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Dissection, media portrayals, and reaction: Black bodies and medical education in nineteenth-century newspapers 解剖、媒体描述和反应:十九世纪报纸上的黑人尸体和医学教育。
IF 2.4 4区 医学 Q1 ANATOMY & MORPHOLOGY Pub Date : 2024-02-26 DOI: 10.1002/ca.24146
Laura Elizabeth Smith

Throughout the nineteenth century, medical schools in both the Northern and Southern regions of the United States required a regular supply of bodies for medical study and experimentation. Physicians and medical students targeted the bodies of African Americans, both freedmen and the enslaved, to meet this demand. Simultaneously, the nation's booming newspaper market became a stage on which debates about the cruelty of slavery and the social consequences of pursuing medical knowledge played out in articles about the dissection of Black bodies. Such stories increased fears about dissection and mistrust towards the medical profession among African American communities, which manifested in riots against physicians, vandalism against medical schools, and corrective responses from African American newspaper editors and journalists. Through an extensive examination of nineteenth-century U.S. newspapers, this article identifies themes evident in the coverage of dissection during this period. Southern newspapers crafted stories of dissection that served the dual purpose of entertaining White readers and humiliating African Americans. This public humiliation fostered what became a popular genre of derogatory and vile humor that reinforced negative and inaccurate racialized stereotypes as well as racist science. Ultimately, such newspaper coverage provoked reactions within Black communities and among antislavery advocates that showcase how people often excluded from practicing medicine themselves viewed issues like medical education. Newspaper rhetoric around these themes amplified tensions between religious and scientific perspectives, reflected differences and similarities between the northern and southern areas of the United States, and fortified racist views in both cultural and scientific contexts.

在整个十九世纪,美国北部和南部地区的医学院都需要定期供应尸体用于医学研究和实验。为了满足这一需求,医生和医科学生将非裔美国人(包括自由人和被奴役者)的尸体作为目标。与此同时,美国蓬勃发展的报业市场成为了一个舞台,关于奴隶制的残酷性和追求医学知识的社会后果的辩论在有关解剖黑人尸体的文章中上演。这些报道增加了非裔美国人社区对解剖的恐惧和对医学专业的不信任,表现为针对医生的骚乱、针对医学院的破坏活动以及非裔美国人报纸编辑和记者的纠正措施。通过对 19 世纪美国报纸的广泛研究,本文确定了这一时期有关解剖报道的明显主题。南方报纸精心制作的解剖故事具有双重目的,既能取悦白人读者,又能羞辱非裔美国人。这种公开羞辱催生了一种流行的贬损和恶俗幽默,强化了负面和不准确的种族刻板印象以及种族主义科学。最终,此类报纸报道在黑人社区和反奴隶制倡导者中激起了反响,展示了经常被排斥在行医之外的人们是如何看待医学教育等问题的。围绕这些主题的报纸言论放大了宗教和科学观点之间的紧张关系,反映了美国北部和南部地区的异同,并强化了文化和科学背景下的种族主义观点。
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引用次数: 0
Microsurgical anatomy of the glossopharyngeal nerve 舌咽神经显微外科解剖。
IF 2.4 4区 医学 Q1 ANATOMY & MORPHOLOGY Pub Date : 2024-02-21 DOI: 10.1002/ca.24143
Wonil Joo

The glossopharyngeal nerve is a complicated and mixed nerve including sensory, motor, parasympathetic, and visceral fibers. It mediates taste, salivation, and swallowing. The low cranial nerves, including IXth, Xth, and XIth, are closely related, sharing some nuclei in the brainstem. The glossopharyngeal nerve arises from the spinal trigeminal nucleus and tract, solitary tract and nucleus, nucleus ambiguous, and inferior salivatory nucleus in the brainstem. There are communicating branches forming a neural anastomotic network between low cranial nerves. Comprehensive knowledge of the anatomy of the glossopharyngeal nerve is crucial for performing surgical procedures without significant complications. This review describes the microsurgical anatomy of the glossopharyngeal nerve and illustrates some pictures involving the glossopharyngeal nerve and its connective and neurovascular structures.

