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Damage control surgery for splenic trauma: "preserve an organ - preserve a life". 脾损伤的控制手术:“保存一个器官-保存一个生命”。
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2021-05-07 DOI: 10.25100/cm.v52i2.4794
Carlos Serna, José Julián Serna, Yaset Caicedo, Natalia Padilla, Linda M Gallego, Alexander Salcedo, Fernando Rodríguez-Holguín, Adolfo González-Hadad, Alberto García, Mario Alain Herrera, Michael W Parra, Carlos A Ordoñez

The spleen is one of the most commonly injured solid organs of the abdominal cavity and an early diagnosis can reduce the associated mortality. Over the past couple of decades, management of splenic injuries has evolved to a prefered non-operative approach even in severely injured cases. However, the optimal surgical management of splenic trauma in severely injured patients remains controversial. This article aims to present an algorithm for the management of splenic trauma in severely injured patients, that includes basic principles of damage control surgery and is based on the experience obtained by the Trauma and Emergency Surgery Group (CTE) of Cali, Colombia. The choice between a conservative or a surgical approach depends on the hemodynamic status of the patient. In hemodynamically stable patients, a computed tomography angiogram should be performed to determine if non-operative management is feasible and if angioembolization is required. While hemodynamically unstable patients should be transferred immediately to the operating room for damage control surgery, which includes splenic packing and placement of a negative pressure dressing, followed by angiography with embolization of any ongoing arterial bleeding. It is our recommendation that both damage control principles and emerging endovascular technologies should be applied to achieve splenic salvage when possible. However, if surgical bleeding persists a splenectomy may be required as a definitive lifesaving maneuver.

脾脏是最常见的腹腔实体器官损伤之一,早期诊断可降低相关死亡率。在过去的几十年里,脾脏损伤的治疗已经演变为非手术治疗的首选方法,即使是严重损伤的病例。然而,脾脏严重损伤患者的最佳手术治疗仍存在争议。本文旨在根据哥伦比亚Cali创伤与急诊外科小组(CTE)的经验,提出一种处理严重损伤患者脾外伤的算法,包括损伤控制手术的基本原则。选择保守治疗还是手术治疗取决于患者的血流动力学状况。对于血流动力学稳定的患者,应进行计算机断层血管造影,以确定非手术治疗是否可行,是否需要血管栓塞。而血流动力学不稳定的患者应立即转移到手术室进行损害控制手术,包括脾脏填塞和放置负压敷料,随后进行血管造影,栓塞任何持续的动脉出血。我们建议在可能的情况下应用损伤控制原理和新兴的血管内技术来实现脾抢救。然而,如果手术出血持续,脾切除术可能需要作为一个明确的救命策略。
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引用次数: 0
Hybrid trauma service: on the leading edge of damage Control. 混合创伤服务:处于损伤控制的前沿。
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2021-05-05 DOI: 10.25100/cm.v52i2.4686
Helmer Emilio Palacios-Rodríguez, Nao Hiroe, Mónica Guzmán-Rodríguez, Yaset Caicedo, Luis Saldarriaga, Carlos A Ordoñez, Tomohiro Funabiki

Trauma damage control seeks to limit life-threatening bleeding. Sequential diagnostic and therapeutic approaches are the current standard. Hybrid Room have reduced hemostasis time by integrating different specialties and technologies. Hybrid Rooms seek to control bleeding in an operating room equipped with specialized personnel and advanced technology including angiography, tomography, eFAST, radiography, endoscopy, infusers, cell retrievers, REBOA, etc. Trauma Hybrid Service is a concept that describes a vertical work scheme that begins with the activation of Trauma Code when admitting a severely injured patient, initiating a continuous resuscitation process led by the trauma surgeon who guides transfer to imaging, angiography and surgery rooms according to the patient's condition and the need for specific interventions. Hybrid rooms integrate different diagnostic and therapeutic tools in one same room, reducing the attention time and increasing all interventions effectiveness.

