Prodrugs are an important strategy for the development and design of therapeutic drugs. They involve the addition of an easily removable group (such as an ester) to a molecule in order to chemically protect it from metabolism, hydrolysis, or interaction with tissues. In the therapeutic drug market, prodrugs may reduce adverse effects, lead to more accurate tissue delivery, increase bioavailability and duration of effects. The same strategy has, however, been used in the illicit drug market. Internationally controlled drugs such as LSD, MDMA and benzodiazepines have been detected in the market with the addition of alkyl chain that can be removed in physiological conditions. Cyclical analogues may also be used, as is the case for 1cP‐LSD and GBL (a prodrug of GHB). Adequate detection requires increased care with extraction and analytical conditions—as the parent drugs may be formed as artifacts during these processes—and an in‐depth knowledge of metabolic pathways to avoid erroneous detection and allow for adequate identification of the drug used. Legislative updates may also be necessary to ensure prodrugs can be controlled at the same level as other illicit drugs.This article is categorized under: Toxicology > New Psychoactive Substances Toxicology > Drug Analysis Toxicology > Analytical
{"title":"The use of prodrugs as drugs of abuse","authors":"Julio de Carvalho Ponce","doi":"10.1002/wfs2.1514","DOIUrl":"https://doi.org/10.1002/wfs2.1514","url":null,"abstract":"Prodrugs are an important strategy for the development and design of therapeutic drugs. They involve the addition of an easily removable group (such as an ester) to a molecule in order to chemically protect it from metabolism, hydrolysis, or interaction with tissues. In the therapeutic drug market, prodrugs may reduce adverse effects, lead to more accurate tissue delivery, increase bioavailability and duration of effects. The same strategy has, however, been used in the illicit drug market. Internationally controlled drugs such as LSD, MDMA and benzodiazepines have been detected in the market with the addition of alkyl chain that can be removed in physiological conditions. Cyclical analogues may also be used, as is the case for 1cP‐LSD and GBL (a prodrug of GHB). Adequate detection requires increased care with extraction and analytical conditions—as the parent drugs may be formed as artifacts during these processes—and an in‐depth knowledge of metabolic pathways to avoid erroneous detection and allow for adequate identification of the drug used. Legislative updates may also be necessary to ensure prodrugs can be controlled at the same level as other illicit drugs.This article is categorized under:\u0000Toxicology > New Psychoactive Substances\u0000Toxicology > Drug Analysis\u0000Toxicology > Analytical\u0000","PeriodicalId":506835,"journal":{"name":"WIREs Forensic Science","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140229812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wim Neuteboom, Alastair Ross, L. Bugeja, Sheila Willis, Claude Roux, Kevin Lothridge
The competencies and attributes of forensic science professionals are a very important pillar of a Quality Management system. However, a recent international survey identified a lack of agreement on the core cognitive competencies required for working in forensic science. The survey also identified the tools for assessing competencies are not necessarily designed to measure cognitive competencies. In this Perspective, we explore further the topic of competencies and in particular, cognitive competencies and attributes with a focus on forensic science professionals. We identify the critical issue and outline a process through which we will seek the views of leaders in the field, both operational and academic, on what the required cognitive competencies and attributes are for forensic science professionals. The tools used will include a questionnaire and direct interviews. Having identified the key competencies and attributes they can then be promoted, and methods developed to assess them within the recruitment process and continuous professional development programs. We argue that further discussion on this topic is warranted as it impacts on forensic science education, training, recruitment, operations, and overall quality.This article is categorized under: Forensic Chemistry and Trace Evidence > Presentation and Evaluation of Forensic Science Output
{"title":"Quality management and competencies in forensic science","authors":"Wim Neuteboom, Alastair Ross, L. Bugeja, Sheila Willis, Claude Roux, Kevin Lothridge","doi":"10.1002/wfs2.1513","DOIUrl":"https://doi.org/10.1002/wfs2.1513","url":null,"abstract":"The competencies and attributes of forensic science professionals are a very important pillar of a Quality Management system. However, a recent international survey identified a lack of agreement on the core cognitive competencies required for working in forensic science. The survey also identified the tools for assessing competencies are not necessarily designed to measure cognitive competencies. In this Perspective, we explore further the topic of competencies and in particular, cognitive competencies and attributes with a focus on forensic science professionals. We identify the critical issue and outline a process through which we will seek the views of leaders in the field, both operational and academic, on what the required cognitive competencies and attributes are for forensic science professionals. The tools used will include a questionnaire and direct interviews. Having identified the key competencies and attributes they can then be promoted, and methods developed to assess them within the recruitment process and continuous professional development programs. We argue that further discussion on this topic is warranted as it impacts on forensic science education, training, recruitment, operations, and overall quality.This article is categorized under:\u0000Forensic Chemistry and Trace Evidence > Presentation and Evaluation of Forensic Science Output\u0000","PeriodicalId":506835,"journal":{"name":"WIREs Forensic Science","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139809447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wim Neuteboom, Alastair Ross, L. Bugeja, Sheila Willis, Claude Roux, Kevin Lothridge