舌咽神经是一种复杂的混合神经,包括感觉、运动、副交感神经和内脏纤维。它介导味觉、流涎和吞咽。第 IX、X 和 XI 等低颅神经关系密切,共用脑干中的一些神经核。舌咽神经起源于脑干的脊髓三叉神经核和束、孤独束和核、模糊核和下唾液核。低颅神经之间有沟通分支形成神经吻合网。全面了解舌咽神经的解剖结构对于手术过程中避免出现严重并发症至关重要。本综述描述了舌咽神经的显微外科解剖,并展示了一些涉及舌咽神经及其结缔和神经血管结构的图片。
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引用次数: 0
Ultrasound clinical references of the healthy toenail unit 健康趾甲单元的超声临床参考。
IF 2.4 4区 医学 Q1 ANATOMY & MORPHOLOGY Pub Date : 2024-02-14 DOI: 10.1002/ca.24145
Olga López Ripado, Julia Villar Rodríguez, Esther Mingorance Álvarez, Ana Mª. Pérez Pico, Agustín García Nogales, Raquel Mayordomo Acevedo

The toenail unit, commonly called the nail, is one of the most frequently examined and treated structures in clinical podiatry. Ultrasound is a standard clinical technique because it is a noninvasive, painless, and rapid diagnostic tool. The main objective of this study was to obtain morphometric data of the healthy toenail unit by ultrasound for clinical application. The nails of 76 participants (152 hallux nails; 38 men, 38 women, average age 26.83 ± 12.20) were examined using a VINNO E35 ultrasound system and an X6-16L linear probe with a frequency of 18 MHz. Five ultrasound measures of the healthy toenail unit were obtained, of which only the distance from the center of the distal phalange to the nail plate varied with age, sex, weight, and foot (p-values ≤ 0.050). The other four parameters were less influenced by the variables analyzed, except sex, which influenced nearly all (p-values ≤ 0.050). In one of these variables, indications of significance were observed (p-values = 0.060), with greater distances in the men than in the women, except for nail plate curvature, which showed a higher value. The other variables studied did not influence the parameters analyzed. High-frequency ultrasound can be used to examine the healthy toenail unit and define anthropometric reference measurements that can be used for more accurate and comparative diagnosis.

趾甲(俗称指甲)是临床足病学中最常检查和治疗的结构之一。超声波是一种无创、无痛、快速的诊断工具,因此是一种标准的临床技术。本研究的主要目的是通过超声波获取健康趾甲单元的形态计量数据,并将其应用于临床。研究人员使用 VINNO E35 超声波系统和频率为 18 MHz 的 X6-16L 线性探头对 76 名参与者(152 个趾甲;38 名男性,38 名女性,平均年龄为 26.83 ± 12.20)的趾甲进行了检查。对健康趾甲单元进行了五项超声测量,其中只有远端趾骨中心到甲板的距离随年龄、性别、体重和足部而变化(p 值≤ 0.050)。其他四个参数受分析变量的影响较小,但性别除外,性别几乎对所有参数都有影响(p 值≤ 0.050)。在其中一个变量中,观察到显著性迹象(p 值 = 0.060),男性的距离大于女性,但甲板弯曲度除外,其值较高。所研究的其他变量对分析参数没有影响。高频超声波可用于检查健康的趾甲单位,并确定人体测量参考值,以便进行更准确的比较诊断。
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引用次数: 0
Cervical enamel projections from a periodontal perspective: A scoping review 从牙周角度看牙颈部釉质突起:范围综述。
IF 2.4 4区 医学 Q1 ANATOMY & MORPHOLOGY Pub Date : 2024-02-13 DOI: 10.1002/ca.24141
Hyun Ju Kim, Sun-Young Kim

Cervical enamel projections (CEPs) represent a unique developmental and anatomical anomaly wherein the enamel structure extends apically beyond the cemento-enamel junction of the tooth. In this scoping review, the existing literature on CEPs was evaluated to delineate their characteristics, prevalence, predilection for specific teeth and surfaces, clinical significance, and management approaches. Searches were conducted on MEDLINE (PubMed), Cochrane Library, and Embase databases using the keywords “enamel projection(s)” or “ectopic enamel.” In total, 24 studies meeting inclusion criteria were included in the review. The prevalence of CEPs varied widely (8.3%–85.1%), predominantly manifesting as grade I or grade III. Mandibular first and second molars exhibited a higher incidence of CEPs, with a notable predilection for buccal surfaces. The consensus in most studies was that CEPs are associated with localized periodontal diseases. Recommendations inclined toward the removal of ectopic enamel during periodontal surgery to enhance periodontal attachment formation. However, decision-making should involve careful consideration of the benefits and drawbacks based on individual circumstances.

