of Heart Failure?: A Comparison between Participants in the “CorBene” CMP and Standard-care Patients on the Basis of Propensity Score Matching 指导原则驱动的心力衰竭治疗会影响入院率(成本)和死亡率吗?基于倾向得分匹配的 "CorBene "CMP参与者与标准护理患者之间的比较
Pub Date : 2024-02-09 DOI: 10.1055/s-0044-1779660
Josef Ehling, Hans Jürgen Noblé, Detlef Gysan, Mareike Möller, Franz Goss, Winfried Haerer, Simon Glück, Paul Martin Bansmann
Heart failure (HF) is one of the most common diagnoses on admission to hospital in Germany, and one which incurs high costs. Integrated care in case management programs (CMPs) aims to improve treatment quality in the sense of guideline-driven treatment, while reducing hospital admissions, hospital costs, and mortality. A total of 1,844 patient data records from 11 German statutory health insurance companies enrolled in the CMP (intervention group [IG]) were compared with 1,844 standard-care patients (control group) using propensity score matching. The two groups were assessed over three follow-up observation periods regarding the endpoints' treatment costs, hospitalization rate, indicators for treatment quality (diagnostics, physician contact), and mortality. The evaluation revealed no significant differences regarding overall costs. The IG incurred significantly higher outpatient costs, but the medication costs and inpatient costs were not significantly different. There were also no significant differences in the number of hospital admissions. Patients within the CMP had significantly more frequent contact with a cardiologist, and underwent echocardiographic examination significantly more frequently. Mortality during the first follow-up observation year was considerably more favorable for the IG. There are indications that treatment quality is improved in HF patients.
在德国,心力衰竭(HF)是最常见的入院诊断之一,也是费用较高的一种疾病。病例管理项目(CMPs)中的综合护理旨在提高指南驱动治疗的治疗质量,同时降低入院率、住院费用和死亡率。我们采用倾向得分匹配法,将来自德国 11 家法定医疗保险公司的 1844 份参加病例管理计划的患者数据记录(干预组 [IG])与 1844 份标准护理患者数据记录(对照组)进行了比较。在三个随访观察期内,对两组患者的治疗费用、住院率、治疗质量指标(诊断、医生联系)和死亡率等终点进行了评估。评估结果显示,两组在总费用方面没有明显差异。IG 的门诊费用明显较高,但药物费用和住院费用没有显著差异。入院次数也无明显差异。CMP患者与心脏病专家接触的频率明显更高,接受超声心动图检查的频率也明显更高。在第一个随访观察年中,IG 的死亡率要高得多。有迹象表明,高血压患者的治疗质量有所提高。
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引用次数: 0
Successful Retrieval of Retained Rotablator Burr in the Mid Left Anterior Descending Coronary Artery using a Retrograde Approach: A Case Report 采用逆行入路成功取出残留在左前降支冠状动脉中段的Rotablator毛刺:病例报告
Pub Date : 2024-02-08 DOI: 10.1055/s-0044-1779662
Yoshitha Inala, Jon Robken, N. Shammas
We present a rare complication of Rotablator (Boston Scientific) atherectomy during percutaneous coronary intervention in a 67-year-old patient with a history of coronary artery disease and prior coronary artery bypass graft (CABG) surgery. The fracture of the Rotablator drive shaft and retention of the Rotablator burr in the mid left anterior descending coronary artery posed significant challenges in patient management. This case demonstrates the successful extraction of the retained Rotablator burr using retrograde total occlusion recanalization and highlights the importance of understanding the potential complications and management strategies in complex interventional cardiology procedures.