The competencies and attributes of forensic science professionals are a very important pillar of a Quality Management system. However, a recent international survey identified a lack of agreement on the core cognitive competencies required for working in forensic science. The survey also identified the tools for assessing competencies are not necessarily designed to measure cognitive competencies. In this Perspective, we explore further the topic of competencies and in particular, cognitive competencies and attributes with a focus on forensic science professionals. We identify the critical issue and outline a process through which we will seek the views of leaders in the field, both operational and academic, on what the required cognitive competencies and attributes are for forensic science professionals. The tools used will include a questionnaire and direct interviews. Having identified the key competencies and attributes they can then be promoted, and methods developed to assess them within the recruitment process and continuous professional development programs. We argue that further discussion on this topic is warranted as it impacts on forensic science education, training, recruitment, operations, and overall quality.This article is categorized under: Forensic Chemistry and Trace Evidence > Presentation and Evaluation of Forensic Science Output
{"title":"Quality management and competencies in forensic science","authors":"Wim Neuteboom, Alastair Ross, L. Bugeja, Sheila Willis, Claude Roux, Kevin Lothridge","doi":"10.1002/wfs2.1513","DOIUrl":"https://doi.org/10.1002/wfs2.1513","url":null,"abstract":"The competencies and attributes of forensic science professionals are a very important pillar of a Quality Management system. However, a recent international survey identified a lack of agreement on the core cognitive competencies required for working in forensic science. The survey also identified the tools for assessing competencies are not necessarily designed to measure cognitive competencies. In this Perspective, we explore further the topic of competencies and in particular, cognitive competencies and attributes with a focus on forensic science professionals. We identify the critical issue and outline a process through which we will seek the views of leaders in the field, both operational and academic, on what the required cognitive competencies and attributes are for forensic science professionals. The tools used will include a questionnaire and direct interviews. Having identified the key competencies and attributes they can then be promoted, and methods developed to assess them within the recruitment process and continuous professional development programs. We argue that further discussion on this topic is warranted as it impacts on forensic science education, training, recruitment, operations, and overall quality.This article is categorized under:\u0000Forensic Chemistry and Trace Evidence > Presentation and Evaluation of Forensic Science Output\u0000","PeriodicalId":506835,"journal":{"name":"WIREs Forensic Science","volume":"17 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139869410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This perspective considers the forensic examination of deceased bodies via the medico‐legal autopsy. It is argued that the decisions we make about what we do with, and to, deceased bodies and body parts is, and should be, limited by the need to treat bodies with dignity and respect. The treatment of parts of bodies has been explored in bioethics, substantially due to organ retention scandals bringing this to the public and political attention. But these cases—although important—represent extremes. This perspective therefore focuses on routine death investigations and the extent to which scientific method should be limited because of the competing interests in the deceased body and its treatment. It is argued that how we treat bodies/body parts matters because they represent once‐living people with contexts, histories, and relationships. They had, and perhaps still have, value as human persons. As humans, we share complex relationships and have different views and interpretations of what our duties are to each other. Dignity and respect aid by providing baseline standards, and are reflected as such in professional codes and regulations. However, the system is imbued with sufficient discretion that it is impossible to achieve consistency of standards or practice. This means that the treatment of deceased bodies in forensic science will differ substantially depending on both context and the practitioners involved.This article is categorized under: Forensic Medicine > Medicolegal Death Investigation Systems