牙颈部釉质突起(CEPs)是一种独特的发育和解剖异常,其釉质结构向顶部延伸,超出了牙齿的牙本质-釉质交界处。在此次范围审查中,我们评估了有关 CEPs 的现有文献,以确定其特征、发病率、对特定牙齿和表面的偏好、临床意义和管理方法。使用关键词 "釉质突起 "或 "异位釉质 "在 MEDLINE (PubMed)、Cochrane Library 和 Embase 数据库中进行了检索。符合纳入标准的研究共有 24 项。CEPs的发病率差异很大(8.3%-85.1%),主要表现为I级或III级。下颌第一和第二磨牙的 CEP 发生率较高,且明显偏向于颊面。大多数研究一致认为,CEPs 与局部牙周疾病有关。建议倾向于在牙周手术中去除异位釉质,以促进牙周附着的形成。不过,在做决定时应根据个人情况仔细考虑利弊。
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引用次数: 0
Has anatomy stood still while all else has been on the march? 当其他一切都在前进时,解剖学是否还在原地踏步?
IF 2.4 4区 医学 Q1 ANATOMY & MORPHOLOGY Pub Date : 2024-02-08 DOI: 10.1002/ca.24140
R. Shane Tubbs

The medical historian, Poyntor (1958), in his analysis of the impact of Gray's Anatomy over its first 100 years since publication in 1858, posed the following question: “Has anatomy stood still while all else has been on the march? Or is it so little regarded that the same manual which instructed our great grandfathers will serve for our sons?” What a marvelous question to raise. Although Poyntor asked this question in regard to a single textbook of anatomy, it can be extrapolated to anatomy as a whole. In this regard, application of the clinical aspects of anatomy will certainly progress our discipline forwards and keep it from “standing still.” This issue of Clinical Anatomy provides our readers with articles that use endoscopy to better visualize the basal cisterns, preoperative imaging for discerning subscapular artery anatomy for use in pedicled free flaps, and MRI analysis for knee joint cartilage change in patients with osteoarthritis. Certainly, such clinical applications of anatomy will keep it on the move.

Frederick Noël Lawrence Poynter (1908–1979) (Figure 1) was a British medical historian, librarian, and director of the Wellcome Institute for the History of Medicine. His influence in the field of medical history is exemplified by the Poynter lecture, named in his honor. He was president of the Bristol Medico-Historical Society and the International Academy of the History of Medicine. Bynum (1980) said, “He possessed a remarkable mixture of scholarly, editorial, and administrative skills which are rarely combined in a single individual.”

医学史学家 Poyntor(1958 年)在分析《格雷氏解剖学》自 1858 年出版以来的 100 年间所产生的影响时,提出了以下问题:"当其他一切都在前进时,解剖学是否停滞不前?或者说,它是如此不受重视,以至于指导我们曾祖父的同一本手册将为我们的儿子服务?这个问题提得真妙。虽然波因托尔是针对一本解剖学教科书提出这个问题的,但它可以推而广之,适用于整个解剖学。在这方面,解剖学的临床应用必将推动我们的学科向前发展,使其不再 "原地踏步"。本期《临床解剖学》为我们的读者提供了以下文章:利用内窥镜更好地观察基底蝶窦、术前成像辨别肩胛下动脉解剖以用于带蒂游离皮瓣,以及核磁共振成像分析骨关节炎患者膝关节软骨的变化。弗雷德里克-诺埃尔-劳伦斯-波因特(Frederick Noël Lawrence Poynter,1908-1979 年)(图 1)是英国医学史学家、图书馆馆长和威康医学史研究所所长。以他的名字命名的 "波因特讲座 "充分体现了他在医学史领域的影响力。他曾任布里斯托尔医学史学会和国际医学史学会主席。拜纳姆(Bynum,1980 年)说:"他拥有卓越的学术、编辑和管理技能,这些技能很少能在一个人身上集于一身"。
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引用次数: 0
Are YouTube videos about skull bone anatomy useful for students? YouTube 上关于头骨解剖的视频对学生有用吗?
IF 2.4 4区 医学 Q1 ANATOMY & MORPHOLOGY Pub Date : 2024-02-03 DOI: 10.1002/ca.24138
Songul Cuglan, Selin Gas