创伤损伤控制旨在限制危及生命的出血。顺序诊断和治疗方法是目前的标准。混合室通过整合不同的专业和技术,缩短了止血时间。混合手术室寻求在配备了专业人员和先进技术的手术室中控制出血,包括血管造影、断层扫描、快速成像、放射照相、内窥镜、输注器、细胞回收器、REBOA等。创伤混合服务是一个描述垂直工作方案的概念,当收治严重受伤的患者时,从激活创伤代码开始,启动由创伤外科医生领导的持续复苏过程,该外科医生根据患者的病情和特定干预的需要引导转移到成像、血管造影和手术室。混合室将不同的诊断和治疗工具集成在同一个房间中,减少了注意时间,提高了所有干预措施的有效性。
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引用次数: 1
Damage control in penetrating duodenal trauma: less is better - the sequel. 十二指肠穿透性创伤的损伤控制:越少越好--续集。
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2021-05-03 DOI: 10.25100/cm.v52i2.4509
Carlos A Ordoñez, Michael W Parra, Mauricio Millán, Yaset Caicedo, Natalia Padilla, Alberto García, María Josefa Franco, Gonzalo Aristizábal, Luis Eduardo Toro, Luis Fernando Pino, Adolfo González-Hadad, Mario Alain Herrera, José Julián Serna, Fernando Rodríguez-Holguín, Alexander Salcedo, Claudia Orlas, Mónica Guzmán-Rodríguez, Fabian Hernández, Ricardo Ferrada, Rao Ivatury

The overall incidence of duodenal injuries in severely injured trauma patients is between 0.2 to 0.6% and the overall prevalence in those suffering from abdominal trauma is 3 to 5%. Approximately 80% of these cases are secondary to penetrating trauma, commonly associated with vascular and adjacent organ injuries. Therefore, defining the best surgical treatment algorithm remains controversial. Mild to moderate duodenal trauma is currently managed via primary repair and simple surgical techniques. However, severe injuries have required complex surgical techniques without significant favorable outcomes and a consequential increase in mortality rates. This article aims to delineate the experience in the surgical management of penetrating duodenal injuries via the creation of a practical and effective algorithm that includes basic principles of damage control surgery that sticks to the philosophy of "Less is Better". Surgical management of all penetrating duodenal trauma should always default when possible to primary repair. When confronted with a complex duodenal injury, hemodynamic instability, and/or significant associated injuries, the default should be damage control surgery. Definitive reconstructive surgery should be postponed until the patient has been adequately resuscitated and the diamond of death has been corrected.

在严重受伤的创伤患者中,十二指肠损伤的总发病率在 0.2% 到 0.6% 之间,而在腹部创伤患者中的总发病率为 3% 到 5%。这些病例中约有 80% 继发于穿透性创伤,通常伴有血管和邻近器官损伤。因此,确定最佳手术治疗算法仍存在争议。目前,轻度至中度十二指肠创伤可通过初级修复和简单的外科技术进行处理。然而,严重的十二指肠创伤需要复杂的外科技术,但效果并不明显,死亡率也随之增加。本文旨在通过建立一套实用有效的算法,包括损害控制手术的基本原则,坚持 "少即是好 "的理念,来阐述十二指肠穿透性损伤的手术治疗经验。所有穿透性十二指肠创伤的手术治疗都应尽可能采用初级修复术。如果十二指肠损伤复杂、血流动力学不稳定和/或伴有严重损伤,则应采取损伤控制手术。确定性的重建手术应推迟到病人得到充分抢救和死亡钻石得到纠正之后再进行。
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引用次数: 0
Damage control surgical management of combined small and large bowel injuries in penetrating trauma: Are ostomies still pertinent? 穿透性创伤合并小肠和大肠损伤的损伤控制外科治疗:造口术是否仍然相关?
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2021-04-27 DOI: 10.25100/cm.v52i2.4425
Carlos A Ordoñez, Michael W Parra, Yaset Caicedo, Natalia Padilla, Edison Angamarca, José Julián Serna, Fernando Rodríguez-Holguín, Alberto García, Alexander Salcedo, Luis Fernando Pino, Adolfo González-Hadad, Mario Alain Herrera, Laureano Quintero, Fabian Hernández, María Josefa Franco, Gonzalo Aristizábal, Luis Eduardo Toro, Mónica Guzmán-Rodríguez, Federico Coccolini, Ricardo Ferrada, Rao Ivatury