{"title":"Pathology and forensic science: Dignity, respect, and the dead body","authors":"Imogen Jones","doi":"10.1002/wfs2.1512","DOIUrl":"https://doi.org/10.1002/wfs2.1512","url":null,"abstract":"This perspective considers the forensic examination of deceased bodies via the medico‐legal autopsy. It is argued that the decisions we make about what we do with, and to, deceased bodies and body parts is, and should be, limited by the need to treat bodies with dignity and respect. The treatment of parts of bodies has been explored in bioethics, substantially due to organ retention scandals bringing this to the public and political attention. But these cases—although important—represent extremes. This perspective therefore focuses on routine death investigations and the extent to which scientific method should be limited because of the competing interests in the deceased body and its treatment. It is argued that how we treat bodies/body parts matters because they represent once‐living people with contexts, histories, and relationships. They had, and perhaps still have, value as human persons. As humans, we share complex relationships and have different views and interpretations of what our duties are to each other. Dignity and respect aid by providing baseline standards, and are reflected as such in professional codes and regulations. However, the system is imbued with sufficient discretion that it is impossible to achieve consistency of standards or practice. This means that the treatment of deceased bodies in forensic science will differ substantially depending on both context and the practitioners involved.This article is categorized under: Forensic Medicine > Medicolegal Death Investigation Systems","PeriodicalId":506835,"journal":{"name":"WIREs Forensic Science","volume":"234 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139184016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The importance of the field of digital forensics (DF) is growing, where digital evidence is increasingly recognized as a crucial part of many investigations. As a result, criminal justice systems rely on DF practitioners to conduct robust investigations of digital devices and their data, and interpret and present these results in a way that can be relied upon. Undertaking this task appropriately requires a practitioner to have a range of skills; however, focus is often placed on the need for and importance of technical competency. Technical skills are vital in this role, that cannot be in dispute; however, this work discusses the need for practitioners to also have an “investigative mindset.”This article is categorized under: Digital and Multimedia Science > Cybercrime Investigation
{"title":"Fostering an “investigating mindset”: Why is it important in digital forensic science education?","authors":"G. Horsman, Elenore Ryser, Brett Shavers","doi":"10.1002/wfs2.1511","DOIUrl":"https://doi.org/10.1002/wfs2.1511","url":null,"abstract":"The importance of the field of digital forensics (DF) is growing, where digital evidence is increasingly recognized as a crucial part of many investigations. As a result, criminal justice systems rely on DF practitioners to conduct robust investigations of digital devices and their data, and interpret and present these results in a way that can be relied upon. Undertaking this task appropriately requires a practitioner to have a range of skills; however, focus is often placed on the need for and importance of technical competency. Technical skills are vital in this role, that cannot be in dispute; however, this work discusses the need for practitioners to also have an “investigative mindset.”This article is categorized under: Digital and Multimedia Science > Cybercrime Investigation","PeriodicalId":506835,"journal":{"name":"WIREs Forensic Science","volume":"12 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139184561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caitlyn Norman, Dorothy Xi Yue Lim, Taylor Henderson, Fabio Casali, N. Daéid, Lorna A. Nisbet, Hervé Ménard
The rapid increase in the production and distribution of illicit drugs has led to vast amounts of data being generated through research and other publications, making it difficult to effectively distill and analyze current and emerging trends. The present study used a scientometric approach to identify trends and challenges in the use of drugs as an evidence type in forensic science by examining reference lists available in the INTERPOL IFSMS reports and the citation database Scopus. It has been identified that “new psychoactive substances” is one of the most frequently used keywords by authors, highlighting the swift response by communities to characterize these emerging compounds. However, it was also noted that despite drugs being a global threat, only limited international collaboration was observed between research groups and the majority of the studies are from authors affiliated within the same country. Finally, an argument is made to encourage a more comprehensive approach in aggregating results on drugs for greater transparency and broader distribution of findings.This article is categorized under: Forensic Chemistry > Mass Casualty Management Forensic Chemistry > Controlled and Emerging Drug Compounds