The aim of this study was to evaluate the content, quality, and functionality of YouTube videos on the anatomy of skull bones and to measure their educational usefulness. In this cross-sectional study, the keywords “skull bones” and “skull anatomy” were searched in the YouTube search tab. Demographic data such as type, source, duration, upload date, and view rates of the videos were recorded. The quality and content of the videos were measured using the total content score (TCS), modified DISCERN scale, JAMA score, and Global Quality Scale (GQS). SPSS 26.0 software was used for statistical analysis. Twenty-five (34.7%) of the first 72 videos found by keyword searches were included in the study. According to the GQS criteria, six of them (24%) were considered useful and 19 (76%) not useful. There was a strong statistically significant correlation between the GQS and DISCERN scores (r = 0.813, p < 0.001). There were strong statistically significant positive correlations between TCS and GQS scores (r = 0.887, p < 0.001) and between TCS and modified DISCERN scores (r = 0.691, p < 0.001). Additionally, there was a moderately strong statistically significant positive correlation between GQS and JAMA scores (r = 0.507, p < 0.05). There were also moderately strong statistically significant correlations between JAMA score and DISCERN score (r = 0.521, p < 0.001), video length (r = 0.416, p < 0.05), number of comments (r = 0.457, p < 0.05), and number of “likes” (r = 0.608, p < 0.001). There was a moderately strong statistically significant positive correlation between TCS and JAMA scores (r = 0.431, p < 0.05). Most YouTube videos have insufficient information about skull bones to meet the expectations of medical and dental school curricula. Anatomists and institutions should be encouraged to prepare and present YouTube videos using assessment systems such as DISCERN, JAMA, GQS, and TCS, in line with current anatomy curricula.

本研究旨在评估YouTube上有关头颅骨解剖的视频的内容、质量和功能,并衡量其教育实用性。在这项横向研究中,我们在 YouTube 搜索标签中搜索了关键词 "颅骨 "和 "颅骨解剖"。记录了视频的类型、来源、持续时间、上传日期和观看率等人口统计学数据。视频的质量和内容采用内容总分(TCS)、修改后的 DISCERN 量表、JAMA 量表和全球质量量表(GQS)进行衡量。统计分析采用 SPSS 26.0 软件。在通过关键词搜索找到的前 72 个视频中,有 25 个(34.7%)被纳入研究范围。根据 GQS 标准,其中 6 个(24%)被认为有用,19 个(76%)被认为无用。GQS 和 DISCERN 分数之间存在统计学意义上的显著相关性(r = 0.813,p < 0.001)。TCS 和 GQS 分数之间(r = 0.887,p <0.001)以及 TCS 和修改后的 DISCERN 分数之间(r = 0.691,p <0.001)存在统计学意义上的强正相关。此外,GQS 和 JAMA 分数之间存在中度统计学意义的正相关(r = 0.507,p < 0.05)。JAMA 分数与 DISCERN 分数(r = 0.521,p < 0.001)、视频长度(r = 0.416,p < 0.05)、评论数量(r = 0.457,p < 0.05)和 "喜欢 "数量(r = 0.608,p < 0.001)之间也存在中等强度的统计意义上的相关性。TCS 和 JAMA 分数之间存在中度统计学意义的正相关(r = 0.431,p < 0.05)。大多数 YouTube 视频中有关头颅骨的信息不足以满足医学院和牙医学院课程的要求。应鼓励解剖学家和机构根据当前的解剖课程,使用 DISCERN、JAMA、GQS 和 TCS 等评估系统准备和展示 YouTube 视频。
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引用次数: 0
History of the hip joint pectineofoveal fold 髋关节pectineofoveal皱褶的历史。
IF 2.3 4区 医学 Q1 ANATOMY & MORPHOLOGY Pub Date : 2024-02-02 DOI: 10.1002/ca.24139
M. O. St-Pierre, S. Sobczak, R. Olry