Hollow viscus injuries represent a significant portion of overall lesions sustained during penetrating trauma. Currently, isolated small or large bowel injuries are commonly managed via primary anastomosis in patients undergoing definitive laparotomy or deferred anastomosis in patients requiring damage control surgery. The traditional surgical dogma of ostomy has proven to be unnecessary and, in many instances, actually increases morbidity. The aim of this article is to delineate the experience obtained in the management of combined hollow viscus injuries of patients suffering from penetrating trauma. We sought out to determine if primary and/or deferred bowel injury repair via anastomosis is the preferred surgical course in patients suffering from combined small and large bowel penetrating injuries. Our experience shows that more than 90% of all combined penetrating bowel injuries can be managed via primary or deferred anastomosis, even in the most severe cases requiring the application of damage control principles. Applying this strategy, the overall need for an ostomy (primary or deferred) could be reduced to less than 10%.

在穿透性创伤中,中空的内脏损伤占整体损伤的很大一部分。目前,孤立的小肠或大肠损伤通常通过一期吻合术治疗确诊剖腹手术患者或延期吻合术治疗需要损伤控制手术的患者。传统的造口手术教条已被证明是不必要的,在许多情况下,实际上增加了发病率。本文的目的是描述的经验,在处理合并空心内脏损伤的患者遭受穿透性创伤。我们试图确定通过吻合术修复原发性和/或延期肠损伤是否是小肠和大肠穿透性损伤合并患者的首选手术方案。我们的经验表明,超过90%的联合穿透性肠损伤可以通过原发性或延期吻合来治疗,即使在最严重的情况下也需要应用损伤控制原则。应用这一策略,造口术(原发性或延期)的总需要可以减少到10%以下。
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引用次数: 4
COVID-19: The African enigma. 2019冠状病毒病:非洲之谜。
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2021-04-24 DOI: 10.25100/cm.v52i2.4816
Robert Colebunders
To the editor   Related article: https://colombiamedica.univalle.edu.co/...iew/4613   We read with interest the paper by Guerrero et al “COVID-19: The Ivermectin African Enigma” . In an ecological study they compared COVID-19 related mortality and infection rates between APOC (African Programme for Onchocerciasis Control) and non-APOC countries. After adjusting for Human Development Index (HDI) and number of performed test, COVID-19 mortality and infection rate were respectively 28% and 8% lower in non-APOC countries compared to APOC countries. The authors suggested that this difference may be related to the community directed treatment with ivermectin (CDTI) programs established in APOC countries.   We agree that it remains to be explained why a lower COVID-19 mortality is observed in many APOC countries compared to other parts of the world. However, we do not believe that this is related to CDTI programs. Indeed, in APOC countries ivermectin is distributed only once (most countries) or twice a year 2. Moreover, April 1st 2020, because of the COVID-19 pandemic, CDTI programs were interrupted and were only recently restarted.   Ivermectin has an in vitro anti-COVID-19 effect and also certain clinical trials suggested a beneficial effect of ivermectin on COVID-19 disease outcome. However, in a recent small double blind, randomized control trial in Colombia, five days of ivermectin, at a 10 times the recommended dose, did not reduce the duration of symptoms of mild COVID-19 disease compared to placebo. Given the half-life of ivermectin, approximately 18h, it is unlikely that CDTI, only one dose of ivermectin once or twice a year, may be able to reduce COVID-19 related mortality.   Many factors could explain the lower COVID-19 mortality in APOC countries. One of them could be exposure to parasitic infections and the immune response induced by these infections. For example, for P. falciparum, a parasitic infection highly prevalent in APOC countries, it has been hypothesised that the immunological memory against P. falciparum merozoites primes SARS-CoV-2 infected cells for early phagocytosis and therefore may protect persons with a recent P. falciparum infection against severe COVID-19 disease. Helminth infections, such as onchocerciasis, may down regulate immune responses and potentially inactivate the inflammatory signalling pathways that may induce acute respiratory distress syndrome (ARDS), one of the causes of death in COVID-19 infected persons