我们介绍了一名 67 岁的患者在经皮冠状动脉介入治疗过程中发生的罕见并发症:Rotablator(波士顿科学公司)动脉瘤切除术,该患者有冠状动脉疾病史,并曾接受过冠状动脉旁路移植手术(CABG)。Rotablator 传动轴的断裂和 Rotablator 毛刺在左前降支冠状动脉中段的滞留给患者的治疗带来了巨大挑战。本病例展示了使用逆行全闭塞再通术成功取出滞留的Rotablator毛刺,并强调了了解复杂介入心脏病学手术潜在并发症和管理策略的重要性。
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引用次数: 0
Successful Retrieval of Retained Rotablator Burr in the Mid Left Anterior Descending Coronary Artery using a Retrograde Approach: A Case Report 采用逆行入路成功取出残留在左前降支冠状动脉中段的Rotablator毛刺:病例报告
Pub Date : 2024-02-08 DOI: 10.1055/s-0044-1779662
Yoshitha Inala, Jon Robken, N. Shammas
We present a rare complication of Rotablator (Boston Scientific) atherectomy during percutaneous coronary intervention in a 67-year-old patient with a history of coronary artery disease and prior coronary artery bypass graft (CABG) surgery. The fracture of the Rotablator drive shaft and retention of the Rotablator burr in the mid left anterior descending coronary artery posed significant challenges in patient management. This case demonstrates the successful extraction of the retained Rotablator burr using retrograde total occlusion recanalization and highlights the importance of understanding the potential complications and management strategies in complex interventional cardiology procedures.
我们介绍了一名 67 岁的患者在经皮冠状动脉介入治疗过程中发生的罕见并发症:Rotablator(波士顿科学公司)动脉瘤切除术,该患者有冠状动脉疾病史,并曾接受过冠状动脉旁路移植手术(CABG)。Rotablator 传动轴的断裂和 Rotablator 毛刺在左前降支冠状动脉中段的滞留给患者的治疗带来了巨大挑战。本病例展示了使用逆行全闭塞再通术成功取出滞留的Rotablator毛刺,并强调了了解复杂介入心脏病学手术潜在并发症和管理策略的重要性。
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引用次数: 0
The Challenge of Managing a Primary Aortic Mural Thrombus: Outcomes and Technical Considerations 处理原发性主动脉壁血栓的挑战:结果和技术考虑因素
Pub Date : 2024-02-06 DOI: 10.1055/s-0044-1779489
D. Mendes, C. Veiga, Rui Machado, Pedro Sá-Pinto, R. Almeida
Background: Embolization to multiple arterial beds associated with primary aortic mural thrombus (PAMT) could result in high morbidity and mortality. There are no recommendations to dictate the best management. This study aims to describe our experience in managing this rare disease. Methods: A retrospective review of all patients affected by PAMT treated at our institution between January 2015 and December 2021 was performed. Recorded data included demographics, prothrombotic risk factors, imaging findings, clinical presentation, and treatment. Primary outcomes comprised thrombus recurrence, major amputation, and death. Results: Thirteen patients with PAMT have been included. The median age was 52 years (36–68 years), and the male/female ratio was 1:1.6. The diagnosis of PAMT was made by computed tomography angiography (CTA) in all cases. Prothrombotic conditions were identified in 92% of cases, and most patients (92%) had thoracic PAMT. The most common presentation was acute limb ischemia after thrombus embolization (85%), requiring surgical revascularization. Anticoagulation was promptly started in all patients. Two patients developed heparin-induced thrombocytopenia. Recurrence of embolization/thrombosis was observed in 54% of patients; two underwent endovascular thrombus exclusion with a stent graft. We identified one PAMT-related death and one major amputation with a median follow-up time of 39 months (12–64 months). Conclusion: Anticoagulation alone as initial therapy could completely resolve PAMT but is associated with high embolization recurrence. Thoracic endovascular aortic repair is feasible and could prevent additional embolization. However, the criteria for its use as a first-line therapy still need to be defined. Our study highlights the importance of closely monitoring these patients.