Although Josias Weitbrecht described the retinacula of the hip joint in his 1742 Syndesmologia, the anatomist Cesare Amantini of Perugia specifically studied the medial retinacula he referred to as the pectineofoveal fold in a late 19th-century monograph. This particular synovial fold stretches from the lesser trochanter to the osteocartilaginous junction of the femoral head along a virtual line connecting the lesser trochanter and the fovea for the ligament of the head. Although mentioned by some anatomists and radiologists, and despite its possible involvement in specific hip joint pathologies (fractures, impingements), it is surprising that Amantini's pectineofoveal fold remains ignored by most anatomy and clinical anatomy books. This study aims to verify if Cesare Amantini effectively drew attention to this synovial fold for the first time and coined the term “pectineofoveal fold,” as well as determine whether most classical textbooks (i.e., published from 1890 to 2017) acknowledge the discovery and include it in the description of the hip joint. A possible evolutionary link between this synovial fold and the ambiens and pectineus muscles exists and should be discussed.

尽管约西亚斯-魏特布莱希特(Josias Weitbrecht)在其 1742 年的《综合解剖学》中描述了髋关节的网膜,但佩鲁贾的解剖学家切萨雷-阿曼提尼(Cesare Amantini)在 19 世纪晚期的一本专著中专门研究了他称为 "pectineofoveal fold "的内侧网膜。这种特殊的滑膜褶皱从股骨小转子一直延伸到股骨头的骨软骨交界处,沿着一条虚拟线连接股骨小转子和股骨头韧带窝。尽管一些解剖学家和放射科医生提到过,尽管它可能与特定的髋关节病变(骨折、撞击)有关,但令人惊讶的是,大多数解剖学和临床解剖学书籍仍然忽视了 Amantini 的栉状窝褶。本研究旨在验证切萨雷-阿芒蒂尼是否首次有效地引起了人们对这一滑膜褶皱的关注,并创造了 "pectineofoveal fold "这一术语,同时确定大多数经典教科书(即 1890 年至 2017 年出版的教科书)是否承认这一发现,并将其纳入髋关节的描述中。这种滑膜褶皱与ambiens肌和pectineus肌之间可能存在进化上的联系,应该加以讨论。
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引用次数: 0
The anatomical pattern of ductal arborization in parotid glands using cone-beam computerized sialography 利用锥形束计算机腮腺造影术观察腮腺导管轴化的解剖模式。
IF 2.3 4区 医学 Q1 ANATOMY & MORPHOLOGY Pub Date : 2024-01-25 DOI: 10.1002/ca.24136
Tevel Amiel, Oren Shauly, Ella Gilenson Istoyler, Michael Alterman, Naama Keshet, Sigal Mazor, Anna Pikovsky, Doron J. Aframian, Leo Joskowicz, Chen Nadler

Cone-Beam Computed Tomography-Sialography (Sialo-CBCT) is used to demonstrate salivary ductal structure. This study aimed to conduct a volumetric analysis of the anatomical morphology of Normal-Appearing Glands (NAGs) in parotid sialo-CBCT. Our retrospective study included 14 parotid sialo-CBCT scans interpreted as NAGs in 11 patients with salivary gland impairment. The main duct length and width, as well as number and width of secondary and tertiary ducts were manually evaluated. We found that the main parotid duct showed an average width of 1.39 mm, 1.15 mm, and 0.98 mm, for the proximal, middle and distal thirds, respectively. The arborization pattern showed approximately 20% more tertiary (average number 11.1 ± 2.7) than secondary ducts (average number 9.0 ± 2.4) and approximately 8% narrower tertiary ducts (average width 0.65 ± 0.11 mm) compared to the secondary ducts (average width 0.77 ± 0.14 mm). Our anatomical analysis of NAGs in parotid sialo-CBCT demonstrated progressive narrowing of the main duct and increasing arborization and decreasing lumen size starting from the primary to the tertiary ducts. This is the most updated study regarding the anatomy of the parotid glands as demonstrated in sialo-CBCT. Our results may provide clinicians with the basic information for understanding aberration from normal morphology, as seen in salivary gland pathologies as well facilitate planning of treatment strategies, such as minimally invasive sialo-endoscopies, commonly practiced today.