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引用次数: 0
Reply to a letter from Robert Colebunders entitled COVID-19: The African Enigma 回复Robert Colebunders题为“COVID-19:非洲之谜”的信
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2021-04-24 DOI: 10.25100/CM.V52I2.4833
Rodrigo Guerrero, L. Bravo, E. Muñoz, Elvia Karina Grillo Ardila, E. Guerrero
We thank Dr. Colebunders for his comments regarding our manuscript. Our study was an ecological study prompted by the low frequency of cases and deaths from the SARS-CoV-2 COVID-19 virus in some African countries. We agree with Dr. Colebunders that other factors could explain the observed association between APOC countries and COVID-19 mortality. However, these unmeasured confounders would have to be strongly associated with Covid-19 mortality to explain the observed 28% reduction. In updated information, as of 12-17-20, APOC countries had a 42% lower risk of death than the non-APOC countries, adjusted for confounders. (Not published) Hellwig et al., in addition to reporting similar findings to ours for African and Asian countries, surmised that they may be connected to ivermectin’s ability to inhibit SARS-CoV-2 replication suggesting other pathways must exist to explain the persistence of such an inhibitory effect after serum levels of ivermectin have declined. As mentioned by Mbow et al. “, it is increasingly recognized that the immune system is shaped not only by genetics but also by environmental factors, such as exposure to microorganisms and parasites. This educates the immune system to protect against invading pathogens not only specifically but also nonspecifically through, for example, “trained immunity,” which involves the reprogramming of innate cells that, on secondary encounter with a pathogen, can show a stronger response.” Those infections, such as onchocerciasis, may downregulate immune responses and potentially inactivate the inflammatory signalling pathways that may induce acute respiratory distress syndrome (ARDS), one of the causes of death in COVID-19 infected persons, seems very attractive explanation.  
我们感谢Colebunders博士对我们手稿的评论。我们的研究是一项生态研究,这是由于一些非洲国家的SARS-CoV-2 COVID-19病毒病例和死亡频率较低而引起的。我们同意Colebunders博士的观点,即其他因素可以解释APOC国家与COVID-19死亡率之间观察到的关联。然而,这些未测量的混杂因素必须与Covid-19死亡率密切相关,才能解释观察到的28%的下降。在最新信息中,截至2012年12月17日,经混杂因素调整后,疟疾控制地区国家的死亡风险比非疟疾控制地区国家低42%。(未发表)Hellwig等人除了报告了与我们在非洲和亚洲国家的类似发现外,还推测它们可能与伊维菌素抑制SARS-CoV-2复制的能力有关,这表明在伊维菌素血清水平下降后,必须存在其他途径来解释这种抑制作用的持久性。正如Mbow等人所提到的,“人们越来越认识到,免疫系统不仅受遗传因素的影响,还受环境因素的影响,例如暴露于微生物和寄生虫。这就教育了免疫系统,使其不仅能特异性地保护病原体,还能非特异性地保护病原体,例如,通过“训练免疫”,对先天细胞进行重新编程,使其在第二次遇到病原体时能表现出更强的反应。盘尾丝虫病等感染可能下调免疫反应,并可能使炎症信号通路失活,从而诱发急性呼吸窘迫综合征(ARDS),这是COVID-19感染者死亡的原因之一,这似乎是一个非常有吸引力的解释。
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引用次数: 0
Damage control of peripheral vascular trauma - Don't be afraid of axillary or popliteal fosses. 周围血管创伤的损伤控制-不要害怕腋窝或腘窝窝。
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2021-04-10 DOI: 10.25100/cm.v52i2.4735
Mario Alain Herrera, Mauricio Millán, Ana Milena Del Valle, Mateo Betancourt-Cajiao, Yaset Caicedo, Isabella Caicedo, Linda M Gallego, Diego Rivera, Michael W Parra, Carlos A Ordoñez