背景:与原发性主动脉壁血栓(PAMT)相关的多动脉床栓塞可能会导致高发病率和高死亡率。目前还没有关于最佳治疗方法的建议。本研究旨在介绍我们处理这种罕见疾病的经验。研究方法对 2015 年 1 月至 2021 年 12 月期间在我院接受治疗的所有 PAMT 患者进行回顾性研究。记录的数据包括人口统计学、血栓前危险因素、影像学检查结果、临床表现和治疗。主要结果包括血栓复发、重大截肢和死亡。结果:共纳入 13 名 PAMT 患者。中位年龄为 52 岁(36-68 岁),男女比例为 1:1.6。所有病例均通过计算机断层扫描血管造影术(CTA)确诊为 PAMT。92%的病例发现了血栓前病变,大多数患者(92%)患有胸部PAMT。最常见的表现是血栓栓塞后急性肢体缺血(85%),需要进行手术血管重建。所有患者都立即开始了抗凝治疗。两名患者出现了肝素诱导的血小板减少症。54%的患者出现栓塞/血栓复发,其中两名患者接受了支架移植物血管内血栓清除术。我们发现了一起与 PAMT 相关的死亡病例和一起重大截肢病例,中位随访时间为 39 个月(12-64 个月)。结论仅将抗凝作为初始治疗可完全治愈 PAMT,但栓塞复发率较高。胸腔内血管主动脉修补术是可行的,可以防止再次栓塞。然而,将其作为一线疗法的标准仍有待确定。我们的研究强调了密切监测这些患者的重要性。
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引用次数: 0
The Challenge of Managing a Primary Aortic Mural Thrombus: Outcomes and Technical Considerations 处理原发性主动脉壁血栓的挑战:结果和技术考虑因素
Pub Date : 2024-02-06 DOI: 10.1055/s-0044-1779489
D. Mendes, C. Veiga, Rui Machado, Pedro Sá-Pinto, R. Almeida
Background: Embolization to multiple arterial beds associated with primary aortic mural thrombus (PAMT) could result in high morbidity and mortality. There are no recommendations to dictate the best management. This study aims to describe our experience in managing this rare disease. Methods: A retrospective review of all patients affected by PAMT treated at our institution between January 2015 and December 2021 was performed. Recorded data included demographics, prothrombotic risk factors, imaging findings, clinical presentation, and treatment. Primary outcomes comprised thrombus recurrence, major amputation, and death. Results: Thirteen patients with PAMT have been included. The median age was 52 years (36–68 years), and the male/female ratio was 1:1.6. The diagnosis of PAMT was made by computed tomography angiography (CTA) in all cases. Prothrombotic conditions were identified in 92% of cases, and most patients (92%) had thoracic PAMT. The most common presentation was acute limb ischemia after thrombus embolization (85%), requiring surgical revascularization. Anticoagulation was promptly started in all patients. Two patients developed heparin-induced thrombocytopenia. Recurrence of embolization/thrombosis was observed in 54% of patients; two underwent endovascular thrombus exclusion with a stent graft. We identified one PAMT-related death and one major amputation with a median follow-up time of 39 months (12–64 months). Conclusion: Anticoagulation alone as initial therapy could completely resolve PAMT but is associated with high embolization recurrence. Thoracic endovascular aortic repair is feasible and could prevent additional embolization. However, the criteria for its use as a first-line therapy still need to be defined. Our study highlights the importance of closely monitoring these patients.
背景:与原发性主动脉壁血栓(PAMT)相关的多动脉床栓塞可能会导致高发病率和高死亡率。目前还没有关于最佳治疗方法的建议。本研究旨在介绍我们处理这种罕见疾病的经验。研究方法对 2015 年 1 月至 2021 年 12 月期间在我院接受治疗的所有 PAMT 患者进行回顾性研究。记录的数据包括人口统计学、血栓前危险因素、影像学检查结果、临床表现和治疗。主要结果包括血栓复发、重大截肢和死亡。结果:共纳入 13 名 PAMT 患者。中位年龄为 52 岁(36-68 岁),男女比例为 1:1.6。所有病例均通过计算机断层扫描血管造影术(CTA)确诊为 PAMT。92%的病例发现了血栓前病变,大多数患者(92%)患有胸部PAMT。最常见的表现是血栓栓塞后急性肢体缺血(85%),需要进行手术血管重建。所有患者都立即开始了抗凝治疗。两名患者出现了肝素诱导的血小板减少症。54%的患者出现栓塞/血栓复发,其中两名患者接受了支架移植物血管内血栓清除术。我们发现了一起与 PAMT 相关的死亡病例和一起重大截肢病例,中位随访时间为 39 个月(12-64 个月)。结论仅将抗凝作为初始治疗可完全治愈 PAMT,但栓塞复发率较高。胸腔内血管主动脉修补术是可行的,可以防止再次栓塞。然而,将其作为一线疗法的标准仍有待确定。我们的研究强调了密切监测这些患者的重要性。
