Fengyan Li, Xinhui Zhou, Wendie Hu, Yujie Du, Jia-yuan Sun, Yaxue Wang
Aim: Our research aimed to determine an optimal cutoff value and investigate the prognostic predictive function of Ki-67. Materials & methods: We retrospectively enrolled 1146 patients diagnosed with stage I–II triple-negative breast cancer. Disease-free and overall survival were analyzed using the Kaplan–Meier method and the Cox regression model. Results: We classified Ki-67 >45% as the high group (n = 716). A Ki-67 level of >45% was associated with poorer disease-free survival (p = 0.039) and overall survival (p = 0.029). Lymph node stage, neoadjuvant chemotherapy, and radiotherapy were independent predictive variables of prognosis. Conclusion: Triple-negative breast cancer may be further subcategorized according to the Ki-67 level. Neoadjuvant chemotherapy and postoperative radiotherapy can improve the prognosis of early triple-negative breast cancer.
{"title":"Prognostic predictive value of Ki-67 in stage I–II triple-negative breast cancer","authors":"Fengyan Li, Xinhui Zhou, Wendie Hu, Yujie Du, Jia-yuan Sun, Yaxue Wang","doi":"10.2144/fsoa-2023-0129","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0129","url":null,"abstract":"Aim: Our research aimed to determine an optimal cutoff value and investigate the prognostic predictive function of Ki-67. Materials & methods: We retrospectively enrolled 1146 patients diagnosed with stage I–II triple-negative breast cancer. Disease-free and overall survival were analyzed using the Kaplan–Meier method and the Cox regression model. Results: We classified Ki-67 >45% as the high group (n = 716). A Ki-67 level of >45% was associated with poorer disease-free survival (p = 0.039) and overall survival (p = 0.029). Lymph node stage, neoadjuvant chemotherapy, and radiotherapy were independent predictive variables of prognosis. Conclusion: Triple-negative breast cancer may be further subcategorized according to the Ki-67 level. Neoadjuvant chemotherapy and postoperative radiotherapy can improve the prognosis of early triple-negative breast cancer.","PeriodicalId":507258,"journal":{"name":"Future Science OA","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139242691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmad Al-Azayzih, Walid Al-Qerem, Z. Kharaba, Lara Albiss, Abdullah Alawneh, Dima Abu-Dalhoum, Laith Yousef, Mohammad Al-Amreen, Zeina Abedrabbo
Aim: We aimed in this study to assess the potential environmental and personal barriers encountered in the community pharmacies in Jordan. Methods: A validated self-administered survey was distributed online to 721 participants from all regions in Jordan. Results: All approached participants (721 subjects) answered the survey. The most common environmental and personal barriers reported were that community pharmacies were not disabled patients friendly (59.4%) and pharmacist's low self-confidence (80.4%), respectively. Socioeconomic characteristics such as being male, married, receiving lower income and having higher educational degrees, were associated with an increase in reported personal communication barriers. Conclusion: Our study indicated that environmental and personal barriers are prevalent in the community pharmacy practice, which could impact the quality of pharmaceutical services provided.
{"title":"Environmental and personal barriers encountered in community pharmacy settings based on public opinions","authors":"Ahmad Al-Azayzih, Walid Al-Qerem, Z. Kharaba, Lara Albiss, Abdullah Alawneh, Dima Abu-Dalhoum, Laith Yousef, Mohammad Al-Amreen, Zeina Abedrabbo","doi":"10.2144/fsoa-2023-0166","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0166","url":null,"abstract":"Aim: We aimed in this study to assess the potential environmental and personal barriers encountered in the community pharmacies in Jordan. Methods: A validated self-administered survey was distributed online to 721 participants from all regions in Jordan. Results: All approached participants (721 subjects) answered the survey. The most common environmental and personal barriers reported were that community pharmacies were not disabled patients friendly (59.4%) and pharmacist's low self-confidence (80.4%), respectively. Socioeconomic characteristics such as being male, married, receiving lower income and having higher educational degrees, were associated with an increase in reported personal communication barriers. Conclusion: Our study indicated that environmental and personal barriers are prevalent in the community pharmacy practice, which could impact the quality of pharmaceutical services provided.","PeriodicalId":507258,"journal":{"name":"Future Science OA","volume":"40 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139245951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Weixing Liu, Yue Liu, Pei Li, Jia Chen, Jiamin Liu, Zhi Shi, Hui Liu, Jin Ye
Aim: Current head and neck squamous cell carcinoma (HNSCC) diagnostic tools are limited, so this study aimed to identify diagnostic microRNA (miRNA) biomarkers from plasma. Materials & methods: A total of 76 HNSCC and 76 noncancerous control (NC) plasma samples underwent microarray analysis and quantitative reverse transcription PCR to screen for diagnostic plasma miRNAs. The diagnostic potential of the miRNAs was evaluated by the receiver operating characteristic curve. Results: miR-95-3p and miR-579-5p expression was shown to be significantly upregulated, and that of miR-1298-3p to be downregulated in HNSCC patients compared with controls. The final diagnostic panel included miR-95-3p, miR-579-5p and miR-1298-3p with an area under the curve of 0.83. Conclusion: This three-miRNA panel has potential for the diagnosis of HNSCC.
{"title":"Identification of candidate plasma miRNA biomarkers for the diagnosis of head and neck squamous cell carcinoma","authors":"Weixing Liu, Yue Liu, Pei Li, Jia Chen, Jiamin Liu, Zhi Shi, Hui Liu, Jin Ye","doi":"10.2144/fsoa-2023-0189","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0189","url":null,"abstract":"Aim: Current head and neck squamous cell carcinoma (HNSCC) diagnostic tools are limited, so this study aimed to identify diagnostic microRNA (miRNA) biomarkers from plasma. Materials & methods: A total of 76 HNSCC and 76 noncancerous control (NC) plasma samples underwent microarray analysis and quantitative reverse transcription PCR to screen for diagnostic plasma miRNAs. The diagnostic potential of the miRNAs was evaluated by the receiver operating characteristic curve. Results: miR-95-3p and miR-579-5p expression was shown to be significantly upregulated, and that of miR-1298-3p to be downregulated in HNSCC patients compared with controls. The final diagnostic panel included miR-95-3p, miR-579-5p and miR-1298-3p with an area under the curve of 0.83. Conclusion: This three-miRNA panel has potential for the diagnosis of HNSCC.","PeriodicalId":507258,"journal":{"name":"Future Science OA","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139250000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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