Peripheral vascular injuries are uncommon in civilian trauma but can threaten the patient's life or the viability of the limb. The definitive control of the vascular injury represents a surgical challenge, especially if the patient is hemodynamically unstable. This article proposes the management of peripheral vascular trauma following damage control surgery principles. It is essential to rapidly identify vascular injury signs and perform temporary bleeding control maneuvers. The surgical approaches according to the anatomical injured region should be selected. We propose two novel approaches to access the axillary and popliteal zones. The priority should be to reestablish limb perfusion via primary repair or damage control techniques (vascular shunt or endovascular approach). Major vascular surgeries should be managed post-operatively in the intensive care unit, which will allow correction of physiological derangement and identification of those developing compartmental syndrome. All permanent or temporary vascular procedures should be followed by a definitive repair within the first 8 hours. An early diagnosis and opportune intervention are fundamental to preserve the function and perfusion of the extremity.

外周血管损伤在民用创伤中并不常见,但可能危及患者的生命或肢体的生存能力。血管损伤的明确控制是手术的一大挑战,特别是当患者血流动力学不稳定时。本文提出了周围血管创伤的处理遵循损伤控制的外科原则。快速识别血管损伤迹象和执行临时出血控制操作是至关重要的。应根据解剖损伤区域选择手术入路。我们提出了两种新的方法来进入腋窝和腘窝区。优先考虑通过初级修复或损伤控制技术(血管分流或血管内入路)重建肢体灌注。大血管手术应该在重症监护病房进行,这将允许纠正生理紊乱和识别那些发展为室室综合征的人。所有永久性或暂时性血管手术应在前8小时内进行最终修复。早期诊断和及时干预是保持肢体功能和血流灌注的基础。
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引用次数: 2
Hemodynamically unstable non-compressible penetrating torso trauma: a practical surgical approach. 血流动力学不稳定的不可压缩穿透性躯干创伤:一种实用的外科方法。
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2021-04-08 DOI: 10.25100/cm.v52i2.4592
Mauricio Millán, Carlos A Ordoñez, Michael W Parra, Yaset Caicedo, Natalia Padilla, Luis Fernando Pino, Fernando Rodríguez-Holguín, Alexander Salcedo, Alberto García, José Julián Serna, Mario Alain Herrera, Laureano Quintero, Fabian Hernández, Carlos Serna, Adolfo González Hadad

Penetrating torso trauma is the second leading cause of death following head injury. Traffic accidents, falls and overall blunt trauma are the most common mechanism of injuries in developed countries; whereas, penetrating trauma which includes gunshot and stabs wounds is more prevalent in developing countries due to ongoing violence and social unrest. Penetrating chest and abdominal trauma have high mortality rates at the scene of the incident when important structures such as the heart, great vessels, or liver are involved. Current controversies surround the optimal surgical approach of these cases including the use of an endovascular device such as the Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) and the timing of additional imaging aids. This article aims to shed light on this subject based on the experience earned during the past 30 years in trauma critical care management of the severely injured patient. We have found that prioritizing the fact that the patient is hemodynamically unstable and obtaining early open or endovascular occlusion of the aorta to gain ground on avoiding the development of the lethal diamond is of utmost importance. Damage control surgery starts with choosing the right surgery of the right cavity in the right patient. For this purpose, we present a practical and simple guide on how to perform the surgical approach to penetrating torso trauma in a hemodynamically unstable patient.