锥形束计算机断层扫描(Sialo-CBCT)用于显示唾液腺导管结构。本研究旨在对腮腺锥形束计算机断层扫描(Sialo-CBCT)中正常外观腺体(NAG)的解剖形态进行容积分析。我们的回顾性研究纳入了 11 名唾液腺功能受损患者的 14 个腮腺ialo-CBCT 扫描结果,这些扫描结果被解释为 NAG。人工评估了主导管的长度和宽度,以及二级和三级导管的数量和宽度。我们发现,腮腺主导管近端、中间和远端三分之二的平均宽度分别为 1.39 毫米、1.15 毫米和 0.98 毫米。从树枝化模式来看,三级导管(平均数量为 11.1 ± 2.7)比二级导管(平均数量为 9.0 ± 2.4)多约 20%,三级导管(平均宽度为 0.65 ± 0.11 毫米)比二级导管(平均宽度为 0.77 ± 0.14 毫米)窄约 8%。我们对腮腺霰粒肿的解剖分析表明,主导管逐渐变窄,从一级导管到三级导管的树枝化程度越来越高,管腔尺寸越来越小。这是在虹膜计算机断层扫描(sialo-CBCT)中显示的腮腺解剖结构方面最新的研究。我们的研究结果可为临床医生提供基本信息,帮助他们了解唾液腺病变中出现的正常形态异常,并有助于制定治疗策略,如目前普遍采用的微创咽内窥镜手术。
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引用次数: 0
Revisiting the Latin vocabulary of Terminologia Histologica: I. Nouns 重温《组织学术语》的拉丁语词汇:I. 名词。
IF 2.4 4区 医学 Q1 ANATOMY & MORPHOLOGY Pub Date : 2024-01-22 DOI: 10.1002/ca.24137
Paul E. Neumann, Mélanie Houle, Stephen Russell, Lewis Stiles, Nicolás E. Ottone, Mariano del Sol

Almost 20% of the Latin nouns (193/993) in Terminologia Histologica (TH), the international standard nomenclature for human histology and cytology, display linguistic problems, particularly in the areas of orthography, gender, and declension. Some anatomists have opposed efforts to restore the quality of the Latin nomenclature as pedantry, preferring to create or modify Latin words so that they resemble words in English and other modern languages. A Latin microanatomical nomenclature is vulnerable to the criticism of anachronism, so the requirement for the use of authentic Latin, including derivation of new words from Greek and Latin words rather than from modern languages, if possible, may be even greater than it is for the anatomical nomenclature. The most common problem identified here appears to have been caused by derivation of Latin nouns by addition of -us and -um second declension endings to English words. Many Latin nouns (128) in TH contain one of six morphemes that have been treated this way even though the original Greek words are either first declension masculine or third declension neuter nouns. Ironically, deriving Latin nouns directly from Greek morphemes often results in words that look more familiar to speakers of Romance and Germanic languages than those derived indirectly through modern languages (e.g., astrocyte, collagene, dendrita, lipochroma, osteoclasta and telomere instead of astrocytus, collagenum, dendritum, lipochromum, osteoclastus, and telomerus).