{"title":"The Challenge of Managing a Primary Aortic Mural Thrombus: Outcomes and Technical Considerations","authors":"D. Mendes, C. Veiga, Rui Machado, Pedro Sá-Pinto, R. Almeida","doi":"10.1055/s-0044-1779489","DOIUrl":"https://doi.org/10.1055/s-0044-1779489","url":null,"abstract":"\u0000 Background: Embolization to multiple arterial beds associated with primary aortic mural thrombus (PAMT) could result in high morbidity and mortality. There are no recommendations to dictate the best management. This study aims to describe our experience in managing this rare disease.\u0000 Methods: A retrospective review of all patients affected by PAMT treated at our institution between January 2015 and December 2021 was performed. Recorded data included demographics, prothrombotic risk factors, imaging findings, clinical presentation, and treatment. Primary outcomes comprised thrombus recurrence, major amputation, and death.\u0000 Results: Thirteen patients with PAMT have been included. The median age was 52 years (36–68 years), and the male/female ratio was 1:1.6. The diagnosis of PAMT was made by computed tomography angiography (CTA) in all cases. Prothrombotic conditions were identified in 92% of cases, and most patients (92%) had thoracic PAMT. The most common presentation was acute limb ischemia after thrombus embolization (85%), requiring surgical revascularization. Anticoagulation was promptly started in all patients. Two patients developed heparin-induced thrombocytopenia. Recurrence of embolization/thrombosis was observed in 54% of patients; two underwent endovascular thrombus exclusion with a stent graft. We identified one PAMT-related death and one major amputation with a median follow-up time of 39 months (12–64 months).\u0000 Conclusion: Anticoagulation alone as initial therapy could completely resolve PAMT but is associated with high embolization recurrence. Thoracic endovascular aortic repair is feasible and could prevent additional embolization. However, the criteria for its use as a first-line therapy still need to be defined. Our study highlights the importance of closely monitoring these patients.","PeriodicalId":506654,"journal":{"name":"International Journal of Angiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139860022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concurrent Chronic Limb Threatening Ischemia and Deep Vein Thrombosis of a Limb in Patient with Systemic Lupus Erythematosus: A Case Report 系统性红斑狼疮患者并发慢性肢体缺血和肢体深静脉血栓:病例报告
Pub Date : 2024-02-02 DOI: 10.1055/s-0044-1779491
A. H. A. Kartamihardja, Raymond Pranata, Margareta Ginanti Ratna Indraswari Suriyanto, B. Tiksnadi, Syarief Hidayat
Concurrent thrombus formation in both the arterial and venous systems is rare and present as a diagnostic challenge in these cases; therefore, we must explore various possible etiologies and mechanisms. Herein, we report a case of concurrent chronic limb threatening ischemia (CLTI) and deep vein thrombosis (DVT) of a limb in a patient with systemic lupus erythematosus (SLE) and chronic heart failure who underwent laboratory examinations and multimodality imaging. A 37-year-old male presented with a complaint of pain and swelling of the lower left extremity since 21 days before admission. Echocardiography showed dilated all chambers with ejection fraction, moderate-to-severe pericardial effusion, and no intracardiac shunt. Doppler ultrasound of the lower extremities showed DVT at the left mid-femoral and popliteal vein, severe stenosis at the left dorsalis pedis artery, moderate stenosis of the left popliteal, anterior, and posterior tibial arteries, and soft tissue swelling in the tibial region. Computed tomography angiography showed significant stenosis of the left popliteal, anterior, and posterior tibial arteries. The patient was diagnosed with CLTI and DVT of the left inferior extremity, heart failure, SLE, and tuberculous meningitis on antituberculosis medication. Primary amputation was performed, and the patient was discharged uneventfully.Concurrent CLTI and DVT in the same limb caused by SLE and heart failure is a rare condition. In this case, the probable causes were hypercoagulable state and vasculitis. Despite exhaustive attempts, the exact mechanism was not fully elucidated in this patient. However, we excluded other possible causes that require specific intervention, such as intracardiac shunt or phlegmasia cerulea dolens.