穿透性躯干创伤是继头部受伤之后的第二大死因。交通事故、跌倒和整体钝性创伤是发达国家最常见的伤害机制;然而,由于持续的暴力和社会动荡,包括枪伤和刺伤在内的穿透性创伤在发展中国家更为普遍。当穿透性胸部和腹部创伤涉及心脏、大血管或肝脏等重要结构时,在事故现场的死亡率很高。目前围绕这些病例的最佳手术方法存在争议,包括使用血管内装置,如复苏血管内球囊闭塞主动脉(REBOA)和额外成像辅助的时机。本文旨在根据过去30年来在重症患者创伤重症监护管理中所获得的经验来阐明这一主题。我们发现,优先考虑患者血流动力学不稳定的事实,并尽早进行主动脉开放或血管内闭塞,以避免致命钻石的发展,这是至关重要的。损伤控制手术首先要选择合适的手术,在合适的病人身上进行合适的手术。为此,我们提出了一个实用的和简单的指导,如何实施手术方法穿透躯干创伤在一个血液动力学不稳定的病人。
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引用次数: 0
Damage control in penetrating cardiac trauma. 穿透性心脏创伤的损伤控制。
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2021-04-03 DOI: 10.25100/cm.v52i2.4519
Adolfo González-Hadad, Carlos A Ordoñez, Michael W Parra, Yaset Caicedo, Natalia Padilla, Mauricio Millán, Alberto García, Jenny Marcela Vidal-Carpio, Luis Fernando Pino, Mario Alain Herrera, Laureano Quintero, Fabian Hernández, Guillermo Flórez, Fernando Rodríguez-Holguín, Alexander Salcedo, José Julián Serna, María Josefa Franco, Ricardo Ferrada, Pradeep H Navsaria

Definitive management of hemodynamically stable patients with penetrating cardiac injuries remains controversial between those who propose aggressive invasive care versus those who opt for a less invasive or non-operative approach. This controversy even extends to cases of hemodynamically unstable patients in which damage control surgery is thought to be useful and effective. The aim of this article is to delineate our experience in the surgical management of penetrating cardiac injuries via the creation of a clear and practical algorithm that includes basic principles of damage control surgery. We recommend that all patients with precordial penetrating injuries undergo trans-thoracic ultrasound screening as an integral component of their initial evaluation. In those patients who arrive hemodynamically stable but have a positive ultrasound, a pericardial window with lavage and drainage should follow. We want to emphasize the importance of the pericardial lavage and drainage in the surgical management algorithm of these patients. Before this concept, all positive pericardial windows ended up in an open chest exploration. With the coming of the pericardial lavage and drainage procedure, the reported literature and our experience have shown that 25% of positive pericardial windows do not benefit and/or require further invasive procedures. However, in hemodynamically unstable patients, damage control surgery may still be required to control ongoing bleeding. For this purpose, we propose a surgical management algorithm that includes all of these essential clinical aspects in the care of these patients.

对于血流动力学稳定的心脏穿透性损伤患者的最终处理方法,在提出积极的侵入性治疗与选择侵入性较小或非手术治疗之间仍存在争议。这种争议甚至延伸到血流动力学不稳定的患者病例,在这些病例中,损伤控制手术被认为是有用和有效的。本文旨在通过建立一套清晰实用的算法,包括损伤控制手术的基本原则,阐述我们在心脏穿透性损伤手术治疗方面的经验。我们建议所有心前区穿透性损伤患者接受经胸超声波筛查,这是初步评估不可或缺的组成部分。对于血流动力学稳定但超声检查呈阳性的患者,应进行心包开窗灌洗和引流。我们要强调的是,心包灌洗和引流在这些患者的手术治疗方案中非常重要。在这一概念提出之前,所有心包造影阳性的患者都需要进行开胸探查。随着心包灌洗和引流术的出现,文献报道和我们的经验表明,25% 的心包窗阳性患者无法获益和/或需要进一步的侵入性手术。然而,对于血流动力学不稳定的患者,可能仍需要进行损伤控制手术来控制持续出血。为此,我们提出了一种手术管理算法,其中包括了护理这些患者的所有这些基本临床方面。
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引用次数: 0
Retinal lipemia as expression of hyperchylomicronemia syndrome. 视网膜脂血症是高乳糜微粒血症综合征的表现。
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2021-03-30 DOI: 10.25100/cm.v52i1.4059
Jon Ortiz de Salido-Menchaca, Manuel Antonio Tazón-Varela, David de la Hera-Vegas, Rosa Herreras-Martínez, Sergio Andrés Álvarez-Agudelo, Nuria Arencibia-Hernández

Case description: Case of lipemia retinalis secondary to hyperchylomicronemia in a 40-year-old man with a history of total body irradiation and immunosuppressive treatment that was attended in this hospital due to decreased visual acuity and abdominal pain.