人类组织学和细胞学的国际标准命名法--《组织学术语》(Terminologia Histologica,TH)中近 20% 的拉丁名词(193/993)存在语言问题,尤其是在正字法、性别和去声方面。一些解剖学家反对恢复拉丁命名法质量的努力,认为这是迂腐的做法,他们更愿意创造或修改拉丁词,使其与英语和其他现代语言中的词相似。拉丁文微型解剖命名法很容易受到不合时宜的批评,因此对使用正宗拉丁文的要求可能比解剖命名法更高,包括尽可能从希腊文和拉丁文中而不是从现代语言中引申出新词。在此发现的最常见问题似乎是在英语词汇中加入-us 和-um 二级词尾而衍生出拉丁名词。在 TH 中,许多拉丁名词(128 个)都包含这样处理的六个词素中的一个,尽管原始希腊语单词要么是第一顺位的阳性名词,要么是第三顺位的中性名词。具有讽刺意味的是,直接从希腊语词素派生拉丁语名词的结果往往是,对于讲罗曼语和日耳曼语的人来说,这些词比通过现代语言间接派生的词更熟悉(例如,astrocyte、collagene、dendrita、lipochroma、osteoclasta 和 telomere,而不是 astrocytus、collagenum、dendritum、lipochromum、osteoclastus 和 telomerus)。
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引用次数: 0
Trabeculations of the porcine and human cardiac ventricles are different in number but similar in total volume 猪和人心室的小梁数量不同,但总体积相似。
IF 2.4 4区 医学 Q1 ANATOMY & MORPHOLOGY Pub Date : 2024-01-13 DOI: 10.1002/ca.24135
Bjarke Jensen, Daniela Salvatori, Jacobine Schouten, Veronique M. F. Meijborg, Henrik Lauridsen, Peter Agger

An intricate meshwork of trabeculations lines the luminal side of cardiac ventricles. Compaction, a developmental process, is thought to reduce trabeculations by adding them to the neighboring compact wall which is then enlarged. When pig, a plausible cardiac donor for xenotransplantation, is compared to human, the ventricular walls appear to have fewer trabeculations. We hypothesized the trabecular volume is proportionally smaller in pig than in human. Macroscopically, we observed in 16 pig hearts that the ventricular walls harbor few but large trabeculations. Close inspection revealed a high number of tiny trabeculations, a few hundred, within the recesses of the large trabeculations. While tiny, these were still larger than embryonic trabeculations and even when considering their number, the total tally of trabeculations in pig was much fewer than in human. Volumetrics based on high-resolution MRI of additional six pig hearts compared to six human hearts, revealed the left ventricles were not significantly differently trabeculated (21.5 versus 22.8%, respectively), and the porcine right ventricles were only slightly less trabeculated (42.1 vs 49.3%, respectively). We then analyzed volumetrically 10 pig embryonic hearts from gestational day 14–35. The trabecular and compact layer always grew, as did the intertrabecular recesses, in contrast to what compaction predicts. The proportions of the trabecular and compact layers changed substantially, nonetheless, due to differences in their growth rate rather than compaction. In conclusion, processes that affect the trabecular morphology do not necessarily affect the proportion of trabecular-to-compact myocardium and they are then distinct from compaction.

心室管腔内有错综复杂的网状小梁。压实是一种发育过程,它被认为是通过将小梁添加到邻近的致密壁来减少小梁,从而使致密壁增大。猪是异种移植的理想心脏供体,与人相比,猪心室壁上的小梁更少。我们假设猪的小梁体积比人的小。从宏观上看,我们在 16 颗猪心中观察到,心室壁上的小梁数量少但体积大。仔细观察发现,在大的小梁凹陷处有大量微小的小梁,有几百个。这些小梁虽然很小,但仍然比胚胎小梁大,即使考虑到它们的数量,猪的小梁总数也比人少得多。根据高分辨率核磁共振成像对另外六颗猪心和六颗人心进行的容积测量显示,猪左心室的小梁差异不大(分别为 21.5% 和 22.8%),猪右心室的小梁也略少(分别为 42.1% 和 49.3%)。然后,我们对孕 14-35 天的 10 个猪胚胎心脏进行了容积分析。小梁层和致密层始终在生长,小梁间凹陷也在生长,这与压实所预测的情况相反。尽管如此,小梁层和致密层的比例还是发生了很大变化,这是因为它们的生长速度不同,而不是因为压实。总之,影响小梁形态的过程并不一定会影响小梁与致密心肌的比例,因此它们与压实是不同的。
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Clinical Anatomy
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