同时在动脉和静脉系统中形成血栓的情况十分罕见,在这些病例中,血栓的形成是一个诊断难题;因此,我们必须探索各种可能的病因和机制。在此,我们报告了一例并发慢性肢体威胁性缺血(CLTI)和肢体深静脉血栓形成(DVT)的病例,患者患有系统性红斑狼疮(SLE)和慢性心力衰竭,并接受了实验室检查和多模态成像检查。一名37岁的男性患者入院前21天开始主诉左下肢疼痛和肿胀。超声心动图显示各腔扩张,射血分数降低,中重度心包积液,无心内分流。下肢多普勒超声显示,左侧股中静脉和腘静脉深静脉血栓,左侧足背动脉严重狭窄,左侧腘动脉、胫前动脉和胫后动脉中度狭窄,胫骨区域软组织肿胀。计算机断层扫描血管造影显示左侧腘动脉、胫前动脉和胫后动脉明显狭窄。患者被诊断为左下肢CLTI和深静脉血栓、心力衰竭、系统性红斑狼疮和结核性脑膜炎,正在服用抗结核药物。由系统性红斑狼疮和心力衰竭引起的同一肢体并发 CLTI 和深静脉血栓是一种罕见病。在该病例中,可能的病因是高凝状态和血管炎。尽管我们做了大量尝试,但仍无法完全阐明该患者的确切发病机制。不过,我们排除了其他需要特殊干预的可能原因,如心内分流或多发性痰症。
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引用次数: 0
Concurrent Chronic Limb Threatening Ischemia and Deep Vein Thrombosis of a Limb in Patient with Systemic Lupus Erythematosus: A Case Report 系统性红斑狼疮患者并发慢性肢体缺血和肢体深静脉血栓:病例报告
Pub Date : 2024-02-02 DOI: 10.1055/s-0044-1779491
A. H. A. Kartamihardja, Raymond Pranata, Margareta Ginanti Ratna Indraswari Suriyanto, B. Tiksnadi, Syarief Hidayat
Concurrent thrombus formation in both the arterial and venous systems is rare and present as a diagnostic challenge in these cases; therefore, we must explore various possible etiologies and mechanisms. Herein, we report a case of concurrent chronic limb threatening ischemia (CLTI) and deep vein thrombosis (DVT) of a limb in a patient with systemic lupus erythematosus (SLE) and chronic heart failure who underwent laboratory examinations and multimodality imaging. A 37-year-old male presented with a complaint of pain and swelling of the lower left extremity since 21 days before admission. Echocardiography showed dilated all chambers with ejection fraction, moderate-to-severe pericardial effusion, and no intracardiac shunt. Doppler ultrasound of the lower extremities showed DVT at the left mid-femoral and popliteal vein, severe stenosis at the left dorsalis pedis artery, moderate stenosis of the left popliteal, anterior, and posterior tibial arteries, and soft tissue swelling in the tibial region. Computed tomography angiography showed significant stenosis of the left popliteal, anterior, and posterior tibial arteries. The patient was diagnosed with CLTI and DVT of the left inferior extremity, heart failure, SLE, and tuberculous meningitis on antituberculosis medication. Primary amputation was performed, and the patient was discharged uneventfully.Concurrent CLTI and DVT in the same limb caused by SLE and heart failure is a rare condition. In this case, the probable causes were hypercoagulable state and vasculitis. Despite exhaustive attempts, the exact mechanism was not fully elucidated in this patient. However, we excluded other possible causes that require specific intervention, such as intracardiac shunt or phlegmasia cerulea dolens.
同时在动脉和静脉系统中形成血栓的情况十分罕见,在这些病例中,血栓的形成是一个诊断难题;因此,我们必须探索各种可能的病因和机制。在此,我们报告了一例并发慢性肢体威胁性缺血(CLTI)和肢体深静脉血栓形成(DVT)的病例,患者患有系统性红斑狼疮(SLE)和慢性心力衰竭,并接受了实验室检查和多模态成像检查。一名37岁的男性患者入院前21天开始主诉左下肢疼痛和肿胀。超声心动图显示各腔扩张,射血分数降低,中重度心包积液,无心内分流。下肢多普勒超声显示,左侧股中静脉和腘静脉深静脉血栓,左侧足背动脉严重狭窄,左侧腘动脉、胫前动脉和胫后动脉中度狭窄,胫骨区域软组织肿胀。计算机断层扫描血管造影显示左侧腘动脉、胫前动脉和胫后动脉明显狭窄。患者被诊断为左下肢CLTI和深静脉血栓、心力衰竭、系统性红斑狼疮和结核性脑膜炎,正在服用抗结核药物。由系统性红斑狼疮和心力衰竭引起的同一肢体并发 CLTI 和深静脉血栓是一种罕见病。在这个病例中,可能的原因是高凝状态和血管炎。尽管我们做了大量尝试,但仍无法完全阐明该患者的确切发病机制。不过,我们排除了其他需要特殊干预的可能原因,如心内分流或多发性痰症。
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引用次数: 0
期刊
International Journal of Angiology
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