Clinical findings: Hyperchylomicronemia caused the development of acute pancreatitis and lipemia retinalis. The latter is an infrequent ocular manifestation that reflects excessive triglyceride blood levels in the organism (>2,000 mg/dL). Lipemia retinalis is characterized by the accumulation of chylomicrons in the retinal vessels, which gives them a white and creamy appearance in direct retinal ophthalmoscopy. The initial clinical suspicion of hyperchylomicronemia was based on the visualization of the supernatant in the analytical tube.

Treatment and result: In the absence of definitive biochemical results, and owing to the need for special processing of the sample, lipid-lowering treatment and serum therapy were established after ophthalmological confirmation of lipemia retinalis, with subsequent full recovery of visual acuity.

Clinical relevance: Given the initial difficulty to determine the accurate triglyceride levels in this kind of patient, early visualization of milky-colored retinal vessels on a salmon-colored eye fundus can help develop an early clinical suspicion of severe hyperchylomicronemia and contribute to limit the severity of complications.

病例描述:一例继发于高乳糜微粒血症的视网膜脂血症,患者为40岁男性,因视力下降和腹痛在该院接受过全身照射和免疫抑制治疗。临床表现:高乳糜微粒血症引起急性胰腺炎和视网膜脂血症的发展。后者是一种罕见的眼部表现,反映机体血液中甘油三酯水平过高(> 2000 mg/dL)。视网膜脂血症的特点是在视网膜血管中积聚乳糜微粒,这使它们在直接视网膜眼科检查中呈现白色和奶油状外观。最初的临床怀疑高乳糜微粒血症是基于分析管中上清的可视化。治疗和结果:在没有明确的生化结果的情况下,由于样品需要特殊处理,在眼科确认视网膜脂血症后,进行了降脂治疗和血清治疗,随后视力完全恢复。临床相关性:考虑到在这类患者中最初很难确定准确的甘油三酯水平,在鲑鱼色眼底早期观察乳白色视网膜血管有助于早期临床怀疑严重的高乳糜小铁血症,并有助于限制并发症的严重程度。
{"title":"Retinal lipemia as expression of hyperchylomicronemia syndrome.","authors":"Jon Ortiz de Salido-Menchaca,&nbsp;Manuel Antonio Tazón-Varela,&nbsp;David de la Hera-Vegas,&nbsp;Rosa Herreras-Martínez,&nbsp;Sergio Andrés Álvarez-Agudelo,&nbsp;Nuria Arencibia-Hernández","doi":"10.25100/cm.v52i1.4059","DOIUrl":"https://doi.org/10.25100/cm.v52i1.4059","url":null,"abstract":"<p><strong>Case description: </strong>Case of lipemia retinalis secondary to hyperchylomicronemia in a 40-year-old man with a history of total body irradiation and immunosuppressive treatment that was attended in this hospital due to decreased visual acuity and abdominal pain.</p><p><strong>Clinical findings: </strong>Hyperchylomicronemia caused the development of acute pancreatitis and lipemia retinalis. The latter is an infrequent ocular manifestation that reflects excessive triglyceride blood levels in the organism (>2,000 mg/dL). Lipemia retinalis is characterized by the accumulation of chylomicrons in the retinal vessels, which gives them a white and creamy appearance in direct retinal ophthalmoscopy. The initial clinical suspicion of hyperchylomicronemia was based on the visualization of the supernatant in the analytical tube.</p><p><strong>Treatment and result: </strong>In the absence of definitive biochemical results, and owing to the need for special processing of the sample, lipid-lowering treatment and serum therapy were established after ophthalmological confirmation of lipemia retinalis, with subsequent full recovery of visual acuity.</p><p><strong>Clinical relevance: </strong>Given the initial difficulty to determine the accurate triglyceride levels in this kind of patient, early visualization of milky-colored retinal vessels on a salmon-colored eye fundus can help develop an early clinical suspicion of severe hyperchylomicronemia and contribute to limit the severity of complications.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/97/19/1657-9534-cm-52-01-e7024059.PMC8054710.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38917991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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Colombia Medica
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