{"title":"Trends and challenges in the use of drugs as forensic evidence: A scientometric approach to map the current literature","authors":"Caitlyn Norman, Dorothy Xi Yue Lim, Taylor Henderson, Fabio Casali, N. Daéid, Lorna A. Nisbet, Hervé Ménard","doi":"10.1002/wfs2.1509","DOIUrl":"https://doi.org/10.1002/wfs2.1509","url":null,"abstract":"The rapid increase in the production and distribution of illicit drugs has led to vast amounts of data being generated through research and other publications, making it difficult to effectively distill and analyze current and emerging trends. The present study used a scientometric approach to identify trends and challenges in the use of drugs as an evidence type in forensic science by examining reference lists available in the INTERPOL IFSMS reports and the citation database Scopus. It has been identified that “new psychoactive substances” is one of the most frequently used keywords by authors, highlighting the swift response by communities to characterize these emerging compounds. However, it was also noted that despite drugs being a global threat, only limited international collaboration was observed between research groups and the majority of the studies are from authors affiliated within the same country. Finally, an argument is made to encourage a more comprehensive approach in aggregating results on drugs for greater transparency and broader distribution of findings.This article is categorized under: Forensic Chemistry > Mass Casualty Management Forensic Chemistry > Controlled and Emerging Drug Compounds","PeriodicalId":506835,"journal":{"name":"WIREs Forensic Science","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139217491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Drowning is the third most common cause of unintentional injury death worldwide. In forensic medicine, drowning refers to an event in which the victim dies due to liquid penetrating into the airways or due to submersion in a liquid. Medico‐legal examination of bodies found in water is a challenging task. Establishing proper cause and manner of death requires the joint efforts of the police, medical examiner, and representatives of postmortem toxicology. Information of the circumstances, the victim's individual characteristics and medical background, together with postmortem findings is required. The presence of alcohol and drugs revealed by postmortem toxicology can give insight into the decedent's medical history, drug abuse history, and possible impairment at the time of death. There is ample epidemiological research indicating that alcohol is the most important single contributing factor for fatal drowning, while hypno‐sedative medicines and illicit drugs, especially amphetamines, also appear to pose a risk. Evidence shows that alcohol can be produced postmortem in a submerged body by microbial contamination and fermentation, and this phenomenon is even more significant the higher the water temperature and the longer the submersion time. The reliability of the blood alcohol concentration obtained can be verified in many ways, for example by comparing the ratios of blood, vitreous and urine alcohol concentrations with reference values, or by testing for non‐oxidative ethanol metabolites, the presence of which suggests antemortem alcohol ingestion. Compared to alcohol postmortem changes, very little is known about the long‐term stability of drugs in bodies found in water.This article is categorized under: Toxicology > Analytical Toxicology > Post‐Mortem
{"title":"Role of postmortem toxicology in drowning investigations","authors":"I. Ojanperä, Pirkko Kriikku","doi":"10.1002/wfs2.1510","DOIUrl":"https://doi.org/10.1002/wfs2.1510","url":null,"abstract":"Drowning is the third most common cause of unintentional injury death worldwide. In forensic medicine, drowning refers to an event in which the victim dies due to liquid penetrating into the airways or due to submersion in a liquid. Medico‐legal examination of bodies found in water is a challenging task. Establishing proper cause and manner of death requires the joint efforts of the police, medical examiner, and representatives of postmortem toxicology. Information of the circumstances, the victim's individual characteristics and medical background, together with postmortem findings is required. The presence of alcohol and drugs revealed by postmortem toxicology can give insight into the decedent's medical history, drug abuse history, and possible impairment at the time of death. There is ample epidemiological research indicating that alcohol is the most important single contributing factor for fatal drowning, while hypno‐sedative medicines and illicit drugs, especially amphetamines, also appear to pose a risk. Evidence shows that alcohol can be produced postmortem in a submerged body by microbial contamination and fermentation, and this phenomenon is even more significant the higher the water temperature and the longer the submersion time. The reliability of the blood alcohol concentration obtained can be verified in many ways, for example by comparing the ratios of blood, vitreous and urine alcohol concentrations with reference values, or by testing for non‐oxidative ethanol metabolites, the presence of which suggests antemortem alcohol ingestion. Compared to alcohol postmortem changes, very little is known about the long‐term stability of drugs in bodies found in water.This article is categorized under: Toxicology > Analytical Toxicology > Post‐Mortem","PeriodicalId":506835,"journal":{"name":"WIREs Forensic Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139226556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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